当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Induction of manganese superoxide dismutase by glucocorticoids in glomerular cells.

Induction of manganese superoxide dismutase by glucocorticoids in glomerular cells.

Abstract：

:Our previous in vivo study demonstrated that methylprednisolone (MP) activates glomerular antioxidant enzymes and attenuates glomerular oxidant injuries, including those in experimental nephrosis. The present study investigates the cellular mechanism of the MP-induced activation of antioxidant enzymes and their contribution to the attenuation of cellular oxidant toxicity. When bovine glomerular endothelial cells (GECs) were treated with 10 microM MP, cellular manganese superoxide dismutase (Mn-SOD, 3.95 +/- 0.33 mu/mg protein, M +/- SE) and catalase (1.64 +/- 0.06 k/mg protein) activities were significantly (P < 0.05) elevated above control GECs (2.23 +/- 0.43 mu/mg protein and 1.06 +/- 0.09 k/mg protein, respectively). When GECs pretreated with MP (10 microM 24 hrs) were exposed to xanthine (0.1 mM)+xanthine oxidase (5 mU/ml) for four hours, levels of specific membrane lipid peroxidation products, that is, phosphatidylcholine- and phosphatidylethanolamine-hydroperoxides, remained at levels 10 to 25% of those measured in non-MP-treated (xanthine/xanthine oxidase-exposed) control cells. Moreover, the degree of cell damage following exposure to the superoxide generating system, assessed by 51Cr release, was significantly attenuated in MP-treated cells (approximately 50% of MP-non-treated controls, N = 6). Thus, MP-treated GECs with elevated antioxidant enzyme activities by MP were more resistant to the toxic effect of reactive oxygen metabolites. The mechanism of antioxidant enzyme induction by MP was studied for Mn-SOD. MP was shown to enhance Mn-SOD mRNA in bovine GECs and rat glomerular mesangial cells (GMCs) in dose-dependent manners.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Kidney Int

journal_title

Kidney international

authors

Yoshioka T,Kawamura T,Meyrick BO,Beckman JK,Hoover RL,Yoshida H,Ichikawa I

doi

10.1038/ki.1994.25

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

211-9

issue

1

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)58298-7

journal_volume

45

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • PAX2 inactivation enhances cisplatin-induced apoptosis in renal carcinoma cells.

    abstract：:Renal cell carcinoma (RCC) is the most common kidney malignancy and has a poor prognosis owing to its resistance to chemotherapy. RCC cells overexpress the transcription factor, PAX2, normally expressed in fetal kidney but downregulated at birth. Since Pax2 suppresses apoptosis during renal development, we reasoned th...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000136

    authors： Hueber PA,Waters P,Clark P,Eccles M,Goodyer P

    更新日期：2006-04-01 00:00:00

  • Outcome of patients with human immunodeficiency virus on maintenance hemodialysis.

    abstract：:Fifty-one adults with HIV infection, including 20 chronic hemodialysis patients with superimposed HIV infection and 31 patients with HIV-associated nephropathy requiring chronic maintenance hemodialysis were followed to evaluate survival on outpatient dialysis in relation to the clinical stage of the HIV infection. Re...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.172

    authors： Ortiz C,Meneses R,Jaffe D,Fernandez JA,Perez G,Bourgoignie JJ

    更新日期：1988-08-01 00:00:00

  • Cardiac hypertrophy and remodeling in relation to ACE and angiotensinogen genes genotypes in Chinese dialysis patients.

    abstract：BACKGROUND:Genetic polymorphisms of the angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) genes are associated with increased risk of hypertension and left ventricular hypertrophy (LVH) in hypertensive subjects. However, the extent to which these polymorphisms are related to LVH and remodeling in dialysis p...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00933.x

    authors： Wang AY,Chan JC,Wang M,Poon E,Lui SF,Li PK,Sanderson J

    更新日期：2003-05-01 00:00:00

  • Identification of a single base insertion in the COL4A5 gene in Alport syndrome.

    abstract：:We identified a novel mutation in the COL4A5 gene of a Japanese patient with Alport syndrome. A combination of in vitro amplification of the exons with single strand conformation polymorphisms (SSCP) analysis suggested the presence of a mutation in exon 48. Sequencing of the amplified DNA revealed a single base (T) in...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1993.353

    authors： Nakazato H,Hattori S,Matsuura T,Koitabashi Y,Endo F,Matsuda I

    更新日期：1993-11-01 00:00:00

  • Intrarenal ghrelin receptors regulate ENaC-dependent sodium reabsorption by a cAMP-dependent pathway.

