Monocyte chemoattractant protein 1 mediates glomerular macrophage infiltration in anti-GBM Ab GN.

abstract：:In early clinical testing, acute addition of alanyl-glutamine (AlaGln) to glucose-based peritoneal dialysis (PD) fluids restored peritoneal cellular stress responses and leukocyte function. This study was designed to test the effect of extended treatment with AlaGln-supplemented PD fluid on biomarkers of peritoneal he...

journal_title：Kidney international

authors： Vychytil A,Herzog R,Probst P,Ribitsch W,Lhotta K,Machold-Fabrizii V,Wiesholzer M,Kaufmann M,Salmhofer H,Windpessl M,Rosenkranz AR,Oberbauer R,König F,Kratochwill K,Aufricht C

更新日期：2018-12-01 00:00:00

abstract：:[Arg(8)]-vasopressin (AVP) has several functions via its three distinct receptors, V1a, V1b, and V2. The V1a vasopressin receptor (V1aR) is expressed in blood vessels and involved in vascular contraction. Recently, we generated V1a receptor-deficient (V1aR(-/-)) mice and found that they were hypotensive. In addition, ...

journal_title：Kidney international

authors： Aoyagi T,Koshimizu TA,Tanoue A

更新日期：2009-11-01 00:00:00

abstract：:Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) are exposed to a continuous infusion of glucose via their peritoneal cavity. We performed studies to quantitate the amount of energy derived from dialysate glucose. Net glucose absorption averaged 182 +/- (SD) 61 g/day in 19 studies with a dialysate ...

journal_title：Kidney international

authors： Grodstein GP,Blumenkrantz MJ,Kopple JD,Moran JK,Coburn JW

更新日期：1981-04-01 00:00:00

abstract：:The cellular redox state is altered in a number of pathological conditions, including various forms of glomerular injury and diabetes. For example, glucose, via the pentose phosphate pathway generates NADPH, which maintains glutathione (GSH) (part of a major intracellular reducing system) in its reduced state. GSH in ...

journal_title：Kidney international

authors： Shan Z,Tan D,Satriano J,Silbiger S,Schlondorff D

更新日期：1994-08-01 00:00:00

abstract：:Crim1 is a cell-surface, transmembrane protein that binds to a variety of cystine knot-containing growth factors, including vascular endothelial growth factor A. In the developing renal glomerulus, Crim1 acts to tether vascular endothelial growth factor A to the podocyte cell surface, thus regulating its release to gl...

journal_title：Kidney international

authors： Wilkinson L,Gilbert T,Sipos A,Toma I,Pennisi DJ,Peti-Peterdi J,Little MH

更新日期：2009-12-01 00:00:00

abstract：:The presence of nitric oxide (NO) in the kidney has been implicated in the pathogenesis of human glomerulonephritis. However, the exact type of glomerular cells that express NO synthase (NOS) and the NOS isoform involved in the local production of NO has not been identified in the human diseased kidney. We examined th...

journal_title：Kidney international

authors： Furusu A,Miyazaki M,Abe K,Tsukasaki S,Shioshita K,Sasaki O,Miyazaki K,Ozono Y,Koji T,Harada T,Sakai H,Kohno S

更新日期：1998-06-01 00:00:00

abstract：:The involvement of sodium/potassium-ATPase in regulating parathyroid hormone (PTH) secretion is inferred from in vitro studies. Recently, the α-klotho-dependent rapid recruitment of this ATPase to the parathyroid cell plasma membrane in response to low extracellular calcium ion was suggested to be linked to increased ...

journal_title：Kidney international

authors： Martuseviciene G,Hofman-Bang J,Clausen T,Olgaard K,Lewin E

更新日期：2011-04-01 00:00:00

abstract：:Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise in thr...

journal_title：Kidney international

authors： Noone DG,Riedl M,Pluthero FG,Bowman ML,Liszewski MK,Lu L,Quan Y,Balgobin S,Schneppenheim R,Schneppenheim S,Budde U,James P,Atkinson JP,Palaniyar N,Kahr WH,Licht C

更新日期：2016-07-01 00:00:00

abstract：:Electron microprobe analysis on freeze-dried cryosections was used to determine the effect of the loop diuretics torasemide and furosemide on intracellular electrolyte concentrations in individual cells of the outer and inner stripe of the outer medulla and on cell rubidium uptake, the latter a measure of basolateral ...

journal_title：Kidney international

authors： Beck FX,Sone M,Dörge A,Thurau K

更新日期：1992-10-01 00:00:00

abstract：:Cisplatin is a platinum-containing antitumor agent whose usefulness is limited by nephrotoxicity. We examined the effects of cisplatin on a representative, transporting epithelium--the frog skin. Cisplatin (10(-3)M) from the mucosal surface increased the active transport of sodium by 35 to 40%, as monitored by short-c...

