Cardiac surgery in patients with congenital heart disease is associated with acute kidney injury and the risk of chronic kidney disease.

abstract：:Effect of varying concentrations (0 to 800 microM) of three different light chains on sodium-dependent L-(14C)alanine and D-(14C)glucose uptake by rat renal brush border membrane vesicles were studied. One kappa and two lambda type light chains (lambda-1 and lambda-2) were isolated from urines of patients with multipl...

journal_title：Kidney international

authors： Batuman V,Sastrasinh M,Sastrasinh S

更新日期：1986-11-01 00:00:00

abstract：:The incidence of acute kidney injury (AKI) is high in elderly people, and is difficult to prevent and treat. One of its major causes is renal ischemia-reperfusion injury (IRI). A young systemic environment may prevent the senescence of old organs. However, it is unknown whether a young milieu may reduce renal IRI in t...

journal_title：Kidney international

authors： Liu D,Lun L,Huang Q,Ning Y,Zhang Y,Wang L,Yin Z,Zhang Y,Xia L,Yin Z,Fu B,Cai G,Sun X,Chen X

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Arteriovenous (AV) fistulas used for hemodialysis access may affect cardiac load by increasing the preload while decreasing the afterload. In dogs, AV fistulas have also been shown to affect coronary perfusion negatively. We investigated the net effect of AV fistulas on cardiac oxygen supply and demand. MET...

journal_title：Kidney international

authors： Bos WJ,Zietse R,Wesseling KH,Westerhof N

更新日期：1999-05-01 00:00:00

abstract：:Erythropoietin (Epo) is essential for erythropoiesis and is mainly produced by the fetal liver and the adult kidney following hypoxic stimulation. Epo regulation is commonly studied in hepatoma cell lines, but differences in Epo regulation between kidney and liver limit the understanding of Epo dysregulation in polycy...

journal_title：Kidney international

authors： Imeri F,Nolan KA,Bapst AM,Santambrogio S,Abreu-Rodríguez I,Spielmann P,Pfundstein S,Libertini S,Crowther L,Orlando IMC,Dahl SL,Keodara A,Kuo W,Kurtcuoglu V,Scholz CC,Qi W,Hummler E,Hoogewijs D,Wenger RH

更新日期：2019-02-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) may be an important negative feedback modulator of endothelin-1 (ET-1)-stimulated mesangial cell proliferation and contraction. Recent studies suggest that ET-1 may induce prolonged mesangial cell PGE2 production, however the mechanism of this effect is unknown. The current study was undertaken...

journal_title：Kidney international

authors： Hughes AK,Padilla E,Kutchera WA,Michael JR,Kohan DE

更新日期：1995-01-01 00:00:00

abstract：:Defective cholesterol metabolism primarily linked to reduced ATP-binding cassette transporter A1 (ABCA1) expression is closely associated with the pathogenesis and progression of kidney diseases, including diabetic kidney disease and Alport Syndrome. However, whether the accumulation of free or esterified cholesterol ...

journal_title：Kidney international

authors： Liu X,Ducasa GM,Mallela SK,Kim JJ,Molina J,Mitrofanova A,Wilbon SS,Ge M,Fontanella A,Pedigo C,Santos JV,Nelson RG,Drexler Y,Contreras G,Al-Ali H,Merscher S,Fornoni A

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Tacrolimus is a relatively new calcineurin inhibitor that has been increasingly used in transplant medicine. The objective of the current work is to report our preliminary experience with tacrolimus in the treatment of diffuse proliferative glomerulonephritis in systemic lupus erythematosus (SLE). METHODS:N...

journal_title：Kidney international

authors： Mok CC,Tong KH,To CH,Siu YP,Au TC

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Prolonged antihypertensive therapy might be less effective in reversing the left ventricular hypertrophy (LVH) in uremics bearing the deleted (DD) allele of the angiotensin converting enzyme (ACE) gene than in patients with the inserted (II) allele or in those heterozygous (ID) for the gene. METHODS:Thirtee...

journal_title：Kidney international

authors： Cannella G,Paoletti E,Barocci S,Massarino F,Delfino R,Ravera G,Di Maio G,Nocera A,Patrone P,Rolla D

更新日期：1998-08-01 00:00:00

abstract：:We have previously shown that the activity of the Na-HCO3 cotransporter is stimulated by protein kinase C (PKC) activation, but the mechanism responsible for this effect is not clear. We have shown that cultured proximal tubule cells of the rabbit have DIDS-sensitive Na-HCO3 cotransporter activity as assessed by HCO3-...

journal_title：Kidney international

authors： Ruiz OS,Wang LJ,Qiu YY,Kear F,Bernardo A,Arruda JA

更新日期：1996-03-01 00:00:00

abstract：:In this mini review, we would like to challenge the well-established 'fact' that lead exposure causes chronic renal failure (CRF). Even though only scarce evidence exists of the relationship between lead and renal failure, a World Health Organization Environmental Health Criteria document summarizes that 'Lead has bee...

