Presence of fructose transporter GLUT5 in the S3 proximal tubules in the rat kidney.

abstract：:The relationship between leukopenia and the complement system during hemodialysis was re-examined by studying not only the in vivo effects of four different dialyzer membranes (cellulose hydrate, cuprophan, cellulose acetate, and polyacrilonitrile) on leukocyte counts and complement levels, but especially by investiga...

journal_title：Kidney international

authors： Amadori A,Candi P,Sasdelli M,Massai G,Favilla S,Passaleva A,Ricci M

更新日期：1983-12-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is an inherited, progressive nephropathy accounting for 4-10% of end stage renal disease worldwide. PKD1 and PKD2 are the most common disease loci, but even accounting for other genetic causes, about 7% of families remain unresolved. Typically, these unsolved cases ...

journal_title：Kidney international

authors： Hopp K,Cornec-Le Gall E,Senum SR,Te Paske IBAW,Raj S,Lavu S,Baheti S,Edwards ME,Madsen CD,Heyer CM,Ong ACM,Bae KT,Fatica R,Steinman TI,Chapman AB,Gitomer B,Perrone RD,Rahbari-Oskoui FF,Torres VE,HALT Progression of

更新日期：2020-02-01 00:00:00

abstract：:Previous studies in living animals have suggested that variations in the serum concentrations of calcium and phosphate directly affect renal tubular bicarbonate transport. To examine this area more directly, we measured the bicarbonate and the fluid transport in isolated rabbit proximal convoluted and straight tubules...

journal_title：Kidney international

authors： McKinney TD,Myers P

更新日期：1982-03-01 00:00:00

abstract：:Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase associated with numerous aspects of health and physiology. Overexpression of SIRT6 has emerged as a protector in cardiac tissues against pathologic cardiac hypertrophy. However, the mechanism of this protective effect is not fully understood. Here, both in vivo and in ...

journal_title：Kidney international

authors： Li Z,Xu K,Zhang N,Amador G,Wang Y,Zhao S,Li L,Qiu Y,Wang Z

更新日期：2018-04-01 00:00:00

abstract：:To investigate mechanisms underlying GFR control in diabetes mellitus, renal hemodynamics and segmental tubular handling of sodium, using lithium clearance, were assessed in 41 insulin-dependent diabetics (IDD) treated by insulin for 11 +/- 8 days, and in 19 normal controls. Average GFR and effective renal plasma flow...

journal_title：Kidney international

authors： Hannedouche TP,Delgado AG,Gnionsahe DA,Boitard C,Lacour B,Grünfeld JP

更新日期：1990-04-01 00:00:00

abstract：:Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal sys...

journal_title：Kidney international

authors： Luciani A,Freedman BS

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Immune response to oxidized low-density lipoprotein (oxLDL) may modulate the process of atherogenesis and cardiovascular disease. METHODS:We performed a prospective, observational cohort study in 249 patients with end-stage renal disease (ESRD) to examine whether the serum titer of anti-oxLDL antibody can p...

journal_title：Kidney international

authors： Shoji T,Fukumoto M,Kimoto E,Shinohara K,Emoto M,Tahara H,Koyama H,Ishimura E,Nakatani T,Miki T,Tsujimoto Y,Tabata T,Nishizawa Y

更新日期：2002-12-01 00:00:00

abstract：:A newly described glomerulotubular feedback loop may explain the relationship between glomerular damage, epitope spreading, tubulointerstitial nephritis, proteinuria as a progression factor, and the importance of the local milieu in kidney damage. It also opens the horizons for exciting innovative approaches to therap...

journal_title：Kidney international

authors： Sung SS,Bolton WK

更新日期：2010-03-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase. Its activation results in beneficial or detrimental consequences, depending on the particular setting. Earlier studies in the animal model of acute kidney injury showed that EGFR activation promotes renal tubular cell proliferation. Activation of E...

journal_title：Kidney international

authors： Tang J,Liu N,Zhuang S

更新日期：2013-05-01 00:00:00

abstract：:Swelling activated anion channels have recently been recognized to play an important role in not only volume regulatory electrolyte movement, but also in organic osmolyte transport. A swelling-activated, outwardly rectifying anion channel termed VSOAC (volume-sensitive organic osmolyte/anion channel) is a major pathwa...

journal_title：Kidney international

authors： Jackson PS,Strange K

更新日期：1996-06-01 00:00:00

abstract：:Whole-genome microarrays identify large numbers of gene expression changes that appear specifically related to disease states such as antineutrophil cytoplasmic autoantibody (ANCA) and systemic lupus erythematosus. Although understanding this enormous volume of esoteric data is difficult, a few basic concepts regardin...

