Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes.

abstract：:Copy number variations associate with different developmental phenotypes and represent a major cause of congenital anomalies of the kidney and urinary tract (CAKUT). Because rare pathogenic copy number variations are often large and contain multiple genes, identification of the underlying genetic drivers has proven to...

journal_title：Kidney international

authors： Westland R,Verbitsky M,Vukojevic K,Perry BJ,Fasel DA,Zwijnenburg PJ,Bökenkamp A,Gille JJ,Saraga-Babic M,Ghiggeri GM,D'Agati VD,Schreuder MF,Gharavi AG,van Wijk JA,Sanna-Cherchi S

更新日期：2015-12-01 00:00:00

abstract：:The increasing use of mice in renal and cardiovascular studies has necessitated adapting physiological methods used for rats to mice, which are far smaller in size. We have adapted measurements of continuous renal blood flow, pressure natriuresis and diuresis, and laser-Doppler cortical and medullary flow to 40 g mice...

journal_title：Kidney international

authors： Gross V,Lippoldt A,Luft FC

更新日期：1997-11-01 00:00:00

abstract：:Nephrons possess a segmental organization where each segment is specialized for the secretion and reabsorption of particular solutes. The developmental control of nephron segment patterning remains one of the enigmas within the field of renal biology. Achieving an understanding of the mechanisms that direct nephron se...

journal_title：Kidney international

authors： Wingert RA,Davidson AJ

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Dialysis efficiency has a great influence on the outcome of patients. Few data are available on the removal of solutes with molecular weights higher than urea and creatinine. The aim of our study was to assess the transport and the removal of substances with molecular weights up to 15 kD and to evaluate the ...

journal_title：Kidney international

authors： Montini G,Amici G,Milan S,Mussap M,Naturale M,Rätsch IM,Ammenti A,Sorino P,Verrina E,Andreetta B,Zacchello G,Italian Registry of Pediatric Peritoneal Dialysis.

更新日期：2002-03-01 00:00:00

abstract：:Meprins are zinc-dependent metalloproteinases that are highly expressed in the brush-border membranes of both the kidney and the intestines. Meprins are capable of proteolytically degrading extracellular matrix proteins, proteolytically processing bioactive proteins, and play a role in inflammatory processes. In this ...

journal_title：Kidney international

authors： Herzog C,Seth R,Shah SV,Kaushal GP

更新日期：2007-05-01 00:00:00

abstract：:Hemodialysis has a profound effect on fluid balance. Since fluid is initially withdrawn from the intravascular compartment, blood volume will decrease rapidly. A fluid shift (refill) from the overhydrated interstitium towards the intravascular compartment counteracts hypovolemia. Underestimation of postdialytic dry we...

journal_title：Kidney international

authors： de Vries JP,Kouw PM,van der Meer NJ,Olthof CG,Oe LP,Donker AJ,de Vries PM

更新日期：1993-10-01 00:00:00

abstract：:Cystinosis as a clinical entity is a progressive dysfunction of multiple organs caused by the accumulation of cystine in the tissues, leading, for example, to end-stage renal failure, diabetes, hypothyroidism, myopathy, and central nervous system deterioration. Brodin-Sartorius and colleagues present a long-term study...

journal_title：Kidney international

authors： Cherqui S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Transplantation is the optimal therapy for pediatric end-stage renal disease (ESRD) patients, but in a subset of patients with peritoneal membrane failure, failed transplants or poor social situations, chronic hemodialysis (HD) remains the only option. Long-term survival of arteriovenous fistulas (AVFs) and ...

journal_title：Kidney international

authors： Sheth RD,Brandt ML,Brewer ED,Nuchtern JG,Kale AS,Goldstein SL

更新日期：2002-11-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common kidney malignancy and has a poor prognosis owing to its resistance to chemotherapy. RCC cells overexpress the transcription factor, PAX2, normally expressed in fetal kidney but downregulated at birth. Since Pax2 suppresses apoptosis during renal development, we reasoned th...

journal_title：Kidney international

authors： Hueber PA,Waters P,Clark P,Eccles M,Goodyer P

更新日期：2006-04-01 00:00:00

abstract：:To investigate whether alpha (alpha)-adrenoceptor agonists have a stimulatory effect on the expression of the angiotensinogen (Ang) gene in opossum kidney (OK) cells, we used OK 27 cells with a fusion gene containing the 5'-flanking regulatory sequence of the rat angiotensinogen gene fused with a human growth hormone ...

