当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Higher net acid excretion is associated with a lower risk of kidney disease progression in patients with diabetes.

Higher net acid excretion is associated with a lower risk of kidney disease progression in patients with diabetes.

Abstract：

:Higher diet-dependent nonvolatile acid load is associated with faster chronic kidney disease (CKD) progression, but most studies have used estimated acid load or measured only components of the gold standard, net acid excretion (NAE). Here we measured NAE as the sum of urine ammonium and titratable acidity in 24-hour urines from a random subset of 980 participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. In multivariable models accounting for demographics, comorbidity and kidney function, higher NAE was significantly associated with lower serum bicarbonate (0.17 mEq/l lower serum bicarbonate per 10 mEq/day higher NAE), consistent with a larger acid load. Over a median of 6 years of follow-up, higher NAE was independently associated with a significantly lower risk of the composite of end-stage renal disease or halving of estimated glomerular filtration rate among diabetics (hazard ratio 0.88 per 10 mEq/day higher NAE), but not those without diabetes (hazard ratio 1.04 per 10 mEq/day higher NAE). For comparison, we estimated the nonvolatile acid load as net endogenous acid production using self-reported food frequency questionnaires from 2848 patients and dietary urine biomarkers from 3385 patients. Higher net endogenous acid production based on biomarkers (urea nitrogen and potassium) was modestly associated with faster CKD progression consistent with prior reports, but only among those without diabetes. Results from the food frequency questionnaires were not associated with CKD progression in any group. Thus, disparate results obtained from analyses of nonvolatile acid load directly measured as NAE and estimated from diet suggest a novel hypothesis that the risk of CKD progression related to low NAE or acid load may be due to diet-independent changes in acid production in diabetes.

journal_name

Kidney Int

journal_title

Kidney international

authors

Scialla JJ,Asplin J,Dobre M,Chang AR,Lash J,Hsu CY,Kallem RR,Hamm LL,Feldman HI,Chen J,Appel LJ,Anderson CA,Wolf M,Chronic Renal Insufficiency Cohort Study Investigators.

doi

10.1016/j.kint.2016.09.012

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

204-215

issue

1

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(16)30538-5

journal_volume

91

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Risk scores-the modern Oracle of Delphi?

    abstract：:Recently, 4 new risk scores for the prediction of mortality and cardiovascular events were especially tailored for hemodialysis patients; these scores performed much better than previous scores. Tripepi et al. found that these risk scores were even more predictive for all-cause and cardiovascular death than the measur...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2016.11.022

    authors： Kronenberg F,Schwaiger JP

    更新日期：2017-03-01 00:00:00

  • 5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion.

    abstract：BACKGROUND:Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme activated by strand breaks in DNA, plays an important role in the development of ischemia/reperfusion (I/R) injury. The aim of this study was to investigate the effects of a water-soluble and potent PARP inhibitor, 5-aminoisoquinolinone (5-AIQ), on the re...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00415.x

    authors： Chatterjee PK,Chatterjee BE,Pedersen H,Sivarajah A,McDonald MC,Mota-Filipe H,Brown PA,Stewart KN,Cuzzocrea S,Threadgill MD,Thiemermann C

    更新日期：2004-02-01 00:00:00

  • Targeting the fatty acid transport protein CD36, a class B scavenger receptor, in the treatment of renal disease.

    abstract：:Augmentation of the CD36 pathway, which involves the uptake of several endogenous ligands including free fatty acids and oxidized low-density lipoprotein, contributes to the damage of proximal tubules and podocytes, whereas ablation of CD36 attenuates renal injury. Souza et al. demonstrate that 5A peptide can inhibit ...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2016.01.009

    authors： Yokoi H,Yanagita M

    更新日期：2016-04-01 00:00:00

  • Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients: a global perspective.

    abstract：:We described the characteristics in a referred cohort of type II diabetic patients in the Developing Education on Microalbuminuria for Awareness of renal and cardiovascular risk in Diabetes study evaluating the global prevalence and determinants of microalbuminuria (MA). A cross-sectional study evaluating 32,208 type ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000377

    authors： Parving HH,Lewis JB,Ravid M,Remuzzi G,Hunsicker LG,DEMAND investigators.

