Immunolocalization of NAD-dependent 11 beta-hydroxysteroid dehydrogenase in human kidney and colon.

abstract：:In this issue, McMahon et al. report that, by combining phenotypic, metabolomic, and genetic data, they could better detect chronic kidney disease at the early stages and provide insight into its pathobiology. The most significant findings of the study are that several urinary metabolites (e.g., glycine and histidine)...

journal_title：Kidney international

authors： Zhang G,Saito R,Sharma K

更新日期：2017-06-01 00:00:00

abstract：:Mitochondria are critical in determining a cell's energy homeostasis and fate, and mitochondrial dysfunction has been implicated in the pathogenesis of chronic kidney disease (CKD). We sought to identify causative mitochondrial microRNAs. A microarray screen of kidney tissue from healthy mice identified 97 microRNAs t...

journal_title：Kidney international

authors： Bai M,Chen H,Ding D,Song R,Lin J,Zhang Y,Guo Y,Chen S,Ding G,Zhang Y,Jia Z,Huang S,He JC,Yang L,Zhang A

更新日期：2019-06-01 00:00:00

abstract：:Insulin resistance from chronic kidney disease (CKD) stimulates muscle protein wasting but mechanisms causing this resistance are controversial. To help resolve this, we used microarray analyses to identify initiators of insulin resistance in the muscles of mice with CKD, glucose intolerance, and insulin resistance. C...

journal_title：Kidney international

authors： Thomas SS,Dong Y,Zhang L,Mitch WE

更新日期：2013-08-01 00:00:00

abstract：:The circumstances under which furosemide increases renal blood flow was examined in mongrel dogs as it may relate to a tubuloglomerular feedback mechanism. Two maneuvers, desoxycorticosterone (DOCA) plus salt treatment and inhibition of tubular fluid flow, were used in the dogs to evaluate the renal vascular effects o...

journal_title：Kidney international

authors： Gerber JG,Nies AS

更新日期：1980-10-01 00:00:00

abstract：:To examine whether hypoxia-inducible factor (HIF)-1α mediates the profibrotic effects of angiotensin II, we treated cultured renal medullary interstitial cells with angiotensin II and found that it increased HIF-1α levels. This was accompanied by a significant upregulation of collagen I/III, the tissue inhibitor of me...

journal_title：Kidney international

authors： Wang Z,Tang L,Zhu Q,Yi F,Zhang F,Li PL,Li N

更新日期：2011-02-01 00:00:00

abstract：:Focal and segmental glomerulosclerosis (FSGS) is a major cause of end-stage kidney disease. Recent advances in molecular genetics show that defects in the podocyte play a major role in its pathogenesis and mutations in inverted formin 2 (INF2) cause autosomal dominant FSGS. In order to delineate the role of INF2 mutat...

journal_title：Kidney international

authors： Gbadegesin RA,Lavin PJ,Hall G,Bartkowiak B,Homstad A,Jiang R,Wu G,Byrd A,Lynn K,Wolfish N,Ottati C,Stevens P,Howell D,Conlon P,Winn MP

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The pathogenesis of progressive nephropathies involves hemodynamic and inflammatory factors. In the 5/6 nephrectomy model, a selective increase of cyclooxygenase-2 (COX-2) expression was shown, whereas treatment with a nonsteroidal anti-inflammatory or a specific COX-2 inhibitor was renoprotective. We invest...

journal_title：Kidney international

authors： Fujihara CK,Antunes GR,Mattar AL,Andreoli N,Malheiros DM,Noronha IL,Zatz R

更新日期：2003-12-01 00:00:00

abstract：:The International Pediatric Peritonitis Registry (IPPR) was created to assess and evaluate the validity of the pediatric peritonitis treatment guidelines issued by the International Society for Peritoneal Dialysis. The study by Schaefer et al., one of the first to emerge from the IPPR, describes regional variability i...

journal_title：Kidney international

authors： Teitelbaum I

更新日期：2007-12-01 00:00:00

abstract：:Primary hyperoxaluria is characterized by severe urolithiasis, nephrocalcinosis, and early renal failure. As treatment options are scarce, we aimed for a new therapeutic tool using colonic degradation of endogenous oxalate by Oxalobactor formigenes. Oxalobacter was orally administered for 4 weeks as frozen paste (IxOC...

journal_title：Kidney international

authors： Hoppe B,Beck B,Gatter N,von Unruh G,Tischer A,Hesse A,Laube N,Kaul P,Sidhu H

更新日期：2006-10-01 00:00:00

abstract：:The hypoxia-inducible factor-1 (HIF-1) was first described as a DNA binding activity that specifically recognizes an 8 bp hypoxia response element (HRE) known to be essential for oxygen-regulated erythropoietin gene expression. In electrophoretic mobility shift assays (EMSAs) HIF-1 DNA binding activity is only detecta...

