Acute graft pyelonephritis and long-term kidney allograft outcome.

abstract：:Osteocytes within the mineralized bone matrix control bone remodeling by regulating osteoblast and osteoclast activity. Osteocytes express the aging suppressor Klotho, but the functional role of this protein in skeletal homeostasis is unknown. Here we identify Klotho expression in osteocytes as a potent regulator of b...

journal_title：Kidney international

authors： Komaba H,Kaludjerovic J,Hu DZ,Nagano K,Amano K,Ide N,Sato T,Densmore MJ,Hanai JI,Olauson H,Bellido T,Larsson TE,Baron R,Lanske B

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:While the most common glomerular lesion associated with human immunodeficiency virus (HIV) infection is collapsing focal segmental glomerulosclerosis (FSGS) [HIV-associated nephropathy (HIVAN)], immune complex-mediated forms of glomerulonephritis have been increasingly reported. One form of glomerulonephriti...

journal_title：Kidney international

authors： Haas M,Kaul S,Eustace JA

更新日期：2005-04-01 00:00:00

abstract：:Measures related to red cell oxygen transport were evaluated in 17 hemodialysis patients receiving androgen therapy, 15 untreated hemodialysis patients and 15 normal subjects. Hemoglobin levels were higher in androgen-treated patients than in the untreated population and were directly related to the reticulocyte index...

journal_title：Kidney international

authors： Hendler ED,Solomon L

更新日期：1987-01-01 00:00:00

abstract：:This study examined the consequences of nephrectomy in United States Army personnel who lost a kidney due to trauma during World War II (WWII). Records of 62 servicemen who underwent nephrectomy at an average age of 25 years were obtained. Mortality was compared with that of WWII servicemen of the same age. Medical re...

journal_title：Kidney international

authors： Narkun-Burgess DM,Nolan CR,Norman JE,Page WF,Miller PL,Meyer TW

更新日期：1993-05-01 00:00:00

abstract：:Recent reports indicate a decreased mortality risk for patients on chronic peritoneal dialysis in the United States. We sought to determine whether a higher use of automated versus continuous ambulatory peritoneal dialysis was associated with this improvement. Analyses were carried out using data from the United State...

journal_title：Kidney international

authors： Mehrotra R,Chiu YW,Kalantar-Zadeh K,Vonesh E

更新日期：2009-07-01 00:00:00

abstract：:Proliferation of mesangial cells is frequently found in glomerulonephritis, such as IgA glomerulonephritis. Recent reports suggest that a brain/embryo-type myosin isoform (MIIB2) is involved in cell proliferation. We have studied the expression of MIIB2 in renal biopsy samples from patients with various renal diseases...

journal_title：Kidney international

authors： Kishino M,Kimura A,Yamaguchi K,Ohtani H,Yamada Y,Takahashi T,Mune M,Mimura K,Maeda T,Matsumura S,Tsuji T,Yukawa S

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Tubulointerstitial inflammation and fibrosis are pathologic hallmarks of end-stage renal disease (ESRD). Here we have used DNA microarray technology to monitor the transcriptomic responses to murine unilateral ureteral obstruction (UUO) with a view to identifying molecular modulators of tubulointerstitial fi...

journal_title：Kidney international

authors： Higgins DF,Lappin DW,Kieran NE,Anders HJ,Watson RW,Strutz F,Schlondorff D,Haase VH,Fitzpatrick JM,Godson C,Brady HR

更新日期：2003-12-01 00:00:00

abstract：:Defective cholesterol metabolism primarily linked to reduced ATP-binding cassette transporter A1 (ABCA1) expression is closely associated with the pathogenesis and progression of kidney diseases, including diabetic kidney disease and Alport Syndrome. However, whether the accumulation of free or esterified cholesterol ...

journal_title：Kidney international

authors： Liu X,Ducasa GM,Mallela SK,Kim JJ,Molina J,Mitrofanova A,Wilbon SS,Ge M,Fontanella A,Pedigo C,Santos JV,Nelson RG,Drexler Y,Contreras G,Al-Ali H,Merscher S,Fornoni A

更新日期：2020-11-01 00:00:00

abstract：:Incretin-based drugs, i.e., glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors, are widely used for the treatment of type 2 diabetes. In addition to the primary role of incretins in stimulating insulin secretion from pancreatic β-cells, they have extra pancreatic functions ...

journal_title：Kidney international

authors： Tanaka T,Higashijima Y,Wada T,Nangaku M

更新日期：2014-10-01 00:00:00

abstract：:The homocysteine hypothesis states that circulating homocysteine is a vascular toxin in concentrations that occur in the general population and in renal failure. This hypothesis is currently being tested in the Kidney and End State Renal Disease Study (HOST), but data have emerged since the HOST began that suggest its...

