Kidney failure and the gut: p-cresol and the dangers from within.

abstract：BACKGROUND:Proteomic techniques have recently become available for large-scale protein analysis. The utility of these techniques in identification of urinary proteins is poorly defined. We constructed a proteome map of normal human urine as a reference protein database by using two differential fractionated techniques ...

journal_title：Kidney international

authors： Thongboonkerd V,McLeish KR,Arthur JM,Klein JB

更新日期：2002-10-01 00:00:00

abstract：:The purpose of this prospective, angiographically controlled study was to determine the diagnostic value of color Doppler sonography with two differing approaches of scanning in patients with clinical clues for renal artery stenosis (RAS). In 135 hypertensive patients peak systolic velocity in the main renal arteries ...

journal_title：Kidney international

authors： Krumme B,Blum U,Schwertfeger E,Flügel P,Höllstin F,Schollmeyer P,Rump LC

更新日期：1996-10-01 00:00:00

abstract：:Zhang et al. found that plasma concentrations of the thiamine antimetabolite oxythiamine are significantly increased in patients with end-stage renal disease. These investigators discuss the potential sources of oxythiamine and the consequences of its plasma elevation. This commentary addresses the significance of the...

journal_title：Kidney international

authors： Moradi H,Said HM

更新日期：2016-08-01 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) and MHC class II (Ia) antigens are increased on proximal tubular epithelial cells (TEC) in autoimmune nephritis and transplant rejection. ICAM-1 is a member of the immunoglobulin gene superfamily that increases the avidity of T cell interactions with antigen-presenting cells ...

journal_title：Kidney international

authors： Jevnikar AM,Wuthrich RP,Takei F,Xu HW,Brennan DC,Glimcher LH,Rubin-Kelley VE

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Middle molecules such as beta2-microglobulin (beta2M) and advanced glycation end products (AGE)-modified proteins contribute to inflammation in uremia. The BetaSorb column is a new adsorptive device, which contains copolymeric beads, suitable for removal of beta2M and other middle molecules. We assessed the ...

journal_title：Kidney international

authors： Morena MD,Guo D,Balakrishnan VS,Brady JA,Winchester JF,Jaber BL

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Rats that recover from acute puromycin nephrosis later develop widespread glomerular and tubulointerstitial injury. The current study sought to identify structural changes present in the recovery phase that could precipitate progressive renal disease. METHODS:Stereologic studies were performed 10 weeks afte...

journal_title：Kidney international

authors： Rasch R,Nyengaard JR,Marcussen N,Meyer TW

更新日期：2002-08-01 00:00:00

abstract：:The hypercalcemia of malignancy is mediated by complex and heterogeneous mechanisms. Once thought of as a simple paraneoplastic syndrome mediated by the effects of tumor production of PTH, it is now clear that multiple mechanisms are involved and that these mechanisms involve abnormalities in calcium transport in bone...

journal_title：Kidney international

authors： Mundy GR

更新日期：1987-01-01 00:00:00

abstract：:In order to study the effects of acute ureteral obstruction on glomerular hemodynamics, glomerular hydrostatic capillary pressure (PG), pressure in the first-order peritubular capillaries (EAP), and intratubular pressure (PT) were directly measured in superficial nephrons on Munich-Wistar rats by micropuncture with a ...

journal_title：Kidney international

authors： Dal Canton A,Stanziale R,Corradi A,Andreucci VE,Migone L

更新日期：1977-12-01 00:00:00

abstract：:Excess fatty acids accompanied by triglyceride accumulation in parenchymal cells of multiple tissues including skeletal and cardiac myocytes, hepatocytes, and pancreatic beta cells results in chronic cellular dysfunction and injury. The process, now termed lipotoxicity, can account for many manifestations of the 'meta...

journal_title：Kidney international

authors： Weinberg JM

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Genetic polymorphisms of the angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) genes are associated with increased risk of hypertension and left ventricular hypertrophy (LVH) in hypertensive subjects. However, the extent to which these polymorphisms are related to LVH and remodeling in dialysis p...

journal_title：Kidney international

authors： Wang AY,Chan JC,Wang M,Poon E,Lui SF,Li PK,Sanderson J

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Determinants of inter-individual variation in blood pressure (BP) response to antihypertensive therapy remain largely unknown. Although differences in race, age and measures of the renin-angiotensin-aldosterone system (RAAS) have been associated with variation in blood pressure response to hydrochlorothiazid...

