当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Tacrolimus for induction therapy of diffuse proliferative lupus nephritis: an open-labeled pilot study.

Tacrolimus for induction therapy of diffuse proliferative lupus nephritis: an open-labeled pilot study.

Abstract：

BACKGROUND:Tacrolimus is a relatively new calcineurin inhibitor that has been increasingly used in transplant medicine. The objective of the current work is to report our preliminary experience with tacrolimus in the treatment of diffuse proliferative glomerulonephritis in systemic lupus erythematosus (SLE). METHODS:Nine consecutive patients who fulfilled the American College of Rheumatology criteria for SLE and with biopsy-proven diffuse proliferative glomerulonephritis were recruited for an open-labeled trial with prednisolone and oral tacrolimus (0.1 mg/kg/day for 2 months, followed by 0.06 mg/kg/day). Prospective data on renal response and serologic lupus activity were collected. The efficacy and safety of this regimen was reported. RESULTS:Baseline characteristics of the patients were: mean age 33.3 +/- 12 years, women to men ratio 2:1, serum creatinine 94.2 +/- 46 micromol/L, daily proteinuria 4.56 +/- 2.4 g, seven (78%) patients were nephrotic, three (33%) were hypertensive, and four (44%) had elevated serum creatinine at the time of renal biopsy. At 6 months of therapy, complete and partial renal response was achieved in six (67%) and two (22%) patients, respectively. Significant improvement in proteinuria, hemoglobin, serum albumin, and C3 levels was observed in comparison with baseline values, starting at the second month. Tacrolimus was generally well tolerated, except for two patients who developed transient hyperglycemia. Infective complications, amenorrhea, hypertrichosis, gingivitis, new-onset hypertension, and significant increase in serum creatinine were not reported. CONCLUSION:Tacrolimus is an effective option for induction treatment of SLE-diffuse proliferative glomerulonephritis. Further trials are necessary to determine the optimal dosage and duration of therapy, and its efficacy in comparison to standard regimens.

journal_name

Kidney Int

journal_title

Kidney international

authors

Mok CC,Tong KH,To CH,Siu YP,Au TC

doi

10.1111/j.1523-1755.2005.00461.x

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

813-7

issue

2

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)50903-4

journal_volume

68

pub_type

临床试验,杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Lipid abnormalities associated with urinary albumin excretion rate in Taiwanese type 2 diabetic patients.

    abstract：BACKGROUND:The purpose of this study was to examine the lipid abnormalities associated with urinary albumin excretion rate (UAER) in type 2 diabetic patients. METHODS:A total of 275 (122 men and 153 women; aged 60.6 +/- 11.1 years) patients were selected with stringent criteria to prevent confounders. Normoalbuminuria...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00235.x

    authors： Tseng CH

    更新日期：2005-04-01 00:00:00

  • The effects of iron dextran on the oxidative stress in cardiovascular tissues of rats with chronic renal failure.

    abstract：BACKGROUND:Redox-active iron can promote oxidative stress and tissue injury by catalyzing hydroxyl radical generation and lipid peroxidation. Intravenous iron preparations are routinely administered in conjunction with erythropoietin to treat anemia in patients with chronic renal failure (CRF), a condition that is mark...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00580.x

    authors： Lim CS,Vaziri ND

    更新日期：2004-05-01 00:00:00

  • De novo pyrimidine nucleotide biosynthesis in isolated rat glomeruli.

    abstract：:Uracil ribonucleotide-sugars and aminosugars are required for glomerular basement membrane (GBM) biosynthesis. Since these nucleotides are metabolic derivatives of uridine 5'-triphosphate (UTP), we have studied the cellular pools of uridine 5'-diphosphoglucose (UDPG), uridine 5'-diphosphoglucuronic acid (UDPGA), uridi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1986.146

    authors： Cortes P,Dumler F,Levin NW

    更新日期：1986-07-01 00:00:00

  • Renal ENaC subunit, Na-K-2Cl and Na-Cl cotransporter abundances in aged, water-restricted F344 x Brown Norway rats.

    abstract：:Renal sodium reabsorption is a key determinant of final urine concentration. Our aim was to determine whether differences existed between aged and young rats in their response to water restriction with regard to the regulation of abundance of any of the major distal renal sodium transporter proteins. Male Fisher 344 x...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000076

    authors： Tian Y,Riazi S,Khan O,Klein JD,Sugimura Y,Verbalis JG,Ecelbarger CA

    更新日期：2006-01-01 00:00:00

  • Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery.

    abstract：:Acute kidney injury (AKI) following cardiac surgery is closely interrelated with hemodynamic instability and sympathetic activity, and adversely influences prognosis. Here, we investigated in a randomized placebo-controlled trial whether dexmedetomidine, an α2 adrenoreceptor agonist, could prevent AKI after valvular h...

