Abstract：
:Recently, 4 new risk scores for the prediction of mortality and cardiovascular events were especially tailored for hemodialysis patients; these scores performed much better than previous scores. Tripepi et al. found that these risk scores were even more predictive for all-cause and cardiovascular death than the measurement of the left ventricular mass index was. Nevertheless, the investigation of left ventricular mass and function has its own place for other reasons.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Kronenberg F,Schwaiger JPdoi
10.1016/j.kint.2016.11.022subject
Has Abstractpub_date
2017-03-01 00:00:00pages
536-538issue
3eissn
0085-2538issn
1523-1755pii
S0085-2538(16)30744-Xjournal_volume
91pub_type
评论,杂志文章abstract：:The structure of the duodenal mucosa was evaluated in duodenal biopsy samples obtained from patients with moderate renal failure (MRF) and in dialysis patients (HD) in an effort to examine the possibility that changes in duodenal mucosa may contribute to the impaired calcium absorption in renal failure (RF). The effec...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1981.23
更新日期：1981-02-01 00:00:00
abstract：:The aging process in humans and in the rat is associated with an impairment in renal tubular reabsorption of Pi and renal tubular adaptation to a low Pi diet. The purposes of the present study were to determine whether changes in the abundance of type II Na-Pi contransporter (NaPi-2) protein and/or mRNA play a role in...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1996.385
更新日期：1996-09-01 00:00:00
abstract：:Incorporation in vivo of labeled orotate into RNA and total nucleotides was measured in isolated glomeruli and whole renal cortex. In 2-day diabetic animals, glomerular RNA was increased, and there was greater incorporation of orotate into total nucleotides and RNA as compared with controls. Insulin reversed the exagg...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1981.166
更新日期：1981-10-01 00:00:00
abstract：:The recent identification of RPGRIP1L as a Joubert syndrome gene brings the total of known genes to five. Three of these are also associated with the lethal Meckel syndrome, and two with Senior-Løken syndrome; both of these disorders share Joubert syndrome phenotypes, illustrating the genetic complexity of this. ...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/sj.ki.5002577
更新日期：2007-12-01 00:00:00
abstract：:Staphylococcal neutral phosphatase (NPtase) is a highly cationic bacterial surface bound protein. It has significant affinity for human and rat immunoglobulins in vitro and an electrostatic interaction may be involved. Radioisotopic studies showed that NPtase had a high affinity for the polyanionic structures of the r...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1996.314
更新日期：1996-07-01 00:00:00
abstract：:Nephrin is a slit diaphragm protein critical for structural and functional integrity of visceral glomerular epithelial cells (podocytes) and is known to be tyrosine phosphorylated by Src family kinases. We studied the role of phosphoinositide 3-kinase (PI3K), activated via the phosphorylation of nephrin, in actin cyto...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5002691
更新日期：2008-03-01 00:00:00
abstract：:Calcitonin secretion is stimulated by acute hypercalcemia. Furthermore, in the rat, the calcemic response to parathyroid hormone (PTH) is decreased by calcitonin stimulation. However, in renal failure, it is not known if an increase in the serum calcium concentration within the physiologic range of serum calcium stimu...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1991.263
更新日期：1991-10-01 00:00:00
abstract：:Chronic kidney disease (CKD) has received increased attention as a leading public health problem worldwide. Globally surveillance systems for kidney disease are still lacking, especially in developing countries like China, which constitutes an obstacle to develop effective preventive strategies. China Kidney Disease N...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2018.11.011
更新日期：2019-03-01 00:00:00
abstract：:Although angiotensin-converting enzyme (ACE) inhibitors are well-established drugs in the treatment of hypertension, they are not supposed to be sufficient in the inhibition of aldosterone formation. The present study analyzes the effect of aldosterone receptor antagonist, spironolactone and ACE inhibitor, captopril o...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5001513
