当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney.

Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney.

Abstract：

BACKGROUND:We aimed to identify genes with kidney specific, developmentally regulated expression. Here we report the cDNA sequence and expression pattern of KS, a novel kidney-specific rat gene. METHODS:A partial cDNA was identified by differential display polymerase chain reaction (PCR) of a renal cell fraction enriched for proximal tubular and renin-expressing cells. Using the partial cDNA as a probe, a rat kidney cDNA library was screened. The full-length KS sequence was obtained by PCR amplification of cDNA ends. The expression pattern of KS was investigated by Northern blot. RNA was extracted from several organs of newborn and adult rats, as well as from the kidneys of rats with altered tubular function, that is, rats that had undergone unilateral nephrectomy, unilateral ureteral obstruction, neonatal losartan treatment, and the appropriate control animals. The expression of KS was also investigated in the kidneys of rats with spontaneous or renovascular hypertension. RESULTS:The KS cDNA (2426 bp) contained one open reading frame encoding a predicted 572 amino acid protein. The derived peptide sequence displayed approximately 70% similarity to the hypertension-related SA gene product and approximately 50% similarity to prokaryotic and eukaryotic acetyl-CoA synthases (EC 6. 2.1.1). KS was expressed in the kidney and not in any other organ assayed. KS RNA was not detected in fetal and newborn rat kidney but became apparent after one week of postnatal life. Gene expression was downregulated in rat models of altered tubular function. KS expression was decreased in spontaneously hypertensive rats but not in renovascular hypertension. CONCLUSION:KS, a novel rat gene, exhibits a unique tissue-specific expression exclusively in mature kidneys. The data suggest KS may encode an adenosine monophosphate binding enzyme.

journal_name

Kidney Int

journal_title

Kidney international

authors

Hilgers KF,Nagaraj SK,Karginova EA,Kazakova IG,Chevalier RL,Carey RM,Pentz ES,Gomez RA

doi

10.1046/j.1523-1755.1998.00143.x

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

1444-54

issue

5

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)30774-2

journal_volume

54

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Arterial hypotension in chronic hemodialyzed patients.

    abstract：:We studied in 32 patients on maintenance hemodialysis (duration of treatment 6 to 133 months) whether duration of dialysis treatment affects blood pressure, plasma noradrenaline levels and alpha 2-adrenoceptor density (assessed in platelet membranes by 3H-yohimbine binding). Plasma noradrenaline levels were a signific...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1987.267

    authors： Daul AE,Wang XL,Michel MC,Brodde OE

    更新日期：1987-11-01 00:00:00

  • Flow-mediated vasodilation and distensibility of the brachial artery in renal allograft recipients.

    abstract：BACKGROUND:Alterations of large artery function and structure are frequently observed in renal allograft recipients. However, endothelial function has not yet been assessed in this population. METHODS:Flow-mediated vasodilation is a useful index of endothelial function. We measured the diameter and distensibility of t...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.0550031104.x

    authors： Hausberg M,Kisters K,Kosch M,Rahn KH,Barenbrock M

    更新日期：1999-03-01 00:00:00

  • Platelet-derived growth factor receptors in the kidney--upregulated expression in inflammation.

    abstract：:Major features of a long-standing inflammation in the kidney are vascular proliferation, glomerulosclerosis, interstitial fibrosis and tubular atrophy, leading to a gradual deterioration of the renal function. In this study we have investigated the expression of B-type receptors for platelet-derived growth factor (PDG...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.306

    authors： Fellström B,Klareskog L,Heldin CH,Larsson E,Rönnstrand L,Terracio L,Tufveson G,Wahlberg J,Rubin K

    更新日期：1989-12-01 00:00:00

  • Effects of arteriovenous fistulas on cardiac oxygen supply and demand.

    abstract：BACKGROUND:Arteriovenous (AV) fistulas used for hemodialysis access may affect cardiac load by increasing the preload while decreasing the afterload. In dogs, AV fistulas have also been shown to affect coronary perfusion negatively. We investigated the net effect of AV fistulas on cardiac oxygen supply and demand. MET...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00433.x

    authors： Bos WJ,Zietse R,Wesseling KH,Westerhof N

    更新日期：1999-05-01 00:00:00

  • Sum of segmental bioimpedance analysis during ultrafiltration and hemodialysis reduces sensitivity to changes in body position.

    abstract：BACKGROUND:Bioimpedance, a noninvasive technique to analyze body composition, has attracted interest in determining body hydration in hemodialysis patients. However, the so-called whole-body (wrist-to-ankle) bioimpedance analysis (WBIA) is sensitive to changes in regional fluid distribution and tends to underestimate f...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00588.x

    authors： Zhu F,Schneditz D,Levin NW

    更新日期：1999-08-01 00:00:00

  • Monocyte chemoattractant protein 1 mediates glomerular macrophage infiltration in anti-GBM Ab GN.