    journal_title：Kidney international

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/ki.2015.306

    authors： Cho JS,Shim JK,Soh S,Kim MK,Kwak YL

    更新日期：2016-03-01 00:00:00

  • Ultrasound dilution evaluation of pediatric hemodialysis vascular access.

    abstract：BACKGROUND:Hemodialysis access thrombosis is a significant cause of morbidity for hemodialysis patients and results from decreased access flow caused by venous outflow tract stenosis. Ultrasound dilution (UD) is a practical, noninvasive, and reliable indicator of access flow and is effective in predicting venous stenos...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1523-1755.2001.00753.x

    authors： Goldstein SL,Allsteadt A

    更新日期：2001-06-01 00:00:00

  • Fibronectin synthesis in tubular epithelial cells: up-regulation of the EDA splice variant by transforming growth factor beta.

    abstract：:The influence of transforming growth factor beta 1 (TGF-beta 1) and of dexamethasone on fibronectin (FN) synthesis of human renal tubular epithelial cells in culture (TEC) was studied. Cocultivation with TGF-beta 1 increased the steady state level of FN RNA within 24 to 48 hours. By PCR and Northern blotting it was fo...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.479

    authors： Viedt C,Bürger A,Hänsch GM

    更新日期：1995-12-01 00:00:00

  • A novel apolipoprotein E mutation, E2 (Arg25Cys), in lipoprotein glomerulopathy.

    abstract：BACKGROUND:Lipoprotein glomerulopathy (LPG) is characterized by intraglomerular lipoprotein thrombosis and high plasma concentrations of apolipoprotein (apo) E. An apo E variant, apo E2 (Arg145Pro) Sendai, was recently identified in three patients with LPG. We detected a novel point mutation in the apo E gene in a pati...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00572.x

    authors： Matsunaga A,Sasaki J,Komatsu T,Kanatsu K,Tsuji E,Moriyama K,Koga T,Arakawa K,Oikawa S,Saito T,Kita T,Doi T

    更新日期：1999-08-01 00:00:00

  • Classical complement pathway activation in membranoproliferative glomerulonephritis.

    abstract：:Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1976.6

    authors： Ooi YM,Vallota EH,West CD

    更新日期：1976-01-01 00:00:00

  • High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta 1.

    abstract：BACKGROUND:The alteration of renal cell growth is one of the early abnormalities in the diabetic nephropathy. However, the effects of high glucose and its action mechanism in renal proximal tubule cell (PTC) proliferation have not been elucidated. METHODS:The effects of 25 mmol/L glucose on cell proliferation, thymidi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.0590051695.x

    authors： Park SH,Choi HJ,Lee JH,Woo CH,Kim JH,Han HJ

    更新日期：2001-05-01 00:00:00

  • Measurement of urinary chemokine and growth factor messenger RNAs: a noninvasive monitoring in lupus nephritis.

    abstract：:Noninvasive molecular tests of urine cells have been developed to monitor the activity of kidney diseases. We evaluate whether measurement of urinary messenger RNA (mRNA) levels of chemokine and growth factor genes could distinguish between diffuse proliferative lupus nephritis (class IV LN) and others and whether it ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000132

    authors： Avihingsanon Y,Phumesin P,Benjachat T,Akkasilpa S,Kittikowit V,Praditpornsilpa K,Wongpiyabavorn J,Eiam-Ong S,Hemachudha T,Tungsanga K,Hirankarn N

    更新日期：2006-02-01 00:00:00

  • Nitric oxide enhances paracellular permeability of opossum kidney cells.

    abstract：BACKGROUND:Nitric oxide (NO) has been shown to be a paracrine/autocrine regulator of proximal tubular transport. In this study, we investigated the effect of NO on the paracellular permeability of opossum kidney (OK) cells, a proximal tubule cell line that possesses a leaky paracellular pathway resembling that of the i...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00465.x

    authors： Liang M,Knox FG

    更新日期：1999-06-01 00:00:00

  • ISCHEMIA in chronic kidney disease: improving the representation of patients with chronic kidney disease in cardiovascular trials.

    abstract：:Despite the high cardiovascular risk associated with chronic kidney disease, a recent systematic review confirmed that patients with kidney disease remain underrepresented in cardiovascular trials. Two ongoing trials are assessing the risk:benefit of aggressive evaluation and intervention for ischemic heart disease in...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2016.03.012

    authors： Wyatt CM,Shineski M,Chertow GM,Bangalore S

    更新日期：2016-06-01 00:00:00

  • Low parathyroid hormone status induced by high dialysate calcium is an independent risk factor for cardiovascular death in hemodialysis patients.

    abstract：:Here we studied a possible association between low parathyroid hormone (PTH) status and mortality in incident patients undergoing hemodialysis . A total of 1983 patients were included at baseline and prospectively followed for 24 months. Patients were classified according to their Kidney Disease: Improving Global Outc...

    journal_title：Kidney international

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.kint.2015.12.001

    authors： Merle E,Roth H,London GM,Jean G,Hannedouche T,Bouchet JL,Drüeke T,Fouque D,Daugas E,French Calcium and Phosphate Observatory.