journal_title：Kidney international

authors： van den Berg EK Jr,Brazy PC,Huang AT,Dennis VW

更新日期：1981-01-01 00:00:00

abstract：:This NIH-funded multicenter randomized study of focal segmental glomerulosclerosis (FSGS) treatment compared the efficacy of a 12-month course of cyclosporine to a combination of oral pulse dexamethasone and mycophenolate mofetil in children and adults with steroid-resistant primary FSGS. Of the 192 patients enrolled,...

journal_title：Kidney international

authors： Gipson DS,Trachtman H,Kaskel FJ,Greene TH,Radeva MK,Gassman JJ,Moxey-Mims MM,Hogg RJ,Watkins SL,Fine RN,Hogan SL,Middleton JP,Vehaskari VM,Flynn PA,Powell LM,Vento SM,McMahan JL,Siegel N,D'Agati VD,Friedman AL

更新日期：2011-10-01 00:00:00

abstract：:Superoxide (O2-) production and Fc alpha R antigen expression of circulating polymorphonuclear leukocytes (PMNL) isolated from patients with IgA nephropathy (IgAN) and non-IgA mesangial proliferative glomerulonephritis (PGN) and healthy volunteers were investigated to establish their biological importance in the immun...

journal_title：Kidney international

authors： Kashem A,Endoh M,Nomoto Y,Sakai H,Nakazawa H

更新日期：1994-03-01 00:00:00

abstract：:It is unknown whether mild chronic kidney disease (CKD) is associated with adverse cardiovascular (CV) prognosis after accounting for coronary artery disease (CAD). Here we evaluated the interplay between CKD and CAD in predicting CV death or myocardial infarction (MI) and all-cause death. We included 1541 consecutive...

journal_title：Kidney international

authors： Bittencourt MS,Hulten EA,Ghoshhajra B,Abbara S,Murthy VL,Divakaran S,Nasir K,Gowdak LH,Riella LV,Chiumiento M,Hoffmann U,Di Carli MF,Blankstein R

更新日期：2015-07-01 00:00:00

abstract：:In this issue, McMahon et al. report that, by combining phenotypic, metabolomic, and genetic data, they could better detect chronic kidney disease at the early stages and provide insight into its pathobiology. The most significant findings of the study are that several urinary metabolites (e.g., glycine and histidine)...

journal_title：Kidney international

authors： Zhang G,Saito R,Sharma K

更新日期：2017-06-01 00:00:00

abstract：:IgG4-related disease is a recently recognized multi-organ disorder characterized by high levels of serum IgG4 and dense infiltration of IgG4-positive cells into several organs. Although the pancreas was the first organ recognized to be affected by IgG4-related disorder in the syndrome of autoimmune pancreatitis, we pr...

journal_title：Kidney international

authors： Saeki T,Nishi S,Imai N,Ito T,Yamazaki H,Kawano M,Yamamoto M,Takahashi H,Matsui S,Nakada S,Origuchi T,Hirabayashi A,Homma N,Tsubata Y,Takata T,Wada Y,Saito A,Fukase S,Ishioka K,Miyazaki K,Masaki Y,Umehara H,Sug

更新日期：2010-11-01 00:00:00

abstract：:Current characterization of the immune risk in renal transplant patients is only focused on the assessment of preformed circulating alloantibodies; however, alloreactive memory T cells are key players in mediating allograft rejection. Immune monitoring of antidonor alloreactive memory/effector T cells using an IFN-γ E...

journal_title：Kidney international

authors： Bestard O,Cruzado JM,Lucia M,Crespo E,Casis L,Sawitzki B,Vogt K,Cantarell C,Torras J,Melilli E,Mast R,Martinez-Castelao A,Gomà M,Reinke P,Volk HD,Grinyó JM

更新日期：2013-12-01 00:00:00

abstract：:Levels of prepro epidermal growth factor (EGF) mRNA in renal cortical tissue and urinary EGF excretion have been determined during cisplatin and ischemia-induced acute renal failure in the rat. Northern analysis of polyadenylated RNAs of kidney cortical tissue showed diminished renal preproEGF mRNA in rats injected wi...

journal_title：Kidney international

authors： Safirstein R,Zelent AZ,Price PM

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:The link between dialysis "vintage" (length of time on dialysis in months to years) and survival has been difficult to define, largely because of selection effects. End-stage renal disease (ESRD) is thought to be a wasting illness, but there are no published reports describing the associations between vintag...

journal_title：Kidney international

authors： Chertow GM,Johansen KL,Lew N,Lazarus JM,Lowrie EG

更新日期：2000-03-01 00:00:00

abstract：:The renal proximal tubule actively transports charged, potentially toxic xenobiotics from blood to lumen. Basolateral uptake of organic anions is indirectly coupled to the sodium gradient through Na-dicarboxylate cotransport and dicarboxylate-organic anion exchange. Upon entry, a significant fraction of intracellular ...

journal_title：Kidney international

authors： Pritchard JB,Miller DS

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:It is currently impossible to reliably predict which diabetic patients will develop nephropathy and progress to kidney failure. Microalbuminuria, often regarded as a predictor of overt diabetic renal disease is, in fact, an indicator of established glomerular damage. We have shown that glomerular expression ...