journal_title：Kidney international

authors： Kvietikova I,Wenger RH,Marti HH,Gassmann M

更新日期：1997-02-01 00:00:00

abstract：:Australia's Indigenous people have high rates of chronic kidney disease and kidney failure. To define renal disease among these people, we reviewed 643 renal biopsies on Indigenous people across Australia, and compared them with 249 biopsies of non-Indigenous patients. The intent was to reach a consensus on pathologic...

journal_title：Kidney international

authors： Hoy WE,Samuel T,Mott SA,Kincaid-Smith PS,Fogo AB,Dowling JP,Hughson MD,Sinniah R,Pugsley DJ,Kirubakaran MG,Douglas-Denton RN,Bertram JF

更新日期：2012-12-01 00:00:00

abstract：:Experiments were performed using a variety of methods to assess the functional status of different nephron populations following 45 min of renal ischemia in the rat. Micropuncture techniques revealed that SNGFR and reabsorption in the surface nephrons are only modestly reduced after ischemia, whereas kidney GFR and re...

journal_title：Kidney international

authors： Mason J,Welsch J,Takabatake T

更新日期：1983-07-01 00:00:00

abstract：:Tenascin-C is an extracellular matrix glycoprotein that plays a critical role in kidney fibrosis by orchestrating a fibrogenic niche. Here, we demonstrate that tenascin-C is a biomarker and a mediator of kidney fibrogenesis by impairing tubular integrity. Tenascin-C was found to be increased in kidney biopsies from pa...

journal_title：Kidney international

authors： Zhu H,Liao J,Zhou X,Hong X,Song D,Hou FF,Liu Y,Fu H

更新日期：2020-05-01 00:00:00

abstract：:The risk of death in hemodialysis patients treated with calcium-containing phosphate binders or sevelamer is not known. We assessed all-cause mortality in 127 patients new to hemodialysis assigned to calcium-containing binders or sevelamer after a median follow-up of 44 months from randomization. This was a predetermi...

journal_title：Kidney international

authors： Block GA,Raggi P,Bellasi A,Kooienga L,Spiegel DM

更新日期：2007-03-01 00:00:00

abstract：:Renal fibrosis is a common pathway leading to the progression of chronic kidney disease, and bone marrow-derived fibroblasts contribute significantly to the development of renal fibrosis. However, the signaling mechanisms underlying the activation of these fibroblasts are not completely understood. Here, we examined t...

journal_title：Kidney international

authors： Liang H,Zhang Z,Yan J,Wang Y,Hu Z,Mitch WE,Wang Y

更新日期：2017-12-01 00:00:00

abstract：:Both single-frequency bioimpedance and multiple-frequency spectroscopy are equally accurate in measuring total-body water and intracellular fluid. Estimates are consistent at a population level but not at the individual level, because of wide limits of agreement. There is no real 'gold standard' method providing estim...

journal_title：Kidney international

authors： Piccoli A

更新日期：2014-04-01 00:00:00

abstract：:Acute kidney injury (AKI) following cardiac surgery is closely interrelated with hemodynamic instability and sympathetic activity, and adversely influences prognosis. Here, we investigated in a randomized placebo-controlled trial whether dexmedetomidine, an α2 adrenoreceptor agonist, could prevent AKI after valvular h...

journal_title：Kidney international

authors： Cho JS,Shim JK,Soh S,Kim MK,Kwak YL

更新日期：2016-03-01 00:00:00

abstract：:Rare autosomal dominant tubulointerstitial kidney disease is caused by mutations in the genes encoding uromodulin (UMOD), hepatocyte nuclear factor-1β (HNF1B), renin (REN), and mucin-1 (MUC1). Multiple names have been proposed for these disorders, including 'Medullary Cystic Kidney Disease (MCKD) type 2', 'Familial Ju...

journal_title：Kidney international

authors： Eckardt KU,Alper SL,Antignac C,Bleyer AJ,Chauveau D,Dahan K,Deltas C,Hosking A,Kmoch S,Rampoldi L,Wiesener M,Wolf MT,Devuyst O,Kidney Disease: Improving Global Outcomes.

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Gentamicin is commonly used in hemodialysis patients. Gentamicin pharmacokinetics during traditional hemodialysis have been described. Slow daily home (SDH) hemodialysis (7 to 9 hours a day/6 days a week) use is increasing due to benefits observed with increased hemodialysis. We determined gentamicin pharmac...

journal_title：Kidney international

authors： Manley HJ,Bailie GR,McClaran ML,Bender WL

更新日期：2003-03-01 00:00:00

abstract：:Hypertriglyceridemia is the most prevalent lipid alteration in end-stage renal disease, and we studied the relationship between serum triglycerides and all-cause and cardiovascular death in these patients. Since abdominal fat modifies the effect of lipids on atherosclerosis, we analyzed the interaction between serum l...

journal_title：Kidney international

authors： Postorino M,Marino C,Tripepi G,Zoccali C,CREDIT Working Group.