    abstract：:The main distal nephron segment sodium transporters are the distal tubule chlorothiazide-sensitive sodium chloride cotransporter (NCC) and the collecting duct amiloride-sensitive epithelial sodium channel (ENaC). The infusion of ghrelin into the renal interstitium stimulates distal nephron-dependent sodium reabsorptio...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.187

    authors： Kemp BA,Howell NL,Gildea JJ,Keller SR,Padia SH

    更新日期：2013-09-01 00:00:00

  • Klotho expression in osteocytes regulates bone metabolism and controls bone formation.

    abstract：:Osteocytes within the mineralized bone matrix control bone remodeling by regulating osteoblast and osteoclast activity. Osteocytes express the aging suppressor Klotho, but the functional role of this protein in skeletal homeostasis is unknown. Here we identify Klotho expression in osteocytes as a potent regulator of b...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2017.02.014

    authors： Komaba H,Kaludjerovic J,Hu DZ,Nagano K,Amano K,Ide N,Sato T,Densmore MJ,Hanai JI,Olauson H,Bellido T,Larsson TE,Baron R,Lanske B

    更新日期：2017-09-01 00:00:00

  • Randall's plaque: pathogenesis and role in calcium oxalate nephrolithiasis.

    abstract：:The purpose of these studies was to test the hypothesis that Randall's plaque develops in unique anatomical sites of the kidney and their formation is conditioned by specific stone-forming pathophysiologies. We performed intraoperative papillary biopsies from kidneys of idiopathic-calcium oxalate (CaOx), intestinal by...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/sj.ki.5000238

    authors： Evan A,Lingeman J,Coe FL,Worcester E

    更新日期：2006-04-01 00:00:00

  • Regulation of renal kallikrein synthesis and activation by glucocorticoids.

    abstract：:The effects of endogenous and exogenous glucocorticoids on renal active and prokallikrein levels (ng/mg protein) and in vivo kallikrein synthesis rate were studied in the conscious rat. Within two hours after low dose methylprednisolone (MP, 0.0125 to 0.05 mg/100 g body wt), active kallikrein and prokallikrein fell (2...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.188

    authors： Jaffa AA,Miller DH,Silva RH,Margolius HS,Mayfield RK

    更新日期：1990-08-01 00:00:00

  • mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases.

    abstract：:Mitochondrial diseases represent a significant clinical challenge. Substantial efforts have been devoted to identifying therapeutic strategies for mitochondrial disorders, but effective interventions have remained elusive. Recently, we reported attenuation of disease in a mouse model of the human mitochondrial disease...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2018.08.038

    authors： Johnson SC,Martinez F,Bitto A,Gonzalez B,Tazaerslan C,Cohen C,Delaval L,Timsit J,Knebelmann B,Terzi F,Mahal T,Zhu Y,Morgan PG,Sedensky MM,Kaeberlein M,Legendre C,Suh Y,Canaud G

    更新日期：2019-02-01 00:00:00

  • Pain, control over treatment, and compliance in dialysis and transplant patients.

    abstract：:Pain was surveyed via structured interview and the McGill Pain Questionnaire in 53 dialysis and 27 transplant patients. Increased patient control over the dialysis procedure was not associated with a reduction in pain though perceived control may have been. Compliance with the dialysis regimen did not predict pain and...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1982.108

    authors： Binik YM,Baker AG,Kalogeropoulos D,Devins GM,Guttmann RD,Hollomby DJ,Barré PE,Hutchison T,Prud'Homme M,McMullen L

    更新日期：1982-06-01 00:00:00

  • Monocytes may promote myofibroblast accumulation and apoptosis in Alport renal fibrosis.

    abstract：BACKGROUND:In interstitial fibrosis, monocytes and myofibroblasts have been directly implicated in scarring, apoptosis, and tissue necrosis. While much has been done to explore the role of these cell types individually in fibrosis, the interactive dependency of monocytes and myofibroblasts has been only marginally expl...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00871.x

    authors： Rodgers KD,Rao V,Meehan DT,Fager N,Gotwals P,Ryan ST,Koteliansky V,Nemori R,Cosgrove D

    更新日期：2003-04-01 00:00:00

  • Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in human mesangial cells.

    abstract：BACKGROUND:The cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 (15dPGJ2) affects mesangial proliferation, survival and production of proinflammatory proteins. During a survey of the mesangial cell proteome after treatment with 15dPGJ2, heat shock protein 70 (HSP70) was found to be the most conspicuous...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00454.x

    authors： Zhang X,Lu L,Dixon C,Wilmer W,Song H,Chen X,Rovin BH

    更新日期：2004-03-01 00:00:00

  • Catch-up growth follows an abnormal pattern in experimental renal insufficiency and growth hormone treatment normalizes it.

    abstract：:The primary goal of this study was to determine if the ability to undergo catch-up growth following a transient injury is preserved in an experimental model of moderate chronic renal failure (CRF) and the effect of growth hormone (GH) administration on such phenomenon. Young rats were subtotally nephrectomized (days 0...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5001949

    authors： Molinos I,Santos F,Carbajo-Perez E,Garcia E,Rodriguez J,Garcia-Alvarez O,Gil H,Ordoñez FA,Loredo V,Mallada L

