Calcitonin, an important factor in the calcemic response to parathyroid hormone in the rat.

abstract：:Measures related to red cell oxygen transport were evaluated in 17 hemodialysis patients receiving androgen therapy, 15 untreated hemodialysis patients and 15 normal subjects. Hemoglobin levels were higher in androgen-treated patients than in the untreated population and were directly related to the reticulocyte index...

journal_title：Kidney international

authors： Hendler ED,Solomon L

更新日期：1987-01-01 00:00:00

abstract：:Congenital chloride diarrhea is due to mutations in the intestinal Cl(-)/HCO(3)(-) exchange (SLC26A3) which results in sodium chloride and fluid depletion leading to hypochloremic and hypokalemic metabolic alkalosis. Although treatment with sodium and potassium chloride offers protection from renal involvement in chil...

journal_title：Kidney international

authors： Wedenoja S,Ormälä T,Berg UB,Halling SF,Jalanko H,Karikoski R,Kere J,Holmberg C,Höglund P

更新日期：2008-10-01 00:00:00

abstract：:Multiphoton excitation fluorescence microscopy is a state-of-the-art confocal imaging technique ideal for deep optical sectioning of living tissues. It is capable of performing ultrasensitive, quantitative imaging of organ functions in health and disease with high spatial and temporal resolution which other imaging mo...

journal_title：Kidney international

authors： Sipos A,Toma I,Kang JJ,Rosivall L,Peti-Peterdi J

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:There is growing evidence pointing to an involvement of cytokines and growth factors in renal osteodystrophy. In this study, the expression of interleukin-l beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), and basic fibroblast growth factor (bFGF) in bone...

journal_title：Kidney international

authors： Santos FR,Moysés RM,Montenegro FL,Jorgetti V,Noronha IL

更新日期：2003-03-01 00:00:00

abstract：:Only some individuals carrying the high-risk APOL1 genotype go on to develop kidney disease phenotypes. In this issue of Kidney International, Nadkarni and colleagues report the associations of several biomarkers with renal outcomes in individuals with high-risk APOL1 genotypes. In the era of precision medicine, these...

journal_title：Kidney international

authors： Kruzel-Davila E,Skorecki K

更新日期：2018-06-01 00:00:00

abstract：:Compared to normal tissue, hyperplastic parathyroid glands of patients with chronic kidney disease on dialysis express lower levels of FGFR1 and Klotho proteins. Similar findings are reported in uremic rats with advanced chronic kidney disease. Moreover, in these animals, FGF23 administration fails to reduce PTH serum...

journal_title：Kidney international

authors： Lafage-Proust MH

更新日期：2010-03-01 00:00:00

abstract：:The following bone density measurements have limited utility in determining bone strength because they do not include bone quality: microarchitecture, mineralization, ability to repair damage, collagen structure, crystal size, or marrow composition. Patients with kidney disease have poor bone quality. Newman et al. no...

journal_title：Kidney international

authors： Ott SM

更新日期：2016-01-01 00:00:00

abstract：:Nitric oxide is synthesized in experimental immune complex glomerulonephritis due to local induction of type 2 nitric oxide synthase (NOS2). To determine the role of NOS2, the course of accelerated anti-glomerular basement membrane glomerulonephritis (anti-GBM) was examined in mice homozygous for disruption of the NOS...

journal_title：Kidney international

authors： Cattell V,Cook HT,Ebrahim H,Waddington SN,Wei XQ,Assmann KJ,Liew FY

更新日期：1998-04-01 00:00:00

abstract：:Recent decades have witnessed the revelation of expanding roles of the vitamin D endocrine system beyond calcium and phosphorus metabolism. Along with these non-calcemic or non-classic actions of vitamin D are newly discovered therapeutic actions of vitamin D analogs in a number of pathological conditions, including k...

journal_title：Kidney international

authors： Li YC

更新日期：2010-07-01 00:00:00

abstract：:Changes in macula densa intracellular pH (pHi) were used to monitor the direction of flux mediated by the apical Na:2Cl:K cotransporter. At the macula densa, a decrease in luminal [Cl] ([Cl]1) from 60 to 1 mM produced cellular alkalinization secondary to a cascade of events involving a decrease in apical Na:2Cl:K cotr...

journal_title：Kidney international

authors： Lapointe JY,Laamarti A,Hurst AM,Fowler BC,Bell PD

更新日期：1995-03-01 00:00:00

abstract：:Inflammation is a protective response to remove dangerous stimuli from the body. The multiprotein complex called the inflammasome regulates inflammation through the cleavage of proinflammatory cytokines into mature forms. Shahzad et al. unravel the importance of the Nlrp3 inflammasome, especially activated in glomerul...

