当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Excess 25-hydroxyvitamin D3 exacerbates tubulointerstitial injury in mice by modulating macrophage phenotype.

Excess 25-hydroxyvitamin D3 exacerbates tubulointerstitial injury in mice by modulating macrophage phenotype.

Abstract：

:Vitamin D hydroxylated at carbon 25 (25(OH)D) is generally recognized as a precursor of active vitamin D. Despite its low affinity for the vitamin D receptor (VDR), both deficient and excessive 25(OH)D levels are associated with poor clinical outcomes. Here we studied direct effects of 25(OH)D3 on the kidney using 25(OH)D-1α-hydroxylase (CYP27B1) knockout mice. The effects of 25(OH)D3 on unilateral ureteral obstruction were analyzed as proximal tubular cells and macrophages are two major cell types that take up 25(OH)D and contribute to the pathogenesis of kidney injury. Excess 25(OH)D3 in obstructed mice worsened oxidative stress and tubulointerstitial fibrosis, whereas moderate levels of 25(OH)D3 had no effects. The exacerbating effects of excess 25(OH)D3 were abolished in CYP27B1/VDR double-knockout mice and in macrophage-depleted CYP27B1 knockout mice. Excess 25(OH)D3 upregulated both M1 marker (TNF-α) and M2 marker (TGF-β1) levels of kidney-infiltrating macrophages. In vitro analyses verified that excess 25(OH)D3 directly upregulated TNF-α and TGF-β1 in cultured macrophages but not in tubular cells. TNF-α and 25(OH)D3 cooperatively induced oxidative stress by upregulating iNOS in tubular cells. Aggravated tubulointerstitial fibrosis in mice with excess 25(OH)D3 indicated that macrophage-derived TGF-β1 also had a key role in the pathogenesis of surplus 25(OH)D3. Thus, excess 25(OH)D3 worsens tubulointerstitial injury by modulating macrophage phenotype.

journal_name

Kidney Int

journal_title

Kidney international

authors

Kusunoki Y,Matsui I,Hamano T,Shimomura A,Mori D,Yonemoto S,Takabatake Y,Tsubakihara Y,St-Arnaud R,Isaka Y,Rakugi H

doi

10.1038/ki.2015.210

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1013-29

issue

5

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)60996-6

journal_volume

88

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Lipoprotein(a) stimulates growth of human mesangial cells and induces activation of phospholipase C via pertussis toxin-sensitive G proteins.

    abstract：BACKGROUND:Renal disease is commonly associated with hyperlipidemia and correlates with glomerular accumulation of atherogenic lipoproteins, for example, lipoprotein(a) [Lp(a)], and mesangial hypercellularity. Specific binding of Lp(a) to mesangial cells and induction of c-myc and c-fos expression has been demonstrated...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00367.x

    authors： Mondorf UF,Piiper A,Herrero M,Olbrich HG,Bender M,Gross W,Scheuermann E,Geiger H

    更新日期：1999-04-01 00:00:00

  • Skeletal X-ray findings and bone histology in patients on hemodialysis.

    abstract：:X-ray films of the hand skeleton (mammography technique), serum chemistry, and quantitative bone histology (micromorphometry of undecalcified sections, iliac crest spongiosa) were compared in 25 patients on maintenance hemodialysis. The X-ray findings correlated better with serum PTH levels than with bone histology. O...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1978.45

    authors： Ritz E,Prager P,Krempien B,Bommer J,Malluche HH,Schmidt-Gayk H

    更新日期：1978-04-01 00:00:00

  • Kidney failure and the gut: p-cresol and the dangers from within.

    abstract：:Previously, uremic toxins were sometimes regarded as a large, mysterious, but also anonymous group of factors potentially contributing to morbidity and mortality in end-stage renal disease. By identifying the protein-bound solute p-cresol as a risk factor for mortality in dialysis patients, Bammens and colleagues for ...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/sj.ki.5000236

    authors： Ketteler M

    更新日期：2006-03-01 00:00:00

  • Differential proteomic analysis of proteins induced by glucocorticoids in cultured murine podocytes.

