当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Treating anemia early in renal failure patients slows the decline of renal function: a randomized controlled trial.

Treating anemia early in renal failure patients slows the decline of renal function: a randomized controlled trial.

Abstract：

BACKGROUND:Erythropoietin is known to improve outcomes in patients with anemia from chronic renal disease. However, there is uncertainty about the optimal timing of initiation of erythropoietin treatment in predialysis patients with non-severe anemia. METHODS:We conducted a randomized controlled trial of early versus deferred initiation of erythropoietin in nondiabetic predialysis patients with serum creatinine 2 to 6 mg/dL and hemoglobin 9 to 11.6 g/dL. The early treatment arm was immediately started on 50 U/kg/wk of erythropoietin alpha with appropriate titration aiming for hemoglobin of > or =13 g/dL. The deferred treatment arm would start erythropoietin only when hemoglobin decreased to <9 g/dL. The primary end point was a composite of doubling of creatinine, renal replacement, or death. RESULTS:Eighty-eight patients were randomized (early treatment N= 45, deferred treatment N= 43) and followed for a median of 22.5 months. During follow-up, 13 versus 23 patients reached the primary end point in the two arms, respectively (log-rank P= 0.0078). The relative hazard for reaching an end point was 0.42 (P= 0.012). Adjusting for baseline serum creatinine, the adjusted relative hazard was 0.37 (P= 0.004), while the risk increased 2.23-fold (P < 0.001) per 1 mg/dL higher creatinine at baseline. The benefit was similar regardless of the baseline hemoglobin and proteinuria. No patients had any severe adverse events. CONCLUSION:Early initiation of erythropoietin in predialysis patients with non-severe anemia significantly slows the progression of renal disease and delays the initiation of renal replacement therapy.

journal_name

Kidney Int

journal_title

Kidney international

authors

Gouva C,Nikolopoulos P,Ioannidis JP,Siamopoulos KC

doi

10.1111/j.1523-1755.2004.00797.x

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

753-60

issue

2

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)50105-1

journal_volume

66

pub_type

临床试验,杂志文章,随机对照试验

相关文献

KIDNEY INTERNATIONAL文献大全
  • Early functional and morphological changes in renal tubular necrosis due to p-aminophenol.

    abstract：:Functional and morphological changes developed rapidly in rats after the intravenous administration of the organic nephrotoxin p-aminophenol. Proximal intratubular pressure remained close to its mean control value of 14.9 +/- 0.9 mm Hg up to 40 min after injection of the nephrotoxin then rose rapidly over the followin...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1983.221

    authors： Davis JM,Emslie KR,Sweet RS,Walker LL,Naughton RJ,Skinner SL,Tange JD

    更新日期：1983-12-01 00:00:00

  • Outcome of patients with human immunodeficiency virus on maintenance hemodialysis.

    abstract：:Fifty-one adults with HIV infection, including 20 chronic hemodialysis patients with superimposed HIV infection and 31 patients with HIV-associated nephropathy requiring chronic maintenance hemodialysis were followed to evaluate survival on outpatient dialysis in relation to the clinical stage of the HIV infection. Re...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.172

    authors： Ortiz C,Meneses R,Jaffe D,Fernandez JA,Perez G,Bourgoignie JJ

    更新日期：1988-08-01 00:00:00

  • A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9.

    abstract：:Genetic variation at the MYH9 locus is linked to the high incidence of focal segmental glomerulosclerosis (FSGS) and non-diabetic end-stage renal disease among African Americans. To further define risk alleles with FSGS we performed a genome-wide association analysis using more than one million single-nucleotide polym...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2010.251

    authors： Genovese G,Tonna SJ,Knob AU,Appel GB,Katz A,Bernhardy AJ,Needham AW,Lazarus R,Pollak MR

    更新日期：2010-10-01 00:00:00

  • Role of diuretics in the preservation of residual renal function in patients on continuous ambulatory peritoneal dialysis.

    abstract：BACKGROUND:Patients on continuous ambulatory peritoneal dialysis (CAPD) are dependent on residual renal function for solute and water clearances, and this declines with time on dialysis. Loop diuretics have been postulated to slow this decline. METHODS:Sixty-one patients new to dialysis were randomly assigned to eithe...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1523-1755.2001.0590031128.x

    authors： Medcalf JF,Harris KP,Walls J

    更新日期：2001-03-01 00:00:00

  • Subtotal nephrectomy impairs ischemia-induced angiogenesis and hindlimb re-perfusion in rats.

