Effect of vitamin D metabolites on calcitriol metabolism in experimental renal failure.

abstract：:Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise in thr...

journal_title：Kidney international

authors： Noone DG,Riedl M,Pluthero FG,Bowman ML,Liszewski MK,Lu L,Quan Y,Balgobin S,Schneppenheim R,Schneppenheim S,Budde U,James P,Atkinson JP,Palaniyar N,Kahr WH,Licht C

更新日期：2016-07-01 00:00:00

abstract：:The ability to pursue gene therapy has been limited by the availability of an effective and safe system for gene delivery, especially to the kidney. Electroporation is an efficient method to transfer physiologically the gene to the cells without complicated preparation. Given that the systemic delivery of the function...

journal_title：Kidney international

authors： Imai E,Isaka Y

更新日期：2002-01-01 00:00:00

abstract：:Transport and metabolism of adenosine were studied in the S1, S2, and S3 segments of the rabbit proximal renal tubule. Isolated segments were perfused in vitro with uniformly labelled 14C-adenosine to measure the lumen-to-bath flux of adenosine. This flux rate was measured by the disappearance of 14C from the luminal ...

journal_title：Kidney international

authors： Barfuss DW,McCann WP,Katholi RE

更新日期：1992-05-01 00:00:00

abstract：:Cardiac surgery associated-acute kidney injury (CS-AKI) occurs in 30-50% of patients undergoing surgery for congenital heart disease. Here we determine if CS-AKI is associated with chronic kidney disease (CKD) in patients with congenital heart disease. Using Danish regional population-based registries, our cohort stud...

journal_title：Kidney international

authors： Madsen NL,Goldstein SL,Frøslev T,Christiansen CF,Olsen M

更新日期：2017-09-01 00:00:00

abstract：:Gap junctions are present in the juxtaglomerular apparatus enabling intercellular communication. Our study determined the location of different connexin subtypes within the juxtaglomerular apparatus of the rat, and the role of these subtypes in renal hemodynamics through the use of specific mimetic peptides. Immunohis...

journal_title：Kidney international

authors： Takenaka T,Inoue T,Kanno Y,Okada H,Meaney KR,Hill CE,Suzuki H

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Idiopathic nephrotic syndrome is a proteinuric disease secondary to the release of a nonidentified circulating glomerular permeability factor by T cells. Because specificities of T-cell activation in idiopathic nephrotic syndrome remain unknown, we evaluated transcriptional activation of T cells in nephrotic...

journal_title：Kidney international

authors： Mansour H,Cheval L,Elalouf JM,Aude JC,Alyanakian MA,Mougenot B,Doucet A,Deschênes G

更新日期：2005-06-01 00:00:00

abstract：:Systemic AA type amyloidosis with renal involvement is the major cause of morbidity and mortality in patients with familial Mediterranean fever (FMF). A histopathological examination is essential to achieve a definite diagnosis in systemic amyloidosis. The diagnostic yield of the procedure varies according to the biop...

journal_title：Kidney international

authors： Sungur C,Sungur A,Ruacan S,Arik N,Yasavul U,Turgan C,Caglar S

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the lipid abnormalities associated with urinary albumin excretion rate (UAER) in type 2 diabetic patients. METHODS:A total of 275 (122 men and 153 women; aged 60.6 +/- 11.1 years) patients were selected with stringent criteria to prevent confounders. Normoalbuminuria...

journal_title：Kidney international

authors： Tseng CH

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:The Banff working formulation of renal transplant pathology is intended to have international application. There remains a need to develop methods to harmonize the application of such grading systems between laboratories. Banff grades do not always permit precise management decisions to be made. Alternative ...

journal_title：Kidney international

authors： Furness PN,Taub N,Convergence of European Renal Transplant Pathology Assessment Procedures (CERTPAP) Project.

