Fc alpha R expression on polymorphonuclear leukocyte and superoxide generation in IgA nephropathy.

abstract：:Cardiac surgery associated-acute kidney injury (CS-AKI) occurs in 30-50% of patients undergoing surgery for congenital heart disease. Here we determine if CS-AKI is associated with chronic kidney disease (CKD) in patients with congenital heart disease. Using Danish regional population-based registries, our cohort stud...

journal_title：Kidney international

authors： Madsen NL,Goldstein SL,Frøslev T,Christiansen CF,Olsen M

更新日期：2017-09-01 00:00:00

abstract：:A substantial body of evidence has accumulated linking an increased incidence of cardiovascular disease in patients with acute kidney injury (AKI), chronic kidney disease (CKD), and end-stage renal disease (ESRD). A multitude of novel risk factors related to decreased kidney function might interact with the renal and ...

journal_title：Kidney international

authors： Swaminathan S,Shah SV

更新日期：2011-09-01 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) and MHC class II (Ia) antigens are increased on proximal tubular epithelial cells (TEC) in autoimmune nephritis and transplant rejection. ICAM-1 is a member of the immunoglobulin gene superfamily that increases the avidity of T cell interactions with antigen-presenting cells ...

journal_title：Kidney international

authors： Jevnikar AM,Wuthrich RP,Takei F,Xu HW,Brennan DC,Glimcher LH,Rubin-Kelley VE

更新日期：1990-09-01 00:00:00

abstract：:Pain was surveyed via structured interview and the McGill Pain Questionnaire in 53 dialysis and 27 transplant patients. Increased patient control over the dialysis procedure was not associated with a reduction in pain though perceived control may have been. Compliance with the dialysis regimen did not predict pain and...

journal_title：Kidney international

authors： Binik YM,Baker AG,Kalogeropoulos D,Devins GM,Guttmann RD,Hollomby DJ,Barré PE,Hutchison T,Prud'Homme M,McMullen L

更新日期：1982-06-01 00:00:00

abstract：:This report describes the occurrence of immune complex glomerulonephritis in a patient with eosinophilic gastroenteritis and food hypersensitivity. A coincident allergen injection may have been a contributing factor in the sudden development of the nephrotic syndrome. Markedly elevated levels of circulating immune com...

journal_title：Kidney international

authors： McCrory WW,Becker CG,Cunningham-Rundles C,Klein RF,Mouradian J,Reisman L

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Patients on continuous ambulatory peritoneal dialysis (CAPD) are dependent on residual renal function for solute and water clearances, and this declines with time on dialysis. Loop diuretics have been postulated to slow this decline. METHODS:Sixty-one patients new to dialysis were randomly assigned to eithe...

journal_title：Kidney international

authors： Medcalf JF,Harris KP,Walls J

更新日期：2001-03-01 00:00:00

abstract：:As an alternative to classical immunosuppressants in experimental lupus nephritis, we looked at bindarit, 2-methyl-2-[[1-phenylmethyl)-1H-indazol-3-y1]methoxy]propanoic acid, a novel molecule devoid of immunosuppressive effects, which selectively reduces chronic inflammation in rat adjuvant arthritis. Two groups of NZ...

journal_title：Kidney international

authors： Zoja C,Corna D,Benedetti G,Morigi M,Donadelli R,Guglielmotti A,Pinza M,Bertani T,Remuzzi G

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Angiotensin type 1 (AT1) receptor-deficient mice (Agtr1-/-), which selectively lack both AT1A and AT1B receptor genes, are characterized by marked intrarenal vascular thickening. In the present study, we explored the possible involvement of the kinin-kallikrein system in the development of this renal vascula...

journal_title：Kidney international

authors： Tsuchida S,Miyazaki Y,Matsusaka T,Hunley TE,Inagami T,Fogo A,Ichikawa I

更新日期：1999-08-01 00:00:00

abstract：:Nephronophthisis is an autosomal recessive kidney disease with high genetic heterogeneity. Understanding the functions of the individual genes contributing to this disease is critical for delineating the pathomechanisms of this disorder. Here, we investigated kidney function of a novel gene associated with nephronopht...

journal_title：Kidney international

authors： Airik R,Airik M,Schueler M,Bates CM,Hildebrandt F

更新日期：2019-08-01 00:00:00

abstract：:In hemodialysis patients with hyperkalemia, i.v. sodium bicarbonate has recently been found to be ineffective in lowering plasma potassium within one hour. In the present study the effect of a prolonged bicarbonate infusion on plasma potassium was investigated. Twelve patients with terminal renal failure who were on h...