journal_title：Kidney international

authors： Chapman AB,Schwartz GL,Boerwinkle E,Turner ST

更新日期：2002-03-01 00:00:00

abstract：:Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), an enzyme that exists in several isoforms. Some studies found that a polymorphism (G894T) in the endothelial NOS gene was associated with decreased nitric oxide bioactivity and vascular complications. However, it is not known whether the enzyme ...

journal_title：Kidney international

authors： Cherney DZ,Scholey JW,Zhou J,Zimpelmann J,Kennedy C,Burns KD,Lai V,Miller JA

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Candidate biomarkers for vasculopathy in systemic lupus erythematosus (SLE) include circulating endothelial cells and the recently identified endothelial protein C receptor (EPCR) which, when shed, promotes a thrombotic diathesis. This study sought correlation between plasma levels of soluble EPCR and diseas...

journal_title：Kidney international

authors： Sesin CA,Yin X,Esmon CT,Buyon JP,Clancy RM

更新日期：2005-07-01 00:00:00

abstract：INTRODUCTION:Transforming growth factor-beta (TGF-beta) is known to play a pivotal role in the regulation of extracellular matrix (ECM) accumulation. Since diabetic nephropathy (DMN) is characterized by basement membrane thickening and mesangial expansion, control of ECM deposition is believed to be important in the pa...

journal_title：Kidney international

authors： Wong TY,Poon P,Chow KM,Szeto CC,Cheung MK,Li PK

更新日期：2003-05-01 00:00:00

abstract：:This report of the NIH-supported National Continuous Ambulatory Peritoneal Dialysis (CAPD) Registry summarizes data on 7,404 patients treated with CAPD during the three-year period 1981 through 1983, or nearly one-half of patients treated in the USA who were treated with CAPD during this time. While age and diabetes m...

journal_title：Kidney international

authors： Nolph KD,Cutler SJ,Steinberg SM,Novak JW

更新日期：1985-08-01 00:00:00

abstract：:Determination of serum oxalate concentration is important for the diagnosis and monitoring of hyperoxalurias, and extends to patients with all types of renal disease. Approximately 5 to 10 ml of blood is required for each test by conventional methods, and the test is not adapted for use in children. We developed a hig...

journal_title：Kidney international

authors： Gaulier JM,Cochat P,Lardet G,Vallon JJ

更新日期：1997-12-01 00:00:00

abstract：:Compelling evidence indicates that vascular endothelial growth factor (VEGF) is a fundamental regulator of normal and abnormal angiogenesis. The loss of a single VEGF allele results in defective vascularization and early embryonic lethality. VEGF plays also a critical role in kidney development, and its inactivation d...

journal_title：Kidney international

authors： Ferrara N

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Idiopathic nephrotic syndrome is a proteinuric disease secondary to the release of a nonidentified circulating glomerular permeability factor by T cells. Because specificities of T-cell activation in idiopathic nephrotic syndrome remain unknown, we evaluated transcriptional activation of T cells in nephrotic...

journal_title：Kidney international

authors： Mansour H,Cheval L,Elalouf JM,Aude JC,Alyanakian MA,Mougenot B,Doucet A,Deschênes G

更新日期：2005-06-01 00:00:00

abstract：:In this issue, McMahon et al. report that, by combining phenotypic, metabolomic, and genetic data, they could better detect chronic kidney disease at the early stages and provide insight into its pathobiology. The most significant findings of the study are that several urinary metabolites (e.g., glycine and histidine)...

journal_title：Kidney international

authors： Zhang G,Saito R,Sharma K

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Various gene transfer vectors as well as delivery systems have been developed; however, many problems remain to be solved. We already achieved a technique to introduce genes into glomerular mesangial cells by hemagglutinating virus of Japan (HVJ) liposome-mediated gene transfer via renal artery. The main lim...

journal_title：Kidney international

authors： Tsujie M,Isaka Y,Nakamura H,Kaneda Y,Imai E,Hori M

更新日期：2001-04-01 00:00:00

abstract：:The proportion of deceased donor kidneys procured for transplant but subsequently discarded has been growing steadily in the United States, but factors contributing to the rising discard rate remain unclear. To assess the reasons for and probability of organ discard we assembled a cohort of 212,305 deceased donor kidn...

