Dietary salt regulates expression of Tamm-Horsfall glycoprotein in rats.

abstract：:Recent insights have defined the central role of podocytes both in rare genetic diseases and as a general determinant of the progression of human glomerular diseases. In a recent issue of Nature, Weavers et al. described a podocyte-like cell type in Drosophila, the nephrocyte, that closely resembles mammalian podocyte...

journal_title：Kidney international

authors： Simons M,Huber TB

更新日期：2009-03-01 00:00:00

abstract：:Coronary artery stenosis induces renal inflammation and kidney injury in pigs even in the absence of myocardial infarction or clinically significant heart failure. This effect is aggravated by experimentally induced renovascular hypertension. Interestingly, oxidative stress originating from the ischemic myocardium was...

journal_title：Kidney international

authors： Rump LC,Stegbauer J

更新日期：2015-04-01 00:00:00

abstract：:Although it has been recognized for more than 140 years that the pacemaker driving pyeloureteric peristalsis resides within the kidney, the cellular mechanisms underlying this autorhythmicity have been little investigated. The demonstration by Hurtado et al. of a role of hyperpolarization-activated cation channels in ...

journal_title：Kidney international

authors： Lang RJ

更新日期：2010-03-01 00:00:00

abstract：:Epigenetic mechanisms have been the focus of intensive research. De Marinis et al. demonstrated that high glucose levels exert stimulatory effects on activation histone marks, leading to the upregulation of thioredoxin-interacting protein (TXNIP) gene expression, which is proinflammatory. They also showed that the eff...

journal_title：Kidney international

authors： Mimura I

更新日期：2016-02-01 00:00:00

abstract：:Experimental studies have demonstrated the cardinal role played by the mononuclear phagocyte system in the removal of antigen-antibody complexes. To assess the functional capacity of phagocytes in patients with renal disease, 33 normal subjects, 10 patients with mesangial proliferative glomerulonephritis, 8 patients w...

journal_title：Kidney international

authors： Ooi YM,Ooi BS

更新日期：1983-06-01 00:00:00

abstract：:We investigated the effects of epidermal growth factor (EGF) and arginine vasopressin (AVP) on Raf-1-MAP kinase cascade, including Raf-1-kinase (Raf-1-K), MAP kinase kinase (MAPKK), MAP kinase (MAPK) and S6 kinase (S6K) in Madin-Darby canine kidney (MDCK) cells. In a dose-dependent manner (10(-10) M to 10(-6) M), EGF ...

journal_title：Kidney international

authors： Yamada T,Terada Y,Homma MK,Nonoguchi H,Sasaki S,Yuasa Y,Tomita K,Marumo F

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:The amount of oxalate excreted in urine has a significant impact on calcium oxalate supersaturation and stone formation. Dietary oxalate is believed to make only a minor (10 to 20%) contribution to the amount of oxalate excreted in urine, but the validity of the experimental observations that support this co...

journal_title：Kidney international

authors： Holmes RP,Goodman HO,Assimos DG

更新日期：2001-01-01 00:00:00

abstract：:Fatal vascular access hemorrhage is considered a rare complication of hemodialysis (HD). Ellingson et al. indicate otherwise, and their data suggest that it causes 0.4-1.6% of deaths in US HD patients. It is more common with grafts than fistulas, and many victims have had previous access hemorrhages. The widespread pr...

journal_title：Kidney international

authors： Blake PG,Quinn RR,Oliver MJ

更新日期：2012-09-01 00:00:00

abstract：:Nephrin is a slit diaphragm protein critical for structural and functional integrity of visceral glomerular epithelial cells (podocytes) and is known to be tyrosine phosphorylated by Src family kinases. We studied the role of phosphoinositide 3-kinase (PI3K), activated via the phosphorylation of nephrin, in actin cyto...

journal_title：Kidney international

authors： Zhu J,Sun N,Aoudjit L,Li H,Kawachi H,Lemay S,Takano T

更新日期：2008-03-01 00:00:00

abstract：:Tuberous sclerosis complex is a genetic disorder characterized by hamartomatous lesions in multiple organs, frequently involving the kidney. We conducted a retrospective review of the clinical and radiographic records of 167 patients with tuberous sclerosis to determine the frequency of renal disease, the likelihood o...

journal_title：Kidney international

authors： Rakowski SK,Winterkorn EB,Paul E,Steele DJ,Halpern EF,Thiele EA

更新日期：2006-11-01 00:00:00

abstract：:We evaluated the effects of the bisphosphonate pamidronate on bone histomorphometry, structure and strength in male rats with uninephrectomy or with chronic renal disease induced by 5/6 nephrectomy. In rats with chronic renal disease the plasma urea, phosphate and parathyroid hormone levels were significantly increase...