    abstract：:Monocyte chemoattractant protein 1 (MCP-1) is a C-C chemokine with potent monocyte chemotactic and activating properties that may contribute to glomerular macrophage infiltration in anti-GBM Ab GN. We have previously reported increased glomerular steady state expression of MCP-1 mRNA relative to GAPDH mRNA in the hete...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.363

    authors： Tang WW,Qi M,Warren JS

    更新日期：1996-08-01 00:00:00

  • Expression, regulation, and function of inhibitor of apoptosis family genes in rat mesangial cells.

    abstract：BACKGROUND:The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. The purpose of this investigation was to examine the expression, regulation, and function of IAP genes in cultured rat mesangial cells. METHODS:Basal and inducible expression of c-IAP1, c-IAP2, ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.060002579.x

    authors： Furusu A,Nakayama K,Xu Q,Konta T,Sugiyama H,Kitamura M

    更新日期：2001-08-01 00:00:00

  • Factors in the dialysis regimen which contribute to alterations in the abnormalities of uremia.

    abstract：:While hemodialysis therapy in its present form is capable of sustaining life, dialysis patients are not metabolically normal and we are unable to say what technical factors contribute adequate therapy. Recent efforts to resolve these problems have led to the assumption that substances in the molecular weight range of ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1976.126

    authors： Lowrie EG,Steinberg SM,Galen MA,Gagneux SA,Lazarus JM,Gottlieb MN,Merrill JP

    更新日期：1976-11-01 00:00:00

  • Metabolic acidosis inhibits soft tissue calcification in uremic rats.

    abstract：:Metabolic acidosis is common in patients with chronic kidney disease, which is known to affect bone metabolism. We examined the effect of metabolic acidosis on the development of vascular and other soft-tissue calcifications in uremic rats treated with calcitriol. Extraskeletal calcification was measured in vivo, in c...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5002646

    authors： Mendoza FJ,Lopez I,Montes de Oca A,Perez J,Rodriguez M,Aguilera-Tejero E

    更新日期：2008-02-01 00:00:00

  • Expanding the use of hepatitis C-viremic kidney donors.

    abstract：:Direct-acting antivirals have revolutionized the treatment of hepatitis C virus (HCV) infection in patients with chronic kidney disease, with implications for the timing of antiviral treatment among kidney transplant candidates and for the use of HCV viremic donors. A recent consensus conference reviewed the available...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2017.09.002

    authors： Sawinski D,Wyatt CM,Locke JE

    更新日期：2017-11-01 00:00:00

  • Reduced p21, p27 and vitamin D receptor in the nodular hyperplasia in patients with advanced secondary hyperparathyroidism.

    abstract：BACKGROUND:In uremic patients with secondary hyperparathyroidism (2HPT), nodular hyperplasia of parathyroid gland shows a monoclonal pattern of cell proliferation, in which a decreased density of vitamin D receptor (VDR) also is demonstrated. The present study aimed at elucidating the mechanism of parathyroid cell prol...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2002.kid585.x

    authors： Tokumoto M,Tsuruya K,Fukuda K,Kanai H,Kuroki S,Hirakata H

    更新日期：2002-10-01 00:00:00

  • Effects of angiotensin-converting enzyme inhibitors on the treatment of anemia with erythropoietin.

    abstract：BACKGROUND:The hypothesis that angiotensin-converting enzyme (ACE) inhibitors interfere with the treatment of anemia with recombinant human erythropoietin (rHuEPO) remains controversial. To test this hypothesis, a retrospective analysis was conducted in a large group of hemodialysis patients with renal anemia. METHODS...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00028.x

    authors： Hayashi K,Hasegawa K,Kobayashi S

    更新日期：2001-11-01 00:00:00

  • Imaging renal structures by X-ray phase-contrast microtomography.

    abstract：:X-ray crystal interferometer-based X-ray phase-contrast microtomography (phase-contrast microtomography) is able to image microstructures within soft tissue without the use of a contrast agent. Here we determined the feasibility of using this technique in the non-destructive inspection of formalin-fixed kidney tissue ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.42

    authors： Wu J,Takeda T,Lwin TT,Momose A,Sunaguchi N,Fukami T,Yuasa T,Akatsuka T

    更新日期：2009-05-01 00:00:00

  • Regulation of the Na+/H+ antiporter in patients with mild chronic renal failure: effect of glucose.

