Effect of parathyroid hormone and cyclic adenosine 3',5'-monophosphate on isotonic fluid reabsorption: polarity of proximal tubular cells.

abstract：:Emerging evidence of crosstalk between glomerular cells in pathological settings provides opportunities for novel therapeutic discovery. Here we investigated underlying mechanisms of early events leading to filtration barrier defects of podocyte and glomerular endothelial cell crosstalk in the mouse models of primary ...

journal_title：Kidney international

authors： Ebefors K,Wiener RJ,Yu L,Azeloglu EU,Yi Z,Jia F,Zhang W,Baron MH,He JC,Haraldsson B,Daehn I

更新日期：2019-10-01 00:00:00

abstract：:Apoptosis mediated by verotoxins (VTs) has been identified in a renal carcinoma cell line, ACHN cells, which are an in vitro model of renal tubular epithelial cells. ACHN cells express the renal tubular marker CD24 as well as globotriaosyl ceramide/CD77, the receptor for VTs. VT binding to the ACHN cell surface was co...

journal_title：Kidney international

authors： Taguchi T,Uchida H,Kiyokawa N,Mori T,Sato N,Horie H,Takeda T,Fujimoto J

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Wegener's granulomatosis (WG) is characterized by systemic vasculitis with crescentic glomerulonephritis (CGN) and circulating autoantibodies directed against neutrophil cytoplasmic antigens (ANCA). Proteinase 3 (PR-3), a neutral serine proteinase in neutrophils implicated in the growth control of myeloid ce...

journal_title：Kidney international

authors： Schwarting A,Hagen D,Odenthal M,Brockmann H,Dienes HP,Wandel E,Rumpelt HJ,Zum Büschenfelde KH,Galle PR,Mayet W

更新日期：2000-06-01 00:00:00

abstract：:Hemodynamic factors may play a role in the development of acute renal failure following administration of contrast media (CM). In this study the effect of intravenous injection of contrast media and mannitol on red blood cell velocity (VRBC) and red blood cell aggregation in renal medullary vessels was studied in 58 r...

journal_title：Kidney international

authors： Liss P,Nygren A,Olsson U,Ulfendahl HR,Erikson U

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:It is currently impossible to reliably predict which diabetic patients will develop nephropathy and progress to kidney failure. Microalbuminuria, often regarded as a predictor of overt diabetic renal disease is, in fact, an indicator of established glomerular damage. We have shown that glomerular expression ...

journal_title：Kidney international

authors： Riser BL,Cortes P,DeNichilo M,Deshmukh PV,Chahal PS,Mohammed AK,Yee J,Kahkonen D

更新日期：2003-08-01 00:00:00

abstract：:Congenital chloride diarrhea is due to mutations in the intestinal Cl(-)/HCO(3)(-) exchange (SLC26A3) which results in sodium chloride and fluid depletion leading to hypochloremic and hypokalemic metabolic alkalosis. Although treatment with sodium and potassium chloride offers protection from renal involvement in chil...

journal_title：Kidney international

authors： Wedenoja S,Ormälä T,Berg UB,Halling SF,Jalanko H,Karikoski R,Kere J,Holmberg C,Höglund P

更新日期：2008-10-01 00:00:00

abstract：:Acute kidney injury (AKI) is a critical condition with a mortality rate as high as 50% and significantly contributes to the burden of end-stage renal disease (ESRD) requiring renal replacement therapy. The incidence and prognosis of AKI have been shown to vary with patient age, with younger individuals being more resi...

journal_title：Kidney international

authors： Fan H,Yang HC,You L,Wang YY,He WJ,Hao CM

更新日期：2013-03-01 00:00:00

abstract：:Although the goal glomerular filtration rate (GFR) for chronic dialysis initiation is currently above 5 ml/min per 1.73 m(2), there is no convincing evidence that patients will benefit from this approach. With close follow-up of advanced chronic kidney disease patients, aiming to start dialysis at an estimated GFR (eG...

journal_title：Kidney international

authors： Rosansky SJ,Durkin MW

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Inbred miniature swine treated for 12 days with high-dose cyclosporine A develop tolerance to histocompatibility complex (MHC) class I-mismatched renal allografts. When this protocol was modified by adding thymectomy before transplant, all animals developed acute rejection. Thereafter, by day 100, one half d...

journal_title：Kidney international

authors： Shimizu A,Yamada K,Sachs DH,Colvin RB

更新日期：2000-12-01 00:00:00

abstract：:Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise in thr...

journal_title：Kidney international

authors： Noone DG,Riedl M,Pluthero FG,Bowman ML,Liszewski MK,Lu L,Quan Y,Balgobin S,Schneppenheim R,Schneppenheim S,Budde U,James P,Atkinson JP,Palaniyar N,Kahr WH,Licht C

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Fistula failure has been classified as early and late. Early failure refers to those cases in which the arteriovenous (AV) fistula never develops to the point that it can be used or fails within the first 3 months of usage. It has been common practice to abandon these early failures; however, aggressive eval...

journal_title：Kidney international

authors： Beathard GA,Arnold P,Jackson J,Litchfield T,Physician Operators Forum of RMS Lifeline.

