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The pathobiology of subclinical pyelonephritis--an experimental evaluation.

Abstract：

:Clinical studies have demonstrated a poor correlation between localization tests, which are designed to determine the site of urinary tract infection, and symptoms of upper urinary tract infection. One explanation is that microorganisms may be present in the kidney but not initiate an inflammatory response with associated symptoms. An animal model has been developed to obtain quantitative information on the comparative pathobiology of lesion-inducing and non-lesion-inducing infections. In this model, non-manipulated kidneys had acquired a persistent microbial flora within 48 hours of the lower urinary tract becoming infected. This bacterial invasion was not associated with gross or histologic changes within the renal parenchyma, but minor foci of inflammatory cells were seen beneath the epithelium lining the calyces. Ureteric urines from such kidneys contained many leukocytes and high numbers of bacteria. These results showed that the kidneys were infected, rather than colonized, and the term "subclinical" infection was appropriate. Antimicrobial agents were variably successful at eradicating the infection. These experimental observations support the concept of subclinical pyelonephritis and may explain the absence of symptoms in the clinically equivalent situation in humans.

journal_name

Kidney Int

journal_title

Kidney international

authors

Miller TE,Findon G,Rainer SP,Gavin JB

doi

10.1038/ki.1992.200

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

1356-65

issue

5

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)57629-1

journal_volume

41

pub_type

杂志文章

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