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the relationship between glomerular filtration rate (GFR) measured at 5 years' diabetes duration and annual urine albumin excretion in a prospective cohort of children with type 1 diabetes (T1DM). METHODS:Three hundred and eight children were followed from diagnosis ...

journal_title：Kidney international

authors： Amin R,Turner C,van Aken S,Bahu TK,Watts A,Lindsell DR,Dalton RN,Dunger DB

更新日期：2005-10-01 00:00:00

abstract：:Neutrophil gelatinase-associated lipocalin (Ngal, 24p3, SIP24, lipocalin 2, or siderocalin) was originally purified from neutrophils, but with unknown function. Recently, it was identified that Ngal activates nephron formation in the embryonic kidney, is rapidly and massively induced in renal failure and possesses kid...

journal_title：Kidney international

authors： Mori K,Nakao K

更新日期：2007-05-01 00:00:00

abstract：:Angiotensin II plays an important role in the regulation of blood pressure, body salt and fluid balance, and urine concentration. Mice with deletion of the AT(1a) receptor develop polyuria and urine concentration defects. We studied the mechanisms of these urine concentration defects by treating wild-type and AT(1a)-k...

journal_title：Kidney international

authors： Li XC,Shao Y,Zhuo JL

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:The interaction between tubular epithelial cells and calcium oxalate crystals or oxalate ions is a very precarious event in the lithogenesis. Urine contains ions, glycoproteins and glycosaminoglycans that inhibit the crystallization process and may protect the kidney against lithogenesis. We examined the eff...

journal_title：Kidney international

authors： Borges FT,Michelacci YM,Aguiar JA,Dalboni MA,Garófalo AS,Schor N

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Adiponectin is an adipocyte-derived cytokine that has anti-inflammatory properties. A preliminary proteomic evaluation of urine for biomarkers of systemic lupus erythematosus (SLE) nephritis demonstrated high levels of adiponectin in SLE urine. This prompted investigation of adiponectin expression in human S...

journal_title：Kidney international

authors： Rovin BH,Song H,Hebert LA,Nadasdy T,Nadasdy G,Birmingham DJ,Yung Yu C,Nagaraja HN

更新日期：2005-10-01 00:00:00

abstract：:Bikunin is a chondroitin-sulphate containing serum protein with a Stokes-Einstein radius and a negative net charge close to those of serum albumin. The plasma half life of bikunin is about 10 minutes, and approximately half of its clearance occurs in the kidneys. The quantitative role of glomerular filtration in the r...

journal_title：Kidney international

authors： Lindström KE,Blom A,Johnsson E,Haraldsson B,Fries E

更新日期：1997-04-01 00:00:00

abstract：:Tubular atrophy and interstitial fibrosis, important in progression of renal diseases, including diabetic (D) and cyclosporine-induced (CSA) nephropathy, have been considered irreversible. Normoglycemia for 10 years following pancreas transplantation alone (PTA) reversed D glomerulopathy lesions. This study quantified...

journal_title：Kidney international

authors： Fioretto P,Sutherland DE,Najafian B,Mauer M

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:This study examined the effects of stent placement for renal artery stenosis on the function of treated and contralateral kidneys. METHODS:Eighteen patients who underwent stent placement for unilateral renal artery stenosis presenting with hypertension and/or renal failure were studied before angiography an...

journal_title：Kidney international

authors： Leertouwer TC,Derkx FH,Pattynama PM,Deinum J,van Dijk LC,Schalekamp MA

更新日期：2002-08-01 00:00:00

abstract：:Extracellular fluid volume expansion is known to produce exaggerated natriuresis in essential hypertension. In order to assess the role of hemodynamic and intrarenal physical factors upon natriuretic response to central volume expansion, two hour water immersion (WI) experiments were made in six uncomplicated essentia...

journal_title：Kidney international

authors： Coruzzi P,Musiari L,Biggi A,Ravanetti C,Vallisa D,Montanari A,Novarini A

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:The mechanisms of cyclosporine (CsA)-induced nephrotoxicity are not fully understood. While hemodynamic changes may be involved in vivo, there is also some evidence for tubular involvement. We previously showed direct toxicity of CsA in the LLC-PK1 renal tubular cell line. In the current study we examined me...

journal_title：Kidney international

authors： Healy E,Dempsey M,Lally C,Ryan MP

更新日期：1998-12-01 00:00:00