    abstract：:Kidney disease is associated with increased cardiovascular morbidity, but underlying mechanisms are poorly understood. We tested the hypothesis that chronic renal insufficiency impairs angioadaptation in a rat model of hindlimb ischemia. Twenty male Sprague-Dawley rats (8 weeks old) underwent subtotal nephrectomy (5/6...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000448

    authors： Jacobi J,Porst M,Cordasic N,Namer B,Schmieder RE,Eckardt KU,Hilgers KF

    更新日期：2006-06-01 00:00:00

  • Mutations in the COL4A4 gene in thin basement membrane disease.

    abstract：BACKGROUND:Patients with thin basement membrane disease (TBMD) are often from families where hematuria segregates with the COL4A3 and COL4A4 genes. These genes also are affected in autosomal recessive Alport syndrome. The aim of this study was to demonstrate COL4A4 mutations in TBMD. METHODS:Forty-eight unrelated indi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00780.x

    authors： Buzza M,Dagher H,Wang YY,Wilson D,Babon JJ,Cotton RG,Savige J

    更新日期：2003-02-01 00:00:00

  • Arteriovenous fistula in the rat tail: a new model of hemodialysis access dysfunction.

    abstract：:Problems with vascular access are an important cause of morbidity and mortality in hemodialysis patients. We established a rodent model of arteriovenous fistula by anastomosing the end of a lateral vein to the side of the ventral artery of the rat tail. All operations were technically successful and in all animals the...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.207

    authors： Lin T,Horsfield C,Robson MG

    更新日期：2008-08-01 00:00:00

  • Coronary artery stenosis: a new risk factor for chronic kidney injury?

    abstract：:Coronary artery stenosis induces renal inflammation and kidney injury in pigs even in the absence of myocardial infarction or clinically significant heart failure. This effect is aggravated by experimentally induced renovascular hypertension. Interestingly, oxidative stress originating from the ischemic myocardium was...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2014.431

    authors： Rump LC,Stegbauer J

    更新日期：2015-04-01 00:00:00

  • Small proteoglycans of normal adult human kidney: distinct expression patterns of decorin, biglycan, fibromodulin, and lumican.

    abstract：BACKGROUND:Among the members of the small leucine-rich proteoglycan family, decorin, biglycan, and fibromodulin have been proposed to be potent modulators of transforming growth factor-beta (TGF-beta) activity, thereby playing an important role in the pathogenesis of fibrotic kidney diseases. Furthermore, decorin expre...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00317.x

    authors： Schaefer L,Gröne HJ,Raslik I,Robenek H,Ugorcakova J,Budny S,Schaefer RM,Kresse H

    更新日期：2000-10-01 00:00:00

  • Mutations in the INF2 gene account for a significant proportion of familial but not sporadic focal and segmental glomerulosclerosis.

    abstract：:Mutations in the inverted formin 2 gene (INF2) have recently been identified as the most common cause of autosomal dominant focal and segmental glomerulosclerosis (FSGS). To quantify the contribution of various genes contributing to FSGS, we sequenced INF2 where all mutations have previously been described (exons 2 to...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2012.349

    authors： Barua M,Brown EJ,Charoonratana VT,Genovese G,Sun H,Pollak MR

    更新日期：2013-02-01 00:00:00

  • Kidney-specific reconstitution of the A1 adenosine receptor in A1 adenosine receptor knockout mice reduces renal ischemia-reperfusion injury.

    abstract：:Genetic deletion of the adenosine A1 receptor (A1AR) increased renal injury following ischemia-reperfusion injury suggesting that receptor activation is protective in vivo. Here we tested this hypothesis by expressing the human-A(1)AR in A(1)AR knockout mice. Renal ischemia-reperfusion was induced in knockout mice 2 d...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.699

    authors： Kim M,Chen SW,Park SW,Kim M,D'Agati VD,Yang J,Lee HT

    更新日期：2009-04-01 00:00:00

  • A common-source outbreak of fulminant hepatitis B in hemodialysis patients induced by precore mutant.

    abstract：:From September 9 to October 3, 1994, five patients on maintenance hemodialysis in a dialysis unit in Tokyo contracted hepatitis B virus (HBV) infection successively, and four of them died of fulminant hepatitis. The unit treated 181 patients three times a week on eight shifts, and all five afflicted patients were on t...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.499

    authors： Tanaka S,Yoshiba M,Iino S,Fukuda M,Nakao H,Tsuda F,Okamoto H,Miyakawa Y,Mayumi M

    更新日期：1995-12-01 00:00:00

  • Longitudinal evaluation of peritoneal macrophage function and activation during CAPD: maturity, cytokine synthesis and arachidonic acid metabolism.

    abstract：:The release of cytokines and prostaglandins (PG) by peritoneal macrophages (PM luminal diameter of) may influence the cytokine network controlling peritoneal inflammation and in the long-term the function of the peritoneum as a dialysis membrane. In the present study, an evaluation of the long-term effects of peritone...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.75

    authors： McGregor SJ,Topley N,Jörres A,Speekenbrink AB,Gordon A,Gahl GM,Junor BJ,Briggs JD,Brock JH