    更新日期：2006-06-01 00:00:00

  • Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension in metabolic syndrome.

    abstract：:Hyperinsulinemia can contribute to hypertension through effects on sodium transport. To test whether the stimulatory effect of insulin on renal proximal tubule sodium transport is preserved in insulin resistance, we compared the effects of insulin on abdominal adipocytes and proximal tubules in rats and humans. Insuli...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2014.351

    authors： Nakamura M,Yamazaki O,Shirai A,Horita S,Satoh N,Suzuki M,Hamasaki Y,Noiri E,Kume H,Enomoto Y,Homma Y,Seki G

    更新日期：2015-03-01 00:00:00

  • Cyclosporine A enhances vasopressin-induced Ca2+ mobilization and contraction in mesangial cells.

    abstract：:A major problem in cyclosporine A (CsA) therapy is its nephrotoxicity, characterized by a marked fall in glomerular filtration rate (GFR). Since the glomerular ultrafiltration area is an important determinant of GFR and has been proposed to be regulated by mesangial (MS) cell contraction, we examined the effect of CsA...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.149

    authors： Meyer-Lehnert H,Schrier RW

    更新日期：1988-07-01 00:00:00

  • A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.

    abstract：:Urinary exosomes have received considerable attention as a potential biomarker source for the diagnosis of renal diseases. Notwithstanding, their use in protein biomarker research is hampered by the lack of efficient methods for vesicle isolation, lysis, and protein quantification. Here we report an improved ultracent...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2012.25

    authors： Raj DA,Fiume I,Capasso G,Pocsfalvi G

    更新日期：2012-06-01 00:00:00

  • Induction of VEGF and VEGF receptor gene expression by hypoxia: divergent regulation in vivo and in vitro.

    abstract：:This study examined the expression of EPO, VEGF and VEGF receptor gene under conditions of reduced oxygen supply in primary cultures of rat hepatocytes, and compared it with the expression of these genes in hypoxic rat livers in vivo. To this end we exposed male Sprague-Dawley rats to hypoxia (10% and 8% O2), carbon m...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.60

    authors： Sandner P,Wolf K,Bergmaier U,Gess B,Kurtz A

    更新日期：1997-02-01 00:00:00

  • Renal fibrosis in mice treated with human recombinant transforming growth factor-beta2.

    abstract：BACKGROUND:The biologic responses to transforming growth factor-beta (TGF-beta) suggest many potential therapeutic applications; however, in the only clinical trial to examine the effect of the systemic administration of a TGF-beta isoform, patients experienced significant but reversible declines in renal function. We ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00420.x

    authors： Ledbetter S,Kurtzberg L,Doyle S,Pratt BM

    更新日期：2000-12-01 00:00:00

  • Are vitamin D receptor agonists like angiotensin-converting enzyme inhibitors without side effects?

    abstract：:Vitamin D receptor agonists (VDRAs) inhibit the renin-angiotensin system (RAS) and reduce podocyte loss and fibrosis over and above RAS blockade. Several studies in humans show that VDRAs are antiproteinuric and have the potential to delay the progression of renal disease. Whether VDRAs will accomplish this goal among...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2010.77

    authors： Agarwal R

    更新日期：2010-06-01 00:00:00

  • Macrophage-Fc-receptor affinity: role in cellular mediation of antibody initiated glomerulonephritis.

    abstract：:The role of immunoglobulin (Ig) Fc-macrophage cell surface receptor affinity (macrophage Fc-affinity) in determining the mediation systems responsible for immune glomerular injury has been studied. Glomerular injury was initiated in rabbits by the passive administration of immunoglobulin preparations directed against ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.228

    authors： Boyce NW,Holdsworth SR

    更新日期：1989-10-01 00:00:00

  • Expression of apoptosis regulatory genes in chronic cyclosporine nephrotoxicity favors apoptosis.

    abstract：UNLABELLED:Expression of apoptosis regulatory genes in chronic cyclosporine nephrotoxicity favors apoptosis. BACKGROUND:Chronic cyclosporine (CsA) nephrotoxicity is characterized by interstitial fibrosis, tubular dropout, and loss of cellularity in areas of fibrosis. Apoptosis was found to play a role in CsA-induced f...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00794.x

    authors： Shihab FS,Andoh TF,Tanner AM,Yi H,Bennett WM

    更新日期：1999-12-01 00:00:00

  • Adoptive transfer of nuclear factor-kappaB-inactive macrophages to the glomerulus.

    abstract：BACKGROUND:Macrophages have been regarded as "blackguards" in the generation of glomerular injury. However, it is still unclear what kind of cellular machinery is responsible for their pathogenic actions. To explore this issue, this investigation aims at developing a novel strategy using adoptive transfer of "loss-of-f...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00893.x

    authors： Kitamura M

    更新日期：2000-02-01 00:00:00

  • Long-term treatment of rats with FGF-2 results in focal segmental glomerulosclerosis.