journal_title：Kidney international

authors： Hoffer LJ

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Proteomic techniques have recently become available for large-scale protein analysis. The utility of these techniques in identification of urinary proteins is poorly defined. We constructed a proteome map of normal human urine as a reference protein database by using two differential fractionated techniques ...

journal_title：Kidney international

authors： Thongboonkerd V,McLeish KR,Arthur JM,Klein JB

更新日期：2002-10-01 00:00:00

abstract：:Thrombomodulin (TM), an endothelial receptor for thrombin, endowed with a powerful anticoagulant activity, plays an important role in the antithrombogenicity of the vascular endothelium. Its presence within the human renal glomerulus is already known but was thought to be only endothelial. We looked for TM expression ...

journal_title：Kidney international

authors： Pruna A,Peyri N,Berard M,Boffa MC

更新日期：1997-03-01 00:00:00

abstract：:From August 1987 through February 1995 we performed 42 surgical procedures in 29 patients with occluded or stenotic radiocephalic arteriovenous fistulae. Operations were designed to preserve native veins for cannulation (Group I) or to preserve access in the same forearm, bypassing the failed fistula (Group II). For 2...

journal_title：Kidney international

authors： Oakes DD,Sherck JP,Cobb LF

更新日期：1998-02-01 00:00:00

abstract：:Autophagy is upregulated during ischemia-reperfusion (IR)-induced and cisplatin-induced acute kidney injury (AKI). Proximal tubule-specific Atg7 knockout mice exhibited increased renal injury compared with wild-type mice following cisplatin- and IR-induced AKI. Inhibition of autophagy by chloroquine aggravated AKI, wh...

journal_title：Kidney international

authors： Kaushal GP

更新日期：2012-12-01 00:00:00

abstract：:Monocyte chemoattractant protein 1 (MCP-1) is a C-C chemokine with potent monocyte chemotactic and activating properties that may contribute to glomerular macrophage infiltration in anti-GBM Ab GN. We have previously reported increased glomerular steady state expression of MCP-1 mRNA relative to GAPDH mRNA in the hete...

journal_title：Kidney international

authors： Tang WW,Qi M,Warren JS

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:The benefit of the potent chemotherapeutic agent cisplatin in treating neoplasms is limited by nephrotoxicity. We tested the hypothesis that CD54 [intercellular adhesion molecule-1 (ICAM-1)] is an important mediator in cisplatin-mediated renal failure. METHODS:The effect of a monoclonal anti-CD54 antibody w...

journal_title：Kidney international

authors： Kelly KJ,Meehan SM,Colvin RB,Williams WW,Bonventre JV

更新日期：1999-09-01 00:00:00

abstract：:The treatment of hyperphosphatemia remains challenging in patients receiving hemodialysis. This Phase 1b study assessed safety and efficacy of EOS789, a novel pan-inhibitor of phosphate transport (NaPi-2b, PiT-1, PiT-2) on intestinal phosphate absorption in patients receiving intermittent hemodialysis therapy. Two cro...

journal_title：Kidney international

authors： Hill Gallant KM,Stremke ER,Trevino L,Moorthi RN,Doshi S,Wastney ME,Hisada N,Sato J,Ogita Y,Fujii N,Matsuda Y,Kake T,Moe SM

更新日期：2020-10-30 00:00:00

abstract：BACKGROUND:Although peritoneal dialysis (PD) is a widely accepted form of renal replacement therapy (RRT), concerns remain regarding the bioincompatible nature of standard PD fluid. In order to evaluate whether a newly formulated fluid of neutral pH, and containing low levels of glucose degradation products (GDP), resu...

journal_title：Kidney international

authors： Williams JD,Topley N,Craig KJ,Mackenzie RK,Pischetsrieder M,Lage C,Passlick-Deetjen J,Euro Balance Trial Group.

更新日期：2004-07-01 00:00:00

abstract：:Effect of insulin-like growth factor-1 (IGF) on the synthesis of glomerular proteoglycans (PGs) in an ex vivo recirculating organ perfusion system was investigated. Kidneys were perfused with a medium (approximately 80 ml) containing [35S]-sulfate (250 microCi/ml) and IGF (62.5 to 625 ng/ml). After radiolabeling, a sm...

journal_title：Kidney international

authors： Watanabe Y,Kashihara N,Makino H,Kanwar YS

更新日期：1992-05-01 00:00:00

abstract：:Serum calcitriol and the free calcitriol index together with factors considered to regulate calcitriol production were measured in eleven patients with moderate chronic renal failure (MCRF) and eleven age- and sex-matched normal subjects. Although the serum dialysable calcium levels were similar in the two groups, the...