journal_title：Kidney international

authors： Sakai N,Wada T

更新日期：2015-01-01 00:00:00

abstract：:To determine whether acute renal failure (ARF) increases the long-term risk of progressive chronic kidney disease (CKD), we studied the outcome of patients whose initial kidney function was normal or near normal but who had an episode of dialysis-requiring ARF and did not develop end-stage renal disease within 30 days...

journal_title：Kidney international

authors： Lo LJ,Go AS,Chertow GM,McCulloch CE,Fan D,Ordoñez JD,Hsu CY

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Angiotensin II (Ang II) can up-regulate nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase, whose product superoxide anion (O2-) can interact with nitric oxide (NO) to form peroxynitrite (ONOO-). We tested the hypothesis that Ang II subtype 1 (AT1) receptor activation enhances oxidative stress and...

journal_title：Kidney international

authors： Onozato ML,Tojo A,Goto A,Fujita T,Wilcox CS

更新日期：2002-01-01 00:00:00

abstract：:It is no a secret that we are confronted by an alarmingly increasing number of patients with progressive renal disease. There is ample evidence for the notion that angiotensin II (Ang II) is a major culprit in progression. The vasopeptide Ang II turned out to have also multiple nonhemodynamic pathophysiologic actions ...

journal_title：Kidney international

authors： Wolf G,Ritz E

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:A considerable diversity in prognosis is seen with lupus glomerulonephritis (LGN). Hence, the clinical usefulness of a recent International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 classification to judge the long-term outcome of human LGN has been investigated. METHODS:We studied retros...

journal_title：Kidney international

authors： Yokoyama H,Wada T,Hara A,Yamahana J,Nakaya I,Kobayashi M,Kitagawa K,Kokubo S,Iwata Y,Yoshimoto K,Shimizu K,Sakai N,Furuichi K,Kanazawa Study Group for Renal Diseases and Hypertension.

更新日期：2004-12-01 00:00:00

abstract：:Adoptive immunotherapy in patients with advanced cancer produces significant regression of metastatic disease in selected patients, but it is complicated by severe side effects. Prevention of these complications is still limited because their precise mechanisms remain unknown. For this reason we have investigated rena...

journal_title：Kidney international

authors： Mercatello A,Hadj-Aïssa A,Négrier S,Allaouchiche B,Coronel B,Tognet E,Bret M,Favrot M,Pozet N,Moskovtchenko JF

更新日期：1991-08-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia emerged in Wuhan, China in December 2019. Unfortunately, there is a lack of evidence about the optimal management of novel coronavirus disease 2019 (COVID-19), and even less is available in patients on maintenance hemodialysis therapy than in the g...

journal_title：Kidney international

authors： Goicoechea M,Sánchez Cámara LA,Macías N,Muñoz de Morales A,Rojas ÁG,Bascuñana A,Arroyo D,Vega A,Abad S,Verde E,García Prieto AM,Verdalles Ú,Barbieri D,Delgado AF,Carbayo J,Mijaylova A,Acosta A,Melero R,Tejedor A,Ben

更新日期：2020-07-01 00:00:00

abstract：:Human mesangial cells (MC) in culture, when stimulated by interleukin 1 alpha(IL-1 alpha) or tumour necrosis factor (TNF alpha), but not with lipopolysaccharide (LPS), express interleukin 8 (IL-8) mRNA, and both cell associated and extracellular IL-8. Dexamethasone treatment of mesangial cells induced partial inhibiti...

journal_title：Kidney international

authors： Brown Z,Strieter RM,Chensue SW,Ceska M,Lindley I,Neild GH,Kunkel SL,Westwick J

更新日期：1991-07-01 00:00:00

abstract：:It is well known that uremia causes an increase in the serum anion gap (AG); however, whether changes in the AG occur earlier in the course of chronic kidney disease is not known. Here we investigated whether different measures of the AG, as a marker of kidney function, are associated with mortality. To do this, we an...

journal_title：Kidney international

authors： Abramowitz MK,Hostetter TH,Melamed ML

更新日期：2012-09-01 00:00:00

abstract：:The formation of the non-sulphated glycosaminoglycan hyaluronan by cells of the renal glomerulus in diabetes may contribute to altered matrix composition. We describe an increased production of hyaluronan from mesangial cell-enriched glomerular cores from diabetic animals, and further show that increased hyaluronan pr...

journal_title：Kidney international

authors： Dunlop ME,Clark S,Mahadevan P,Muggli E,Larkins RG

更新日期：1996-07-01 00:00:00

abstract：:There is an urgent need for therapeutic agents that target humoral alloimmunity in solid organ transplantation. This includes sensitized patients with preformed donor-specific human leukocyte antigen antibodies and patients who develop de novo donor-specific antibodies, both of which are associated with acute and chro...

