当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Vintage, nutritional status, and survival in hemodialysis patients.

Vintage, nutritional status, and survival in hemodialysis patients.

Abstract：

BACKGROUND:The link between dialysis "vintage" (length of time on dialysis in months to years) and survival has been difficult to define, largely because of selection effects. End-stage renal disease (ESRD) is thought to be a wasting illness, but there are no published reports describing the associations between vintage and body composition in hemodialysis patients. METHODS:We explored the relationships among vintage, nutritional status, and survival in a 3009 patient cohort of prevalent hemodialysis patients. Body weight, total body water, body cell mass, and phase angle by bioelectrical impedance analysis were the body composition parameters of interest. We examined vintage as an explanatory variable in multiple linear regression analyses (adjusted for age, gender, race, and diabetes) using body composition parameters and biochemical indicators of nutritional status as dependent variables. Proportional hazards regression was used to evaluate the association of vintage and survival with and without adjustment for case mix and laboratory variables. RESULTS:Dialysis vintage was 3.8 +/- 3.7 (median 2.6) years. Body composition parameters tended to be lower after dialysis year 2. Linear estimates per year of vintage beyond year 2 include -0.66 kg body wt (P < 0.0001), -0.17 kg total body water (P = 0.0003), -0.14 kg body cell mass (P < 0.0001), and -0.07 degrees phase angle (P < 0.0001). In unadjusted analyses, vintage was not associated with survival, either as a linear or higher order term. The adjustment for case mix yielded a vintage term associated with an increased relative risk (RR) of death (RR 1.04 (95% CI, 1.01 to 1.07 per year). A further adjustment for laboratory data yielded a RR of 1.06 (95% CI, 1.03 to 1.09 per year). CONCLUSION:Dialysis vintage is related to nutritional status in hemodialysis patients, with vintage of more than years associated with a significant decline in all measured nutritional parameters. Cross-sectional analyses probably underestimate these effects. A year accrued on dialysis is associated with a 6% increase in the risk of death, all else equal. Longitudinal assessments of nutritional status, including body composition, are required to better understand the natural history of wasting with ESRD and its implications for long-term survival.

journal_name

Kidney Int

journal_title

Kidney international

authors

Chertow GM,Johansen KL,Lew N,Lazarus JM,Lowrie EG

doi

10.1046/j.1523-1755.2000.00945.x

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

1176-81

issue

3

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)46849-8

journal_volume

57

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Defining hypercalciuria in nephrolithiasis.

    abstract：:The classic definition of hypercalciuria, an upper normal limit of 200  mg/day, is based on a constant diet restricted in calcium, sodium, and animal protein; however, random diet data challenge this. Here our retrospective study determined the validity of the classic definition of hypercalciuria by comparing data fro...

    journal_title：Kidney international

    pub_type： 杂志文章,meta分析,评审

    doi：10.1038/ki.2011.227

    authors： Pak CY,Sakhaee K,Moe OW,Poindexter J,Adams-Huet B,Pearle MS,Zerwekh JE,Preminger GM,Wills MR,Breslau NA,Bartter FC,Brater DC,Heller HJ,Odvina CV,Wabner CL,Fordtran JS,Oh M,Garg A,Harvey JA,Alpern RJ,Snyder WH,Pe

    更新日期：2011-10-01 00:00:00

  • Developmental changes in rat renal 11 beta-hydroxysteroid dehydrogenase.

    abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) transforms endogenous glucocorticoids to their respective "biologically inert" 11-dehydro derivatives. A decrease in enzyme activity allows glucocorticoids to induce mineralocorticoid-like renal sodium retention. Since positive sodium balance is required for optimum ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1994.91

    authors： Brem AS,Bina B,Matheson KL,Barnes JL,Morris DJ

    更新日期：1994-03-01 00:00:00

  • Genetics of hypercalciuric stone forming diseases.