更新日期：2006-07-01 00:00:00
abstract：:Micropuncture studies were carried out in surface nephrons of rats with nephrotoxic-serum (NTS)-induced nephrotic syndrome during a period of active sodium and water retention. It was found that hydrostatic pressure and tubular diameter were increased in the proximal tubules (13.4 +/- 0.2 vs. 10.4 +/- 0.2 mm Hg; 31.3 ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1979.166
更新日期：1979-11-01 00:00:00
abstract：:Dopamine plays an important role in regulation of renal sodium transport. Proximal tubule cells produce dopamine after decarboxylation of L-DOPA via the enzyme aromatic L-amino acid decarboxylase (AADC). The presence and cellular localization of AADC-like immunoreactivity (-LI) and AADC mRNA were examined during pre- ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1992.326
更新日期：1992-09-01 00:00:00
abstract：:The effects of chronic respiratory alkalosis on divalent ion homeostasis have not been reported in any species. We studied four normal male subjects during a four-day control period (residence at 500 m), during six days of chronic respiratory alkalosis induced by hypobaric hypoxia (residence at 3450 m), followed by a ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1992.340
更新日期：1992-09-01 00:00:00
abstract：:Compelling evidence indicates that vascular endothelial growth factor (VEGF) is a fundamental regulator of normal and abnormal angiogenesis. The loss of a single VEGF allele results in defective vascularization and early embryonic lethality. VEGF plays also a critical role in kidney development, and its inactivation d...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1046/j.1523-1755.1999.00610.x
更新日期：1999-09-01 00:00:00
abstract：:Polycystic kidney disease progresses more rapidly in men than in women. To investigate the basis for this sexual dimorphism, we exposed Madin-Darby canine kidney (MDCK) cells grown on collagen-coated cell culture inserts to control media, or to estradiol or testosterone (1 nM-1 microM). Compared to control and estradi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1997.211
更新日期：1997-05-01 00:00:00
abstract：:Monocyte chemoattractant protein 1 (MCP-1) is a C-C chemokine with potent monocyte chemotactic and activating properties that may contribute to glomerular macrophage infiltration in anti-GBM Ab GN. We have previously reported increased glomerular steady state expression of MCP-1 mRNA relative to GAPDH mRNA in the hete...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1996.363
更新日期：1996-08-01 00:00:00
abstract：:Familial aggregation of non-diabetic end-stage renal disease (ESRD) is found in African Americans and variants in the apolipoprotein L1 gene (APOL1) contribute to this risk. To detect genetic associations with milder forms of nephropathy in the high-risk families, analyses were performed using generalized estimating e...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2012.217
更新日期：2012-10-01 00:00:00
abstract：:In experimental membranous nephropathy, antibody binding to glomerular epithelial cell membrane antigens results in complement activation and formation of complement C5b-9 membrane attack complexes in glomeruli. During active disease, the C5b-9 complexes are shed into the urine. To test the hypothesis that a similar m...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1991.242
更新日期：1991-09-01 00:00:00
abstract：BACKGROUND:Several lines of evidence suggest that cellular immune mechanisms contribute to glomerulonephritis. METHODS:The roles of alphabeta and gammadelta T cells in the pathogenesis of glomerulonephritis were investigated in a model of nephrotoxic nephritis in mice deficient in either T-cell population [T-cell rece...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2000.00263.x
更新日期：2000-09-01 00:00:00
abstract：:Genetic variation at the MYH9 locus is linked to the high incidence of focal segmental glomerulosclerosis (FSGS) and non-diabetic end-stage renal disease among African Americans. To further define risk alleles with FSGS we performed a genome-wide association analysis using more than one million single-nucleotide polym...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2010.251
更新日期：2010-10-01 00:00:00
abstract：:Antibodies against purified rat-kidney-cortex pyruvate carboxylase were raised in rabbits. These polyspecific antibodies recognize pyruvate carboxylase enzymes alone without cross reactivity with other carboxylases as detected by immunoblotting. The abundance of pyruvate carboxylase in the various renal fractions was ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1991.147
