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Erythropoietin and iron-a conflicted alliance?

Abstract：

:Suzuki et al. analyzed a mouse model of erythropoietin-deficient anemia to show that during iron overload renal interstitial fibroblasts accumulate iron, and this impairs the hypoxia-driven transcription of the erythropoietin gene. The authors show that excess iron decreases levels of hypoxia-inducible transcription factor 2α (HIF2α), the main driver of erythropoietin production in hypoxia and anemia. The work advances our understanding of the effect of iron on hypoxia signaling, but its implications for anemia treatment are less clear.

journal_name

Kidney Int

journal_title

Kidney international

authors

Ganz T

doi

10.1016/j.kint.2018.07.027

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

851-853

issue

5

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(18)30623-9

journal_volume

94

pub_type

评论,杂志文章

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