Macrophage-Fc-receptor affinity: role in cellular mediation of antibody initiated glomerulonephritis.

abstract：BACKGROUND:The superiority of renin-angiotensin system (RAS) blockade in providing renoprotection has been attributed to class-specific blood pressure "(BP)-independent" mechanisms. However, the conventional BP measurement methodology on which such conclusions are based is inherently limited for an accurate assessment ...

journal_title：Kidney international

authors： Bidani AK,Griffin KA,Bakris G,Picken MM

更新日期：2000-04-01 00:00:00

abstract：:Neutrophil (PMN) recruitment into the peritoneum during acute bacterial peritonitis is an important part of the host defense barrier in CAPD patients. However, the subsequent phagocytosis of bacteria may also lead to PMN degranulation and the release of lysosomal enzymes. We determined the concentration of neutrophil ...

journal_title：Kidney international

authors： Donovan KL,Pacholok S,Humes JL,Coles GA,Williams JD

更新日期：1993-07-01 00:00:00

abstract：:Experiments in rodents have demonstrated an important role for selectins in kidney ischemia-reperfusion injury (IRI). However, the relevance of this in larger mammals, as well as the impact on long-term structure and function is unknown. We tested the hypothesis that small molecule selectin ligand inhibition attenuate...

journal_title：Kidney international

authors： Jayle C,Milinkevitch S,Favreau F,Doucet C,Richer JP,Deretz S,Mauco G,Rabb H,Hauet T

更新日期：2006-05-01 00:00:00

abstract：:Proximal tubular (PT) epithelial cells express MHC class II (Ia) antigens in immunologically-mediated renal injury. To study the role of PT as accessory cells, we generated several murine PT-like epithelial cell lines by transformation with origin-defective SV40 DNA. These transformed cell lines display typical alkali...

journal_title：Kidney international

authors： Wuthrich RP,Glimcher LH,Yui MA,Jevnikar AM,Dumas SE,Kelley VE

更新日期：1990-02-01 00:00:00

abstract：:Previous studies in living animals have suggested that variations in the serum concentrations of calcium and phosphate directly affect renal tubular bicarbonate transport. To examine this area more directly, we measured the bicarbonate and the fluid transport in isolated rabbit proximal convoluted and straight tubules...

journal_title：Kidney international

authors： McKinney TD,Myers P

更新日期：1982-03-01 00:00:00

abstract：:Our previous in vivo study demonstrated that methylprednisolone (MP) activates glomerular antioxidant enzymes and attenuates glomerular oxidant injuries, including those in experimental nephrosis. The present study investigates the cellular mechanism of the MP-induced activation of antioxidant enzymes and their contri...

journal_title：Kidney international

authors： Yoshioka T,Kawamura T,Meyrick BO,Beckman JK,Hoover RL,Yoshida H,Ichikawa I

更新日期：1994-01-01 00:00:00

abstract：:The present studies were undertaken to assess the effects of 5'-N-ethylcarboxamideadenosine (NECA), an adenosine analogue, on erythropoietin (Epo) production. NECA (0.05 and 0.1 mumol/kg i.v.) produced significant increases in serum Epo levels (368.8 +/- 56.1 and 384.6 +/- 45.9 mU/ml, respectively) in exhypoxic polycy...

journal_title：Kidney international

authors： Nakashima J,Ohigashi T,Brookins JW,Beckman BS,Agrawal KC,Fisher JW

更新日期：1993-10-01 00:00:00

abstract：:In contrast to other nonsteroidal anti-inflammatory drugs (NSAIDs), sulindac has been reported to inhibit systemic prostaglandins (PGs) while not affecting renal PGs. We studied 11 normal volunteers who received placebo, ibuprofen, naproxen, or sulindac in a randomized, double-blind fashion. After control periods asse...

journal_title：Kidney international

authors： Brater DC,Anderson S,Baird B,Campbell WB

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Since the cloning of the gene for autosomal dominant polycystic kidney disease type 2 (PKD2), approximately 40 different mutations of that gene have been reported to be associated with the disease. The relationship between the PKD2 genotype and phenotype, however, remains unclear. METHODS:Detailed clinical ...

journal_title：Kidney international

authors： Hateboer N,Veldhuisen B,Peters D,Breuning MH,San-Millán JL,Bogdanova N,Coto E,van Dijk MA,Afzal AR,Jeffery S,Saggar-Malik AK,Torra R,Dimitrakov D,Martinez I,de Castro SS,Krawczak M,Ravine D

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Ischemic acute renal failure (iARF) is associated with increased nitric oxide (NO) production during the reperfusion period, as endothelial nitric oxide synthase (eNOS) is maximally activated, and renal tubular inducible NOS (iNOS) is stimulated. Increased NO production leads to augmented tubular injury, pro...