journal_title：Kidney international

authors： Evans M,Elinder CG

更新日期：2011-02-01 00:00:00

abstract：:The purpose of these studies was to quantitatively assess the role of endogenous angiotensin II activity in controlling transport in the proximal convoluted tubule (PCT) and whole nephron. We used the nonpeptide angiotensin II receptor antagonist DuP 753, which lacks the agonist and kinin/prostaglandin-inducing proper...

journal_title：Kidney international

authors： Xie MH,Liu FY,Wong PC,Timmermans PB,Cogan MG

更新日期：1990-09-01 00:00:00

abstract：:In a double-blind, randomized, placebo-controlled cross-over study, we investigated in seven patients with chronic renal failure the effect of conjugated estrogens (0.6 mg/kg/day for 5 days) on template bleeding time and on thromboxane A2 (TxA2), beta-thromboglobulin (beta-TG) and prostacyclin (PGI2) concentrations in...

journal_title：Kidney international

authors： Heistinger M,Stockenhuber F,Schneider B,Pabinger I,Brenner B,Wagner B,Balcke P,Lechner K,Kyrle PA

更新日期：1990-12-01 00:00:00

abstract：:The beneficial effects of post-insult administration of pentoxifylline, a novel hemorheologic agent experimentally studied in various ischemic diseases, were evaluated in two models of acute renal failure (ARF): direct nephrotoxicity (mercuric chloride 4 mg/kg via femoral vein) and hemoglobinuria (glycerol 10 ml/kg i....

journal_title：Kidney international

authors： Vadiei K,Brunner LJ,Luke DR

更新日期：1989-09-01 00:00:00

abstract：:The relationship between commonly occurring genetic variants (G1 and G2) in the APOL1 gene in African Americans and different disease traits, such as kidney disease, cardiovascular disease, and pre-eclampsia, remains the subject of controversy. Here we took a genotype-first approach, a phenome-wide association study, ...

journal_title：Kidney international

authors： Bajaj A,Ihegword A,Qiu C,Small AM,Wei WQ,Bastarache L,Feng Q,Kember RL,Risman M,Bloom RD,Birtwell DL,Williams H,Shaffer CM,Chen J,Center RG,Denny JC,Rader DJ,Stein CM,Damrauer SM,Susztak K

更新日期：2020-05-01 00:00:00

abstract：:Monocyte chemoattractant protein 1 (MCP-1) is a C-C chemokine with potent monocyte chemotactic and activating properties that may contribute to glomerular macrophage infiltration in anti-GBM Ab GN. We have previously reported increased glomerular steady state expression of MCP-1 mRNA relative to GAPDH mRNA in the hete...

journal_title：Kidney international

authors： Tang WW,Qi M,Warren JS

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:The cardiovascular effects of angiotensin II are mediated by the angiotensin II type 1 receptor (AGT1R); one polymorphism of the AGT1R gene, A1166-->C, has been associated with hypertension. The hemodynamic response to angiotensin II is blunted in women compared to men, but interactions between gender, blood...

journal_title：Kidney international

authors： Reich H,Duncan JA,Weinstein J,Cattran DC,Scholey JW,Miller JA

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:In a prior study the 21-aminosteroid (lazaroid) U74389F provided in vivo protection from oxidative stress when used as a preventive therapy in ischemia-reperfusion injury in the kidney. As the cell membrane is the principal site for lipoperoxidation, in the current study the very lipophilic 2-methylaminochro...

journal_title：Kidney international

authors： De Vecchi E,Lubatti L,Beretta C,Ferrero S,Rinaldi P,Galli Kienle M,Trazzi R,Paroni R

更新日期：1998-09-01 00:00:00

abstract：:The present study was undertaken to evaluate some pathophysiological mechanisms of edema formation in diabetic nephropathy. Sixty-three subjects were investigated: 9 normal subjects (I), 9 normoalbuminuric Type 1 (insulin-dependent) diabetic patients (II), 15 microalbuminuric Type 1 diabetic patients (III), 16 Type 1 ...

journal_title：Kidney international

authors： Hommel E,Mathiesen ER,Aukland K,Parving HH

更新日期：1990-12-01 00:00:00

abstract：:Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise in thr...

journal_title：Kidney international

authors： Noone DG,Riedl M,Pluthero FG,Bowman ML,Liszewski MK,Lu L,Quan Y,Balgobin S,Schneppenheim R,Schneppenheim S,Budde U,James P,Atkinson JP,Palaniyar N,Kahr WH,Licht C

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:There is accumulating evidence that adult bone marrow (BM) cells show unexpected plasticity, and can differentiate into a wide range of specialized cells. In the case of intrinsic renal glomerular cells, BM-derived cells have been reported to differentiate into both mesangial cells and podocytes. However, th...

journal_title：Kidney international

authors： Ikarashi K,Li B,Suwa M,Kawamura K,Morioka T,Yao J,Khan F,Uchiyama M,Oite T