    abstract：:With a lifetime incidence of up to 12% in man and 6% in woman, nephrolithiasis is a major health problem worldwide. Approximately, 80% of kidney stones are composed of calcium and hypercalciuria is found in up to 40% of stone-formers. Although the mechanisms resulting in precipitation and growth of calcium crystals in...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/sj.ki.5002441

    authors： Devuyst O,Pirson Y

    更新日期：2007-11-01 00:00:00

  • Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis.

    abstract：:Chronic kidney disease (CKD) remains one of the leading causes of death in the developed world, and acute kidney injury (AKI) is now recognized as a major risk factor in its development. Understanding the factors leading to CKD after acute injury are limited by current animal models of AKI, which concurrently target v...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2012.20

    authors： Grgic I,Campanholle G,Bijol V,Wang C,Sabbisetti VS,Ichimura T,Humphreys BD,Bonventre JV

    更新日期：2012-07-01 00:00:00

  • Lipopolysaccharide induces filtrate leakage from renal tubular lumina into the interstitial space via a proximal tubular Toll-like receptor 4-dependent pathway and limits sensitivity to fluid therapy in mice.

    abstract：:Sustained oliguria during fluid resuscitation represents a perplexing problem in patients undergoing therapy for septic acute kidney injury. Here, we tested whether lipopolysaccharide induces filtrate leakage from the proximal tubular lumen into the interstitium, thus disturbing the recovery of urine output during the...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2019.11.024

    authors： Nakano D,Kitada K,Wan N,Zhang Y,Wiig H,Wararat K,Yanagita M,Lee S,Jia L,Titze JM,Nishiyama A

    更新日期：2020-05-01 00:00:00

  • Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury.

    abstract：:Podocyte injury and loss contribute to the progression of glomerular diseases, including diabetic kidney disease. We previously found that the glomerular expression of Sirtuin-1 (SIRT1) is reduced in human diabetic glomeruli and that the podocyte-specific loss of SIRT1 aggravated albuminuria and worsened kidney diseas...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2017.12.008

    authors： Hong Q,Zhang L,Das B,Li Z,Liu B,Cai G,Chen X,Chuang PY,He JC,Lee K

    更新日期：2018-06-01 00:00:00

  • Erythropoiesis after withdrawal of enalapril in post-transplant erythrocytosis.

    abstract：:Enalapril effectively decreases hematocrits in patients with postrenal transplant erythrocytosis (PTE). We studied the effect of enalapril withdrawal on erythropoiesis in 18 patients with PTE who had been treated for 13 +/- 8 months. Hematocrit, reticulocyte count, plasma erythropoietin, and plasma insulin-like growth...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1994.411

    authors： Julian BA,Gaston RS,Barker CV,Krystal G,Diethelm AG,Curtis JJ

    更新日期：1994-11-01 00:00:00

  • The prolactin gene is expressed in the mouse kidney.

    abstract：BACKGROUND:Prolactin (PRL), originally identified as an anterior pituitary hormone exhibiting lactogenic activity, is now recognized as a versatile hormone expressed in a wide variety of tissues. METHODS:In this study, the expression of PRL in the mouse kidney was investigated by solution-phase and in situ reverse tra...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.055003833.x

    authors： Sakai Y,Hiraoka Y,Ogawa M,Takeuchi Y,Aiso S

    更新日期：1999-03-01 00:00:00

  • Two channels for one job.

    abstract：:The study by Rieg et al. is the first to examine potassium handling in BK(-/-) mice, thereby addressing many unanswered questions regarding the separate roles of BK and ROMK channels in renal potassium secretion. This Commentary is an interpretation and opinion of their results, by two researchers who have been studyi...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/sj.ki.5002438

    authors： Sansom SC,Welling PA

    更新日期：2007-09-01 00:00:00

  • Ammonia partitioning between glutamine and urea: interorgan participation in metabolic acidosis.