journal_title：Kidney international

authors： Wang TT,Lachance S,Delalandre A,Carrière S,Chan JS

更新日期：1995-07-01 00:00:00

abstract：:Although the goal glomerular filtration rate (GFR) for chronic dialysis initiation is currently above 5 ml/min per 1.73 m(2), there is no convincing evidence that patients will benefit from this approach. With close follow-up of advanced chronic kidney disease patients, aiming to start dialysis at an estimated GFR (eG...

journal_title：Kidney international

authors： Rosansky SJ,Durkin MW

更新日期：2014-10-01 00:00:00

abstract：:Many features of chronic kidney disease may be reversed, but it is unclear whether advanced lesions, such as adhesions of sclerotic glomerular tufts to Bowman's capsule (synechiae), can resolve during treatment. We previously showed, using a renal ablation model, that the renoprotective effect of the AT-1 receptor blo...

journal_title：Kidney international

authors： Teles F,Machado FG,Ventura BH,Malheiros DM,Fujihara CK,Silva LF,Zatz R

更新日期：2009-01-01 00:00:00

abstract：UNLABELLED:Hereditary systemic amyloidosis associated with a new apolipoprotein AII stop codon mutation Stop78Arg. BACKGROUND:Mutations in the gene for apolipoprotein AII (apoAII) have recently been found to cause hereditary renal amyloidosis. In each case amyloid deposition has been associated with a peptide extensio...

journal_title：Kidney international

authors： Yazaki M,Liepnieks JJ,Barats MS,Cohen AH,Benson MD

更新日期：2003-07-01 00:00:00

abstract：:We have developed an immunological procedure for measuring advanced glycosylation end-products (AGEs) in serum. Using this method, we measured AGEs in healthy volunteers, patients with diabetes, renal failure without treatment and in patients with renal failure, treated with hemodialysis (HD) or continuous ambulatory ...

journal_title：Kidney international

authors： Papanastasiou P,Grass L,Rodela H,Patrikarea A,Oreopoulos D,Diamandis EP

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Acute renal allograft rejection with intimal arteritis is designated by the widely used Banff 97 classification as type 2A or 2B depending on the extent of arteritis, without regard to interstitial inflammation or tubulitis. We examined whether the distinction between type 2A and 2B is relevant to short- and...

journal_title：Kidney international

authors： Haas M,Kraus ES,Samaniego-Picota M,Racusen LC,Ni W,Eustace JA

更新日期：2002-04-01 00:00:00

abstract：:We report the stepwise application of the RIFLE classification in 155,624 admissions in the UK Intensive Care National Audit & Research Centre Case Mix Programme database. The assumptions required to define RIFLE and their relationship with renal replacement therapy (RRT) and ICU mortality were assessed. Previous repo...

journal_title：Kidney international

authors： Harris SK,Lewington AJ,Harrison DA,Rowan KM

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The next phase of the molecular revolution will bring functional genomics down to the level of individual cells in a tissue. Laser capture microdissection (LCM) coupled with reverse transcription-polymerase chain reaction (RT-PCR) can measure gene expression in normal, cancerous, injured, or fibrotic tissue....

journal_title：Kidney international

authors： Murakami H,Liotta L,Star RA

更新日期：2000-09-01 00:00:00

abstract：:The high serum fibroblast growth factor 23 (FGF23) levels in patients with acute kidney injury (AKI) and chronic kidney disease (CKD) are associated with increased morbidity and mortality. Mice with folic acid-induced AKI had an increase in bone FGF23 mRNA expression together with an increase in serum FGF23 and severa...

journal_title：Kidney international

authors： Durlacher-Betzer K,Hassan A,Levi R,Axelrod J,Silver J,Naveh-Many T

更新日期：2018-08-01 00:00:00

abstract：:Neutrophil gelatinase-associated lipocalin (Ngal) is a biomarker for acute and chronic renal injuries, including polycystic kidney disease (PKD). However, the effect of Ngal on PKD progression remains unexplored. To study this, we generated 3 strains of mice with different expression levels of Ngal within an establish...

journal_title：Kidney international

authors： Wang E,Chiou YY,Jeng WY,Lin HK,Lin HH,Chin HJ,Leo Wang CK,Yu SS,Tsai SC,Chiang CY,Cheng PH,Lin HJ,Jiang ST,Chiu ST,Hsieh-Li HM

更新日期：2017-02-01 00:00:00

abstract：:Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare. Current studies of such 'double-positive' cases report small numbers and variable outcomes. To study this further we retrospectively analyzed clinical features and long-term outcomes of a large cohort of 568 contemporary patients ...

journal_title：Kidney international

authors： McAdoo SP,Tanna A,Hrušková Z,Holm L,Weiner M,Arulkumaran N,Kang A,Satrapová V,Levy J,Ohlsson S,Tesar V,Segelmark M,Pusey CD