journal_title：Kidney international

authors： Stegall MD,Park W

更新日期：2007-10-01 00:00:00

abstract：:International clinical practice guidelines for the management of anemia in chronic kidney disease suggest target hemoglobin levels ≤ 11.5 g/dl (115 g/l), with individualized consideration of slightly higher hemoglobin targets to improve quality of life. An updated meta-analysis of randomized trials demonstrates no sig...

journal_title：Kidney international

authors： Wyatt CM,Drueke TB

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Recently, we observed that the severity of glomerulonephritis in an experimental model of immunoglobulin A nephropathy (IgAN) induced by Sendai virus differs between C57BL/6 and BALB/c mouse strains. The determinants of differing renal insufficiency are not understood. In the present study, we examine the ca...

journal_title：Kidney international

authors： Kobayashi N,Bagheri N,Nedrud JG,Strieter RM,Tomino Y,Lamm ME,Emancipator SN

更新日期：2003-11-01 00:00:00

abstract：:We have previously shown that the activity of the Na-HCO3 cotransporter is stimulated by protein kinase C (PKC) activation, but the mechanism responsible for this effect is not clear. We have shown that cultured proximal tubule cells of the rabbit have DIDS-sensitive Na-HCO3 cotransporter activity as assessed by HCO3-...

journal_title：Kidney international

authors： Ruiz OS,Wang LJ,Qiu YY,Kear F,Bernardo A,Arruda JA

更新日期：1996-03-01 00:00:00

abstract：:The autoregulatory ability of the renal vascular system in the split hydronephrotic kidney was quantitated with intravital microscopy. The luminal diameters of the arcuate and interlobular arteries as well as the afferent and efferent arterioles were measured. Glomerular blood flow was determined by the dual slit tech...

journal_title：Kidney international

authors： Steinhausen M,Blum M,Fleming JT,Holz FG,Parekh N,Wiegman DL

更新日期：1989-05-01 00:00:00

abstract：:Hyperhomocysteinemia, an arteriosclerotic risk factor, persists in 75% of dialysis patients despite routine low dose supplementation with the B-vitamin co-factors/substrates for homocysteine (Hcy) metabolism, and normal or supernormal plasma status of these vitamins (Atherosclerosis 114:93, 1995). We conducted a place...

journal_title：Kidney international

authors： Bostom AG,Shemin D,Lapane KL,Hume AL,Yoburn D,Nadeau MR,Bendich A,Selhub J,Rosenberg IH

更新日期：1996-01-01 00:00:00

abstract：:Spleen tyrosine kinase (SYK) is an important component of the intracellular signaling pathway for various immunoreceptors. Inhibition of SYK has shown promise in preclinical models of autoimmune and glomerular disease. However, the description of SYK expression in human renal tissue, which would be desirable ahead of ...

journal_title：Kidney international

authors： McAdoo SP,Bhangal G,Page T,Cook HT,Pusey CD,Tam FW

更新日期：2015-07-01 00:00:00

abstract：:We have previously shown that ultrasonography can detect hyperechogenic crystal deposits in the kidney medulla of patients with gout. In this cross-sectional study we investigated the frequency and clinical correlates of hyperechogenic kidney medulla in 502 consecutive primary consultants for gout (ACR/EULAR criteria)...

journal_title：Kidney international

authors： Bardin T,Nguyen QD,Tran KM,Le NH,Do MD,Richette P,Letavernier E,Correas JM,Resche-Rigon M

更新日期：2021-01-01 00:00:00

abstract：:Renal stone disease, which affects 12% of males and 5% of females by the seventh decade, occurs as an inherited disorder in 45% of patients and is most commonly associated with hypercalciuria. The biochemical basis for hereditary nephrolithiasis and hypercalciuria is unknown, and this has therefore been investigated b...

journal_title：Kidney international

authors： Thakker RV

更新日期：2000-03-01 00:00:00

abstract：:Leucocyte interaction with other cells is facilitated by the adhesion molecules, leucocyte function-associated antigen-1 (LFA-1)-binding to intercellular adhesion molecule-1 (ICAM-1) and for T cells and natural killer (NK) cells the binding of LFA-2 (CD2) to LFA-3. As these interactions are critical for the mediation ...

journal_title：Kidney international

authors： Bishop GA,Hall BM

更新日期：1989-12-01 00:00:00

abstract：:We demonstrate that salts of diatrizoate and iothalamate, radiographic contrast agents, depress the active transport of sodium in the urinary bladder of the Columbian toad, Bufo marinus. Isolated toad bladders were incubated in isotonic Ringer's solutions with isosmolar displacement of sodium chloride by contrast medi...