    更新日期：2016-03-01 00:00:00

  • Global trends in the rates of living kidney donation.

    abstract：:As the worldwide prevalence of end-stage renal disease increases it is important to evaluate the rate of living kidney donation in various countries; however there is no comprehensive global assessment of these rates. To measure this, we compiled data from representatives, renal registries, transplant networks, publis...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.20

    authors： Horvat LD,Shariff SZ,Garg AX,Donor Nephrectomy Outcomes Research (DONOR) Network.

    更新日期：2009-05-01 00:00:00

  • Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease.

    abstract：:To determine whether acute renal failure (ARF) increases the long-term risk of progressive chronic kidney disease (CKD), we studied the outcome of patients whose initial kidney function was normal or near normal but who had an episode of dialysis-requiring ARF and did not develop end-stage renal disease within 30 days...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.289

    authors： Lo LJ,Go AS,Chertow GM,McCulloch CE,Fan D,Ordoñez JD,Hsu CY

    更新日期：2009-10-01 00:00:00

  • Flying podocytes.

    abstract：:Recent insights have defined the central role of podocytes both in rare genetic diseases and as a general determinant of the progression of human glomerular diseases. In a recent issue of Nature, Weavers et al. described a podocyte-like cell type in Drosophila, the nephrocyte, that closely resembles mammalian podocyte...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.653

    authors： Simons M,Huber TB

    更新日期：2009-03-01 00:00:00

  • Enzyme activity in obstructive uropathy: basis for salt wastage and the acidification defect.

    abstract：:Unilateral ureteral obstruction results in marked changes in renal function throughout the nephron, including impaired acid and potassium secretion and salt wastage. The nephron site believed responsible for the acidification defect is the collecting duct. It has been presumed, although not demonstrated, that the cell...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.11

    authors： Sabatini S,Kurtzman NA

    更新日期：1990-01-01 00:00:00

  • Magnetic resonance imaging accurately tracks kidney pathology and heterogeneity in the transition from acute kidney injury to chronic kidney disease.

    abstract：:Acute kidney injury (AKI) increases the risk for chronic kidney disease (CKD). However, there are few tools to detect microstructural changes after AKI. Here, cationic ferritin-enhanced magnetic resonance imaging (CFE-MRI) was applied to examine the heterogeneity of kidney pathology in the transition from AKI to CKD. ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2020.08.021

    authors： Charlton JR,Xu Y,Wu T,deRonde KA,Hughes JL,Dutta S,Oxley GT,Cwiek A,Cathro HP,Charlton NP,Conaway MR,Baldelomar EJ,Parvin N,Bennett KM

    更新日期：2021-01-01 00:00:00

  • The spectrum of bone disease in end-stage renal failure--an evolving disorder.

    abstract：:We have assessed the bone histology in 259 chronic dialysis patients, all of whom were in the same dialysis program. All patients had bone biopsies with quantitative histomorphometry, intact parathyroid hormone (PTH) measurements, basal and deferoxamine stimulated serum aluminum levels. Results demonstrate the increas...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1993.64

    authors： Sherrard DJ,Hercz G,Pei Y,Maloney NA,Greenwood C,Manuel A,Saiphoo C,Fenton SS,Segre GV

    更新日期：1993-02-01 00:00:00

  • Safety and efficacy of long-acting somatostatin treatment in autosomal-dominant polycystic kidney disease.

    abstract：BACKGROUND:The fluid filling renal cysts in human polycystic kidneys is secreted chiefly by the tubular epithelium lining the cysts via secondary chloride transport. Inhibiting this process by somatostatin therapy should induce shrinking of renal cysts. METHODS:In this randomized, cross-over, placebo-controlled trial ...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1523-1755.2005.00395.x

    authors： Ruggenenti P,Remuzzi A,Ondei P,Fasolini G,Antiga L,Ene-Iordache B,Remuzzi G,Epstein FH

    更新日期：2005-07-01 00:00:00

  • Learning about the practice of peritoneal dialysis.