更新日期：2005-05-01 00:00:00

abstract：UNLABELLED:Inhibition of pressure natriuresis in mice lacking the AT2 receptor. BACKGROUND:Angiotensin II type 2 (AT2) receptor knockout mice have higher blood pressures than wild-type mice; however, the hypertension is imperfectly defined. We tested the hypothesis that renal mechanisms could be contributory. METHODS...

journal_title：Kidney international

authors： Gross V,Schunck WH,Honeck H,Milia AF,Kärgel E,Walther T,Bader M,Inagami T,Schneider W,Luft FC

更新日期：2000-01-01 00:00:00

abstract：:Spleen tyrosine kinase (SYK) is an important component of the intracellular signaling pathway for various immunoreceptors. Inhibition of SYK has shown promise in preclinical models of autoimmune and glomerular disease. However, the description of SYK expression in human renal tissue, which would be desirable ahead of ...

journal_title：Kidney international

authors： McAdoo SP,Bhangal G,Page T,Cook HT,Pusey CD,Tam FW

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Podocytes are highly differentiated glomerular epithelial cells with limited potential to divide. They are responsible for maintaining and supporting the glomerular basement membrane so as to facilitate efficient filtration. The hypothesis tested was whether the development of glomerulosclerosis in the purom...

journal_title：Kidney international

authors： Kim YH,Goyal M,Kurnit D,Wharram B,Wiggins J,Holzman L,Kershaw D,Wiggins R

更新日期：2001-09-01 00:00:00

abstract：:Early kidney transplant results in children lagged behind corresponding results in adults. Multiple advances over the past three decades have eliminated that gap. Most children now have equal or superior long-term allograft and patient survival compared with adult recipients. However, black children in the United Stat...

journal_title：Kidney international

authors： Dharnidharka VR,Seifert ME

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:The parathyroid (PT) hyperplasia induced by renal failure can be further enhanced by high dietary phosphate (P) or completely abolished by P restriction. To identify potential mechanisms mediating these opposing effects of dietary P on PT growth, this study first focused on p21(WAF1) (p21) because high P red...

journal_title：Kidney international

authors： Dusso AS,Pavlopoulos T,Naumovich L,Lu Y,Finch J,Brown AJ,Morrissey J,Slatopolsky E

更新日期：2001-03-01 00:00:00

abstract：:Inflammatory responses in the kidney lead to tubulointerstitial fibrosis, a common feature of chronic kidney diseases. Here we examined the role of prostaglandin E(2) (PGE(2)) in the development of tubulointerstitial fibrosis. In the kidneys of wild-type mice, unilateral ureteral obstruction leads to progressive tubul...

journal_title：Kidney international

authors： Nakagawa N,Yuhki K,Kawabe J,Fujino T,Takahata O,Kabara M,Abe K,Kojima F,Kashiwagi H,Hasebe N,Kikuchi K,Sugimoto Y,Narumiya S,Ushikubi F

更新日期：2012-07-01 00:00:00

abstract：:Tuberous sclerosis complex is a genetic disorder characterized by hamartomatous lesions in multiple organs, frequently involving the kidney. We conducted a retrospective review of the clinical and radiographic records of 167 patients with tuberous sclerosis to determine the frequency of renal disease, the likelihood o...

journal_title：Kidney international

authors： Rakowski SK,Winterkorn EB,Paul E,Steele DJ,Halpern EF,Thiele EA

更新日期：2006-11-01 00:00:00

abstract：:Progressive kidney fibrosis precedes end-stage renal failure in up to a third of patients with diabetes mellitus. Elevated intra-renal transforming growth factor-beta (TGF-beta) is thought to underlie disease progression by promoting deposition of extracellular matrix and epithelial-mesenchymal transition. GW788388 is...

journal_title：Kidney international

authors： Petersen M,Thorikay M,Deckers M,van Dinther M,Grygielko ET,Gellibert F,de Gouville AC,Huet S,ten Dijke P,Laping NJ

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:We evaluated the effects of different concentrations of iron dextran administered through the intraperitoneal route, in iron-deficient rats, on hematocrit (Hct in percentage), serum iron (mg/dL), total iron binding capacity (TIBC in mg/dL), and the function and histology of the peritoneal membrane. METHODS:...

journal_title：Kidney international

authors： Reddy DK,Moore HL,Lee JH,Saran R,Nolph KD,Khanna R,Twardowski ZJ

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:The development of strategies to enhance the survival of transplanted organs and to potentially lower or even discontinue immunosuppressive therapy would represent a significant advancement in post-transplant patient care. METHODS:We studied the effect of pretransplant infusion of donor leukocytes alone or ...

journal_title：Kidney international

authors： Noris M,Azzollini N,Mister M,Pezzotta A,Piccinini G,Casiraghi F,Cugini D,Perico N,Orisio S,Remuzzi G

更新日期：1999-09-01 00:00:00