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Atherosclerotic vascular disease is the leading cause of death in patients with diabetes mellitus and end-stage renal disease. Advanced glycation end products (AGEs) are strongly suggested to be involved in the pathogenesis of atherosclerosis in these patients who also frequently experience infectious compli...

journal_title：Kidney international

authors： Sengoelge G,Födinger M,Skoupy S,Ferrara I,Zangerle C,Rogy M,Hörl WH,Sunder-Plassmann G,Menzel J

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Macrophages have been regarded as "blackguards" in the generation of glomerular injury. However, it is still unclear what kind of cellular machinery is responsible for their pathogenic actions. To explore this issue, this investigation aims at developing a novel strategy using adoptive transfer of "loss-of-f...

journal_title：Kidney international

authors： Kitamura M

更新日期：2000-02-01 00:00:00

abstract：:This report describes the occurrence of immune complex glomerulonephritis in a patient with eosinophilic gastroenteritis and food hypersensitivity. A coincident allergen injection may have been a contributing factor in the sudden development of the nephrotic syndrome. Markedly elevated levels of circulating immune com...

journal_title：Kidney international

authors： McCrory WW,Becker CG,Cunningham-Rundles C,Klein RF,Mouradian J,Reisman L

更新日期：1986-10-01 00:00:00

abstract：:Aldosterone exerts its biological effects through binding to mineralocorticoid receptor (MR). Ligand binding induces a receptor transconformation within the ligand-binding domain and dissociation of associated proteins from the receptor. The ligand-activated receptor binds as a dimer to the response elements present i...

journal_title：Kidney international

authors： Hellal-Levy C,Fagart J,Souque A,Rafestin-Oblin ME

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Normal human podocytes are terminally differentiated and quiescent cells. It is not known why podocytes fail to proliferate in response to most forms of injury. Proliferation is regulated by cell cycle proteins and their inhibitors. The Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors (p21, p27, p5...

journal_title：Kidney international

authors： Shankland SJ,Eitner F,Hudkins KL,Goodpaster T,D'Agati V,Alpers CE

更新日期：2000-08-01 00:00:00

abstract：:The treatment of hyperphosphatemia remains challenging in patients receiving hemodialysis. This Phase 1b study assessed safety and efficacy of EOS789, a novel pan-inhibitor of phosphate transport (NaPi-2b, PiT-1, PiT-2) on intestinal phosphate absorption in patients receiving intermittent hemodialysis therapy. Two cro...

journal_title：Kidney international

authors： Hill Gallant KM,Stremke ER,Trevino L,Moorthi RN,Doshi S,Wastney ME,Hisada N,Sato J,Ogita Y,Fujii N,Matsuda Y,Kake T,Moe SM

更新日期：2020-10-30 00:00:00

abstract：:Zhang and co-workers report on the renoprotective role of the vitamin D receptor (VDR) in diabetic nephropathy using the method of streptozotocin-induced hyperglycemia in wild-type and VDR(-/-) mice. Also, experiments with cultured mesangial cells and podocytes confirm the effect of the active vitamin D metabolite 1,2...

journal_title：Kidney international

authors： Klaus G

更新日期：2008-01-01 00:00:00

abstract：:Proximal tubular (PT) epithelial cells express MHC class II (Ia) antigens in immunologically-mediated renal injury. To study the role of PT as accessory cells, we generated several murine PT-like epithelial cell lines by transformation with origin-defective SV40 DNA. These transformed cell lines display typical alkali...

journal_title：Kidney international

authors： Wuthrich RP,Glimcher LH,Yui MA,Jevnikar AM,Dumas SE,Kelley VE

更新日期：1990-02-01 00:00:00

abstract：:Nitric oxide is synthesized in experimental immune complex glomerulonephritis due to local induction of type 2 nitric oxide synthase (NOS2). To determine the role of NOS2, the course of accelerated anti-glomerular basement membrane glomerulonephritis (anti-GBM) was examined in mice homozygous for disruption of the NOS...

journal_title：Kidney international

authors： Cattell V,Cook HT,Ebrahim H,Waddington SN,Wei XQ,Assmann KJ,Liew FY

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:A need exists for a therapy that lowers parathyroid hormone (PTH) without increasing calcium x phosphorus in patients with secondary hyperparathyroidism. The calcimimetic AMG 073 increases the sensitivity of the parathyroid calcium-sensing receptor to extracellular calcium, thereby reducing PTH secretion. Co...

journal_title：Kidney international

authors： Lindberg JS,Moe SM,Goodman WG,Coburn JW,Sprague SM,Liu W,Blaisdell PW,Brenner RM,Turner SA,Martin KJ

更新日期：2003-01-01 00:00:00