Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects.

abstract：:The existence of a tissue renin-angiotensin (RAS) system independent of the circulating RAS has prompted the search for cellular binding sites for angiotensinogen and for renin in order to explain their tissue uptake. Two receptors that bind with similar affinity mature renin and prorenin were identified, the mannose-...

journal_title：Kidney international

authors： Nguyen G

更新日期：2006-05-01 00:00:00

abstract：:The generation of reactive oxygen species has a pivotal role in both acute and chronic glomerular injuries in patients with lupus nephritis. As the transcription factor Nrf2 is a major regulator of the antioxidant response and is a primary cellular defense mechanism, we sought to determine a role of Nrf2 in the progre...

journal_title：Kidney international

authors： Jiang T,Tian F,Zheng H,Whitman SA,Lin Y,Zhang Z,Zhang N,Zhang DD

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Knowledge of the long-term renal prognosis of diarrhea associated hemolytic uremic syndrome (HUS) is important for patient counseling and follow-up. However, estimates of long-term risk are highly variable, with previous studies not using a healthy control group. METHODS:A municipal water system in the smal...

journal_title：Kidney international

authors： Garg AX,Clark WF,Salvadori M,Macnab J,Suri RS,Haynes RB,Matsell D,Walkerton Health Study Investigators.

更新日期：2005-04-01 00:00:00

abstract：:Intravital multiphoton microscopy is a powerful tool to study kidney physiology in living animals. However, certain technical issues have curbed its usage to date, including limited depth of tissue penetration and high background emission of endogenous signals. Most previous studies have used the excitation range 700–...

journal_title：Kidney international

authors： Schuh CD,Haenni D,Craigie E,Ziegler U,Weber B,Devuyst O,Hall AM

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The aim of this study was to establish whether there is a differential effect of mode of dialysis, hemodialysis (HD), or continuous ambulatory peritoneal dialysis (CAPD) on the dyslipidemia of renal failure. METHODS:The lipoprotein profile was determined in 61 non-diabetic patients on chronic HD (N = 30) an...

journal_title：Kidney international

authors： Attman PO,Samuelsson OG,Moberly J,Johansson AC,Ljungman S,Weiss LG,Knight-Gibson C,Alaupovic P

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Erythropoietin is known to improve outcomes in patients with anemia from chronic renal disease. However, there is uncertainty about the optimal timing of initiation of erythropoietin treatment in predialysis patients with non-severe anemia. METHODS:We conducted a randomized controlled trial of early versus ...

journal_title：Kidney international

authors： Gouva C,Nikolopoulos P,Ioannidis JP,Siamopoulos KC

更新日期：2004-08-01 00:00:00

abstract：:We have previously identified the engulfment and cell motility 1 (ELMO1) as a susceptibility gene for diabetic nephropathy. To elucidate the role of ELMO1 in the pathogenesis of chronic renal injury, we examined the expression of Elmo1 in the kidney of a rat model for chronic glomerulonephritis (uninephrectomy plus an...

journal_title：Kidney international

authors： Shimazaki A,Tanaka Y,Shinosaki T,Ikeda M,Watada H,Hirose T,Kawamori R,Maeda S

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. The purpose of this investigation was to examine the expression, regulation, and function of IAP genes in cultured rat mesangial cells. METHODS:Basal and inducible expression of c-IAP1, c-IAP2, ...

journal_title：Kidney international

authors： Furusu A,Nakayama K,Xu Q,Konta T,Sugiyama H,Kitamura M

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:The Banff working formulation of renal transplant pathology is intended to have international application. There remains a need to develop methods to harmonize the application of such grading systems between laboratories. Banff grades do not always permit precise management decisions to be made. Alternative ...

journal_title：Kidney international

authors： Furness PN,Taub N,Convergence of European Renal Transplant Pathology Assessment Procedures (CERTPAP) Project.