更新日期：2001-11-01 00:00:00

abstract：:Osteonectin (SPARC, culture shock protein, BM-40) is a widely distributed glycoprotein which binds calcium and several extracellular matrix proteins, including interstitial collagens and thrombospondin, but whose physiologic role remains undefined. In the present studies, we have demonstrated that immunoreactive osteo...

journal_title：Kidney international

authors： Kopp JB,Bianco P,Young MF,Termine JD,Robey PG

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Hyperoxaluria may be idiopathic, secondary, or due to primary hyperoxaluria (PH). Hepatic alanine:glyoxylate aminotransferase (AGT) or glyoxylate/hydroxypyruvate reductase (GR/HPR) deficiency causes PHI or PHII, respectively. Hepatic glycolate oxidase (GO) is a candidate enzyme for a third form of inherited ...

journal_title：Kidney international

authors： Monico CG,Persson M,Ford GC,Rumsby G,Milliner DS

更新日期：2002-08-01 00:00:00

abstract：:Tubular atrophy and interstitial fibrosis, important in progression of renal diseases, including diabetic (D) and cyclosporine-induced (CSA) nephropathy, have been considered irreversible. Normoglycemia for 10 years following pancreas transplantation alone (PTA) reversed D glomerulopathy lesions. This study quantified...

journal_title：Kidney international

authors： Fioretto P,Sutherland DE,Najafian B,Mauer M

更新日期：2006-03-01 00:00:00

abstract：:Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal sys...

journal_title：Kidney international

authors： Luciani A,Freedman BS

更新日期：2020-07-01 00:00:00

abstract：:To investigate the cause and the mechanisms responsible of the compulsive thirst and excessive fluid intake observed in many patients on chronic dialysis treatment, we measured plasma antidiuretic hormone (ADH), angiotensin II (Ang II) and some hemodynamic parameters in seven polydipsic and in six normodipsic patients...

journal_title：Kidney international

authors： Graziani G,Badalamenti S,Del Bo A,Marabini M,Gazzano G,Como G,Viganò E,Ambroso G,Morganti A

更新日期：1993-07-01 00:00:00

abstract：:The study by Rieg et al. is the first to examine potassium handling in BK(-/-) mice, thereby addressing many unanswered questions regarding the separate roles of BK and ROMK channels in renal potassium secretion. This Commentary is an interpretation and opinion of their results, by two researchers who have been studyi...

journal_title：Kidney international

authors： Sansom SC,Welling PA

更新日期：2007-09-01 00:00:00

abstract：:Despite the increasing knowledge of the role of gangliosides in normal and diseased tissues, little is known of the presence, distribution and functions of these molecules in the kidney. In this study we analyzed the main gangliosides of isolated glomeruli and cortical, medullary and papillary fractions of the human, ...

journal_title：Kidney international

authors： Holthöfer H,Reivinen J,Miettinen A

更新日期：1994-01-01 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) and MHC class II (Ia) antigens are increased on proximal tubular epithelial cells (TEC) in autoimmune nephritis and transplant rejection. ICAM-1 is a member of the immunoglobulin gene superfamily that increases the avidity of T cell interactions with antigen-presenting cells ...

journal_title：Kidney international

authors： Jevnikar AM,Wuthrich RP,Takei F,Xu HW,Brennan DC,Glimcher LH,Rubin-Kelley VE

更新日期：1990-09-01 00:00:00

abstract：:The terminally differentiated podocyte, also called glomerular visceral epithelial cell, are highly specialized cells. They function as a critical size and charge barrier to prevent proteinuria. Podocytes are injured in diabetic and non-diabetic renal diseases. The clinical signature of podocyte injury is proteinuria,...

journal_title：Kidney international

authors： Shankland SJ

更新日期：2006-06-01 00:00:00

abstract：:Hyperlipidemia can induce or aggravate renal tubulointerstitial injury. Experiments in a complex rat model with chronic glomerulonephritis and long-standing, coexisting hyperlipidemia suggested that induction of xanthine oxidase (XO), with increased oxygen radical generation, is involved in aggravation of tubulointers...

journal_title：Kidney international

authors： Gwinner W,Scheuer H,Haller H,Brandes RP,Groene HJ

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Angiotensin II type 2 receptor-deficient mice (AT(2)-/y) provide an opportunity to study the relationship between the angiotensin II type 1 receptor (AT(1)) and nitric oxide synthase (NOS) isoforms without concomitant AT(2) receptor-related effects. To test this relationship, the expression of renal NOS isof...

journal_title：Kidney international

authors： Obst M,Gross V,Bonartsev A,Janke J,Müller DN,Park JK,Kärgel E,Luft FC

更新日期：2004-06-01 00:00:00

abstract：:We have developed an immunological procedure for measuring advanced glycosylation end-products (AGEs) in serum. Using this method, we measured AGEs in healthy volunteers, patients with diabetes, renal failure without treatment and in patients with renal failure, treated with hemodialysis (HD) or continuous ambulatory ...