    abstract：BACKGROUND:The glomerular podocyte is the kidney cell most affected during the development of nephrotic syndrome, and mutations in podocyte proteins are responsible for a variety of inherited forms of nephrotic syndrome. Although glucocorticoids are a primary treatment for nephrotic syndrome, neither their target cell ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00205.x

    authors： Ransom RF,Vega-Warner V,Smoyer WE,Klein J

    更新日期：2005-04-01 00:00:00

  • High-affinity binding sites for VIP in renal cortical membranes: possible role of VIP in renal transport.

    abstract：:We studied binding and degradation of vasoactive intestinal peptide (VIP) by highly purified brush border and basolateral membranes from rabbit kidney cortex. Brush border and basolateral membranes were capable of 73 and 49% degradation of VIP after 20 minutes, and the degradation was totally prevented by bacitracin. ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1991.32

    authors： Kniaz D,Pahlavan P,Valaitis D,Arruda JA

    更新日期：1991-02-01 00:00:00

  • Renal fibrosis is the common feature of autosomal dominant tubulointerstitial kidney diseases caused by mutations in mucin 1 or uromodulin.

    abstract：:For decades, ill-defined autosomal dominant renal diseases have been reported, which originate from tubular cells and lead to tubular atrophy and interstitial fibrosis. These diseases are clinically indistinguishable, but caused by mutations in at least four different genes: UMOD, HNF1B, REN, and, as recently describe...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2014.72

    authors： Ekici AB,Hackenbeck T,Morinière V,Pannes A,Buettner M,Uebe S,Janka R,Wiesener A,Hermann I,Grupp S,Hornberger M,Huber TB,Isbel N,Mangos G,McGinn S,Soreth-Rieke D,Beck BB,Uder M,Amann K,Antignac C,Reis A,Eckardt K

    更新日期：2014-09-01 00:00:00

  • IgM in the kidney: a multiple personality disorder.

    abstract：:IgM in the blood of normal individuals consists mainly of 'natural' polyreactive antibodies. Natural IgM is thought to provide an initial defense against infection and to promote the healing of wounded cells. Yet, as Panzer and colleagues show, these benefits can be eclipsed when the IgM binds to damaged cells of the ...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2015.153

    authors： Platt JL,Cascalho M

    更新日期：2015-09-01 00:00:00

  • Cardiac screening prior to renal transplantation-good intentions, rather than good evidence, dictate practice.

    abstract：:Cardiovascular disease is the leading cause of death in kidney transplant recipients in many transplant registries. An analysis of transplant recipients from the United Kingdom using propensity score matching (PSM) suggests there are limited or no benefits to cardiovascular screening before transplant listing. We sugg...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2020.10.043

    authors： Rankin AJ,Mark PB

    更新日期：2021-02-01 00:00:00

  • Forty-five year follow-up after uninephrectomy.

    abstract：:This study examined the consequences of nephrectomy in United States Army personnel who lost a kidney due to trauma during World War II (WWII). Records of 62 servicemen who underwent nephrectomy at an average age of 25 years were obtained. Mortality was compared with that of WWII servicemen of the same age. Medical re...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1993.156

    authors： Narkun-Burgess DM,Nolan CR,Norman JE,Page WF,Miller PL,Meyer TW

    更新日期：1993-05-01 00:00:00

  • Higher net acid excretion is associated with a lower risk of kidney disease progression in patients with diabetes.

    abstract：:Higher diet-dependent nonvolatile acid load is associated with faster chronic kidney disease (CKD) progression, but most studies have used estimated acid load or measured only components of the gold standard, net acid excretion (NAE). Here we measured NAE as the sum of urine ammonium and titratable acidity in 24-hour ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.09.012

    authors： Scialla JJ,Asplin J,Dobre M,Chang AR,Lash J,Hsu CY,Kallem RR,Hamm LL,Feldman HI,Chen J,Appel LJ,Anderson CA,Wolf M,Chronic Renal Insufficiency Cohort Study Investigators.