journal_title：Kidney international

authors： Ziegler TW,Ludens JH,Fanestil DD,Talner LB

更新日期：1975-02-01 00:00:00

abstract：:Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results...

journal_title：Kidney international

authors： Ooi YM,Vallota EH,West CD

更新日期：1976-01-01 00:00:00

abstract：:The present study was undertaken to evaluate some pathophysiological mechanisms of edema formation in diabetic nephropathy. Sixty-three subjects were investigated: 9 normal subjects (I), 9 normoalbuminuric Type 1 (insulin-dependent) diabetic patients (II), 15 microalbuminuric Type 1 diabetic patients (III), 16 Type 1 ...

journal_title：Kidney international

authors： Hommel E,Mathiesen ER,Aukland K,Parving HH

更新日期：1990-12-01 00:00:00

abstract：:Dysfunction and loss of podocytes (glomerular epithelial cells) are the hallmarks of focal segmental glomerulosclerosis (FSGS). In recent years, activation and proliferation of parietal epithelial cells (PECs) have been increasingly appreciated in FSGS. The functional role of PECs in FSGS is still a hotly debated issu...

journal_title：Kidney international

authors： Sweetwyne MT,Susztak K

更新日期：2013-06-01 00:00:00

abstract：:Mitochondria are critical in determining a cell's energy homeostasis and fate, and mitochondrial dysfunction has been implicated in the pathogenesis of chronic kidney disease (CKD). We sought to identify causative mitochondrial microRNAs. A microarray screen of kidney tissue from healthy mice identified 97 microRNAs t...

journal_title：Kidney international

authors： Bai M,Chen H,Ding D,Song R,Lin J,Zhang Y,Guo Y,Chen S,Ding G,Zhang Y,Jia Z,Huang S,He JC,Yang L,Zhang A

更新日期：2019-06-01 00:00:00

abstract：:Isolated perfused rat kidneys were passively sensitized by addition of either mouse ascitic fluid containing monoclonal IgE against dinitrophenol (DNP) or DNP-specific purified IgE. After washing the organ, defined doses of DNP-bovine serum albumin were given as bolus injection via the kidney artery. Antigen challenge...

journal_title：Kidney international

authors： Pirotzky E,Pintos-Morell G,Burtin C,Boudet J,Bidault J,Benveniste J

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:An imbalance between protein load and folding capacity is referred to as endoplasmic reticulum (ER) stress. As a defense mechanism, cells express ER stress inducible chaperons, such as oxygen-regulated proteins 150 (ORP150) and glucose-regulated proteins (GRPs). While ER stress is important in various diseas...

journal_title：Kidney international

authors： Inagi R,Nangaku M,Onogi H,Ueyama H,Kitao Y,Nakazato K,Ogawa S,Kurokawa K,Couser WG,Miyata T

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Angiotensin II type 2 receptor-deficient mice (AT(2)-/y) provide an opportunity to study the relationship between the angiotensin II type 1 receptor (AT(1)) and nitric oxide synthase (NOS) isoforms without concomitant AT(2) receptor-related effects. To test this relationship, the expression of renal NOS isof...

journal_title：Kidney international

authors： Obst M,Gross V,Bonartsev A,Janke J,Müller DN,Park JK,Kärgel E,Luft FC

更新日期：2004-06-01 00:00:00

abstract：:Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) are exposed to a continuous infusion of glucose via their peritoneal cavity. We performed studies to quantitate the amount of energy derived from dialysate glucose. Net glucose absorption averaged 182 +/- (SD) 61 g/day in 19 studies with a dialysate ...

journal_title：Kidney international

authors： Grodstein GP,Blumenkrantz MJ,Kopple JD,Moran JK,Coburn JW

更新日期：1981-04-01 00:00:00

abstract：:Copy number variations associate with different developmental phenotypes and represent a major cause of congenital anomalies of the kidney and urinary tract (CAKUT). Because rare pathogenic copy number variations are often large and contain multiple genes, identification of the underlying genetic drivers has proven to...

journal_title：Kidney international

authors： Westland R,Verbitsky M,Vukojevic K,Perry BJ,Fasel DA,Zwijnenburg PJ,Bökenkamp A,Gille JJ,Saraga-Babic M,Ghiggeri GM,D'Agati VD,Schreuder MF,Gharavi AG,van Wijk JA,Sanna-Cherchi S

更新日期：2015-12-01 00:00:00