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Genetic polymorphisms of the angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) genes are associated with increased risk of hypertension and left ventricular hypertrophy (LVH) in hypertensive subjects. However, the extent to which these polymorphisms are related to LVH and remodeling in dialysis p...

journal_title：Kidney international

authors： Wang AY,Chan JC,Wang M,Poon E,Lui SF,Li PK,Sanderson J

更新日期：2003-05-01 00:00:00

abstract：:Mesangial cells are known to secrete metalloproteinases that are capable of degrading the constituents of the GBM, and hence are potentially involved not only in the regular maintenance of the ECM components in the glomerulus, but also of contributing to any damage to these components that occurs in disease states. In...

journal_title：Kidney international

authors： Martin J,Knowlden J,Davies M,Williams JD

更新日期：1994-09-01 00:00:00

abstract：:It has been shown that somatostatin inhibits the antidiuretic action of vasopressin in toad urinary bladder in vitro and in dogs and rats in vivo. The presence of somatostatin-like immunoreactivity (SLI) in the urinary bladder and kidney of the toad has suggested the possibility that somatostatin may act as a local pa...

journal_title：Kidney international

authors： Kurokawa K,Aponte GW,Fujibayashi S,Yamada T

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:Pre-eclampsia is characterized by hypertension, proteinuria and edema. Simultaneous studies of kidney function and structure have not been reported. We wished to explore the degree and nature of glomerular dysfunction in pre-eclampsia. METHODS:Physiologic techniques were used to estimate glomerular filtrati...

journal_title：Kidney international

authors： Lafayette RA,Druzin M,Sibley R,Derby G,Malik T,Huie P,Polhemus C,Deen WM,Myers BD

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Tamm-Horsfall glycoprotein (THP) is a unique protein that is produced exclusively by cells of the thick ascending limb of Henle's loop (TALH). This study examined whether dietary salt altered renal THP production. METHODS:Male Sprague-Dawley rats were examined on days 1, 4, and 15 following placement in met...

journal_title：Kidney international

authors： Ying WZ,Sanders PW

更新日期：1998-10-01 00:00:00

abstract：:The risk of developing contrast media-induced acute renal failure was studied in 49 randomly selected nonazotemic type 2 adult diabetic patients subjected to IVU. There were 19 men and 30 women in the group whose mean age was 62 +/- 10 years (range, 38 to 82 years). In preparation for IVU, patients were neither dehydr...

journal_title：Kidney international

authors： Shieh SD,Hirsch SR,Boshell BR,Pino JA,Alexander LJ,Witten DM,Friedman EA

更新日期：1982-05-01 00:00:00

abstract：BACKGROUND:Intrauterine growth retardation (IUGR) is associated with higher morbidity and mortality not only in perinatal life but also in later life. The purpose of our study was to determine whether IUGR has any effect on the course of minimal change nephrotic syndrome (MCNS) in children. METHODS:Forty children who ...

journal_title：Kidney international

authors： Zidar N,Avgustin Cavić M,Kenda RB,Ferluga D

更新日期：1998-10-01 00:00:00

abstract：:Ambient glucose concentrations alter type 1 angiotensin II receptor (AT1R) expression in renal tissues. The direction of change in AT1R density may depend on the specific cell type and the capacity for that cell type to use glucose as an energy substrate. Given the effects of angiotensin II (Ang II) in proximal tubule...

journal_title：Kidney international

authors： Becker BN,Kondo S,Cheng HF,Harris RC

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Proteoglycans are integral components of the mesangial matrix and glomerular permeability barrier. Recent studies have shown that changes in glomerular proteoglycan expression may play a major role in the pathogenesis of renal disease. Steroid hormones are used as first-choice therapy for the treatment of gl...

journal_title：Kidney international

authors： Kuroda M,Sasamura H,Shimizu-Hirota R,Mifune M,Nakaya H,Kobayashi E,Hayashi M,Saruta T