journal_title：Kidney international

authors： Prince RL,Hutchison BG,Kent JC,Kent GN,Retallack RW

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Aquaporin-2 (AQP-2) proteins are mainly expressed at the apical region of the collecting duct cells. We previously reported three different mutations in the C-terminus of AQP-2 that all-cause autosomal-dominant nephrogenic diabetes insipidus. When one of these mutant AQP-2s was expressed in Madin-Darby canin...

journal_title：Kidney international

authors： Kuwahara M,Asai T,Terada Y,Sasaki S

更新日期：2005-11-01 00:00:00

abstract：:Chronic inflammation is a complication of conventional hemodialysis that induces progressive cardiovascular damage. An apparently straightforward manipulation to treat this-removal of a large amount of uremic toxins by convection-has proven that the relationships between inflammation and convective techniques such as ...

journal_title：Kidney international

authors： Santoro A,Mancini E

更新日期：2014-08-01 00:00:00

abstract：:The presence of nitric oxide (NO) in the kidney has been implicated in the pathogenesis of human glomerulonephritis. However, the exact type of glomerular cells that express NO synthase (NOS) and the NOS isoform involved in the local production of NO has not been identified in the human diseased kidney. We examined th...

journal_title：Kidney international

authors： Furusu A,Miyazaki M,Abe K,Tsukasaki S,Shioshita K,Sasaki O,Miyazaki K,Ozono Y,Koji T,Harada T,Sakai H,Kohno S

更新日期：1998-06-01 00:00:00

abstract：:Erythropoietin (Epo) is essential for erythropoiesis and is mainly produced by the fetal liver and the adult kidney following hypoxic stimulation. Epo regulation is commonly studied in hepatoma cell lines, but differences in Epo regulation between kidney and liver limit the understanding of Epo dysregulation in polycy...

journal_title：Kidney international

authors： Imeri F,Nolan KA,Bapst AM,Santambrogio S,Abreu-Rodríguez I,Spielmann P,Pfundstein S,Libertini S,Crowther L,Orlando IMC,Dahl SL,Keodara A,Kuo W,Kurtcuoglu V,Scholz CC,Qi W,Hummler E,Hoogewijs D,Wenger RH

更新日期：2019-02-01 00:00:00

abstract：:The role of immunoglobulin (Ig) Fc-macrophage cell surface receptor affinity (macrophage Fc-affinity) in determining the mediation systems responsible for immune glomerular injury has been studied. Glomerular injury was initiated in rabbits by the passive administration of immunoglobulin preparations directed against ...

journal_title：Kidney international

authors： Boyce NW,Holdsworth SR

更新日期：1989-10-01 00:00:00

abstract：:Fixed anionic sites within the glomerular capillary wall influence the permeation of serum proteins, the localization of various antigens, and the deposition of antibody in the subepithelial space. In anti-GBM nephritis antibody deposition occurs very rapidly to antigenic sites located relatively proximal in the glome...

journal_title：Kidney international

authors： Madaio MP,Salant DJ,Adler S,Darby C,Couser WG

更新日期：1984-10-01 00:00:00

abstract：:Major temporal changes in the case mix of patients accepted for renal replacement therapy impede analysis of long-term mortality trends in end-stage renal disease patients. A record linkage study of 2 large electronic hospital inpatient data sets with national mortality data used standardization by age, sex, and comor...

journal_title：Kidney international

authors： Stengel B

更新日期：2018-05-01 00:00:00

abstract：:Risk factors for disease states are rigorously defined. This analysis considers the definition of a risk factor as applied to the question of whether the serum phosphorus level is a risk factor for cardiovascular disease. Observational studies strongly suggest that phosphorus is associated with cardiovascular risk, an...

journal_title：Kidney international

authors： Hruska K,Mathew S,Lund R,Fang Y,Sugatani T

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:The genetic dissection of a polygenic, multifactorial, quantitative disease such as arterial hypertension is hampered by a large environmental variance and by genetic heterogeneity. METHODS:To reduce the environmental variance, we measured the pressor response to a saline load (PRSL) and the basal plasma re...

journal_title：Kidney international

authors： Barlassina C,Schork NJ,Manunta P,Citterio L,Sciarrone M,Lanella G,Bianchi G,Cusi D

更新日期：2000-03-01 00:00:00

abstract：:Normal urine contains thousands of proteins, largely due to the presence of 'exosomes,' tiny vesicles secreted into the urine by renal epithelial cells. These exosomes, demonstrated by Keller and colleagues to be also retrievable from amniotic fluid, offer great promise for future disease biomarker discovery studies. ...

journal_title：Kidney international

authors： Knepper MA,Pisitkun T

更新日期：2007-11-01 00:00:00