journal_title：Kidney international

authors： Blumberg A,Weidmann P,Ferrari P

更新日期：1992-02-01 00:00:00

abstract：:We evaluated the contribution of intrarenal factors in the increased renal accumulation of bovine serum albumin (BSA) in chronic serum sickness (CSS). Renal transplantation was used to study 125I BSA uptake (single and paired label techniques) in normal and CSS kidneys exposed to the same immunologic milieu. In CSS, t...

journal_title：Kidney international

authors： Ward DM,Lee S,Wilson CB

更新日期：1986-11-01 00:00:00

abstract：:Major features of a long-standing inflammation in the kidney are vascular proliferation, glomerulosclerosis, interstitial fibrosis and tubular atrophy, leading to a gradual deterioration of the renal function. In this study we have investigated the expression of B-type receptors for platelet-derived growth factor (PDG...

journal_title：Kidney international

authors： Fellström B,Klareskog L,Heldin CH,Larsson E,Rönnstrand L,Terracio L,Tufveson G,Wahlberg J,Rubin K

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:In X-linked Alport syndrome, mutations in the COL4A5 gene encoding the alpha 5 chain of type IV collagen result in progressive renal failure. This nephropathy appears to relate to the arrest of a switch from an alpha 1/alpha 2 to an alpha 3/alpha 4/alpha 5 network of type IV collagen in the developing glomer...

journal_title：Kidney international

authors： Harvey SJ,Zheng K,Sado Y,Naito I,Ninomiya Y,Jacobs RM,Hudson BG,Thorner PS

更新日期：1998-12-01 00:00:00

abstract：:VLDL receptor (VLDL-R) is a novel member of the LDL receptor gene family with distinct tissue distribution and function. It binds and internalizes VLDL particles and is primarily expressed in skeletal muscle, heart, brain and adipose tissue, which use fatty acids for energy production or storage. CRF is associated wit...

journal_title：Kidney international

authors： Vaziri ND,Liang K

更新日期：1997-03-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) is known to regulate various biological responses by binding to LPA receptors. The serum level of LPA is elevated in diabetes, but the involvement of LPA in the development of diabetes and its complications remains unknown. Therefore, we studied LPA signaling in diabetic nephropathy and the...

journal_title：Kidney international

authors： Li HY,Oh YS,Choi JW,Jung JY,Jun HS

更新日期：2017-06-01 00:00:00

abstract：:To determine the prognosis and risk factors for ischemic heart disease in chronic uremia, a cohort of 432 dialysis patients were followed prospectively from start of dialysis therapy until death or renal transplantation. Baseline demographic, clinical and echocardiographic data were obtained. After the initiation of d...

journal_title：Kidney international

authors： Parfrey PS,Foley RN,Harnett JD,Kent GM,Murray D,Barre PE

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Reactive carbonyl compounds (RCOs) present in peritoneal dialysis (PD) fluid have been incriminated in the progressive deterioration of the peritoneal membrane in long-term PD patients. They are initially present in fresh conventional heat-sterilized glucose PD fluid and are supplemented during dwell time by...

journal_title：Kidney international

authors： Ishikawa N,Miyata T,Ueda Y,Inagi R,Izuhara Y,Yuzawa H,Onogi H,Nishina M,Nangaku M,Van Ypersele De Strihou C,Kurokawa K

更新日期：2003-01-01 00:00:00

abstract：:International clinical practice guidelines for the management of anemia in chronic kidney disease suggest target hemoglobin levels ≤ 11.5 g/dl (115 g/l), with individualized consideration of slightly higher hemoglobin targets to improve quality of life. An updated meta-analysis of randomized trials demonstrates no sig...

journal_title：Kidney international

authors： Wyatt CM,Drueke TB

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:While metabolically generated oxidants are produced locally in experimental glomerular diseases, little is still known of their significance and the respective scavenger systems in human glomerular diseases. METHODS:Here we studied kidneys from patients with congenital nephrotic syndrome of the Finnish type...

journal_title：Kidney international

authors： Solin ML,Ahola H,Haltia A,Ursini F,Montine T,Roveri A,Kerjaschki D,Holthöfer H

更新日期：2001-02-01 00:00:00

abstract：:The impact of high-flux hemodialysis on clinical outcomes remains controversial. We have previously shown that in vivo transmigrated leukocytes from patients with low-flux bioincompatible hemodialysis have an impaired capacity to upregulate CD11b at the site of interstitial inflammation. In the present study, we inves...

journal_title：Kidney international

authors： Olsson J,Dadfar E,Paulsson J,Lundahl J,Moshfegh A,Jacobson SH

更新日期：2007-03-01 00:00:00

abstract：:X-linked Alport syndrome (AS) associated with diffuse esophageal leiomyomatosis (DL) has been reported to be due to deletions removing the 5' ends of both the COL4A5 and COL4A6 genes, encoding the alpha 5 and alpha 6 chains of type IV collagen, respectively, whereas a variety of mutations in COL4A5 has been identified...