journal_title：Kidney international

authors： Jokihaara J,Pörsti IH,Kööbi P,Jolma PM,Mustonen JT,Saha HH,Sievänen H,Kannus P,Iwaniec UT,Turner RT,Järvinen TL

更新日期：2008-08-01 00:00:00

abstract：:Elevated serum levels of uric acid consistently correlate with hypertension, but the directionality of the association remains debated. To help define this relationship, we used a controlled setting within a homogeneous Amish community and the Mendelian randomization of a nonsynonymous coding single-nucleotide polymor...

journal_title：Kidney international

authors： Parsa A,Brown E,Weir MR,Fink JC,Shuldiner AR,Mitchell BD,McArdle PF

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Fabry disease is an X-linked generalized progressive debilitating lysosomal storage disorder. The disease usually manifests in childhood, but the diagnosis is often made following the occurrence of late-stage complications such as progressive kidney failure. In order to identify key novel renal diagnostic im...

journal_title：Kidney international

authors： Ries M,Bettis KE,Choyke P,Kopp JB,Austin HA 3rd,Brady RO,Schiffmann R

更新日期：2004-09-01 00:00:00

abstract：:Alterations in myocardial wall texture stand out among ADPKD cardiovascular manifestations in hypertensive and normotensive patients. To elucidate their pathogenesis, we analyzed the cardiac phenotype in Pkd1(cond/cond)Nestin(cre) (CYG+) cystic mice exposed to increased blood pressure, at 5 to 6 and 20 to 24 weeks of ...

journal_title：Kidney international

authors： Balbo BE,Amaral AG,Fonseca JM,de Castro I,Salemi VM,Souza LE,Dos Santos F,Irigoyen MC,Qian F,Chammas R,Onuchic LF

更新日期：2016-09-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of kidney cysts leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Identification of an early biomarker that can predict progression of CKD is urgently needed. In an earlier Consortium for Radiolog...

journal_title：Kidney international

authors： Yu ASL,Shen C,Landsittel DP,Harris PC,Torres VE,Mrug M,Bae KT,Grantham JJ,Rahbari-Oskoui FF,Flessner MF,Bennett WM,Chapman AB,Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP).

更新日期：2018-03-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common kidney malignancy and has a poor prognosis owing to its resistance to chemotherapy. RCC cells overexpress the transcription factor, PAX2, normally expressed in fetal kidney but downregulated at birth. Since Pax2 suppresses apoptosis during renal development, we reasoned th...

journal_title：Kidney international

authors： Hueber PA,Waters P,Clark P,Eccles M,Goodyer P

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:We aimed to identify genes with kidney specific, developmentally regulated expression. Here we report the cDNA sequence and expression pattern of KS, a novel kidney-specific rat gene. METHODS:A partial cDNA was identified by differential display polymerase chain reaction (PCR) of a renal cell fraction enric...

journal_title：Kidney international

authors： Hilgers KF,Nagaraj SK,Karginova EA,Kazakova IG,Chevalier RL,Carey RM,Pentz ES,Gomez RA

更新日期：1998-11-01 00:00:00

abstract：:In recent years, a substantial body of experimental and clinical work has been devoted to C3 glomerulopathy and Ig-mediated membranoproliferative glomerulonephritis. Despite the rapid accumulation of data, several uncertainties about these 2 rare forms of nephropathies persist. They concern their pathophysiology, clas...

journal_title：Kidney international

authors： Fakhouri F,Le Quintrec M,Frémeaux-Bacchi V

更新日期：2020-11-01 00:00:00

abstract：:This study examined the utility of interleukin-10 (IL-10), a cytokine with potent anti-macrophage and anti-Th1 activity, in the treatment of experimental anti-glomerular basement membrane (GBM) nephritis in the rat. Accelerated anti-GBM disease was induced in Sprague-Dawley rats by immunization with rabbit IgG, follow...

journal_title：Kidney international

authors： Chadban SJ,Tesch GH,Lan HY,Atkins RC,Nikolic-Paterson DJ

更新日期：1997-06-01 00:00:00

abstract：:The effect of intravenous infusion of angiotensin II on microvascular parameters of the renal microcirculation of rats was studied. With the aid of fluorescence microscopy and a high sensitivity video system we observed the passage of fluorescence-labeled erythrocytes through single glomerular capillaries on the surfa...

journal_title：Kidney international

authors： Zimmerhackl B,Parekh N,Kücherer H,Steinhausen M

更新日期：1985-01-01 00:00:00

abstract：:Podocyte injury and loss contribute to the progression of glomerular diseases, including diabetic kidney disease. We previously found that the glomerular expression of Sirtuin-1 (SIRT1) is reduced in human diabetic glomeruli and that the podocyte-specific loss of SIRT1 aggravated albuminuria and worsened kidney diseas...