更新日期：2001-11-01 00:00:00

abstract：:Anecdotal reports of complement component deficiencies in patients with immune complex disease led to a systematic study of the levels of seven complement components in serum specimens from 178 patients with glomerulonephritis and 163 normal subjects. Deficiencies were found with significantly higher frequency (22.7%)...

journal_title：Kidney international

authors： Coleman TH,Forristal J,Kosaka T,West CD

更新日期：1983-11-01 00:00:00

abstract：:Low-density lipoprotein was derived from carbamyl (carbamyl-LDL) by incubating LDL in potassium cyanate (KCNO). The proportion of free amino groups in the carbamyl-LDL was negatively correlated (r = -0.95) with the time of incubation in potassium cyanate (ranged from 5 to 360 min). The carbamylation did not change the...

journal_title：Kidney international

authors： Hörkkö S,Savolainen MJ,Kervinen K,Kesäniemi YA

更新日期：1992-05-01 00:00:00

abstract：:To analyze the role of clusterin in renal diseases involving a regenerative process, we have used a novel rodent model to compare temporal and spatial expression of clusterin mRNA. Thus, renal artery stenosis was used to induce unilateral non-infarctive renal atrophy. After several weeks, when cellular pathology of at...

journal_title：Kidney international

authors： Gobé GC,Buttyan R,Wyburn KR,Etheridge MR,Smith PJ

更新日期：1995-02-01 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) and MHC class II (Ia) antigens are increased on proximal tubular epithelial cells (TEC) in autoimmune nephritis and transplant rejection. ICAM-1 is a member of the immunoglobulin gene superfamily that increases the avidity of T cell interactions with antigen-presenting cells ...

journal_title：Kidney international

authors： Jevnikar AM,Wuthrich RP,Takei F,Xu HW,Brennan DC,Glimcher LH,Rubin-Kelley VE

更新日期：1990-09-01 00:00:00

abstract：:Prior studies reported associations of APOL1 nephropathy risk variants with subclinical atherosclerosis. However, these findings were limited to older individuals with high comorbidities. To evaluate this in younger individuals, we calculated associations of APOL1 risk variants (high risk [2 risk variants] vs. low ris...

journal_title：Kidney international

authors： Gutiérrez OM,Limou S,Lin F,Peralta CA,Kramer HJ,Carr JJ,Bibbins-Domingo K,Winkler CA,Lewis CE,Kopp JB

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Endothelium-derived nitric oxide and reactive oxygen species (ROS) have been proposed to regulate vascular tone by complex mechanisms, including the modulation of ion channel function. In endothelial function itself, activation of Ca2+-activated K+ channels (KCa) plays a crucial role by inducing hyperpolariz...

journal_title：Kidney international

authors： Brakemeier S,Eichler I,Knorr A,Fassheber T,Köhler R,Hoyer J

更新日期：2003-07-01 00:00:00

abstract：:We have studied acid-base balance in 32 patients attending the renal clinic of Mount Sinai Hospital. The parameters of acid-base balance measured included acid production measured as urinary sulfate and organic anions, net acid excretion measured as urinary ammonia plus titratable acid minus bicarbonate, and net GI ab...

journal_title：Kidney international

authors： Uribarri J,Douyon H,Oh MS

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Macrophage (Mphi) infiltration may contribute to chronic renal injury. We therefore sought to examine the expression of genes associated with Mphi recruitment in the rat remnant kidney model. METHODS:Male Munich Wistar rats underwent 5/6 nephrectomy or sham operation (SHM, N = 18) and received no treatment ...

journal_title：Kidney international

authors： Taal MW,Zandi-Nejad K,Weening B,Shahsafaei A,Kato S,Lee KW,Ziai F,Jiang T,Brenner BM,MacKenzie HS

更新日期：2000-10-01 00:00:00

abstract：:The subcellular distribution of immunoreactive kallikrein was described in the rat nephron using ultrastructural immunocytochemistry. The renal tissue was fixed with a mixture of buffered picric acid-paraformaldehyde-glutaraldehyde and immunostained with the peroxidase-antiperoxidase method for the electron microscope...

journal_title：Kidney international

authors： Vío CP,Figueroa CD

更新日期：1985-07-01 00:00:00

abstract：:The effects of endogenous and exogenous glucocorticoids on renal active and prokallikrein levels (ng/mg protein) and in vivo kallikrein synthesis rate were studied in the conscious rat. Within two hours after low dose methylprednisolone (MP, 0.0125 to 0.05 mg/100 g body wt), active kallikrein and prokallikrein fell (2...

journal_title：Kidney international

authors： Jaffa AA,Miller DH,Silva RH,Margolius HS,Mayfield RK

更新日期：1990-08-01 00:00:00

abstract：:Kidney transplant patients receiving phenytoin or phenobarbital may have decreased graft survival. These drugs have been shown to enhance the metabolism of glucocorticoids. We determined the disposition of total and unbound prednisolone in six stable kidney transplant patients receiving prednisone for immunosuppressio...

journal_title：Kidney international

authors： Gambertoglio JG,Holford NH,Kapusnik JE,Nishikawa R,Saltiel M,Stanik-Lizak P,Birnbaum JL,Hau T,Amend WJ Jr