journal_title：Kidney international

authors： Papanastasiou P,Grass L,Rodela H,Patrikarea A,Oreopoulos D,Diamandis EP

更新日期：1994-07-01 00:00:00

abstract：:In summary, it is evident that malnutrition is highly prevalent in ESRD patients. This is clearly related to multiple factors encountered during the pre-dialysis stage, as well as during maintenance dialysis therapy. A body of evidence highlights the existence of relationship between malnutrition and outcome in this p...

journal_title：Kidney international

authors： Ikizler TA,Hakim RM

更新日期：1996-08-01 00:00:00

abstract：:It is known that in rodents recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor (rhIGF-1) increase renal mass. It is uncertain, however, whether renal mass increases in proportion to body growth, or whether renal growth is stimulated selectively. In 120 to 150 g female Sprague-Dawl...

journal_title：Kidney international

authors： Mehls O,Irzynjec T,Ritz E,Eden S,Kovàcs G,Klaus G,Floege J,Mall G

更新日期：1993-12-01 00:00:00

abstract：:The epidemic of chronic kidney disease in Nicaragua (Mesoamerican nephropathy) has been linked with recurrent dehydration. Here we tested whether recurrent dehydration may cause renal injury by activation of the polyol pathway, resulting in the generation of endogenous fructose in the kidney that might subsequently in...

journal_title：Kidney international

authors： Roncal Jimenez CA,Ishimoto T,Lanaspa MA,Rivard CJ,Nakagawa T,Ejaz AA,Cicerchi C,Inaba S,Le M,Miyazaki M,Glaser J,Correa-Rotter R,González MA,Aragón A,Wesseling C,Sánchez-Lozada LG,Johnson RJ

更新日期：2014-08-01 00:00:00

abstract：:The impacts of IgA nephropathy and pregnancy on each other were evaluated in 118 women who conceived 168 times between 1970 and 1988. Rates of spontaneous abortion, normal delivery, live birth and perinatal death were 9, 66, 87 and 4%, respectively. Infants born to women with glomerular filtration rates (GFR) lower th...

journal_title：Kidney international

authors： Abe S

更新日期：1991-12-01 00:00:00

abstract：:Acute kidney injury (AKI) is associated with progression to advanced chronic kidney disease (CKD). We tested whether patients who survive AKI and are at higher risk for CKD progression can be identified during their hospital admission, thus providing opportunities to intervene. This was assessed in patients in the Dep...

journal_title：Kidney international

authors： Chawla LS,Amdur RL,Amodeo S,Kimmel PL,Palant CE

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Hyperuricemia has been linked to cardiovascular and renal diseases, possibly through the generation of reactive oxygen species (ROS) and subsequent endothelial dysfunction. The enzymatic effect of xanthine oxidase is the production of ROS and uric acid. Studies have shown that inhibiting xanthine oxidase wit...

journal_title：Kidney international

authors： Khosla UM,Zharikov S,Finch JL,Nakagawa T,Roncal C,Mu W,Krotova K,Block ER,Prabhakar S,Johnson RJ

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Susceptibility to skin cancer after transplantation is multifactorial, and risk factors include skin type, sun exposure, and level of immunosuppression. A major mechanism of carcinogenesis is ultraviolet radiation-induced free radical damage, and genetically determined ability to metabolize free radicals may...

journal_title：Kidney international

authors： Marshall SE,Bordea C,Haldar NA,Mullighan CG,Wojnarowska F,Morris PJ,Welsh KI

更新日期：2000-11-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is a renal hereditary disorder associated with increased cardiovascular mortality, due to mutations in polycystin-1 and polycystin-2 genes. Endothelial polycystin-deficient cells have an altered mechanosensitivity to fluid shear stress and subsequent deficit in calc...

journal_title：Kidney international

authors： Lorthioir A,Joannidès R,Rémy-Jouet I,Fréguin-Bouilland C,Iacob M,Roche C,Monteil C,Lucas D,Renet S,Audrézet MP,Godin M,Richard V,Thuillez C,Guerrot D,Bellien J

更新日期：2015-02-01 00:00:00

abstract：:Previous studies from our laboratory have characterized the peripheral metabolism of parathyroid hormone (PTH) in the dog using radioimmunoassay techniques following injection or infusion of biologically active, bovine PTH preparations. Other investigators have used biologically-inactive labelled PTH and interpreted t...

journal_title：Kidney international

authors： Martin KJ,Finch JL,Hruska K,Slatopolsky E

更新日期：1987-04-01 00:00:00