The risks of vascular access.

abstract：:Ischemia-reperfusion occurs in a great many clinical settings and contributes to organ failure or dysfunction. CD154-CD40 signaling in leukocyte-endothelial cell interactions or T-cell activation facilitates tissue inflammation and injury. Here we tested a siRNA anti-CD40 in rodent warm and cold ischemia models to che...

journal_title：Kidney international

authors： de Ramon L,Ripoll E,Merino A,Lúcia M,Aran JM,Pérez-Rentero S,Lloberas N,Cruzado JM,Grinyó JM,Torras J

更新日期：2015-09-01 00:00:00

abstract：:The kidney is influenced by circadian rhythms and is entrained to the sleep-wake cycle allowing anticipation of the metabolic and physiological demands of the kidney throughout a 24-hour cycle. Although sleep disruption has been studied extensively in cardiovascular and metabolic disease, its association with chronic ...

journal_title：Kidney international

authors： McMullan CJ,Curhan GC,Forman JP

更新日期：2016-06-01 00:00:00

abstract：:To determine whether Cyclosporine A (CsA) alters the intrarenal expression of the renin and type 1 angiotensin II receptor genes, male adult Sprague-Dawley rats were given 25 mg/kg/day CsA s.c. for three weeks (CsA, N = 20) and were compared to pair-fed vehicle treated rats (Con, N = 20). The intrarenal distribution o...

journal_title：Kidney international

authors： Tufro-McReddie A,Gomez RA,Norling LL,Omar AA,Moore LC,Kaskel FJ

更新日期：1993-03-01 00:00:00

abstract：:Glutamine accumulation in rat kidney was investigated by giving large loads of gluta, mate and aspartate and measuring glutamine changes in seven completely defined portions of the nephron and in small patches from the thin limb area and from the papilla. Both glutamate and aspartate (which is partly coverted to gluta...

journal_title：Kidney international

authors： Burch HB,Chan AW,Alvey TR,Lowry OH

更新日期：1978-11-01 00:00:00

abstract：:Ischemia-reperfusion injury (IRI) is the outcome of an inflammatory process that is triggered when an organ undergoes a transient reduction or cessation of blood flow, followed by re-establishment of perfusion. In the clinical setting, IRI contributes to significant acute kidney injury, patient morbidity and mortality...

journal_title：Kidney international

authors： Pefanis A,Ierino FL,Murphy JM,Cowan PJ

更新日期：2019-08-01 00:00:00

abstract：:Although the pathogenesis of steroid-sensitive nephrotic syndrome (SSNS) remains elusive, multiple epidemiologic, clinical, and experimental studies converge on the common theme of immune dysregulation. Initially, T-cell adaptive immunity was solely emphasized; however, the role of humoral immunity in nephrotic syndro...

journal_title：Kidney international

authors： Chambers ET,Gbadegesin RA

更新日期：2019-10-01 00:00:00

abstract：:In rodents, mercuric chloride (HgCl2) causes an autoimmune disorder with glomerulonephritis (GN), and represents an animal model for the pathogenesis of GN. We have tested the hypothesis that HgCl2 induces major histocompatibility complex (MHC) expression in renal parenchymal cells, and studied the kinetics of this in...

journal_title：Kidney international

authors： Madrenas J,Parfrey NA,Halloran PF

更新日期：1991-02-01 00:00:00

abstract：:When patients develop acute kidney injury, a small fraction of them will develop end-stage renal disease later. The severity of renal impairment in the remaining patients is uncertain because studies have not carefully examined renal function over time or the precise timing of entry into a late stage of chronic kidney...

journal_title：Kidney international

authors： Amdur RL,Chawla LS,Amodeo S,Kimmel PL,Palant CE

更新日期：2009-11-01 00:00:00

abstract：:Bovine serum albumin (BSA, pI 4.9) was maleylated to yield highly anionic MBSA (pI 3.0). Maleylation of BSA lead to an expansion of molecular size of native BSA from an effective molecular radius (EMR) of 37 A to 57 A for MBSA as assessed by gel filtration chromatography. MBSA, but not BSA, bound to the peripheral cap...

journal_title：Kidney international

authors： Barnes JL,Reznicek MJ,Radnik RA,Venkatachalam MA

更新日期：1988-08-01 00:00:00

abstract：:Among Canadians starting dialysis, patients of East Asian and Indo Asian background are less likely than whites to receive a renal allograft. Although the reasons for such variation are complex, less living donation may contribute significantly. More studies are needed to confirm these differences and to evaluate stra...

