Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature.

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of kidney cysts leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Identification of an early biomarker that can predict progression of CKD is urgently needed. In an earlier Consortium for Radiolog...

journal_title：Kidney international

authors： Yu ASL,Shen C,Landsittel DP,Harris PC,Torres VE,Mrug M,Bae KT,Grantham JJ,Rahbari-Oskoui FF,Flessner MF,Bennett WM,Chapman AB,Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP).

更新日期：2018-03-01 00:00:00

abstract：:Autologous and allogeneic bone marrow grafting both require cytoreductive therapy but only the allogeneic procedure requires immunosuppressive agents. Allogeneic bone marrow transplantation has been reported to be associated with a high incidence of both renal failure and veno-occlusive disease (VOD) of the liver, the...

journal_title：Kidney international

authors： Merouani A,Shpall EJ,Jones RB,Archer PG,Schrier RW

更新日期：1996-09-01 00:00:00

abstract：:Chronic cyclosporine nephrotoxicity is a poorly understood drug side-effect characterized by renal cortical interstitial scarring. To evaluate procollagen mRNA levels as an early factor in the development of this form of renal fibrosis, we measured renal procollagen alpha 1 (I), alpha 1 (III), alpha 1 (IV) and beta-ac...

journal_title：Kidney international

authors： Nast CC,Adler SG,Artishevsky A,Kresser CT,Ahmed K,Anderson PS

更新日期：1991-04-01 00:00:00

abstract：:Vitamin D hydroxylated at carbon 25 (25(OH)D) is generally recognized as a precursor of active vitamin D. Despite its low affinity for the vitamin D receptor (VDR), both deficient and excessive 25(OH)D levels are associated with poor clinical outcomes. Here we studied direct effects of 25(OH)D3 on the kidney using 25(...

journal_title：Kidney international

authors： Kusunoki Y,Matsui I,Hamano T,Shimomura A,Mori D,Yonemoto S,Takabatake Y,Tsubakihara Y,St-Arnaud R,Isaka Y,Rakugi H

更新日期：2015-11-01 00:00:00

abstract：:Gain-of-function variants in CFB encoding factor B (FB), a component of the alternative pathway C3 convertase, have been reported in a minority of patients with aHUS and result in massive C3 activation. Zhang et al. describe the functional characterization of a novel FB variant (p.Ser367Arg) that they identified in 2 ...

journal_title：Kidney international

authors： Noris M,Remuzzi G

更新日期：2020-11-01 00:00:00

abstract：:One hundred six patients with terminal renal insufficiency and 29 medical personnel were given three doses of hepatitis B vaccine at an interval of 0, 1, and 6 months (Merck, Sharp and Dohme, West Point, Pennsylvania, part of a joint study no. 649). Chronic hemodialysis patients (N = 99) received 40 micrograms vaccine...

journal_title：Kidney international

authors： Köhler H,Arnold W,Renschin G,Dormeyer HH,Meyer zum Büschenfelde KH

更新日期：1984-01-01 00:00:00

abstract：:Long-term outcomes of kidney allografts have shown only marginal improvement over the last three decades, despite the remarkable improvement in acute rejection and one-year graft survival. Novel biomarkers of tubular injury may prevent irreversible damage to the tubulointerstitial compartment and improve allograft sur...

journal_title：Kidney international

authors： Abulezz S

更新日期：2008-03-01 00:00:00

abstract：:Membranous nephropathy is a major cause of nephrotic syndrome in adults where podocyte injuries were found to mediate the development of proteinuria. Triptolide, a major active component of Tripterygium wilfordii Hook F, has potent immunosuppressive, anti-inflammatory and antiproteinuric effects. To study its antiprot...

journal_title：Kidney international

authors： Chen ZH,Qin WS,Zeng CH,Zheng CX,Hong YM,Lu YZ,Li LS,Liu ZH

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Regular access monitoring is recommended to detect and treat access stenosis in order to prevent access thrombosis and failure. METHODS:In 1999, we instituted monthly access blood flow monitoring using the ultrasound dilution technique (UDT). In a sequential observational trial, 222 patients were studied fo...

journal_title：Kidney international

authors： Shahin H,Reddy G,Sharafuddin M,Katz D,Franzwa BS,Dixon BS

更新日期：2005-11-01 00:00:00

abstract：:Disturbed pulsatile LH secretion has been suggested to play a role in the etiology of delayed puberty and disturbed reproductive function in chronic renal failure (CRF), but interpretation of gonadotropin secretion from plasma concentration measurements is confounded by alterations in hormone metabolic clearance. To s...