journal_title：Kidney international

authors： Schwartz IF,Schwartz D,Traskonov M,Chernichovsky T,Wollman Y,Gnessin E,Topilsky I,Levo Y,Iaina A

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Carriers of autosomal-recessive and X-linked Alport syndrome often have a thinned glomerular basement membrane (GBM) and have mutations in the COL4A3/COL4A4 and COL4A5 genes respectively. Recently, we have shown that many individuals with thin basement membrane disease (TBMD) are also from families where hem...

journal_title：Kidney international

authors： Buzza M,Wang YY,Dagher H,Babon JJ,Cotton RG,Powell H,Dowling J,Savige J

更新日期：2001-08-01 00:00:00

abstract：:Macrophages are inflammatory cells with important roles in the propagation of renal injury. More recently they have also been shown to be important in the resolution of inflammation. Wang et al. show that macrophages can be modulated ex vivo by cytokine stimulation, localize to renal tissue, and slow progression of ex...

journal_title：Kidney international

authors： Kluth DC

更新日期：2007-08-01 00:00:00

abstract：:Orskov and colleagues demonstrate the impact of birth weight on the mean age of end-stage renal disease (ESRD) in a large Danish ADPKD cohort. Each kilogram of birth weight extended the mean age of ESRD onset by 1.7 years. Placental insufficiency, activation of the renin-angiotensin-aldosterone system, increased fetal...

journal_title：Kidney international

authors： Chapman AB

更新日期：2012-05-01 00:00:00

abstract：:It has been convincingly documented that reactive oxygen species released from activated neutrophils mediate glomerular damage in experimental glomerulonephritis. Recent findings that antineutrophil cytoplasmic autoantibodies (ANCA) induce neutrophils to degranulate and produce oxygen radicals in vitro led us to explo...

journal_title：Kidney international

authors： Macconi D,Zanoli AF,Orisio S,Longaretti L,Magrini L,Rota S,Radice A,Pozzi C,Remuzzi G

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:To study the molecular mechanism responsible for cadmium-induced Fanconi syndrome, an in vitro mouse model has been used. We have previously shown that exposure of primary cultures of kidney cortical cells to micromolar concentrations of cadmium inhibited uptake of the glucose analog, [14C] methyl alpha-d-gl...

journal_title：Kidney international

authors： Tabatabai NM,Blumenthal SS,Lewand DL,Petering DH

更新日期：2003-10-01 00:00:00

abstract：:Suzuki et al. analyzed a mouse model of erythropoietin-deficient anemia to show that during iron overload renal interstitial fibroblasts accumulate iron, and this impairs the hypoxia-driven transcription of the erythropoietin gene. The authors show that excess iron decreases levels of hypoxia-inducible transcription f...

journal_title：Kidney international

authors： Ganz T

更新日期：2018-11-01 00:00:00

abstract：:Because the size of renal cysts in the native kidneys of patients with ADPKD who have been transplanted was found to be reduced when rapamycin was the immunosuppressant, we tested the involvement of the mTOR pathway in cyst enlargement. Here, male pcy mice, with mutation in one of the nephronophthisis genes, were trea...

journal_title：Kidney international

authors： Gattone VH 2nd,Sinders RM,Hornberger TA,Robling AG

更新日期：2009-07-01 00:00:00

abstract：:Gap junctions are present in the juxtaglomerular apparatus enabling intercellular communication. Our study determined the location of different connexin subtypes within the juxtaglomerular apparatus of the rat, and the role of these subtypes in renal hemodynamics through the use of specific mimetic peptides. Immunohis...

journal_title：Kidney international

authors： Takenaka T,Inoue T,Kanno Y,Okada H,Meaney KR,Hill CE,Suzuki H

更新日期：2008-02-01 00:00:00

abstract：:Few studies have examined tubular function after subtotal nephrectomy (Nx) and conservative treatments. The effects of 70% and 80% Nx (associated with dietary phosphate restriction in the latter case) on the apical brush border membrane (BBM) enzymes 5'-nucleotidase, gamma glutamyl-transferase and alkaline-phosphatase...

journal_title：Kidney international

authors： Laouari D,Friedlander G,Burtin M,Silve C,Dechaux M,Garabedian M,Kleinknecht C

更新日期：1997-12-01 00:00:00

abstract：:The safety of dietary protein and phosphorous restriction was evaluated in the Modification of Diet in Renal Disease (MDRD) Study. In Study A, 585 patients with a glomerular filtration rate (GFR) of 25 to 55 ml/min/1.73 m2 were randomly assigned to a usual-protein diet (1.3 g/kg/day) or a low-protein diet (0.58 g/kg/d...

