Abstract：
:We demonstrate that salts of diatrizoate and iothalamate, radiographic contrast agents, depress the active transport of sodium in the urinary bladder of the Columbian toad, Bufo marinus. Isolated toad bladders were incubated in isotonic Ringer's solutions with isosmolar displacement of sodium chloride by contrast media in experimental solutions. Sodium transport as measured both by short-circuit current (SCC) and by isotopic sodium flux was significantly depressed in the presence of sodium diatrizoate. Sodium transport measured by SCC was significantly depressed with sodium iothalamate and meglumine iothalamate. Equimolar methylsulfate Ringer's solution did not depress SCC. Although contrast media in isotonic Ringer's solutions depressed basal SCC, the vasopressin-stimulated increment in SCC was not depressed by contrast media. Separate experiments with hyperosmolar solutions (786 mM, as utilized in angiography) demonstrated equivalent suppression of SCC by contrast media and by other solutions made hyperosmolar with glucose or sodium methylsulfate, implying a general or nonspecific effect of hyperosomolarity. Inhibition of SCC by contrast media was reversible when the agents were removed by serial changes with standard Ringer's solution. Inhibition of sodium transport by contrast media might provide a basis for studies on some of the clinical toxicities of these agents.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Ziegler TW,Ludens JH,Fanestil DD,Talner LBdoi
10.1038/ki.1975.11subject
Has Abstractpub_date
1975-02-01 00:00:00pages
68-76issue
2eissn
0085-2538issn
1523-1755pii
S0085-2538(15)31419-8journal_volume
7pub_type
杂志文章abstract：BACKGROUND:Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme activated by strand breaks in DNA, plays an important role in the development of ischemia/reperfusion (I/R) injury. The aim of this study was to investigate the effects of a water-soluble and potent PARP inhibitor, 5-aminoisoquinolinone (5-AIQ), on the re...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2004.00415.x
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to examine the relationship between glomerular filtration rate (GFR) measured at 5 years' diabetes duration and annual urine albumin excretion in a prospective cohort of children with type 1 diabetes (T1DM). METHODS:Three hundred and eight children were followed from diagnosis ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.00590.x
更新日期：2005-10-01 00:00:00
abstract：:Cisplatin is a platinum-containing antitumor agent whose usefulness is limited by nephrotoxicity. We examined the effects of cisplatin on a representative, transporting epithelium--the frog skin. Cisplatin (10(-3)M) from the mucosal surface increased the active transport of sodium by 35 to 40%, as monitored by short-c...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1981.2
更新日期：1981-01-01 00:00:00
abstract：UNLABELLED:Expression of apoptosis regulatory genes in chronic cyclosporine nephrotoxicity favors apoptosis. BACKGROUND:Chronic cyclosporine (CsA) nephrotoxicity is characterized by interstitial fibrosis, tubular dropout, and loss of cellularity in areas of fibrosis. Apoptosis was found to play a role in CsA-induced f...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.1999.00794.x
更新日期：1999-12-01 00:00:00
abstract：:Recently, 4 new risk scores for the prediction of mortality and cardiovascular events were especially tailored for hemodialysis patients; these scores performed much better than previous scores. Tripepi et al. found that these risk scores were even more predictive for all-cause and cardiovascular death than the measur...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2016.11.022
更新日期：2017-03-01 00:00:00
abstract：:Mutations in the inverted formin 2 gene (INF2) have recently been identified as the most common cause of autosomal dominant focal and segmental glomerulosclerosis (FSGS). To quantify the contribution of various genes contributing to FSGS, we sequenced INF2 where all mutations have previously been described (exons 2 to...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2012.349
更新日期：2013-02-01 00:00:00