journal_title：Kidney international

authors： Dahan K,Heidet L,Zhou J,Mettler G,Leppig KA,Proesmans W,David A,Roussel B,Mongeau JG,Gould JM

更新日期：1995-12-01 00:00:00

abstract：:A cyclical corticosteroid-cyclophosphamide regimen is recommended for patients with primary membranous nephropathy at high risk of progression. We hypothesized that sequential therapy with tacrolimus and rituximab is superior to cyclical alternating treatment with corticosteroids and cyclophosphamide in inducing persi...

journal_title：Kidney international

authors： Fernández-Juárez G,Rojas-Rivera J,Logt AV,Justino J,Sevillano A,Caravaca-Fontán F,Ávila A,Rabasco C,Cabello V,Varela A,Díez M,Martín-Reyes G,Diezhandino MG,Quintana LF,Agraz I,Gómez-Martino JR,Cao M,Rodríguez-Moreno A,

更新日期：2020-11-07 00:00:00

abstract：:The highly amiloride-sensitive epithelial sodium channel (ENaC) is an apical membrane constituent of cells of many salt-absorbing epithelia. In the kidney, the functional relevance of ENaC expression has been well established. ENaC mediates the aldosterone-dependent sodium reabsorption in the distal nephron and is inv...

journal_title：Kidney international

authors： Bonny O,Hummler E

更新日期：2000-04-01 00:00:00

abstract：:The treatment of hyperphosphatemia remains challenging in patients receiving hemodialysis. This Phase 1b study assessed safety and efficacy of EOS789, a novel pan-inhibitor of phosphate transport (NaPi-2b, PiT-1, PiT-2) on intestinal phosphate absorption in patients receiving intermittent hemodialysis therapy. Two cro...

journal_title：Kidney international

authors： Hill Gallant KM,Stremke ER,Trevino L,Moorthi RN,Doshi S,Wastney ME,Hisada N,Sato J,Ogita Y,Fujii N,Matsuda Y,Kake T,Moe SM

更新日期：2020-10-30 00:00:00

abstract：:In summary, the three major segments of the collecting duct subserve three different functions in the urinary concentrating mechanism. The main function of the cortical collecting tubule is to raise the fractional solute contribution and absolute concentration of urea in fluid that it delivers to the outer medullary c...

journal_title：Kidney international

authors： Kokko JP

更新日期：1987-02-01 00:00:00

abstract：:An effective therapeutic means to remove relatively large polypeptide uremic toxins seems to be a hemofiltration (HF) or hemodiafiltration (HDF) employing a larger-pore membrane, that is, a protein-permeable membrane. With either method, however, a significant amount of albumin will be lost into the ultrafiltrate or d...

journal_title：Kidney international

authors： Shinzato T,Miwa M,Nakai S,Takai I,Matsumoto Y,Morita H,Miyata T,Maeda K

更新日期：1996-08-01 00:00:00

abstract：:Sodium depletion has a protective effect on target-organ damage in hypertension independent of blood pressure. Here we tested whether chronic dietary sodium restriction may prevent the development of renal alterations associated with insulin resistance by reducing the inflammatory and oxidant state. Rats were fed norm...

journal_title：Kidney international

authors： Oudot C,Lajoix AD,Jover B,Rugale C

更新日期：2013-04-01 00:00:00

abstract：:This study examined the utility of interleukin-10 (IL-10), a cytokine with potent anti-macrophage and anti-Th1 activity, in the treatment of experimental anti-glomerular basement membrane (GBM) nephritis in the rat. Accelerated anti-GBM disease was induced in Sprague-Dawley rats by immunization with rabbit IgG, follow...

journal_title：Kidney international

authors： Chadban SJ,Tesch GH,Lan HY,Atkins RC,Nikolic-Paterson DJ

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Endothelium-derived nitric oxide and reactive oxygen species (ROS) have been proposed to regulate vascular tone by complex mechanisms, including the modulation of ion channel function. In endothelial function itself, activation of Ca2+-activated K+ channels (KCa) plays a crucial role by inducing hyperpolariz...

journal_title：Kidney international

authors： Brakemeier S,Eichler I,Knorr A,Fassheber T,Köhler R,Hoyer J

更新日期：2003-07-01 00:00:00

abstract：:The role of calcitonin on the calcemic response to parathyroid hormone (PTH) in renal failure has not been evaluated previously. Often animal studies evaluating the calcemic response to PTH in renal failure are performed in thyroparathyroidectomized (TPTX) animals, and thus eliminate any potential physiologic effect o...

journal_title：Kidney international

authors： Rodriguez M,Felsenfeld AJ,Torres A,Pederson L,Llach F

更新日期：1991-08-01 00:00:00