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Rho proteins are small guanine 5'-triphosphate (GTP)-binding proteins felt to be important regulators of several aspects of cell function, including the organization of the actin cytoskeleton. The effects of Rho proteins on the regulation of renal tubular epithelial cell function are not known. METHODS:Sele...

journal_title：Kidney international

authors： Anderson RJ,Ray CJ,Popoff MR

更新日期：2000-11-01 00:00:00

abstract：:Proteomics-based assays have substantially improved diagnostic accuracy in systemic amyloidosis and have led to the discovery of novel amyloidogenic proteins. The observation that human apolipoproteins are increasingly represented is intriguing and highlights the complex, and partially known, mutual effects of the mis...

journal_title：Kidney international

authors： Obici L,Nuvolone M,Merlini G

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Chronic oversecretion of parathyroid hormone (PTH) is associated with parathyroid hyperplasia, reflecting a disturbed balance between cell proliferation and apoptosis. This study addressed the unsolved issue of apoptosis in hyperparathyroidism. METHODS:Parathyroid glands from 19 patients with primary (1 deg...

journal_title：Kidney international

authors： Zhang P,Duchambon P,Gogusev J,Nabarra B,Sarfati E,Bourdeau A,Drüeke TB

更新日期：2000-02-01 00:00:00

abstract：:Chronic cyclosporine (CsA) nephrotoxicity is a major complication of heart, bone marrow, and renal transplantation, and is characterized in humans by striped interstitial fibrosis, tubular dilatation and atrophy, and hyalinization of hilar arterioles. This last feature is highly specific for cyclosporine injury and ha...

journal_title：Kidney international

authors： Young BA,Burdmann EA,Johnson RJ,Andoh T,Bennett WM,Couser WG,Alpers CE

更新日期：1995-08-01 00:00:00

abstract：:Orskov and colleagues demonstrate the impact of birth weight on the mean age of end-stage renal disease (ESRD) in a large Danish ADPKD cohort. Each kilogram of birth weight extended the mean age of ESRD onset by 1.7 years. Placental insufficiency, activation of the renin-angiotensin-aldosterone system, increased fetal...

journal_title：Kidney international

authors： Chapman AB

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus-associated nephropathy (HIVAN) has become the third leading cause of end-stage renal disease (ESRD) in African Americans, and is expected to grow exponentially. Highly active antiretroviral therapy (HAART) has significantly prolonged the survival of patients with HIV infection. D...

journal_title：Kidney international

authors： Kumar MS,Sierka DR,Damask AM,Fyfe B,McAlack RF,Heifets M,Moritz MJ,Alvarez D,Kumar A

更新日期：2005-04-01 00:00:00

abstract：:The effects of intravenous (i.v.) and intracarotid (IC) angiotensin II (AII) infusion on systemic and renal hemodynamics, renal water excretion, and plasma antidiuretic hormone (ADH) levels were examined in six conscious dogs under water loaded and hydropenic conditions. In the first group of seven studies, AII in a m...

journal_title：Kidney international

authors： Henrich WL,Walker BR,Handelman WA,Erickson AL,Arnold PE,Schrier RW

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Endotoxin is an important factor in the development of acute renal failure related to infection and in acceleration of chronic nephritis. Lipopolysaccharide (LPS; the major component of endotoxin) is one of the most potent triggers for renal cells to produce monocyte chemoattractant protein-1 (MCP-1), a key ...

journal_title：Kidney international

authors： Wang Y,Rangan GK,Goodwin B,Tay YC,Harris DC

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Immune response to oxidized low-density lipoprotein (oxLDL) may modulate the process of atherogenesis and cardiovascular disease. METHODS:We performed a prospective, observational cohort study in 249 patients with end-stage renal disease (ESRD) to examine whether the serum titer of anti-oxLDL antibody can p...

journal_title：Kidney international

authors： Shoji T,Fukumoto M,Kimoto E,Shinohara K,Emoto M,Tahara H,Koyama H,Ishimura E,Nakatani T,Miki T,Tsujimoto Y,Tabata T,Nishizawa Y

更新日期：2002-12-01 00:00:00

abstract：:We examined the role of the plasminogen activator/plasmin system in extracellular matrix (ECM) degradation by human mesangial cells cultured on thin films of 125I-labeled ECM (Matrigel). ECM degradation (release of 125I into the medium) was dependent on exogenous plasminogen, proportional to the number of mesangial ce...

journal_title：Kidney international

authors： Baricos WH,Cortez SL,el-Dahr SS,Schnaper HW

更新日期：1995-04-01 00:00:00