    更新日期：2017-01-01 00:00:00

  • Detection and characterization of mosaicism in autosomal dominant polycystic kidney disease.

    abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is an inherited, progressive nephropathy accounting for 4-10% of end stage renal disease worldwide. PKD1 and PKD2 are the most common disease loci, but even accounting for other genetic causes, about 7% of families remain unresolved. Typically, these unsolved cases ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2019.08.038

    authors： Hopp K,Cornec-Le Gall E,Senum SR,Te Paske IBAW,Raj S,Lavu S,Baheti S,Edwards ME,Madsen CD,Heyer CM,Ong ACM,Bae KT,Fatica R,Steinman TI,Chapman AB,Gitomer B,Perrone RD,Rahbari-Oskoui FF,Torres VE,HALT Progression of

    更新日期：2020-02-01 00:00:00

  • Albumin interaction with the glomerular capillary wall in vitro.

    abstract：:The binding of albumin to the glomerular capillary wall was studied using albumin-gold in perfused kidneys, the interaction of [3H]albumin with isolated glomeruli at 37 degrees C and 4 degrees C and the interaction at [3H]albumin with purified basement membrane. The albumin-gold was found to bind predominantly to the ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.149

    authors： Adal Y,Smit MF,Osicka TM,Comper WD

    更新日期：1995-04-01 00:00:00

  • Kidney-specific reconstitution of the A1 adenosine receptor in A1 adenosine receptor knockout mice reduces renal ischemia-reperfusion injury.

    abstract：:Genetic deletion of the adenosine A1 receptor (A1AR) increased renal injury following ischemia-reperfusion injury suggesting that receptor activation is protective in vivo. Here we tested this hypothesis by expressing the human-A(1)AR in A(1)AR knockout mice. Renal ischemia-reperfusion was induced in knockout mice 2 d...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.699

    authors： Kim M,Chen SW,Park SW,Kim M,D'Agati VD,Yang J,Lee HT

    更新日期：2009-04-01 00:00:00

  • Apoptosis in parathyroid hyperplasia of patients with primary or secondary uremic hyperparathyroidism.

    abstract：BACKGROUND:Chronic oversecretion of parathyroid hormone (PTH) is associated with parathyroid hyperplasia, reflecting a disturbed balance between cell proliferation and apoptosis. This study addressed the unsolved issue of apoptosis in hyperparathyroidism. METHODS:Parathyroid glands from 19 patients with primary (1 deg...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00863.x

    authors： Zhang P,Duchambon P,Gogusev J,Nabarra B,Sarfati E,Bourdeau A,Drüeke TB

    更新日期：2000-02-01 00:00:00

  • Synthetic oleanane triterpenoids: magic bullets or not?

    abstract：:A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2013.38

    authors： Abboud HE

    更新日期：2013-05-01 00:00:00

  • Tidal peritoneal dialysis: comparison of different tidal regimens and automated peritoneal dialysis.

    abstract：BACKGROUND:The National Kidney Foundation Dialysis Outcomes Quality Initiative (DOQI) clinical practice guidelines have suggested minimal weekly Kt/V urea and creatinine clearance goals for peritoneal dialysis patients maintained on continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1523-1755.2000.00120.x

    authors： Juergensen PH,Murphy AL,Pherson KA,Kliger AS,Finkelstein FO

    更新日期：2000-06-01 00:00:00

  • Hereditary systemic amyloidosis associated with a new apolipoprotein AII stop codon mutation Stop78Arg.