    abstract：:Long-term treatment (8 and 13 weeks) of rats with FGF-2 led to albuminuria and to increase in serum creatinine indicating the development of chronic renal failure. Histologically, the classic picture of focal segmental glomerulosclerosis (FSGS) was found; males were more severely affected than females. Among the early...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.433

    authors： Kriz W,Hähnel B,Rösener S,Elger M

    更新日期：1995-11-01 00:00:00

  • The pathobiology of subclinical pyelonephritis--an experimental evaluation.

    abstract：:Clinical studies have demonstrated a poor correlation between localization tests, which are designed to determine the site of urinary tract infection, and symptoms of upper urinary tract infection. One explanation is that microorganisms may be present in the kidney but not initiate an inflammatory response with associ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1992.200

    authors： Miller TE,Findon G,Rainer SP,Gavin JB

    更新日期：1992-05-01 00:00:00

  • Dual RAAS blockade is desirable in kidney disease: con.

    abstract：:Dual renin-angiotensin aldosterone (RAAS) blockade is associated with higher risk of hyperkalemia and has not been shown, in any outcome trial of validated renal end points, that is, doubling of creatinine, time to dialysis, or death, to be superior over other approaches. It shows promise in advanced proteinuric nephr...

    journal_title：Kidney international

    pub_type： 评论,杂志文章,评审

    doi：10.1038/ki.2010.226

    authors： Bakris GL

    更新日期：2010-09-01 00:00:00

  • Electrophysiological indices of CNS function in hemodialysis and CAPD.

    abstract：:Fourteen Center hemodialysis (CHD) patients, 13 continuous ambulatory peritoneal dialysis (CAPD) patients, and 10 normals matched by group for age and sex were compared using a battery of evoked (EP) and event-related (ERP) brain potential measures to determine the effects on central nervous system (CNS) functioning o...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1986.279

    authors： Marsh JT,Brown WS,Wolcott D,Landsverk J,Nissenson AR

    更新日期：1986-12-01 00:00:00

  • Glycated and carboxy-methylated proteins do not directly activate human vascular smooth muscle cells.

    abstract：BACKGROUND:Advanced glycation end products (AGEs) accumulate in patients with diabetes, particularly at sites of vascular damage and within atherosclerotic lesions, but whether they have direct actions on vascular smooth muscle cells (VSMCs) is controversial. METHODS:AGEs were constructed and characterized by protein ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00746.x

    authors： Ballinger ML,Thomas MC,Nigro J,Ivey ME,Dilley RJ,Little PJ

    更新日期：2005-12-01 00:00:00

  • Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery.

    abstract：:Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the urine from all nephron segments, and may carry protein markers of renal dysfunction and structural injury. We studied methods for collection, storage, and preservation of urinary exosomal proteins. We collected urine fro...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000273

    authors： Zhou H,Yuen PS,Pisitkun T,Gonzales PA,Yasuda H,Dear JW,Gross P,Knepper MA,Star RA

    更新日期：2006-04-01 00:00:00

  • Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus.

    abstract：BACKGROUND:The plasma concentrations of total homocysteine (tHcy) and total cysteine (tCys) are determined by intracellular metabolism and by renal plasma clearance, and we hypothesized that glomerular filtration is a major determinant of plasma tHcy and tCys. We studied the relationships between the glomerular filtrat...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.0550031028.x

    authors： Wollesen F,Brattström L,Refsum H,Ueland PM,Berglund L,Berne C

    更新日期：1999-03-01 00:00:00

  • Therapeutic effects of oral nutritional supplementation during hemodialysis.

    abstract：BACKGROUND:Protein-calorie malnutrition is common in chronic hemodialysis (CHD) patients and correlates with morbidity and mortality in these patients. There are limited trials evaluating the efficacy of oral nutritional supplementation in malnourished CHD patients. METHODS:Eighty-five CHD patients with evidence of ma...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1523-1755.2002.00530.x

    authors： Caglar K,Fedje L,Dimmitt R,Hakim RM,Shyr Y,Ikizler TA

    更新日期：2002-09-01 00:00:00

  • Estimation of podocyte number: a comparison of methods.

    abstract：BACKGROUND:The podocyte is the focus of much research into the mechanisms of renal disease progression, and the number of podocytes per glomerulus has thus become a parameter of much interest. When counting podocytes, the actual particle counted is the cell nucleus. The majority of published studies estimating podocyte...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1523-1755.2004.00787.x

    authors： White KE,Bilous RW

    更新日期：2004-08-01 00:00:00

  • Presence of lipids in urine, crystals and stones: implications for the formation of kidney stones.