journal_title：Kidney international

authors： Schaefer F,Veldhuis JD,Robertson WR,Dunger D,Schärer K

更新日期：1994-05-01 00:00:00

abstract：:Serum fibroblast growth factor 23 (FGF23) is a novel phosphaturic factor and important for the regulation of inorganic phosphate (Pi) homeostasis. In this study, we examined an acute effect of oral Pi loading on serum FGF23 levels to clarify the role in rapid adjustment of serum Pi level. We performed a randomized, do...

journal_title：Kidney international

authors： Nishida Y,Taketani Y,Yamanaka-Okumura H,Imamura F,Taniguchi A,Sato T,Shuto E,Nashiki K,Arai H,Yamamoto H,Takeda E

更新日期：2006-12-01 00:00:00

abstract：:Tremendous progress has been made over recent years in the understanding of the mechanisms regulating calcium, phosphorus, vitamin D, and parathyroid hormone homeostasis in the normal human body and in patients with different degrees of renal failure. In addition, some of these findings have been translated into clini...

journal_title：Kidney international

authors： De Broe ME

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Home nocturnal hemodialysis is an intensive form of hemodialysis, where patients perform their treatments at home for about 7 hours approximately 6 nights a week. Compared with in-center conventional hemodialysis, home nocturnal hemodialysis has been shown to improve physiologic parameters and reduce health ...

journal_title：Kidney international

authors： McFarlane PA,Bayoumi AM,Pierratos A,Redelmeier DA

更新日期：2003-09-01 00:00:00

abstract：:Conventional peritoneal dialysis (PD) fluids are known to inhibit polymorphonuclear cells (PMN) phagocytosis, oxidative burst and enzyme release. However, the relative contributions of apoptosis and/or necrosis to this dysfunction have not been examined. We investigated the effects of osmolality, glucose concentration...

journal_title：Kidney international

authors： Cendoroglo M,Sundaram S,Groves C,Ucci AA,Jaber BL,Pereira BJ

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:The relationship between low hematocrit and contrast-induced nephropathy has not been investigated. METHODS:Of 6,773 consecutive patients treated with percutaneous coronary intervention, contrast-induced nephropathy (an increase of >/=25% or >/=0.5 mg/dL in preprocedure serum creatinine, at 48 hours postpro...

journal_title：Kidney international

authors： Nikolsky E,Mehran R,Lasic Z,Mintz GS,Lansky AJ,Na Y,Pocock S,Negoita M,Moussa I,Stone GW,Moses JW,Leon MB,Dangas G

更新日期：2005-02-01 00:00:00

abstract：:To investigate whether alpha (alpha)-adrenoceptor agonists have a stimulatory effect on the expression of the angiotensinogen (Ang) gene in opossum kidney (OK) cells, we used OK 27 cells with a fusion gene containing the 5'-flanking regulatory sequence of the rat angiotensinogen gene fused with a human growth hormone ...

journal_title：Kidney international

authors： Wang TT,Lachance S,Delalandre A,Carrière S,Chan JS

更新日期：1995-07-01 00:00:00

abstract：:The present study examined the effect of elevated glucose on glomerular cell membrane lipid peroxidation. Glomeruli were isolated from male Sprague-Dawley rat kidneys utilizing a standard sieving method and incubated in medium containing different concentrations of glucose at 37 degrees C for one and 48 hours. The lev...

journal_title：Kidney international

authors： Ha H,Yoon SJ,Kim KH

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Left ventricular enlargement is very common at the inception of dialysis therapy, and highly predictive of future cardiac morbidity and mortality. It is not known whether cardiac size increases further while on dialysis therapy and whether potentially reversible risk factors for later progression can be iden...

journal_title：Kidney international

authors： Foley RN,Parfrey PS,Kent GM,Harnett JD,Murray DC,Barre PE

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:In addition to nitric oxide (NO) and prostacyclin (PGI2), the vascular endothelium can influence local vascular tone by a mechanism involving the hyperpolarization of vascular smooth muscle cells. This response is attributed to the release of an endothelium-derived hyperpolarizing factor (EDHF). The present ...

journal_title：Kidney international

authors： Büssemaker E,Popp R,Binder J,Busse R,Fleming I

更新日期：2003-05-01 00:00:00

abstract：:There is an urgent need for therapeutic agents that target humoral alloimmunity in solid organ transplantation. This includes sensitized patients with preformed donor-specific human leukocyte antigen antibodies and patients who develop de novo donor-specific antibodies, both of which are associated with acute and chro...

journal_title：Kidney international

authors： Leibler C,Thiolat A,Elsner RA,El Karoui K,Samson C,Grimbert P

更新日期：2019-04-01 00:00:00

abstract：:Mineralocorticoid hormones stimulate Na+ absorption and K+ secretion by the cortical collecting tubule. There is good evidence that this stimulation involves increasing luminal membrane Na+ permeability and the turnover rate (or number) of the Na+-K+ pumps. These experiments were designed to examine whether mineraloco...