journal_title：Kidney international

authors： Prasad GV

更新日期：2007-08-01 00:00:00

abstract：:Defects in the primary cilium/basal body complex of renal tubular cells cause polycystic kidney disease (PKD). To uncover pathways associated with disease progression, we determined the kidney transcriptome of 10-day-old severely and mildly affected cpk mice, a model of recessive PKD. In the severe phenotype, the most...

journal_title：Kidney international

authors： Mrug M,Zhou J,Woo Y,Cui X,Szalai AJ,Novak J,Churchill GA,Guay-Woodford LM

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Thiazide diuretics have the unique characteristic of increasing renal Na+ excretion, while decreasing Ca2+ excretion. However, the molecular mechanism responsible for this thiazide-induced hypocalciuria remains unclear. The present study investigates the effect of thiazides on the expression of the protein...

journal_title：Kidney international

authors： Nijenhuis T,Hoenderop JG,Loffing J,van der Kemp AW,van Os CH,Bindels RJ

更新日期：2003-08-01 00:00:00

abstract：:Eight patients with chronic renal failure (GFR 18.8 +/- 2.7 ml/min) were randomized to a crossover comparison of a very low protein diet (VLPD) containing 0.28 g protein and 35 kcal per kg per day, plus an isosmolar mixture of either ketoacids (KA) or essential amino acids (EAA). Subjects initiated the diets 14 days b...

journal_title：Kidney international

authors： Masud T,Young VR,Chapman T,Maroni BJ

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:While metabolically generated oxidants are produced locally in experimental glomerular diseases, little is still known of their significance and the respective scavenger systems in human glomerular diseases. METHODS:Here we studied kidneys from patients with congenital nephrotic syndrome of the Finnish type...

journal_title：Kidney international

authors： Solin ML,Ahola H,Haltia A,Ursini F,Montine T,Roveri A,Kerjaschki D,Holthöfer H

更新日期：2001-02-01 00:00:00

abstract：:We examined the process of receptor-mediated endocytosis in A-9 lung fibroblast and chinese hamster ovary (CHO) cells transfected with the recently cloned vasopressin V1a receptor (51). We used a fluorescent labeled vasopressin analog (rhodamine-mercaptopropionic acid lysine vasopressin) and radiolabeled vasopressin t...

journal_title：Kidney international

authors： Lutz W,Sanders M,Salisbury J,Lolait S,O'Carroll AM,Kumar R

更新日期：1993-04-01 00:00:00

abstract：:The introduction of two-photon microscopy, along with the development of new fluorescent probes and innovative computer software, has advanced the study of intracellular and intercellular processes in the tissues of living organisms. Researchers can now determine the distribution, behavior, and interactions of labeled...

journal_title：Kidney international

authors： Ashworth SL,Sandoval RM,Tanner GA,Molitoris BA

更新日期：2007-08-01 00:00:00

abstract：:Human renal dysplasia is frequently associated with urinary tract obstruction and the abnormal expression of mitogen-activated protein kinase (MAPK). Here, we determined the renal responses and MAPK expression in developing kidneys that were obstructed in fetal lambs. Kidneys were harvested at various times after obst...

journal_title：Kidney international

authors： Omori S,Kitagawa H,Koike J,Fujita H,Hida M,Pringle KC,Awazu M

更新日期：2008-05-01 00:00:00

abstract：:The maximum rate of inorganic phosphorus (P1) reabsorption (Tmp1) was measured during phosphate infusion in chronically parathyroidectomized rats. In either initially hydropenic rats or others which underwent moderate preliminary saline loading, Tmp1 tended to rise during early phosphate infusion and then decline, so ...

journal_title：Kidney international

authors： Engle JE,Steele TH

更新日期：1975-08-01 00:00:00

abstract：:Autologous and allogeneic bone marrow grafting both require cytoreductive therapy but only the allogeneic procedure requires immunosuppressive agents. Allogeneic bone marrow transplantation has been reported to be associated with a high incidence of both renal failure and veno-occlusive disease (VOD) of the liver, the...

journal_title：Kidney international

authors： Merouani A,Shpall EJ,Jones RB,Archer PG,Schrier RW

更新日期：1996-09-01 00:00:00

abstract：:To determine the prognosis and risk factors for ischemic heart disease in chronic uremia, a cohort of 432 dialysis patients were followed prospectively from start of dialysis therapy until death or renal transplantation. Baseline demographic, clinical and echocardiographic data were obtained. After the initiation of d...