journal_title：Kidney international

authors： Riser BL,Cortes P,DeNichilo M,Deshmukh PV,Chahal PS,Mohammed AK,Yee J,Kahkonen D

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Wegener's granulomatosis (WG) is characterized by systemic vasculitis with crescentic glomerulonephritis (CGN) and circulating autoantibodies directed against neutrophil cytoplasmic antigens (ANCA). Proteinase 3 (PR-3), a neutral serine proteinase in neutrophils implicated in the growth control of myeloid ce...

journal_title：Kidney international

authors： Schwarting A,Hagen D,Odenthal M,Brockmann H,Dienes HP,Wandel E,Rumpelt HJ,Zum Büschenfelde KH,Galle PR,Mayet W

更新日期：2000-06-01 00:00:00

abstract：:Many subjects nowadays present with end-stage renal failure and its attendant cardiovascular complications without known prior renal damage. In this report we review the evidence available to strongly suggest that the present practice of secondary prevention in those with known prior renal disease should be extended t...

journal_title：Kidney international

authors： de Jong PE,Brenner BM

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Cisplatin (CP) induced polyuria in rats is associated with a reduction in medullary hypertonicity, normally generated by the thick ascending limb (TAL) salt transporters, and the collecting duct urea transporters (UT). To investigate the molecular basis of this abnormality, we determined the protein abundanc...

journal_title：Kidney international

authors： Ecelbarger CA,Sands JM,Doran JJ,Cacini W,Kishore BK

更新日期：2001-12-01 00:00:00

abstract：:Mice chronically infected with the virus of lymphocytic choriomeningitis (LCM) develop immune complex glomerulonephritis. Others have shown that adoptive immunization of these mice by the i.p. injection of syngeneic immune spleen cells terminates the chronic viral carrier state. The present studies were designed to de...

journal_title：Kidney international

authors： Hoffsten PE,Villalobos R,Hill C,Klahr S

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:The obstructed kidney in unilateral ureteral obstruction (UUO) is characterized by renal atrophy and tissue loss, which is mediated by renal tubular apoptosis. We sought to determine whether NO is involved in renal tubular apoptosis in vitro and in vivo. METHODS:Rat renal tubular epithelial cells (NRK-52E) ...

journal_title：Kidney international

authors： Miyajima A,Chen J,Poppas DP,Vaughan ED Jr,Felsen D

更新日期：2001-04-01 00:00:00

abstract：:Innate lymphoid cells are a recently recognized group of immune cells with critical roles in tissue homeostasis and inflammation. Regulatory innate lymphoid cells are a newly identified subset of innate lymphoid cells, which play a suppressive role in the innate immune response, favoring the resolution of intestinal i...

journal_title：Kidney international

authors： Cao Q,Wang R,Wang Y,Niu Z,Chen T,Wang C,Jin L,Huang Q,Li Q,Wang XM,Azmi F,Lee VWS,Wang YM,Zheng G,Alexander SI,Harris DCH

更新日期：2020-01-01 00:00:00

abstract：:Renal toxicity, possibly due to vasoconstriction and vascular injury, is the most relevant side-effect of chronic cyclosporine (CsA) therapy given to prevent graft rejection. In kidney transplant recipients each oral dose of CsA is invariably followed by a transient reduction in renal plasma flow (RPF) and glomerular ...

journal_title：Kidney international

authors： Ruggenenti P,Perico N,Mosconi L,Gaspari F,Benigni A,Amuchastegui CS,Bruzzi I,Remuzzi G

更新日期：1993-03-01 00:00:00

abstract：:The in vitro heparin sensitivity of 18 nephrotic children was compared with that of 10 normal children and 13 children with other renal diseases. The influence of age on the heparin sensitivity of 52 normal subjects (aged 12 to 85 years) was also studied. The heparin sensitivity was calculated from the dose-response c...

journal_title：Kidney international

authors： Vermylen CG,Levin M,Lanham JG,Hardisty RM,Barratt TM

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Recently, the in vivo pathogenic role of anti-neutrophil cytoplasm autoantibodies (ANCA) in ANCA-associated vasculitis has been challenged by Abdel-Salam et al. In their report, they observed that ANCA directed against proteinase 3 (PR3) cannot bind to their target autoantigen PR3 on circulating neutrophils ...

journal_title：Kidney international

authors： Van Rossum AP,van der Geld YM,Limburg PC,Kallenberg CG

更新日期：2005-08-01 00:00:00

abstract：:Reducing proteinuria and blood pressure in chronic kidney disease (CKD) decreases rate of progression. Inhibition of the renin-angiotensin system by angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers is beneficial in reducing proteinuria but incomplete in suppressing aldosterone production a...

journal_title：Kidney international

authors： Weinberger MH,Luft FC

更新日期：2006-12-01 00:00:00