    abstract：BACKGROUND:The aim of this study was to determine the glucose-dependent regulation of the sodium-proton-antiporter (Na+/H+ antiporter) in patients with mild chronic renal failure (CRF). METHODS:We measured plasma glucose concentrations, plasma insulin concentrations, plasma C peptide concentrations, arterial blood pre...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00510.x

    authors： Tepel M,van der Giet M,Brukamp K,Weyer J,Zidek W

    更新日期：1999-07-01 00:00:00

  • A clinical study of anti-NDP in the sera of patients in a large repetitive hemodialysis program.

    abstract：:Anti-NDP has been detected in the sera of 38 of 430 patients on regular hemodialysis at the Regional Kidney Disease Program in Minneapolis. It developed in these patients from 7 to 58 months after commencement of dialysis. Bacterial infection appeared temporally related to the development of anti-NDP in 12 patients. H...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1976.133

    authors： Crosson JT,Moulds J,Comty CM,Polesky HF

    更新日期：1976-12-01 00:00:00

  • Increased nitric oxide inactivation by reactive oxygen species in lead-induced hypertension.

    abstract：BACKGROUND:We have recently found evidence for increased reactive oxygen species (ROS) in rats with lead-induced hypertension. We hypothesized that increased ROS activity may contribute to hypertension by enhancing inactivation of nitric oxide (NO) in this model. METHODS:Rats were treated for 12 weeks with either lead...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00670.x

    authors： Vaziri ND,Liang K,Ding Y

    更新日期：1999-10-01 00:00:00

  • Small proteoglycans of normal adult human kidney: distinct expression patterns of decorin, biglycan, fibromodulin, and lumican.

    abstract：BACKGROUND:Among the members of the small leucine-rich proteoglycan family, decorin, biglycan, and fibromodulin have been proposed to be potent modulators of transforming growth factor-beta (TGF-beta) activity, thereby playing an important role in the pathogenesis of fibrotic kidney diseases. Furthermore, decorin expre...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00317.x

    authors： Schaefer L,Gröne HJ,Raslik I,Robenek H,Ugorcakova J,Budny S,Schaefer RM,Kresse H

    更新日期：2000-10-01 00:00:00

  • The effect of angiotensin-converting-enzyme inhibitors on progression of advanced polycystic kidney disease.

    abstract：BACKGROUND:It is not known whether angiotensin-converting-enzyme (ACE) inhibitors slow the progression of polycystic kidney disease (PKD). We performed a patient-level meta-analysis to compare the effect of antihypertensive regimens, including ACE inhibitors, to those without ACE inhibitors (controls) on kidney disease...

    journal_title：Kidney international

    pub_type： 杂志文章,meta分析

    doi：10.1111/j.1523-1755.2005.00077.x

    authors： Jafar TH,Stark PC,Schmid CH,Strandgaard S,Kamper AL,Maschio G,Becker G,Perrone RD,Levey AS,ACE Inhibition in Progressive Renal Disease (AIPRD) Study Group.

    更新日期：2005-01-01 00:00:00

  • Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells.

    abstract：BACKGROUND:Cellular and molecular mechanisms responsible for cisplatin-induced nephrotoxicity to renal tubular epithelial cells are not well understood. Although caspases play a critical role in the execution of the cell death pathway, their specific role in toxic injury to renal tubular epithelial cells has not been e...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00026.x

    authors： Kaushal GP,Kaushal V,Hong X,Shah SV

    更新日期：2001-11-01 00:00:00

  • Synthetic oleanane triterpenoids: magic bullets or not?

    abstract：:A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2013.38

    authors： Abboud HE

    更新日期：2013-05-01 00:00:00

  • Single-cell RNA-sequence analysis of mouse glomerular mesangial cells uncovers mesangial cell essential genes.

    abstract：:Mesangial cells are essential for the structure and function of glomeruli, but the mechanisms underlying these roles are not well understood. Here, we performed a single-cell RNA-sequence (RNA-seq) analysis of mouse mesangial cells using the Fluidigm C1 platform. We found that gene expression in individual mesangial c...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2017.01.016

    authors： Lu Y,Ye Y,Yang Q,Shi S

    更新日期：2017-08-01 00:00:00

  • Renal function and glomerular hemodynamics in male endotoxemic rats.

    abstract：:The renal effects of a single intravenous dose of two different E. coli lipopolysaccharides (LPS 0111:B4 and LPS 0127:B8), at the same dose of 100 micrograms/kg, were evaluated in euvolemic Munich-Wistar (MW) rats by whole kidney clearance techniques and micropuncture studies. Following LPS infusion, a significant dec...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.232

    authors： Lugon JR,Boim MA,Ramos OL,Ajzen H,Schor N

    更新日期：1989-10-01 00:00:00

  • Expression and role of connexins in the rat renal vasculature.