    更新日期：1996-02-01 00:00:00

  • High glucose levels inhibit focal adhesion kinase-mediated wound healing of rat peritoneal mesothelial cells.

    abstract：BACKGROUND:The peritoneum is progressively denuded of its mesothelial cell monolayer in patients on continuous ambulatory peritoneal dialysis (CAPD). These alterations of the mesothelium cause membrane dysfunction and progressive peritoneal fibrosis. Integrins regulate cell motility and play an important role in wound ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00772.x

    authors： Tamura M,Osajima A,Nakayamada S,Anai H,Kabashima N,Kanegae K,Ota T,Tanaka Y,Nakashima Y

    更新日期：2003-02-01 00:00:00

  • Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease.

    abstract：:Insulin resistance from chronic kidney disease (CKD) stimulates muscle protein wasting but mechanisms causing this resistance are controversial. To help resolve this, we used microarray analyses to identify initiators of insulin resistance in the muscles of mice with CKD, glucose intolerance, and insulin resistance. C...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.97

    authors： Thomas SS,Dong Y,Zhang L,Mitch WE

    更新日期：2013-08-01 00:00:00

  • Antibody to oxidized low-density lipoprotein and cardiovascular mortality in end-stage renal disease.

    abstract：BACKGROUND:Immune response to oxidized low-density lipoprotein (oxLDL) may modulate the process of atherogenesis and cardiovascular disease. METHODS:We performed a prospective, observational cohort study in 249 patients with end-stage renal disease (ESRD) to examine whether the serum titer of anti-oxLDL antibody can p...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00692.x

    authors： Shoji T,Fukumoto M,Kimoto E,Shinohara K,Emoto M,Tahara H,Koyama H,Ishimura E,Nakatani T,Miki T,Tsujimoto Y,Tabata T,Nishizawa Y

    更新日期：2002-12-01 00:00:00

  • Rebound kinetics of beta2-microglobulin after hemodialysis.

    abstract：BACKGROUND:Evaluation of beta2-microglobulin (beta2m) removal during hemodialysis using predialysis and immediate postdialysis plasma concentrations is only valid in the absence of postdialysis rebound. Postdialysis rebound of beta2m has not been studied extensively, and its importance in the determination of beta2m cl...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1523-1755.1999.00669.x

    authors： Leypoldt JK,Cheung AK,Deeter RB

    更新日期：1999-10-01 00:00:00

  • Beta blockers in the management of chronic kidney disease.

    abstract：:The sympathetic nervous system modulates renal function through its receptors namely beta1 (cardiac output and renin release), alpha1 (systemic and renovascular constriction), and beta2 renovascular dilation. Sympathetic overactivity is commonly seen in chronic kidney disease (CKD) and is an important contributor to i...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/sj.ki.5001835

    authors： Bakris GL,Hart P,Ritz E

    更新日期：2006-12-01 00:00:00

  • Expression of heat shock proteins 47 and 70 in the peritoneum of patients on continuous ambulatory peritoneal dialysis.

    abstract：BACKGROUND:Peritoneal sclerosis, characterized by collagen accumulation, is a serious complication in continuous ambulatory peritoneal dialysis (CAPD) therapy. Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperon and is closely associated with collagen synthesis. METHODS:We determined the expression...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00883.x

    authors： Shioshita K,Miyazaki M,Ozono Y,Abe K,Taura K,Harada T,Koji T,Taguchi T,Kohno S

    更新日期：2000-02-01 00:00:00

  • Dialysis costs: results of a diverse sample study.

    abstract：:A study of dialysis costs in five major dialysis centers throughout the United States was conducted in 1973. When available, home, home training, limited care, satellite and in-hospital-full-care dialysis were included. The study's objective was to determine the cost per dialysis for each separate dialysis modality. A...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1976.31

    authors： Hoffstein PA,Krueger KK,Wineman RJ

    更新日期：1976-03-01 00:00:00

  • Influence of the renin-angiotensin system on epidermal growth factor expression in normal and cyclosporine-treated rat kidney.

    abstract：BACKGROUND:Epidermal growth factor (EGF) plays an important role in renal tubular regeneration after ischemic injury in kidney. The present study reports the association between the renin-angiotensin system (RAS) and EGF, and the effect of angiotensin II blockade with losartan (LSRT) on EGF expression in an experimenta...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.060003847.x

    authors： Yang CW,Ahn HJ,Kim WY,Shin MJ,Kim SK,Park JH,Kim YO,Kim YS,Kim J,Bang BK