journal_title：Kidney international

authors： Mohan S,Chiles MC,Patzer RE,Pastan SO,Husain SA,Carpenter DJ,Dube GK,Crew RJ,Ratner LE,Cohen DJ

更新日期：2018-07-01 00:00:00

abstract：:Tubular function studies have shown that nephrectomy leads to a sharp increase in potassium secretion by initial collecting tubules. The aim of this study was to examine the relationship between potassium transport and the cellular morphology of the distal nephron. Clearance and ultrastructural studies were conducted ...

journal_title：Kidney international

authors： Zalups RK,Stanton BA,Wade JB,Giebisch G

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:In cultured renal epithelial cells, exposure to oxalate, a constituent of many kidney stones, elicits a cascade of responses that often leads to cell death. Oxalate toxicity is mediated via generation of reactive oxygen species (ROS) in a process that depends at least in part upon lipid signaling molecules t...

journal_title：Kidney international

authors： Cao LC,Honeyman TW,Cooney R,Kennington L,Scheid CR,Jonassen JA

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Angiotensin II (Ang II) can up-regulate nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase, whose product superoxide anion (O2-) can interact with nitric oxide (NO) to form peroxynitrite (ONOO-). We tested the hypothesis that Ang II subtype 1 (AT1) receptor activation enhances oxidative stress and...

journal_title：Kidney international

authors： Onozato ML,Tojo A,Goto A,Fujita T,Wilcox CS

更新日期：2002-01-01 00:00:00

abstract：:Chronic kidney disease (CKD) promotes development of cardiac abnormalities and is highly prevalent in patients with heart failure, particularly in those with preserved ejection fraction. CKD is associated with endothelial dysfunction, however, whether CKD can induce impairment of endothelium-to-cardiomyocyte crosstalk...

journal_title：Kidney international

authors： Juni RP,Al-Shama R,Kuster DWD,van der Velden J,Hamer HM,Vervloet MG,Eringa EC,Koolwijk P,van Hinsbergh VWM

更新日期：2020-12-22 00:00:00

abstract：:Early graft loss (EGL) is a feared outcome of kidney transplantation. Consequently, kidneys with an anticipated risk of EGL are declined for transplantation. In the most favorable scenario, with optimal use of available donor kidneys, the donor pool size is balanced by the risk of EGL, with a tradeoff dictated by the ...

journal_title：Kidney international

authors： de Kok MJ,Schaapherder AF,Mensink JW,de Vries AP,Reinders ME,Konijn C,Bemelman FJ,van de Wetering J,van Zuilen AD,Christiaans MH,Baas MC,Nurmohamed AS,Berger SP,Ploeg RJ,Alwayn IP,Lindeman JH

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Endothelium-derived nitric oxide and reactive oxygen species (ROS) have been proposed to regulate vascular tone by complex mechanisms, including the modulation of ion channel function. In endothelial function itself, activation of Ca2+-activated K+ channels (KCa) plays a crucial role by inducing hyperpolariz...

journal_title：Kidney international

authors： Brakemeier S,Eichler I,Knorr A,Fassheber T,Köhler R,Hoyer J

更新日期：2003-07-01 00:00:00

abstract：:Circulating immune complexes (CIC), measured by the solid-phase Clq method, were found to be in abnormal concentration in about half of 39 patients with membranoproliferative glomerulonephritis (MPGN). In contrast, they were present, usually in higher concentration, in nearly all patients with active lupus nephritis. ...

journal_title：Kidney international

authors： Davis CA,Marder H,West CD

更新日期：1981-12-01 00:00:00

abstract：:Spontaneous and aspirated blood samples were collected from the welling points of surface efferent arterioles in the rat kidney. The amount of tubular reabsorbate in each sample was calculated from measurements of the inulin concentration in the sample and systemic arterial plasma. Both spontaneous and aspirated sampl...

journal_title：Kidney international

authors： Jensen PK,Blaehr H,Steven K

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND:The superiority of renin-angiotensin system (RAS) blockade in providing renoprotection has been attributed to class-specific blood pressure "(BP)-independent" mechanisms. However, the conventional BP measurement methodology on which such conclusions are based is inherently limited for an accurate assessment ...

journal_title：Kidney international

authors： Bidani AK,Griffin KA,Bakris G,Picken MM

更新日期：2000-04-01 00:00:00