    abstract：UNLABELLED:Hereditary systemic amyloidosis associated with a new apolipoprotein AII stop codon mutation Stop78Arg. BACKGROUND:Mutations in the gene for apolipoprotein AII (apoAII) have recently been found to cause hereditary renal amyloidosis. In each case amyloid deposition has been associated with a peptide extensio...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00047.x

    authors： Yazaki M,Liepnieks JJ,Barats MS,Cohen AH,Benson MD

    更新日期：2003-07-01 00:00:00

  • The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury.

    abstract：:Acute kidney injury (AKI) is a critical condition with a mortality rate as high as 50% and significantly contributes to the burden of end-stage renal disease (ESRD) requiring renal replacement therapy. The incidence and prognosis of AKI have been shown to vary with patient age, with younger individuals being more resi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2012.394

    authors： Fan H,Yang HC,You L,Wang YY,He WJ,Hao CM

    更新日期：2013-03-01 00:00:00

  • International variation in the interpretation of renal transplant biopsies: report of the CERTPAP Project.

    abstract：BACKGROUND:The Banff working formulation of renal transplant pathology is intended to have international application. There remains a need to develop methods to harmonize the application of such grading systems between laboratories. Banff grades do not always permit precise management decisions to be made. Alternative ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00030.x

    authors： Furness PN,Taub N,Convergence of European Renal Transplant Pathology Assessment Procedures (CERTPAP) Project.

    更新日期：2001-11-01 00:00:00

  • Role of different dialysis membranes in the release of interleukin-6-soluble receptor in uremic patients.

    abstract：BACKGROUND:Interleukin-6 (IL-6) exerts its actions through a cell-surface receptor system that consists of two transmembrane subunits: the IL-6 binding glycoprotein gp 80 (IL-6R) and the signal-transducing component (gp 130). Soluble forms of the IL-6R (sIL-6R) are generated by shedding of the membrane-associated prote...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00181.x

    authors： Memoli B,Postiglione L,Cianciaruso B,Bisesti V,Cimmaruta C,Marzano L,Minutolo R,Cuomo V,Guida B,Andreucci M,Rossi G

    更新日期：2000-07-01 00:00:00

  • The calcimimetic AMG 073 reduces parathyroid hormone and calcium x phosphorus in secondary hyperparathyroidism.

    abstract：BACKGROUND:A need exists for a therapy that lowers parathyroid hormone (PTH) without increasing calcium x phosphorus in patients with secondary hyperparathyroidism. The calcimimetic AMG 073 increases the sensitivity of the parathyroid calcium-sensing receptor to extracellular calcium, thereby reducing PTH secretion. Co...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1046/j.1523-1755.2003.00720.x

    authors： Lindberg JS,Moe SM,Goodman WG,Coburn JW,Sprague SM,Liu W,Blaisdell PW,Brenner RM,Turner SA,Martin KJ

    更新日期：2003-01-01 00:00:00

  • Effects of rhGH and rhIGF-1 on renal growth and morphology.

    abstract：:It is known that in rodents recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor (rhIGF-1) increase renal mass. It is uncertain, however, whether renal mass increases in proportion to body growth, or whether renal growth is stimulated selectively. In 120 to 150 g female Sprague-Dawl...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1993.376

    authors： Mehls O,Irzynjec T,Ritz E,Eden S,Kovàcs G,Klaus G,Floege J,Mall G

    更新日期：1993-12-01 00:00:00

  • Effect of fluvastatin on endothelium-dependent brachial artery vasodilation in patients after renal transplantation.

    abstract：BACKGROUND:Hypercholesterolemia may affect both endothelial function and arterial distensibility (DC). Renal transplant recipients (NTX) exhibit advanced structural and functional alterations of arterial vessel walls. The aim of this double-blind, randomized trial was to evaluate the effects of fluvastatin (FLU) on bra...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1523-1755.2001.0590041473.x

    authors： Hausberg M,Kosch M,Stam F,Heidenreich S,Kisters K,Rahn KH,Barenbrock M

    更新日期：2001-04-01 00:00:00

  • Defining hypercalciuria in nephrolithiasis.

