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The fetal environment: a critical phase that determines future renal outcomes in autosomal dominant polycystic kidney disease.

Abstract：

:Orskov and colleagues demonstrate the impact of birth weight on the mean age of end-stage renal disease (ESRD) in a large Danish ADPKD cohort. Each kilogram of birth weight extended the mean age of ESRD onset by 1.7 years. Placental insufficiency, activation of the renin-angiotensin-aldosterone system, increased fetal vasopressin levels, compensatory increases in insulin like growth factor-I, and a reduction in total nephron number may all contribute to this observation. Collectively, these changes result in an accelerated pace of cyst formation and expansion, and an inability to maintain glomerular hyperfiltration during kidney expansion which results in a more rapid progression to ESRD. Therefore the intrauterine environment may play a critical role in disease severity in ADPKD.

journal_name

Kidney Int

journal_title

Kidney international

authors

Chapman AB

doi

10.1038/ki.2012.8

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

814-5

issue

9

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)55418-5

journal_volume

81

pub_type

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