abstract：:Acute urinary obstruction causes interstitial inflammation with leukocyte accumulation and the secretion of soluble mediators. Here we show that unilateral ureteral ligation caused a progressive increase in renal F4/80(+) and F4/80(-) dendritic cells, monocytes, neutrophils and T-cells 24-72 h following obstruction. D...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2008.394
更新日期：2008-11-01 00:00:00
abstract：:Injury resulting from ischemia-reperfusion injury is a multifactorial process involving compromised function in both the tubular and the vascular compartments. Multiple vasoactive compounds have been implicated in the profound vasoconstriction that occurs in response to ischemia-reperfusion injury, and many of these f...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2011.145
更新日期：2011-08-01 00:00:00
abstract：:Multiphoton excitation fluorescence microscopy is a state-of-the-art confocal imaging technique ideal for deep optical sectioning of living tissues. It is capable of performing ultrasensitive, quantitative imaging of organ functions in health and disease with high spatial and temporal resolution which other imaging mo...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/sj.ki.5002461
更新日期：2007-11-01 00:00:00
abstract：:Inflammation is a protective response to remove dangerous stimuli from the body. The multiprotein complex called the inflammasome regulates inflammation through the cleavage of proinflammatory cytokines into mature forms. Shahzad et al. unravel the importance of the Nlrp3 inflammasome, especially activated in glomerul...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2014.322
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:The cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 (15dPGJ2) affects mesangial proliferation, survival and production of proinflammatory proteins. During a survey of the mesangial cell proteome after treatment with 15dPGJ2, heat shock protein 70 (HSP70) was found to be the most conspicuous...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2004.00454.x
更新日期：2004-03-01 00:00:00
abstract：:Previous work has documented an acceleration of proteolysis and branched-chain amino acid oxidation when muscles from rats with chronic metabolic acidosis were incubated in vitro. The present study examines the impact of chronic metabolic acidosis on whole body amino acid turnover and oxidation in chronically catheter...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1992.223
更新日期：1992-06-01 00:00:00
abstract：:Transforming growth factor-β1 (TGF-β1) upregulation occurs in virtually all chronic kidney diseases and is associated with podocyte injury and proteinuria; however, the mechanisms contributing to this in vivo are ambiguous. In vitro, incubation of podocytes with TGF-β1 induced Wnt1 expression, β-catenin activation, an...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2011.255
更新日期：2011-12-01 00:00:00
abstract：:Eight patients with chronic renal failure (GFR 18.8 +/- 2.7 ml/min) were randomized to a crossover comparison of a very low protein diet (VLPD) containing 0.28 g protein and 35 kcal per kg per day, plus an isosmolar mixture of either ketoacids (KA) or essential amino acids (EAA). Subjects initiated the diets 14 days b...
journal_title：Kidney international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/ki.1994.157
更新日期：1994-04-01 00:00:00
abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) and its receptors have been implicated in the pathogenesis of diabetic nephropathy. The objective of this study was to determine whether alterations of the plasma and urinary VEGF and sFLT-1 levels were related to the stages and risk factors of diabetic nephropathy. ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.00067.x
更新日期：2005-01-01 00:00:00
abstract：:Freeze-fracture and thin-section electron microscopy and morphometry were used to characterize further the response of the rat medullary collecting duct to potassium depletion. In freeze-fracture replicas, principal cells and intercalated cells were identified based on the assumption that intercalated cells possess a ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1980.6
更新日期：1980-01-01 00:00:00
abstract：:Vascular calcification (VC) is an important reason for the high burden of vascular disease among chronic dialysis patients. Chronic kidney disease (CKD) is associated with increased promoters and decreased inhibitors of VC. The circulating levels of fetuin-A, a well-described inhibitor of calcification, regulate the c...