    abstract：:Gap junctions are present in the juxtaglomerular apparatus enabling intercellular communication. Our study determined the location of different connexin subtypes within the juxtaglomerular apparatus of the rat, and the role of these subtypes in renal hemodynamics through the use of specific mimetic peptides. Immunohis...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5002673

    authors： Takenaka T,Inoue T,Kanno Y,Okada H,Meaney KR,Hill CE,Suzuki H

    更新日期：2008-02-01 00:00:00

  • Executive summary for the 2015 Annual Data Report of the China Kidney Disease Network (CK-NET).

    abstract：:Chronic kidney disease (CKD) has received increased attention as a leading public health problem worldwide. Globally surveillance systems for kidney disease are still lacking, especially in developing countries like China, which constitutes an obstacle to develop effective preventive strategies. China Kidney Disease N...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2018.11.011

    authors： Wang F,Yang C,Long J,Zhao X,Tang W,Zhang D,Bai K,Su Z,Gao B,Chu H,Wang J,Sun X,Wang S,Zuo L,Wang Y,Yu F,Wang H,Zhang L,Zhao MH

    更新日期：2019-03-01 00:00:00

  • High glucose levels inhibit focal adhesion kinase-mediated wound healing of rat peritoneal mesothelial cells.

    abstract：BACKGROUND:The peritoneum is progressively denuded of its mesothelial cell monolayer in patients on continuous ambulatory peritoneal dialysis (CAPD). These alterations of the mesothelium cause membrane dysfunction and progressive peritoneal fibrosis. Integrins regulate cell motility and play an important role in wound ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00772.x

    authors： Tamura M,Osajima A,Nakayamada S,Anai H,Kabashima N,Kanegae K,Ota T,Tanaka Y,Nakashima Y

    更新日期：2003-02-01 00:00:00

  • The chemokine receptor 5 Delta32 mutation is associated with increased renal survival in patients with IgA nephropathy.

    abstract：BACKGROUND:Chemokine receptor 5 (CCR5) plays an important role in the recruitment of monocytes and T cells in inflammation and experimental studies suggest that CCR5 might be involved in the pathogenesis of IgA nephropathy. A mutation in the CCR5 gene (CCR5 Delta32), leading to a nonfunctional receptor, was recently de...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00057.x

    authors： Panzer U,Schneider A,Steinmetz OM,Wenzel U,Barth P,Reinking R,Becker JU,Harendza S,Zahner G,Fischereder M,Krämer BK,Schlöndorff D,Ostendorf T,Floege J,Helmchen U,Stahl RA

    更新日期：2005-01-01 00:00:00

  • A metabolite-GWAS (mGWAS) approach to unveil chronic kidney disease progression.

    abstract：:In this issue, McMahon et al. report that, by combining phenotypic, metabolomic, and genetic data, they could better detect chronic kidney disease at the early stages and provide insight into its pathobiology. The most significant findings of the study are that several urinary metabolites (e.g., glycine and histidine)...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2017.03.022

    authors： Zhang G,Saito R,Sharma K

    更新日期：2017-06-01 00:00:00

  • Clusterin expression and apoptosis in tissue remodeling associated with renal regeneration.

    abstract：:To analyze the role of clusterin in renal diseases involving a regenerative process, we have used a novel rodent model to compare temporal and spatial expression of clusterin mRNA. Thus, renal artery stenosis was used to induce unilateral non-infarctive renal atrophy. After several weeks, when cellular pathology of at...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.54

    authors： Gobé GC,Buttyan R,Wyburn KR,Etheridge MR,Smith PJ

    更新日期：1995-02-01 00:00:00

  • Elevated glucose alters paracellular transport of cultured human proximal tubule cells.

    abstract：:Cultures of human proximal tubule cells were exposed to elevated concentrations of glucose and dome formation was assessed over a 22 day period of growth. Cultures grown on 5.5 mM glucose formed five domes per microscopic field while those exposed to elevated glucose concentrations (11.0 mM to 27.5 mM) formed only two...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.5

    authors： Hazen-Martin DJ,Sens MA,Detrisac CJ,Blackburn JG,Sens DA

    更新日期：1989-01-01 00:00:00

  • Enhanced renoprotective effects of ultrahigh doses of irbesartan in patients with type 2 diabetes and microalbuminuria.

    abstract：BACKGROUND:The purpose of this study was to evaluate the renoprotective effect as reflected by short-term changes in albuminuria of ultrahigh doses of irbesartan in type 2 diabetic patients with microalbuminuria. METHODS:This double-masked randomized crossover trial included 52 (41 males) hypertensive type 2 diabetic ...

    journal_title：Kidney international

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1523-1755.2005.00511.x

    authors： Rossing K,Schjoedt KJ,Jensen BR,Boomsma F,Parving HH

    更新日期：2005-09-01 00:00:00