journal_title：Kidney international

authors： Leibler C,Thiolat A,Elsner RA,El Karoui K,Samson C,Grimbert P

更新日期：2019-04-01 00:00:00

abstract：:Systemic AA type amyloidosis with renal involvement is the major cause of morbidity and mortality in patients with familial Mediterranean fever (FMF). A histopathological examination is essential to achieve a definite diagnosis in systemic amyloidosis. The diagnostic yield of the procedure varies according to the biop...

journal_title：Kidney international

authors： Sungur C,Sungur A,Ruacan S,Arik N,Yasavul U,Turgan C,Caglar S

更新日期：1993-10-01 00:00:00

abstract：:The effect of intravenous infusion of angiotensin II on microvascular parameters of the renal microcirculation of rats was studied. With the aid of fluorescence microscopy and a high sensitivity video system we observed the passage of fluorescence-labeled erythrocytes through single glomerular capillaries on the surfa...

journal_title：Kidney international

authors： Zimmerhackl B,Parekh N,Kücherer H,Steinhausen M

更新日期：1985-01-01 00:00:00

abstract：:Fibrates, the PPAR alpha ligand-like compounds increase the expression of proximal tubule liver fatty acid binding protein (L-FABP) and significantly decrease cisplatin-induced acute kidney injury. To study whether the bezafibrate-mediated upregulation of renal L-FABP was involved in this cytoprotective effect we trea...

journal_title：Kidney international

authors： Negishi K,Noiri E,Maeda R,Portilla D,Sugaya T,Fujita T

更新日期：2008-06-01 00:00:00

abstract：:Zhang et al. found that plasma concentrations of the thiamine antimetabolite oxythiamine are significantly increased in patients with end-stage renal disease. These investigators discuss the potential sources of oxythiamine and the consequences of its plasma elevation. This commentary addresses the significance of the...

journal_title：Kidney international

authors： Moradi H,Said HM

更新日期：2016-08-01 00:00:00

abstract：:We examined the role of the plasminogen activator/plasmin system in extracellular matrix (ECM) degradation by human mesangial cells cultured on thin films of 125I-labeled ECM (Matrigel). ECM degradation (release of 125I into the medium) was dependent on exogenous plasminogen, proportional to the number of mesangial ce...

journal_title：Kidney international

authors： Baricos WH,Cortez SL,el-Dahr SS,Schnaper HW

更新日期：1995-04-01 00:00:00

abstract：:Vitamin D hydroxylated at carbon 25 (25(OH)D) is generally recognized as a precursor of active vitamin D. Despite its low affinity for the vitamin D receptor (VDR), both deficient and excessive 25(OH)D levels are associated with poor clinical outcomes. Here we studied direct effects of 25(OH)D3 on the kidney using 25(...

journal_title：Kidney international

authors： Kusunoki Y,Matsui I,Hamano T,Shimomura A,Mori D,Yonemoto S,Takabatake Y,Tsubakihara Y,St-Arnaud R,Isaka Y,Rakugi H

更新日期：2015-11-01 00:00:00

abstract：:Autologous and allogeneic bone marrow grafting both require cytoreductive therapy but only the allogeneic procedure requires immunosuppressive agents. Allogeneic bone marrow transplantation has been reported to be associated with a high incidence of both renal failure and veno-occlusive disease (VOD) of the liver, the...

journal_title：Kidney international

authors： Merouani A,Shpall EJ,Jones RB,Archer PG,Schrier RW

更新日期：1996-09-01 00:00:00

abstract：:Pathological classifications in current use for the assessment of glomerular disease have been typically opinion-based and built on the expert assumptions of renal pathologists about lesions historically thought to be relevant to prognosis. Here we develop a unique approach for the pathological classification of a glo...

journal_title：Kidney international

authors： Working Group of the International IgA Nephropathy Network and the Renal Pathology Society.,Roberts IS,Cook HT,Troyanov S,Alpers CE,Amore A,Barratt J,Berthoux F,Bonsib S,Bruijn JA,Cattran DC,Coppo R,D'Agati V,D'Amico G,Emanci

更新日期：2009-09-01 00:00:00

abstract：:To determine whether the induction of immune-mediated glomerular injury influences the formation of cyclooxygenase products by glomerular cells, we determined prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) (as the stable metabolite of TXA2) formation in isolated glomeruli of rats with passive Heymann nephritis (PHN...

journal_title：Kidney international

authors： Stahl RA,Adler S,Baker PJ,Chen YP,Pritzl PM,Couser WG

更新日期：1987-05-01 00:00:00