journal_title：Kidney international

authors： Parfrey PS,Foley RN,Harnett JD,Kent GM,Murray D,Barre PE

更新日期：1996-05-01 00:00:00

abstract：:Hypoalbuminemia is the most powerful predictor of mortality in end-stage renal disease. Since protein-calorie malnutrition can decrease albumin synthesis it is assumed that hypoalbuminemia results principally from malnutrition in these patients, but albumin synthesis may also be decreased as part of the acute-phase re...

journal_title：Kidney international

authors： Kaysen GA,Rathore V,Shearer GC,Depner TA

更新日期：1995-08-01 00:00:00

abstract：:The vascular endothelium normally is maintained in a quiescent state, but under certain conditions it is induced to undergo marked changes in behavior and form new vascular structures. A complex interaction among various growth and differentiation factors and the extracellular milieu regulates this behavior. One serie...

journal_title：Kidney international

authors： Schnaper HW,Kleinman HK,Grant DS

更新日期：1993-01-01 00:00:00

abstract：:Management of idiopathic glomerular disease associated with nephrotic syndrome (INS) remains controversial and one of the most complex areas relates to utilization of the drug cyclosporin. This is despite its demonstrated effectiveness in several histologic types of the INS in randomized controlled trials. Cyclosporin...

journal_title：Kidney international

authors： Cattran DC,Alexopoulos E,Heering P,Hoyer PF,Johnston A,Meyrier A,Ponticelli C,Saito T,Choukroun G,Nachman P,Praga M,Yoshikawa N

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Glucocorticoids (GC) represent the mainstay of treatment of idiopathic nephrotic syndrome (INS) and might be involved in the pathogenesis of the disease. We evaluated basal secretion of cortisol, number and affinity of glucocorticoid receptors, dexamethasone (Dex)-mediated inhibition of concanavalin-A (Con-A...

journal_title：Kidney international

authors： Carlotti AP,Franco PB,Elias LL,Facincani I,Costa EL,Foss N,Moreira AC,de Castro M

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Both high glucose (HG) and angiotensin II (Ang II) causes glomerular mesangial cell (GMC) growth and increased synthesis of matrix proteins like collagen IV contributing to diabetic nephropathy. We have recently found that exposure of vascular smooth muscle cells to HG augments the Ang II activation of the g...

journal_title：Kidney international

authors： Amiri F,Shaw S,Wang X,Tang J,Waller JL,Eaton DC,Marrero MB

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Inbred miniature swine treated for 12 days with high-dose cyclosporine A develop tolerance to histocompatibility complex (MHC) class I-mismatched renal allografts. When this protocol was modified by adding thymectomy before transplant, all animals developed acute rejection. Thereafter, by day 100, one half d...

journal_title：Kidney international

authors： Shimizu A,Yamada K,Sachs DH,Colvin RB

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Cardiovascular death continues to be a major problem in renal failure. Structural abnormalities of the heart and the vasculature contribute to the increased cardiovascular risk. They are ameliorated by angiotensin-converting enzyme (ACE) inhibitors, but because of the nonspecifity of ACE inhibition, it is un...

journal_title：Kidney international

authors： Amann K,Gassmann P,Buzello M,Orth SR,Törnig J,Gross ML,Magener A,Mall G,Ritz E

更新日期：2000-07-01 00:00:00

abstract：:Urinary exosomes have received considerable attention as a potential biomarker source for the diagnosis of renal diseases. Notwithstanding, their use in protein biomarker research is hampered by the lack of efficient methods for vesicle isolation, lysis, and protein quantification. Here we report an improved ultracent...

journal_title：Kidney international

authors： Raj DA,Fiume I,Capasso G,Pocsfalvi G

更新日期：2012-06-01 00:00:00

abstract：:Identifying subjects with progressive chronic kidney disease will be important both in clinical practice and in conducting clinical trials. Pruijm et al. (in this issue) demonstrate for the first time that cortical oxygenation as evaluated by blood oxygenation level-dependent magnetic resonance imaging can predict fut...

journal_title：Kidney international

authors： Prasad PV

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Optimal nutrient intake is important in the maintenance of a positive nitrogen balance in hemodialysis (HD) patients. The objectives of this study were (1) to assess the influence of two levels of protein intakes on nitrogen balance in stable adult HD patients, and (2) to identify a minimum level of protein ...

journal_title：Kidney international

authors： Rao M,Sharma M,Juneja R,Jacob S,Jacob CK

更新日期：2000-07-01 00:00:00