    abstract：:The distribution of precursor nitrogen between urea and glutamine was studied in control and acidotic rats. Acidosis, either acutely induced with hydrochloric acid or chronically induced with ammonium chloride, resulted in a rise in ammonia and a fall in urinary urea excretion; the percent of urinary nitrogen excreted...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1981.182

    authors： Phromphetcharat V,Jackson A,Dass PD,Welbourne TC

    更新日期：1981-11-01 00:00:00

  • Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis.

    abstract：:IgG4-related disease is a recently recognized multi-organ disorder characterized by high levels of serum IgG4 and dense infiltration of IgG4-positive cells into several organs. Although the pancreas was the first organ recognized to be affected by IgG4-related disorder in the syndrome of autoimmune pancreatitis, we pr...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2010.271

    authors： Saeki T,Nishi S,Imai N,Ito T,Yamazaki H,Kawano M,Yamamoto M,Takahashi H,Matsui S,Nakada S,Origuchi T,Hirabayashi A,Homma N,Tsubata Y,Takata T,Wada Y,Saito A,Fukase S,Ishioka K,Miyazaki K,Masaki Y,Umehara H,Sug

    更新日期：2010-11-01 00:00:00

  • Expression of decay accelerating factor mRNA and complement C3 mRNA in human diseased kidney.

    abstract：BACKGROUND:Decay accelerating factor (DAF), a product of mesangial cells in vitro, is expressed on the surface of cells and is a candidate for the focal suppression of complement activation. It is not clear at present whether the levels of expression of DAF and intrarenal C3 synthesis correlate with the level of tissue...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00961.x

    authors： Abe K,Miyazaki M,Koji T,Furusu A,Ozono Y,Harada T,Sakai H,Nakane PK,Kohno S

    更新日期：1998-07-01 00:00:00

  • The contentious ontogeny of fibrosis in the kidney.

    abstract：:Arguably, no cell biology related to the loss of renal function is more debated than the ontogeny of fibrosis in the kidney. Recent studies suggest that the fibroblasts depositing most of the excess extracellular matrix in diseased kidneys derive from epithelial cells versus pericytes resident within the kidney. Reich...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2013.107

    authors： Nelson PJ

    更新日期：2013-07-01 00:00:00

  • The calcimimetic AMG 073 reduces parathyroid hormone and calcium x phosphorus in secondary hyperparathyroidism.

    abstract：BACKGROUND:A need exists for a therapy that lowers parathyroid hormone (PTH) without increasing calcium x phosphorus in patients with secondary hyperparathyroidism. The calcimimetic AMG 073 increases the sensitivity of the parathyroid calcium-sensing receptor to extracellular calcium, thereby reducing PTH secretion. Co...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1046/j.1523-1755.2003.00720.x

    authors： Lindberg JS,Moe SM,Goodman WG,Coburn JW,Sprague SM,Liu W,Blaisdell PW,Brenner RM,Turner SA,Martin KJ

    更新日期：2003-01-01 00:00:00

  • Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells.

    abstract：BACKGROUND:The glomerular endothelial cell is a specialized microvascular cell type involved in the regulation of glomerular ultrafiltration. During gram-negative sepsis, glomerulonephritis, and acute renal failure, bacterial lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha) may cause severe cell dam...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00473.x

    authors： Messmer UK,Briner VA,Pfeilschifter J

    更新日期：1999-06-01 00:00:00

  • Vasopressin receptor-mediated endocytosis in cells transfected with V1-type vasopressin receptors.

    abstract：:We examined the process of receptor-mediated endocytosis in A-9 lung fibroblast and chinese hamster ovary (CHO) cells transfected with the recently cloned vasopressin V1a receptor (51). We used a fluorescent labeled vasopressin analog (rhodamine-mercaptopropionic acid lysine vasopressin) and radiolabeled vasopressin t...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1993.119

    authors： Lutz W,Sanders M,Salisbury J,Lolait S,O'Carroll AM,Kumar R

    更新日期：1993-04-01 00:00:00

  • Early and late adjustment to potassium loading in humans.