    abstract：BACKGROUND:Cell membranes and their lipids play critical roles in calcification. Specific membrane phospholipids promote the formation of calcium phosphate and become a part of the organic matrix of growing calcification. We propose that membrane lipids also promote the formation of calcium oxalate (CaOx) and calcium p...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00676.x

    authors： Khan SR,Glenton PA,Backov R,Talham DR

    更新日期：2002-12-01 00:00:00

  • Intrauterine growth retardation aggravates the course of acute mesangioproliferative glomerulonephritis in the rat.

    abstract：:Intrauterine growth retardation (IUGR) aggravates the course of acute mesangioproliferative glomerulonephritis (GN) in the rat. Observational studies in children suggest that IUGR may be associated with a severe course of kidney diseases such as IgA nephropathy. We tested the hypothesis that IUGR leads to aggravation ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5001966

    authors： Plank C,Ostreicher I,Hartner A,Marek I,Struwe FG,Amann K,Hilgers KF,Rascher W,Dötsch J

    更新日期：2006-12-01 00:00:00

  • The International Pediatric Peritonitis Registry: starting to walk.

    abstract：:The International Pediatric Peritonitis Registry (IPPR) was created to assess and evaluate the validity of the pediatric peritonitis treatment guidelines issued by the International Society for Peritoneal Dialysis. The study by Schaefer et al., one of the first to emerge from the IPPR, describes regional variability i...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/sj.ki.5002529

    authors： Teitelbaum I

    更新日期：2007-12-01 00:00:00

  • Decreased sensitivity to heparin in vitro in steroid-responsive nephrotic syndrome.

    abstract：:The in vitro heparin sensitivity of 18 nephrotic children was compared with that of 10 normal children and 13 children with other renal diseases. The influence of age on the heparin sensitivity of 52 normal subjects (aged 12 to 85 years) was also studied. The heparin sensitivity was calculated from the dose-response c...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1987.155

    authors： Vermylen CG,Levin M,Lanham JG,Hardisty RM,Barratt TM

    更新日期：1987-06-01 00:00:00

  • Theophylline prevents the hypoxemia-induced renal hemodynamic changes in rabbits.

    abstract：:The acute renal effects of hypoxemia and the ability of theophylline to prevent these effects were assessed in anesthetized and mechanically-ventilated newborn and adult rabbits. Renal blood flow (RBF) and glomerular filtration rate (GFR) were determined by the clearance of para-aminohippuric acid and inulin, respecti...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.114

    authors： Gouyon JB,Guignard JP

    更新日期：1988-06-01 00:00:00

  • A controlled trial of cyclosporine in patients with progressive membranous nephropathy. Canadian Glomerulonephritis Study Group.

    abstract：:A controlled trial of cyclosporine in patients diagnosed with progressive membranous nephropathy (MGN) was carried out to determine whether cyclosporine (D) would be more effective than placebo (P) in reducing the rate of deterioration in renal function. Patients (N = 64) with MGN were placed on a restricted protein d...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/ki.1995.161

    authors： Cattran DC,Greenwood C,Ritchie S,Bernstein K,Churchill DN,Clark WF,Morrin PA,Lavoie S

    更新日期：1995-04-01 00:00:00

  • Effect of vitamin D metabolites on calcitriol metabolism in experimental renal failure.

    abstract：:Previous studies from our laboratory have demonstrated that metabolic clearance rate (MCR) of calcitriol is decreased in experimental renal failure. In this experiment, we examined the effects of calcitriol, 25-hydroxyvitamin D3 (25(OH)D3) and 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) on the MCR of calcitriol in renal ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.185

    authors： Patel S,Simpson RU,Hsu CH

    更新日期：1989-08-01 00:00:00

  • A common-source outbreak of fulminant hepatitis B in hemodialysis patients induced by precore mutant.

    abstract：:From September 9 to October 3, 1994, five patients on maintenance hemodialysis in a dialysis unit in Tokyo contracted hepatitis B virus (HBV) infection successively, and four of them died of fulminant hepatitis. The unit treated 181 patients three times a week on eight shifts, and all five afflicted patients were on t...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.499

    authors： Tanaka S,Yoshiba M,Iino S,Fukuda M,Nakao H,Tsuda F,Okamoto H,Miyakawa Y,Mayumi M

    更新日期：1995-12-01 00:00:00