journal_title：Kidney international

authors： Stokes JB

更新日期：1985-10-01 00:00:00

abstract：:Low density lipoprotein (LDL) deposition and local oxidation play a key role in the pathogenesis of atherosclerosis and may likewise contribute to glomerular injury. These studies were designed to determine whether cultured human mesangial cells oxidize homologous LDL and to compare the effects of unmodified and oxidi...

journal_title：Kidney international

authors： Wheeler DC,Chana RS,Topley N,Petersen MM,Davies M,Williams JD

更新日期：1994-06-01 00:00:00

abstract：:Pathogenesis of vascular calcification in chronic kidney disease. Background. Hyperphosphatemia and hypercalcemia are independent risk factors for higher incidence of cardiovascular events in patients with chronic kidney disease. In addition to increased calcium-phosphate product, hyperphosphatemia accelerates the pro...

journal_title：Kidney international

authors： Cozzolino M,Brancaccio D,Gallieni M,Slatopolsky E

更新日期：2005-08-01 00:00:00

abstract：:Our previous in vivo study demonstrated that methylprednisolone (MP) activates glomerular antioxidant enzymes and attenuates glomerular oxidant injuries, including those in experimental nephrosis. The present study investigates the cellular mechanism of the MP-induced activation of antioxidant enzymes and their contri...

journal_title：Kidney international

authors： Yoshioka T,Kawamura T,Meyrick BO,Beckman JK,Hoover RL,Yoshida H,Ichikawa I

更新日期：1994-01-01 00:00:00

abstract：:Idiopathic retroperitoneal fibrosis (IRF) is a rare disease often causing obstructive uropathy. We evaluated the clinicopathologic features of 24 patients with IRF to characterize the histopathology of the disease and to provide a framework for the differential diagnosis with other retroperitoneal fibrosing conditions...

journal_title：Kidney international

authors： Corradi D,Maestri R,Palmisano A,Bosio S,Greco P,Manenti L,Ferretti S,Cobelli R,Moroni G,Dei Tos AP,Buzio C,Vaglio A

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Current renal substitution therapy for acute or chronic renal failure with hemodialysis or hemofiltration is life sustaining, but continues to have unacceptably high morbidity and mortality rates. This therapy is not complete renal replacement therapy because it does not provide active transport nor metaboli...

journal_title：Kidney international

authors： Humes HD,MacKay SM,Funke AJ,Buffington DA

更新日期：1999-06-01 00:00:00

abstract：:We sought to determine whether artherosclerosis may be accelerated in uremic patients on maintenance hemodialysis and investigated the risk factors for carotid and femoral atherosclerosis in such patients. High-resolution B-mode ultrasonography was used to determine the intima-media thickness (IMT) of the carotid and ...

journal_title：Kidney international

authors： Kawagishi T,Nishizawa Y,Konishi T,Kawasaki K,Emoto M,Shoji T,Tabata T,Inoue T,Morii H

更新日期：1995-09-01 00:00:00

abstract：:Anthropometric measurements and circulating growth factors were studied serially in 44 prepubertal children with growth failure and chronic renal failure (GFR = 10 to 40 ml/min/1.73 m2) who were randomized to receive either recombinant human growth hormone (rhGH; N = 30) or no treatment (N = 14). RhGH was given as Nut...

journal_title：Kidney international

authors： Powell DR,Liu F,Baker BK,Hintz RL,Lee PD,Durham SK,Brewer ED,Frane JW,Watkins SL,Hogg RJ

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Random, nontimed blood pressure (BP) measurements in the outpatient clinic may fail to provide reliable information on actual daily BP control in renal patients on chronic antihypertensive therapy. METHODS:In a cohort of 163 patients with proteinuric chronic nephropathies followed prospectively with repeate...

journal_title：Kidney international

authors： Ruggenenti P,Perna A,Lesti M,Pisoni R,Mosconi L,Arnoldi F,Ciocca I,Gaspari F,Remuzzi G

更新日期：2000-11-01 00:00:00

abstract：:Congenital nephrotic syndrome is clinically and genetically heterogeneous. The majority of cases can be attributed to mutations in the genes NPHS1, NPHS2, and WT1. By homozygosity mapping in a consanguineous family with isolated congenital nephrotic syndrome, we identified a potential candidate region on chromosome 3p...

journal_title：Kidney international

authors： Hasselbacher K,Wiggins RC,Matejas V,Hinkes BG,Mucha B,Hoskins BE,Ozaltin F,Nürnberg G,Becker C,Hangan D,Pohl M,Kuwertz-Bröking E,Griebel M,Schumacher V,Royer-Pokora B,Bakkaloglu A,Nürnberg P,Zenker M,Hildebrandt F

更新日期：2006-09-01 00:00:00