journal_title：Kidney international

authors： Kopple JD,Levey AS,Greene T,Chumlea WC,Gassman JJ,Hollinger DL,Maroni BJ,Merrill D,Scherch LK,Schulman G,Wang SR,Zimmer GS

更新日期：1997-09-01 00:00:00

abstract：:Ischemia-reperfusion injury is an important cause of graft failure. Because carnitine regulates substrate flux and energy balance across membranes which may be deranged in ischemia we determined whether its use was effective in preventing kidney injury in an allogeneic transplant model. Brown Norway rats received a Le...

journal_title：Kidney international

authors： Azzollini N,Cugini D,Cassis P,Pezzotta A,Gagliardini E,Abbate M,Arduini A,Peschechera A,Remuzzi G,Noris M

更新日期：2008-12-01 00:00:00

abstract：:The relationship of protein intake to urinary oxalate and glycolate excretion was examined in a large cohort (N = 101) of normal individuals on self-selected diets and in 11 individuals on controlled protein diets. On self-selected diets no correlation was detected between protein intake and urinary oxalate or glycola...

journal_title：Kidney international

authors： Holmes RP,Goodman HO,Hart LJ,Assimos DG

更新日期：1993-08-01 00:00:00

abstract：:Hyper-activation of Rac1, a small GTPase, in glomerular podocytes has been implicated in the pathogenesis of familial proteinuric kidney diseases. However, the role of Rac1 in acquired nephrotic syndrome is unknown. To gain direct insights into this, we generated a transgenic mouse model expressing a doxycycline-induc...

journal_title：Kidney international

authors： Robins R,Baldwin C,Aoudjit L,Côté JF,Gupta IR,Takano T

更新日期：2017-08-01 00:00:00

abstract：:Leptin is an adipocyte-derived hormone that acts as a major regulator of food intake and energy homeostasis. It circulates both as a free and as a protein-bound entity. Leptin is released into the blood in proportion to the amount of body fat and exerts sustained inhibitory effects on food intake while increasing ener...

journal_title：Kidney international

authors： Mak RH,Cheung W,Cone RD,Marks DL

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Torsemide has predictable absorption compared to furosemide. Thereby, torsemide results in more constant exposure to active drug. Our hypothesis was that this pharmacokinetic difference between these commonly used loop diuretics may translate into disparate antihypertensive responses in patients with chronic...

journal_title：Kidney international

authors： Vasavada N,Saha C,Agarwal R

更新日期：2003-08-01 00:00:00

abstract：:We compared growth rate, food conversion ratio and morphology of the growth zone in female Sprague-Dawley rats with subtotal nephrectomy or sham operation. Both groups were either given vehicle or 1.4 IU/day recombinant human growth hormone (GH) by s.c. osmotic minipump, or 2.5 IU twice daily intraperitoneally for 14 ...

journal_title：Kidney international

authors： Mehls O,Ritz E,Hunziker EB,Eggli P,Heinrich U,Zapf J

更新日期：1988-01-01 00:00:00

abstract：:In this mini review, we would like to challenge the well-established 'fact' that lead exposure causes chronic renal failure (CRF). Even though only scarce evidence exists of the relationship between lead and renal failure, a World Health Organization Environmental Health Criteria document summarizes that 'Lead has bee...

journal_title：Kidney international

authors： Evans M,Elinder CG

更新日期：2011-02-01 00:00:00

abstract：:In this study, we have evaluated 50 children (30 girls and 20 boys; mean age, 10.1 years) with a variety of renal diseases in whom renal biopsy specimens showed crescents in greater than or equal to 50% of glomeruli. Initial clinical features included edema in 61%; hypertension in 51%; gross hematuria in 73%; 3 to 4+ ...

journal_title：Kidney international

authors：

更新日期：1985-02-01 00:00:00

abstract：:Tremendous progress has been made over recent years in the understanding of the mechanisms regulating calcium, phosphorus, vitamin D, and parathyroid hormone homeostasis in the normal human body and in patients with different degrees of renal failure. In addition, some of these findings have been translated into clini...

journal_title：Kidney international

authors： De Broe ME

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:The detailed mechanisms of glucocorticoid action in idiopathic nephrotic syndrome and progressive glomerulonephritides have not been clearly elucidated. The pharmacological actions of glucocorticoids are mediated by their binding to an intracellular protein, the glucocorticoid receptor (GR). The determinatio...

journal_title：Kidney international

authors： Yan K,Kudo A,Hirano H,Watanabe T,Tasaka T,Kataoka S,Nakajima N,Nishibori Y,Shibata T,Kohsaka T,Higashihara E,Tanaka H,Watanabe H,Nagasawa T,Awa S

更新日期：1999-07-01 00:00:00