    abstract：:We studied the adaptation to early (72 hr) and late (20 days) K loading (400 mmol/day, 4 equal meals every 6 hour) in six healthy humans. Throughout the study, each single K meal was followed by an acute transient rise in plasma K, aldosterone and kaliuresis. "K balance" (urinary K excretion approximately 80% of intak...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.295

    authors： Rabelink TJ,Koomans HA,Hené RJ,Dorhout Mees EJ

    更新日期：1990-11-01 00:00:00

  • High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein.

    abstract：:High glucose evokes a variety of signals in mesangial cells that alter cellular functions responsible for the development of diabetic glomerulopathy. The hypoxia-inducible factor-1alpha (HIF-1alpha) regulates cellular homeostasis under hypoxic conditions, but it also has pleiotropic effects in response to cellular str...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2010.99

    authors： Isoe T,Makino Y,Mizumoto K,Sakagami H,Fujita Y,Honjo J,Takiyama Y,Itoh H,Haneda M

    更新日期：2010-07-01 00:00:00

  • Cardiovascular risk factors in chronic kidney disease: does phosphate qualify?

    abstract：:Risk factors for disease states are rigorously defined. This analysis considers the definition of a risk factor as applied to the question of whether the serum phosphorus level is a risk factor for cardiovascular disease. Observational studies strongly suggest that phosphorus is associated with cardiovascular risk, an...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.2011.24

    authors： Hruska K,Mathew S,Lund R,Fang Y,Sugatani T

    更新日期：2011-04-01 00:00:00

  • Albumin interaction with the glomerular capillary wall in vitro.

    abstract：:The binding of albumin to the glomerular capillary wall was studied using albumin-gold in perfused kidneys, the interaction of [3H]albumin with isolated glomeruli at 37 degrees C and 4 degrees C and the interaction at [3H]albumin with purified basement membrane. The albumin-gold was found to bind predominantly to the ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.149

    authors： Adal Y,Smit MF,Osicka TM,Comper WD

    更新日期：1995-04-01 00:00:00

  • Acute renal failure independently predicts mortality after myeloablative allogeneic hematopoietic cell transplant.

    abstract：BACKGROUND:Patients undergoing myeloablative allogeneic hematopoietic cell transplantation (HCT) have a high incidence of acute renal failure (ARF). However, it is unclear if ARF is independently associated with mortality after this procedure. METHODS:We performed meta-analysis of published reports on ARF after myeloa...

    journal_title：Kidney international

    pub_type： 杂志文章,meta分析

    doi：10.1111/j.1523-1755.2005.00301.x

    authors： Parikh CR,McSweeney P,Schrier RW

    更新日期：2005-05-01 00:00:00

  • Immunolocalization of NAD-dependent 11 beta-hydroxysteroid dehydrogenase in human kidney and colon.

    abstract：:The inactivation of physiological glucocorticoids by 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) confers mineralocorticoid specificity to certain aldosterone target tissues. Both NADP, and NAD-dependent isoforms of 11 beta-HSD have been described. An NAD-dependent isoform of 11 beta-HSD (11 beta-HSD2) was recen...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.39

    authors： Kyossev Z,Walker PD,Reeves WB

    更新日期：1996-01-01 00:00:00

  • Augmented arginine uptake, through modulation of cationic amino acid transporter-1, increases GFR in diabetic rats.

    abstract：BACKGROUND:It is suggested that either arginine or its metabolites, nitric oxide and polyamines play a role in the renal hemodynamic alterations observed in the early stages of diabetes. Yet, the regulation of arginine transport in diabetic kidneys has never been studied. METHODS:Arginine uptake was determined in glom...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00508.x

    authors： Schwartz IF,Iaina A,Benedict Y,Wollman Y,Chernichovski T,Brasowski E,Misonzhnik F,Ben-Dor A,Blum M,Levo Y,Schwartz D