更新日期：1984-01-01 00:00:00

abstract：:Impaired olfactory function is a marker of neurologic dysfunction in the uremic state. Retained uremic toxins not adequately cleared with dialysis may undermine the integrity of the olfactory epithelium and olfactory bulb and malign central olfactory processing. The evidence suggests that only renal transplantation, w...

journal_title：Kidney international

authors： Bomback AS,Raff AC

更新日期：2011-10-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) upregulation occurs in virtually all chronic kidney diseases and is associated with podocyte injury and proteinuria; however, the mechanisms contributing to this in vivo are ambiguous. In vitro, incubation of podocytes with TGF-β1 induced Wnt1 expression, β-catenin activation, an...

journal_title：Kidney international

authors： Wang D,Dai C,Li Y,Liu Y

更新日期：2011-12-01 00:00:00

abstract：:Isotomic fluid reabsorption (JV) of rat renal proximal tubules was examined by the shrinking droplet method in combination with simulatneous perfusion of blood capillaries. Sensitivity of JV measurement was improved by using each punctured tubule for control measurements: 1) Parathyroid hormoen (PTH) on the contralumi...

journal_title：Kidney international

authors： Baumann K,Chan YL,Bode F,Papavassiliou F

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:Various gene transfer vectors as well as delivery systems have been developed; however, many problems remain to be solved. We already achieved a technique to introduce genes into glomerular mesangial cells by hemagglutinating virus of Japan (HVJ) liposome-mediated gene transfer via renal artery. The main lim...

journal_title：Kidney international

authors： Tsujie M,Isaka Y,Nakamura H,Kaneda Y,Imai E,Hori M

更新日期：2001-04-01 00:00:00

abstract：:Risk factors for disease states are rigorously defined. This analysis considers the definition of a risk factor as applied to the question of whether the serum phosphorus level is a risk factor for cardiovascular disease. Observational studies strongly suggest that phosphorus is associated with cardiovascular risk, an...

journal_title：Kidney international

authors： Hruska K,Mathew S,Lund R,Fang Y,Sugatani T

更新日期：2011-04-01 00:00:00

abstract：:An effective therapeutic means to remove relatively large polypeptide uremic toxins seems to be a hemofiltration (HF) or hemodiafiltration (HDF) employing a larger-pore membrane, that is, a protein-permeable membrane. With either method, however, a significant amount of albumin will be lost into the ultrafiltrate or d...

journal_title：Kidney international

authors： Shinzato T,Miwa M,Nakai S,Takai I,Matsumoto Y,Morita H,Miyata T,Maeda K

更新日期：1996-08-01 00:00:00

abstract：:We investigated the effect of the potent immunosuppressive agent, FK506, on experimental glomerular thrombosis in rats by combined injections of nephrotoxic serum (NTS) and lipopolysaccharide (LPS). Either FK506 or placebo was administered intramuscularly three hours prior to injection of NTS that was followed one hou...

journal_title：Kidney international

authors： Hiromura K,Hayashi J,Tsukada Y,Ono K,Tsuchida A,Yano S,Naruse T

更新日期：1994-06-01 00:00:00

abstract：:While hemodialysis therapy in its present form is capable of sustaining life, dialysis patients are not metabolically normal and we are unable to say what technical factors contribute adequate therapy. Recent efforts to resolve these problems have led to the assumption that substances in the molecular weight range of ...

journal_title：Kidney international

authors： Lowrie EG,Steinberg SM,Galen MA,Gagneux SA,Lazarus JM,Gottlieb MN,Merrill JP

更新日期：1976-11-01 00:00:00

abstract：:In this study, we have evaluated 50 children (30 girls and 20 boys; mean age, 10.1 years) with a variety of renal diseases in whom renal biopsy specimens showed crescents in greater than or equal to 50% of glomeruli. Initial clinical features included edema in 61%; hypertension in 51%; gross hematuria in 73%; 3 to 4+ ...

journal_title：Kidney international

authors：

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:Middle molecules such as beta2-microglobulin (beta2M) and advanced glycation end products (AGE)-modified proteins contribute to inflammation in uremia. The BetaSorb column is a new adsorptive device, which contains copolymeric beads, suitable for removal of beta2M and other middle molecules. We assessed the ...

journal_title：Kidney international

authors： Morena MD,Guo D,Balakrishnan VS,Brady JA,Winchester JF,Jaber BL

更新日期：2003-03-01 00:00:00