journal_title：Kidney international
pub_type： 评论,杂志文章,评审
doi：10.1038/sj.ki.5002355
更新日期：2007-07-01 00:00:00
abstract：:The study by Rieg et al. is the first to examine potassium handling in BK(-/-) mice, thereby addressing many unanswered questions regarding the separate roles of BK and ROMK channels in renal potassium secretion. This Commentary is an interpretation and opinion of their results, by two researchers who have been studyi...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/sj.ki.5002438
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Epithelial cells in the renal inner medulla accumulate osmolytes such as betaine to maintain normal cell volume during prolonged extracellular hypertonic stress. Betaine accumulation is the result of activation of transcription of the BGT1 transporter gene followed by increased betaine transport. METHODS:We...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.00733.x
更新日期：2001-06-01 00:00:00
abstract：:Indomethacin antagonizes the natriuretic and chloruretic response to hydrochlorothiazide in most studies. Neither the mechanism nor nephron site of this antagonism has been determined. To identify sites and potential mechanisms, cortical micropuncture was performed during hydrochlorothiazide treatment in control and i...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1987.114
更新日期：1987-05-01 00:00:00
abstract：:In order to study the effects of acute ureteral obstruction on glomerular hemodynamics, glomerular hydrostatic capillary pressure (PG), pressure in the first-order peritubular capillaries (EAP), and intratubular pressure (PT) were directly measured in superficial nephrons on Munich-Wistar rats by micropuncture with a ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1977.131
更新日期：1977-12-01 00:00:00
abstract：:In organ transplantation, ischemia/reperfusion (I/R) results in damage that may affect cell viability and lead to organ failure. I/R injury involves a complex cascade of events, including loss of energy, derangement of the ionic hemostasis, production of reactive oxygen species, and cell death. In this context, mitoch...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1111/j.1523-1755.2004.761_9.x
更新日期：2004-08-01 00:00:00
abstract：:While it is known that risk of death from sepsis is higher in patients with pre-existing chronic kidney disease its mechanism is unknown. To study this we established a two-stage mouse model where renal disease was first induced by folic acid injection followed by sub-lethal cecal ligation and puncture to induce sepsi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2008.346
更新日期：2008-10-01 00:00:00
abstract：:Bone marrow (BM) cells are reported to contribute to the process of regeneration following myocardial infarction. The present study examined two independent clonal studies to determine the origin of bone marrow (BM)-derived cardiomyocytes. First, we transplanted single CD34(-)c-kit(+)Sca-1(+)lineage(-) side population...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1111/j.1523-1755.2005.00624.x
更新日期：2005-11-01 00:00:00
abstract：:Our previous in vivo study demonstrated that methylprednisolone (MP) activates glomerular antioxidant enzymes and attenuates glomerular oxidant injuries, including those in experimental nephrosis. The present study investigates the cellular mechanism of the MP-induced activation of antioxidant enzymes and their contri...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1994.25
更新日期：1994-01-01 00:00:00
abstract：:Segerer et al. report the expression and localization of macrophage and dendritic-cell markers in human renal biopsies and indicate that both cell types express CD68, findings that resonate with murine studies. The functional and phenotypic distinction between macrophages and dendritic cells is discussed. ...
journal_title：Kidney international
pub_type： 评论,杂志文章,评审
doi：10.1038/ki.2008.189
更新日期：2008-07-01 00:00:00
abstract：:The association between dietary sodium and potassium intake with the development of kidney disease remains unclear, particularly among younger individuals. Here, we determined whether dietary sodium and potassium intake are associated with incident chronic kidney disease (CKD) using data from 1,030 adults (age 23-35 i...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.02.037
更新日期：2020-07-01 00:00:00
abstract：:The Standardized Outcomes in Nephrology (SONG) initiative is designed to improve research productivity by building consensus. Stakeholders involved with peritoneal dialysis (PD) have put life participation on top of their list, along with treatment-related infection, cardiovascular complications, and patient and techn...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2019.05.002
更新日期：2019-09-01 00:00:00
abstract：:The effect of intravenous infusion of angiotensin II on microvascular parameters of the renal microcirculation of rats was studied. With the aid of fluorescence microscopy and a high sensitivity video system we observed the passage of fluorescence-labeled erythrocytes through single glomerular capillaries on the surfa...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1985.4
更新日期：1985-01-01 00:00:00
abstract：:To verify the hypothesis that angiotensin-converting enzyme (ACE) inhibitors possess a unique renoprotective effect in progressive chronic renal disease, we decided to compare the effects of an ACE inhibitor and a calcium antagonist on both hypertension and the progression of non-diabetic renal insufficiency in a long...
journal_title：Kidney international
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/ki.1992.309
更新日期：1992-08-01 00:00:00