更新日期：1991-06-01 00:00:00
abstract：:Clofibrate, a peroxisome proliferator-activated receptor-alpha (PPAR alpha) agonist, increases renal tubular cytochrome P450 4a (Cyp4a) expression thereby increasing 20-hydroxyeicosatetraenoic acid (20-HETE) production. To determine if clofibrate affects blood pressure regulation we studied mice with DOCA-salt induced...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2008.300
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:The link between dialysis "vintage" (length of time on dialysis in months to years) and survival has been difficult to define, largely because of selection effects. End-stage renal disease (ESRD) is thought to be a wasting illness, but there are no published reports describing the associations between vintag...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2000.00945.x
更新日期：2000-03-01 00:00:00
abstract：:Innate lymphoid cells are a recently recognized group of immune cells with critical roles in tissue homeostasis and inflammation. Regulatory innate lymphoid cells are a newly identified subset of innate lymphoid cells, which play a suppressive role in the innate immune response, favoring the resolution of intestinal i...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2019.07.019
更新日期：2020-01-01 00:00:00
abstract：:Sustained oliguria during fluid resuscitation represents a perplexing problem in patients undergoing therapy for septic acute kidney injury. Here, we tested whether lipopolysaccharide induces filtrate leakage from the proximal tubular lumen into the interstitium, thus disturbing the recovery of urine output during the...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2019.11.024
更新日期：2020-05-01 00:00:00
abstract：:Antibody-mediated rejection represents the first cause of graft loss in renal transplant recipients, and it is imperative to identify appropriate tools to enable risk stratification of such patients. Lately, the usefulness of measuring complement-binding anti-human leukocyte antigen (HLA) donor-specific antibodies (DS...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2018.06.032
更新日期：2018-10-01 00:00:00
abstract：:To verify the hypothesis that angiotensin-converting enzyme (ACE) inhibitors possess a unique renoprotective effect in progressive chronic renal disease, we decided to compare the effects of an ACE inhibitor and a calcium antagonist on both hypertension and the progression of non-diabetic renal insufficiency in a long...
journal_title：Kidney international
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/ki.1992.309
更新日期：1992-08-01 00:00:00
abstract：:Disturbances in mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and are an important cause of morbidity, decreased quality of life, and extraskeletal calcification that have been associated with increased cardiovascular mortality. These disturbances have traditionally been termed renal osteod...
journal_title：Kidney international
pub_type： 共识发展会议,杂志文章
doi：10.1038/sj.ki.5000414
更新日期：2006-06-01 00:00:00
abstract：:A genome-wide association scan of the Genetics of Kidneys in Diabetes (GoKinD) collections identified four novel susceptibility loci, located on chromosomes 7p14.3, 9q21.32, 11p15.4, and 13q33.3 associated with type 1 diabetic nephropathy. A recent evaluation of these loci in Japanese patients with type 2 diabetes sup...
journal_title：Kidney international
pub_type： 杂志文章,meta分析
doi：10.1038/ki.2011.64
更新日期：2011-07-01 00:00:00
abstract：:The influence of transforming growth factor beta 1 (TGF-beta 1) and of dexamethasone on fibronectin (FN) synthesis of human renal tubular epithelial cells in culture (TEC) was studied. Cocultivation with TGF-beta 1 increased the steady state level of FN RNA within 24 to 48 hours. By PCR and Northern blotting it was fo...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1995.479
更新日期：1995-12-01 00:00:00
abstract：:We have shown that cisplatin inhibits fatty acid oxidation, and that fibrate treatment ameliorates renal function by preventing the inhibition of fatty acid oxidation and proximal tubule cell death. Urine samples of mice treated with single injection of cisplatin (20 mg/kg body weight) were collected for 3 days and an...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5000433
更新日期：2006-06-01 00:00:00