    更新日期：2001-09-01 00:00:00

  • Induced pluripotent stem cells provide mega insights into kidney disease.

    abstract：:Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal sys...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2020.04.033

    authors： Luciani A,Freedman BS

    更新日期：2020-07-01 00:00:00

  • Prolongation of canine allograft survival with donor pretreatment.

    abstract：:Donor pretreatment of 100 mg/kg each of cyclophosphamide (CY) and methylprednisolone (P) infused 5 hours before nephrectomy invariably prolongs the survival of DLA mismatched, MLC incompatible nonlittermate Beagle renal allografts as well as the survival of mongrel renal allografts. The effect of donor pretreatment ap...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1982.25

    authors： Brom HL,van Breda Vriesman PJ,Terpstra JL

    更新日期：1982-02-01 00:00:00

  • Structural adaptation in initial collecting tubule following reduction in renal mass.

    abstract：:Tubular function studies have shown that nephrectomy leads to a sharp increase in potassium secretion by initial collecting tubules. The aim of this study was to examine the relationship between potassium transport and the cellular morphology of the distal nephron. Clearance and ultrastructural studies were conducted ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1985.58

    authors： Zalups RK,Stanton BA,Wade JB,Giebisch G

    更新日期：1985-04-01 00:00:00

  • Innate immune receptors and autophagy: implications for autoimmune kidney injury.

    abstract：:Inflammation is the immune system's response to infectious or noninfectious sources of danger. Danger recognition is facilitated by various innate immune receptor families including the Toll-like receptors (TLRs), which detect danger signals in extracellular and intracellular compartments. It is an evolving concept th...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.2010.111

    authors： Anders HJ,Schlondorff DO

    更新日期：2010-07-01 00:00:00

  • Risk HLA class II alleles and amino acid residues in myeloperoxidase-ANCA-associated vasculitis.

    abstract：:A genome-wide association study (GWAS) indicated that myeloperoxidase-ANCA associated vasculitis (AAV) is associated with HLA-DQ. However, susceptibility alleles in these loci have been under-investigated. Here we genotyped 258 Chinese patients with myeloperoxidase-AAV and 597 healthy control individuals at HLA DRB1, ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2019.06.015

    authors： Wang HY,Cui Z,Pei ZY,Fang SB,Chen SF,Zhu L,Chen M,Chen N,Zhao MH

    更新日期：2019-10-01 00:00:00

  • Endothelin-1 induction of cyclooxygenase-2 expression in rat mesangial cells.

    abstract：:Prostaglandin E2 (PGE2) may be an important negative feedback modulator of endothelin-1 (ET-1)-stimulated mesangial cell proliferation and contraction. Recent studies suggest that ET-1 may induce prolonged mesangial cell PGE2 production, however the mechanism of this effect is unknown. The current study was undertaken...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.6

    authors： Hughes AK,Padilla E,Kutchera WA,Michael JR,Kohan DE

    更新日期：1995-01-01 00:00:00

  • The proto-oncogene c-Fos transcriptionally regulates VEGF production during peritoneal inflammation.

    abstract：:Vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) are key mediators of adverse peritoneal membrane remodeling in peritoneal dialysis eventually leading to ultrafiltration failure. Both are pleiotropic growth factors with cell type-dependent regulation of expression and biological eff...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.217

    authors： Catar R,Witowski J,Wagner P,Annett Schramm I,Kawka E,Philippe A,Dragun D,Jörres A

    更新日期：2013-12-01 00:00:00

  • Cell survival or death in renal tubular epithelium after ischemia-reperfusion injury.

    abstract：:A major contributor to the development and progression of ischemia-reperfusion (IR)-induced acute renal failure (ARF) is the loss of functioning tubular epithelial cells by means of various cell deletion or death processes. Although the term "acute tubular necrosis" is still used to describe the pathology of ARF, this...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00701.x

    authors： Gobé G,Willgoss D,Hogg N,Schoch E,Endre Z

    更新日期：1999-10-01 00:00:00

  • Increased expression of a brain/embryo-type myosin heavy chain isoform (MIIB2) in mesangial proliferative glomerulonephritis.

    abstract：:Proliferation of mesangial cells is frequently found in glomerulonephritis, such as IgA glomerulonephritis. Recent reports suggest that a brain/embryo-type myosin isoform (MIIB2) is involved in cell proliferation. We have studied the expression of MIIB2 in renal biopsy samples from patients with various renal diseases...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.191

    authors： Kishino M,Kimura A,Yamaguchi K,Ohtani H,Yamada Y,Takahashi T,Mune M,Mimura K,Maeda T,Matsumura S,Tsuji T,Yukawa S

    更新日期：1996-05-01 00:00:00