    更新日期：2004-04-01 00:00:00

  • Active hepatitis B vaccination of dialysis patients and medical staff.

    abstract：:One hundred six patients with terminal renal insufficiency and 29 medical personnel were given three doses of hepatitis B vaccine at an interval of 0, 1, and 6 months (Merck, Sharp and Dohme, West Point, Pennsylvania, part of a joint study no. 649). Chronic hemodialysis patients (N = 99) received 40 micrograms vaccine...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1984.18

    authors： Köhler H,Arnold W,Renschin G,Dormeyer HH,Meyer zum Büschenfelde KH

    更新日期：1984-01-01 00:00:00

  • A cross-sectional study of 502 patients found a diffuse hyperechoic kidney medulla pattern in patients with severe gout.

    abstract：:We have previously shown that ultrasonography can detect hyperechogenic crystal deposits in the kidney medulla of patients with gout. In this cross-sectional study we investigated the frequency and clinical correlates of hyperechogenic kidney medulla in 502 consecutive primary consultants for gout (ACR/EULAR criteria)...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2020.08.024

    authors： Bardin T,Nguyen QD,Tran KM,Le NH,Do MD,Richette P,Letavernier E,Correas JM,Resche-Rigon M

    更新日期：2021-01-01 00:00:00

  • Changes in plasma 1,25 and 24,25-dihydroxyvitamin D after renal transplantation in children.

    abstract：:The purpose of this investigation is to analyze changes in plasma 1,25-(OH)2D and 24,25-(OH)2D after successful renal transplantation in 20 children and young adults. Studies were performed on 8 subjects between the 1st and 10th month and on 12 others between the 20th and 30th to 36th month. Samples were assayed for p...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1981.153

    authors： Garabedian M,Silve C,Levy-Bentolila D,Bourdeau A,Ulmann A,Nguyen TM,Lieberherr M,Broyer M,Balsan S

    更新日期：1981-09-01 00:00:00

  • MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice.

    abstract：:Murine double minute (MDM)-2, an E3 ubiquitin ligase, promotes cancer cell survival and growth, by degrading the cell cycle regulator p53. Antagonism of MDM2 by the small-molecule cis-imidazoline nutlin analogs is under current study for cancer therapy. To test whether MDM2 also promotes regenerative cell growth, we d...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2011.482

    authors： Mulay SR,Thomasova D,Ryu M,Anders HJ

    更新日期：2012-06-01 00:00:00

  • Induction of stress response proteins and experimental renal ischemia/reperfusion.

    abstract：BACKGROUND:The induction of stress response (heat shock) proteins (HSPs) is a highly conserved response that protects many cell types from diverse physiological and environmental stressors. We tested the hypothesis that the induction of HSPs is protective in experimental renal ischemia/reperfusion injury. METHODS:The ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.0590051798.x

    authors： Kelly KJ,Baird NR,Greene AL

    更新日期：2001-05-01 00:00:00

  • Phosphate: despite advances in research, the benefits to patients remain limited.

    abstract：:Tremendous progress has been made over recent years in the understanding of the mechanisms regulating calcium, phosphorus, vitamin D, and parathyroid hormone homeostasis in the normal human body and in patients with different degrees of renal failure. In addition, some of these findings have been translated into clini...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.692

    authors： De Broe ME

    更新日期：2009-05-01 00:00:00

  • Glomerular hemodynamic changes vs. hypertrophy in experimental glomerular sclerosis.

    abstract：:In a variety of recent studies in animals with chronic renal diseases, investigators have found a tight correlation between the elevation in glomerular pressures and flows versus glomerular hypertrophy. To investigate a possible causal link between the glomerular hyperfunction and hypertrophy, we studied the functiona...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.35

    authors： Yoshida Y,Fogo A,Ichikawa I

    更新日期：1989-02-01 00:00:00