    abstract：:The classic definition of hypercalciuria, an upper normal limit of 200  mg/day, is based on a constant diet restricted in calcium, sodium, and animal protein; however, random diet data challenge this. Here our retrospective study determined the validity of the classic definition of hypercalciuria by comparing data fro...

    journal_title：Kidney international

    pub_type： 杂志文章,meta分析,评审

    doi：10.1038/ki.2011.227

    authors： Pak CY,Sakhaee K,Moe OW,Poindexter J,Adams-Huet B,Pearle MS,Zerwekh JE,Preminger GM,Wills MR,Breslau NA,Bartter FC,Brater DC,Heller HJ,Odvina CV,Wabner CL,Fordtran JS,Oh M,Garg A,Harvey JA,Alpern RJ,Snyder WH,Pe

    更新日期：2011-10-01 00:00:00

  • Visualization of renal autoregulation in the split hydronephrotic kidney of rats.

    abstract：:The autoregulatory ability of the renal vascular system in the split hydronephrotic kidney was quantitated with intravital microscopy. The luminal diameters of the arcuate and interlobular arteries as well as the afferent and efferent arterioles were measured. Glomerular blood flow was determined by the dual slit tech...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.104

    authors： Steinhausen M,Blum M,Fleming JT,Holz FG,Parekh N,Wiegman DL

    更新日期：1989-05-01 00:00:00

  • KDIGO guideline for the care of kidney transplant recipients will be resource challenged.

    abstract：:The Executive Summary of the KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients is presented in this issue of Kidney International. This guideline will require careful attention for implementation in the context of available resources within each country, especially those with underdevelope...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2009.468

    authors： Delmonico FL

    更新日期：2010-02-01 00:00:00

  • Effects of C-peptide on glomerular and renal size and renal function in diabetic rats.

    abstract：BACKGROUND:Strict glycemic control and antihypertensive treatment may decrease but not eliminate the risk of progressive nephropathy in diabetic patients. C-peptide has been shown to exert beneficial effects on complications, including incipient nephropathy, in type 1 diabetes. METHODS:Renal effects of 14 days of intr...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00964.x

    authors： Samnegård B,Jacobson SH,Jaremko G,Johansson BL,Sjöquist M

    更新日期：2001-10-01 00:00:00

  • Aldosterone enhances renal calcium reabsorption by two types of channels.

    abstract：BACKGROUND:Aldosterone has been known for many years to increase sodium (Na(+)) reabsorption by the distal nephron. The present in vitro experiments investigated the effect of the hormone on calcium (Ca(2+)) transport by the luminal membrane of the rabbit nephron, independent of any systemic influence. METHODS:Proxima...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00725.x

    authors： Leclerc M,Brunette MG,Couchourel D

    更新日期：2004-07-01 00:00:00

  • G protein beta3 subunit C825T polymorphism in primary IgA nephropathy.

    abstract：BACKGROUND:The T allele of the G protein beta3 subunit (GNB3) C825T polymorphism has been associated with increased signal transduction, increased activity of the kidney Na+/H+ exchanger, and also with late-onset essential hypertension. Hypertension is a strong independent risk factor for progression in IgA nephropathy...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00734.x

    authors： Thibaudin L,Berthoux P,Thibaudin D,Mariat C,Berthoux F

    更新日期：2004-07-01 00:00:00

  • TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis.

    abstract：:Severe sepsis is often accompanied by acute kidney injury (AKI) and albuminuria. Here we studied whether the AKI and albuminuria associated with lipopolysaccharide (LPS) treatment in mice reflects impairment of the glomerular endothelium with its associated endothelial surface layer. LPS treatment decreased the abunda...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.286

    authors： Xu C,Chang A,Hack BK,Eadon MT,Alper SL,Cunningham PN

    更新日期：2014-01-01 00:00:00