journal_title：Kidney international

authors： Hong Q,Zhang L,Das B,Li Z,Liu B,Cai G,Chen X,Chuang PY,He JC,Lee K

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Decreased red blood cell survival contributes to the anemia of chronic renal failure patients. Because patients on chronic dialysis therapy are frequently exposed to excessive complement activation, we investigated the susceptibility of this patient population to erythrocyte C5b-9 deposition, complement-medi...

journal_title：Kidney international

authors： Himmelfarb J,McMonagle E,Holbrook D,Hakim R

更新日期：1999-02-01 00:00:00

abstract：:Hypocalcemia, hyperphosphatemia, and resistance to the action of PTH are well characterized features in the setting of advanced chronic renal failure (CRF). Although the underlying mechanisms are ill-understood, clinical and experimental evidence points to both PTH receptor down-regulation and post-receptor abnormalit...

journal_title：Kidney international

authors： Ureña P,Kubrusly M,Mannstadt M,Hruby M,Trinh MM,Silve C,Lacour B,Abou-Samra AB,Segre GV,Drüeke T

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Tubulointerstitial fibrosis is a morphologic hallmark of chronic kidney disease and is a key factor in the prediction of progression to end-stage renal failure. Disruption of tubular basement membrane and interstitial extracellular matrix (ECM) via cytokine-induced alterations in matrix metalloproteinases (M...

journal_title：Kidney international

authors： Nee LE,McMorrow T,Campbell E,Slattery C,Ryan MP

更新日期：2004-10-01 00:00:00

abstract：:The increasing use of mice in renal and cardiovascular studies has necessitated adapting physiological methods used for rats to mice, which are far smaller in size. We have adapted measurements of continuous renal blood flow, pressure natriuresis and diuresis, and laser-Doppler cortical and medullary flow to 40 g mice...

journal_title：Kidney international

authors： Gross V,Lippoldt A,Luft FC

更新日期：1997-11-01 00:00:00

abstract：:The ankyrin repeat and sterile α motif (SAM) domain-containing six gene (Anks6) is a candidate for polycystic kidney disease (PKD). Originally identified in the PKD/Mhm(cy/+) rat model of PKD, the disease is caused by a mutation (R823W) in the SAM domain of the encoded protein. Recent studies support the etiological r...

journal_title：Kidney international

authors： Bakey Z,Bihoreau MT,Piedagnel R,Delestré L,Arnould C,de Villiers Ad,Devuyst O,Hoffmann S,Ronco P,Gauguier D,Lelongt B

更新日期：2015-08-01 00:00:00

abstract：:Extracellular fluid volume expansion is known to produce exaggerated natriuresis in essential hypertension. In order to assess the role of hemodynamic and intrarenal physical factors upon natriuretic response to central volume expansion, two hour water immersion (WI) experiments were made in six uncomplicated essentia...

journal_title：Kidney international

authors： Coruzzi P,Musiari L,Biggi A,Ravanetti C,Vallisa D,Montanari A,Novarini A

更新日期：1988-04-01 00:00:00

abstract：:We studied the specific binding of radiolabeled bradykinin ([3H]BK) and vasopressin ([3H]AVP) to membrane preparations of bovine and porcine kidney medulla. [3H]BK reversibly labeled a single site (Kd = 1.06 nM) in bovine kidney medulla independently of [Mg2+]. The number of BK receptors in bovine kidney medulla, Bmax...

journal_title：Kidney international

authors： Howl J,Yarwood NJ,Davies AR,Wheatley M

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:To identify susceptibility genes for diabetic nephropathy, GeneChip Expression Analysis was employed to survey the gene expression profile of diabetic KK/Ta mouse kidneys. METHODS:Kidneys from three KK/Ta and two BALB/c mice at 20 weeks of age were dissected. Total RNA was extracted and labeled for hybridiz...

journal_title：Kidney international

authors： Fan Q,Shike T,Shigihara T,Tanimoto M,Gohda T,Makita Y,Wang LN,Horikoshi S,Tomino Y

更新日期：2003-12-01 00:00:00

abstract：:To test the contribution of bicarbonate (Bi) to hemodynamic stability during hemodialysis (HD), we compared the effects of ultrafiltration dialysis with bicarbonate and with acetate under conditions of high-sodium (141 mEq/liter) and low-sodium (130 mEq/liter) dialysate concentrations in 12 stable HD patients. Group 1...

journal_title：Kidney international

authors： Velez RL,Woodard TD,Henrich WL

更新日期：1984-07-01 00:00:00