    abstract：:Observational studies are valuable and provocative. We are learning about how we practice peritoneal dialysis (PD) and how we might improve on that practice. For example, outcomes of PD therapy are not worse in large patients. Perhaps this will encourage physicians and patients to utilize PD in large patients. In addi...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2009.65

    authors： Golper TA

    更新日期：2009-07-01 00:00:00

  • Cardiovascular risk factors in chronic kidney disease: does phosphate qualify?

    abstract：:Risk factors for disease states are rigorously defined. This analysis considers the definition of a risk factor as applied to the question of whether the serum phosphorus level is a risk factor for cardiovascular disease. Observational studies strongly suggest that phosphorus is associated with cardiovascular risk, an...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.2011.24

    authors： Hruska K,Mathew S,Lund R,Fang Y,Sugatani T

    更新日期：2011-04-01 00:00:00

  • Cystatin C is not a better estimator of GFR than plasma creatinine in the general population.

    abstract：:Accurate measurement of glomerular filtration rate (GFR) is complicated and costly; therefore, GFR is commonly estimated by assessing creatinine or cystatin C concentrations. Because estimates based on cystatin C predict cardiovascular disease better than creatinine, these estimates have been hypothesized to be superi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2010.321

    authors： Eriksen BO,Mathisen UD,Melsom T,Ingebretsen OC,Jenssen TG,Njølstad I,Solbu MD,Toft I

    更新日期：2010-12-01 00:00:00

  • Identification of a monocyte phagocytic defect in a subpopulation of patients with nephritis.

    abstract：:Experimental studies have demonstrated the cardinal role played by the mononuclear phagocyte system in the removal of antigen-antibody complexes. To assess the functional capacity of phagocytes in patients with renal disease, 33 normal subjects, 10 patients with mesangial proliferative glomerulonephritis, 8 patients w...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1983.105

    authors： Ooi YM,Ooi BS

    更新日期：1983-06-01 00:00:00

  • The effect of angiotensin-converting-enzyme inhibitors on progression of advanced polycystic kidney disease.

    abstract：BACKGROUND:It is not known whether angiotensin-converting-enzyme (ACE) inhibitors slow the progression of polycystic kidney disease (PKD). We performed a patient-level meta-analysis to compare the effect of antihypertensive regimens, including ACE inhibitors, to those without ACE inhibitors (controls) on kidney disease...

    journal_title：Kidney international

    pub_type： 杂志文章,meta分析

    doi：10.1111/j.1523-1755.2005.00077.x

    authors： Jafar TH,Stark PC,Schmid CH,Strandgaard S,Kamper AL,Maschio G,Becker G,Perrone RD,Levey AS,ACE Inhibition in Progressive Renal Disease (AIPRD) Study Group.

    更新日期：2005-01-01 00:00:00

  • Regulation of transforming growth factor-beta1 by insulin in prediabetic African Americans.

    abstract：:Insulin resistance has been associated with kidney disease even in the absence of diabetes; however, pathways linking insulin resistance to kidney disease are unclear. The purpose of this study was to determine if transforming growth factor (TGF)-beta1, a key cytokine associated with kidney disease, responds to circul...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2010.109

    authors： Huan Y,DeLoach S,Daskalakis C,Dunn SR,Sharma K,Falkner B

    更新日期：2010-08-01 00:00:00

  • Lead chelation therapy and urate excretion in patients with chronic renal diseases and gout.

    abstract：BACKGROUND:It is known that chronic renal insufficiency (CRI) patients with gout may have subtle lead poisoning. In addition, gout episodes frequently aggravate progressive renal insufficiency because of the use of nephrotoxic drugs and urate deposition. Our study was arranged to evaluate the causal effect of environme...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1523-1755.2001.00795.x

    authors： Lin JL,Yu CC,Lin-Tan DT,Ho HH

    更新日期：2001-07-01 00:00:00

  • Presence of fructose transporter GLUT5 in the S3 proximal tubules in the rat kidney.

    abstract：BACKGROUND:Fructose is a nutrient as well as a potent agent for the formation of advanced glycation end product in diabetes. GLUT5 is a facilitated-diffusion fructose transporter expressed in the small intestine and kidney. Previous reports on the localization of GLUT5 by in situ hybridization and immunohistochemistry ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00635.x

    authors： Sugawara-Yokoo M,Suzuki T,Matsuzaki T,Naruse T,Takata K

    更新日期：1999-09-01 00:00:00

  • Gene therapy in renal diseases.

    abstract：:Kidney-targeted gene therapy could be an ideal treatment for renal diseases since the therapeutic molecule is limited in the kidney and the systemic effect may be minimized. The technical development of the gene delivery to kidney and the identification of the responsive gene for a particular disease encourage the cha...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1111/j.1523-1755.2004.05409.x

    authors： Imai E,Takabatake Y,Mizui M,Isaka Y

    更新日期：2004-05-01 00:00:00