    更新日期：2006-12-01 00:00:00

  • Role of an improvement in acid-base status and nutrition in CAPD patients.

    abstract：:Short-term correction of metabolic acidosis in normal and uremic subjects has been shown to decrease protein degradation, but the long-term effects of better correction of acidosis on nutrition in ESRF are unknown. The aim of this study was to assess the possible benefits, in the nutritional state and morbidity, of im...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/ki.1997.433

    authors： Stein A,Moorhouse J,Iles-Smith H,Baker F,Johnstone J,James G,Troughton J,Bircher G,Walls J

    更新日期：1997-10-01 00:00:00

  • Apoptosis and necrosis: mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line.

    abstract：BACKGROUND:The mechanisms of cyclosporine (CsA)-induced nephrotoxicity are not fully understood. While hemodynamic changes may be involved in vivo, there is also some evidence for tubular involvement. We previously showed direct toxicity of CsA in the LLC-PK1 renal tubular cell line. In the current study we examined me...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00202.x

    authors： Healy E,Dempsey M,Lally C,Ryan MP

    更新日期：1998-12-01 00:00:00

  • Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease: pathophysiology and indications.

    abstract：:It is no a secret that we are confronted by an alarmingly increasing number of patients with progressive renal disease. There is ample evidence for the notion that angiotensin II (Ang II) is a major culprit in progression. The vasopeptide Ang II turned out to have also multiple nonhemodynamic pathophysiologic actions ...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1111/j.1523-1755.2005.00145.x

    authors： Wolf G,Ritz E

    更新日期：2005-03-01 00:00:00

  • Suramin promotes recovery from renal ischemia/reperfusion injury in mice.

    abstract：:Suramin is a polysulfonated naphthylurea originally designed as a treatment for trypanosomiasis; but that has also been used to treat rodent models of fulminant hepatic failure and focal brain ischemia. In this study, we determined the effects of suramin on renal ischemia/reperfusion-induced acute kidney injury in mic...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.506

    authors： Zhuang S,Lu B,Daubert RA,Chavin KD,Wang L,Schnellmann RG

    更新日期：2009-02-01 00:00:00

  • Cyclosporine A enhances vasopressin-induced Ca2+ mobilization and contraction in mesangial cells.

    abstract：:A major problem in cyclosporine A (CsA) therapy is its nephrotoxicity, characterized by a marked fall in glomerular filtration rate (GFR). Since the glomerular ultrafiltration area is an important determinant of GFR and has been proposed to be regulated by mesangial (MS) cell contraction, we examined the effect of CsA...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.149

    authors： Meyer-Lehnert H,Schrier RW

    更新日期：1988-07-01 00:00:00

  • Recovery from postischemic acute renal failure in the rat.

    abstract：:To define the pattern of recovery from postischemic acute renal failure (ARF), we performed clearance and micropuncture studies at intervals of 1, 2, 4, and 8 weeks following 60 min of complete unilateral renal artery occlusion in the rat. At 1 week, the inulin clearance (CIn) of the postischemic kidney was less than ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1979.112

    authors： Finn WF,Chevalier RL

    更新日期：1979-08-01 00:00:00

  • Structural adaptation in initial collecting tubule following reduction in renal mass.

    abstract：:Tubular function studies have shown that nephrectomy leads to a sharp increase in potassium secretion by initial collecting tubules. The aim of this study was to examine the relationship between potassium transport and the cellular morphology of the distal nephron. Clearance and ultrastructural studies were conducted ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1985.58

    authors： Zalups RK,Stanton BA,Wade JB,Giebisch G

    更新日期：1985-04-01 00:00:00

  • HIV-associated immune complex glomerulonephritis with "lupus-like" features: a clinicopathologic study of 14 cases.

    abstract：BACKGROUND:While the most common glomerular lesion associated with human immunodeficiency virus (HIV) infection is collapsing focal segmental glomerulosclerosis (FSGS) [HIV-associated nephropathy (HIVAN)], immune complex-mediated forms of glomerulonephritis have been increasingly reported. One form of glomerulonephriti...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00215.x

    authors： Haas M,Kaul S,Eustace JA

    更新日期：2005-04-01 00:00:00

  • Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients.

    abstract：:Antibodies to human leukocyte antigens (HLAs) are a risk factor for acute renal allograft rejection and loss. The role of non-HLAs and their significance to allograft rejection have gained recent attention. Here, we applied protein microarray technology, with the capacity to simultaneously identify 5056 potential anti...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.384

    authors： Sutherland SM,Li L,Sigdel TK,Wadia PP,Miklos DB,Butte AJ,Sarwal MM

    更新日期：2009-12-01 00:00:00

  • The cystic fibrosis transmembrane conductance regulator mediates transepithelial fluid secretion by human autosomal dominant polycystic kidney disease epithelium in vitro.

    abstract：:Transepithelial fluid secretion promotes the progressive enlargement of cysts in autosomal dominant polycystic kidney disease (ADPKD). Recent indirect evidence indicated that active chloride transport may drive net fluid secretion in cultures of epithelia derived from ADPKD cysts. We now report that forskolin, which s...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.304

    authors： Davidow CJ,Maser RL,Rome LA,Calvet JP,Grantham JJ

    更新日期：1996-07-01 00:00:00

  • Urinary matrix calculi consisting of microfibrillar protein in patients on maintenance hemodialysis.

    abstract：:In seven patients on maintenance hemodialysis, de novo recurrent renal stone formation was observed. In all patients, the underlying disease was glomerulonephritis, with or without the nephrotic syndrome. All patients had considerable persistent proteinuria. The stones consisted predominantly of protein, as revealed b...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1979.188

    authors： Bommer J,Ritz E,Tschöpe W,Waldherr R,Gebhardt M

    更新日期：1979-12-01 00:00:00

  • The fetal environment: a critical phase that determines future renal outcomes in autosomal dominant polycystic kidney disease.

    abstract：:Orskov and colleagues demonstrate the impact of birth weight on the mean age of end-stage renal disease (ESRD) in a large Danish ADPKD cohort. Each kilogram of birth weight extended the mean age of ESRD onset by 1.7 years. Placental insufficiency, activation of the renin-angiotensin-aldosterone system, increased fetal...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2012.8

    authors： Chapman AB

    更新日期：2012-05-01 00:00:00

  • Permanent hemodialysis vascular access survival in children and adolescents with end-stage renal disease.

    abstract：BACKGROUND:Transplantation is the optimal therapy for pediatric end-stage renal disease (ESRD) patients, but in a subset of patients with peritoneal membrane failure, failed transplants or poor social situations, chronic hemodialysis (HD) remains the only option. Long-term survival of arteriovenous fistulas (AVFs) and ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00630.x

    authors： Sheth RD,Brandt ML,Brewer ED,Nuchtern JG,Kale AS,Goldstein SL

    更新日期：2002-11-01 00:00:00

  • Neural epidermal growth factor-like 1 protein (NELL-1) associated membranous nephropathy.

    abstract：:Membranous nephropathy is characterized by deposition of immune complexes along the glomerular basement membrane. PLA2R and THSD7A are target antigens in 70% and 1-5% of primary membranous nephropathy cases, respectively. In the remaining cases, the target antigen is unknown. Here, laser microdissection of glomeruli f...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2019.09.014

    authors： Sethi S,Debiec H,Madden B,Charlesworth MC,Morelle J,Gross L,Ravindran A,Buob D,Jadoul M,Fervenza FC,Ronco P

    更新日期：2020-01-01 00:00:00

  • Acute phosphate nephropathy.

    abstract：:Acute phosphate nephropathy (APhN) is a clinical pathological entity characterized by acute and subsequent chronic renal failure following exposure to oral sodium phosphate (OSP) bowel purgatives. Renal biopsy findings include acute and chronic tubular injury with prominent tubular and interstitial calcium phosphate d...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.2009.308

    authors： Markowitz GS,Perazella MA

    更新日期：2009-11-01 00:00:00

  • Sodium thiosulfate improves renal function and oxygenation in L-NNA-induced hypertension in rats.

    abstract：:Sodium thiosulfate, a reversible oxidation product of hydrogen sulfide, has vasodilating and anti-oxidative properties, making it an attractive agent to alleviate damaging effects of hypertension. In experimental settings, inhibition of nitric oxide synthase causes hypertension, renal dysfunction and damage. We hypoth...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2020.02.020

    authors： Nguyen ITN,Klooster A,Minnion M,Feelisch M,Verhaar MC,van Goor H,Joles JA

    更新日期：2020-08-01 00:00:00

  • Role of different dialysis membranes in the release of interleukin-6-soluble receptor in uremic patients.

    abstract：BACKGROUND:Interleukin-6 (IL-6) exerts its actions through a cell-surface receptor system that consists of two transmembrane subunits: the IL-6 binding glycoprotein gp 80 (IL-6R) and the signal-transducing component (gp 130). Soluble forms of the IL-6R (sIL-6R) are generated by shedding of the membrane-associated prote...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00181.x

    authors： Memoli B,Postiglione L,Cianciaruso B,Bisesti V,Cimmaruta C,Marzano L,Minutolo R,Cuomo V,Guida B,Andreucci M,Rossi G

    更新日期：2000-07-01 00:00:00