Characterization of glycosaminoglycans in tubular epithelial cells: calcium oxalate and oxalate ions effects.

abstract：:Albuminuria and a reduced glomerular filtration rate are conventional predictors of a future decline in kidney function in patients with type 2 diabetes mellitus. Using a nested case-control study we assessed whether circulating transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) levels mor...

journal_title：Kidney international

authors： Wong MG,Perkovic V,Woodward M,Chalmers J,Li Q,Hillis GS,Yaghobian Azari D,Jun M,Poulter N,Hamet P,Williams B,Neal B,Mancia G,Cooper M,Pollock CA

更新日期：2013-02-01 00:00:00

abstract：:In a variety of recent studies in animals with chronic renal diseases, investigators have found a tight correlation between the elevation in glomerular pressures and flows versus glomerular hypertrophy. To investigate a possible causal link between the glomerular hyperfunction and hypertrophy, we studied the functiona...

journal_title：Kidney international

authors： Yoshida Y,Fogo A,Ichikawa I

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Protein-calorie malnutrition is common in chronic hemodialysis (CHD) patients and correlates with morbidity and mortality in these patients. There are limited trials evaluating the efficacy of oral nutritional supplementation in malnourished CHD patients. METHODS:Eighty-five CHD patients with evidence of ma...

journal_title：Kidney international

authors： Caglar K,Fedje L,Dimmitt R,Hakim RM,Shyr Y,Ikizler TA

更新日期：2002-09-01 00:00:00

abstract：:Multiple-relapsing minimal-change disease (MCD) often requires exposure to potentially toxic agents in an attempt to achieve a lasting remission of nephrotic syndrome. Munyentwali and co-workers describe an experience using rituximab in adults with multiple-relapsing MCD that supports both efficacy and safety of this ...

journal_title：Kidney international

authors： Glassock RJ

更新日期：2013-03-01 00:00:00

abstract：:The highly amiloride-sensitive epithelial sodium channel (ENaC) is an apical membrane constituent of cells of many salt-absorbing epithelia. In the kidney, the functional relevance of ENaC expression has been well established. ENaC mediates the aldosterone-dependent sodium reabsorption in the distal nephron and is inv...

journal_title：Kidney international

authors： Bonny O,Hummler E

更新日期：2000-04-01 00:00:00

abstract：:Acute kidney injury (AKI) occurs in about half of patients in septic shock and the mortality of AKI with sepsis is extremely high. An effective therapeutic intervention is urgently required. Statins are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors that also have pleiotropic actions. They have been report...

journal_title：Kidney international

authors： Yasuda H,Yuen PS,Hu X,Zhou H,Star RA

更新日期：2006-05-01 00:00:00

abstract：:Transport and metabolism of adenosine were studied in the S1, S2, and S3 segments of the rabbit proximal renal tubule. Isolated segments were perfused in vitro with uniformly labelled 14C-adenosine to measure the lumen-to-bath flux of adenosine. This flux rate was measured by the disappearance of 14C from the luminal ...

journal_title：Kidney international

authors： Barfuss DW,McCann WP,Katholi RE

更新日期：1992-05-01 00:00:00

abstract：:Although the pathogenesis of steroid-sensitive nephrotic syndrome (SSNS) remains elusive, multiple epidemiologic, clinical, and experimental studies converge on the common theme of immune dysregulation. Initially, T-cell adaptive immunity was solely emphasized; however, the role of humoral immunity in nephrotic syndro...

journal_title：Kidney international

authors： Chambers ET,Gbadegesin RA

更新日期：2019-10-01 00:00:00

abstract：:Anecdotal reports of complement component deficiencies in patients with immune complex disease led to a systematic study of the levels of seven complement components in serum specimens from 178 patients with glomerulonephritis and 163 normal subjects. Deficiencies were found with significantly higher frequency (22.7%)...

journal_title：Kidney international

authors： Coleman TH,Forristal J,Kosaka T,West CD

更新日期：1983-11-01 00:00:00

abstract：:The metabolism of phenylalanine and tyrosine was evaluated in six normal men, five chronically uremic men, and three men undergoing maintenance hemodialysis. Phenylalanine, tyrosine, and 13 acidic metabolites of those amino acids were measured in plasma postabsorptively and in plasma and urine after a phenylalanine lo...

journal_title：Kidney international

authors： Jones MR,Kopple JD,Swendseid ME

更新日期：1978-08-01 00:00:00

abstract：:There is a paucity of studies describing malignancy-related mortality after kidney transplantation. To help quantify this, we extracted data for all kidney-alone transplant procedures performed in England between April 2001 and March 2012. Data linkage analysis was performed between Hospital Episode Statistics and the...

journal_title：Kidney international

authors： Farrugia D,Mahboob S,Cheshire J,Begaj I,Khosla S,Ray D,Sharif A

更新日期：2014-06-01 00:00:00

abstract：:Interstitial monocytic infiltration of the kidney occurs within hours of acute kidney injury and is an important determinant of functional decline and fibrosis. Li et al. used several surface markers to distinguish between dendritic cells and inflammatory monocytes following acute kidney injury and to identify two che...

journal_title：Kidney international

authors： Swaminathan S,Griffin MD

更新日期：2008-12-01 00:00:00

abstract：:The thick ascending limb of Henle's loop ( TAL ) develops a specific and consistent structural lesion during perfusion of the isolated rat kidney that progresses from mitochondrial swelling at 15 min to complete cellular disruption at 90 min. Because it seemed possible that damage localized to this metabolically activ...

journal_title：Kidney international

authors： Brezis M,Rosen S,Silva P,Epstein FH

更新日期：1984-01-01 00:00:00

abstract：:More than two isoforms have been identified for angiotensin receptors based on their ligand selectivity. The objective of this study is to determine the molecular structure of angiotensin type 2 receptor (AT2), whose physiological functions are still an enigma despite extensive studies on its distribution in fetal tis...

journal_title：Kidney international

authors： Kambayashi Y,Takahashi K,Bardhan S,Inagami T

更新日期：1994-12-01 00:00:00

abstract：:The hypoxia-inducible factor-1 (HIF-1) was first described as a DNA binding activity that specifically recognizes an 8 bp hypoxia response element (HRE) known to be essential for oxygen-regulated erythropoietin gene expression. In electrophoretic mobility shift assays (EMSAs) HIF-1 DNA binding activity is only detecta...

journal_title：Kidney international

authors： Kvietikova I,Wenger RH,Marti HH,Gassmann M

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:A nationwide survey of urolithiasis in Japan was made in order to evaluate the chronological trend of upper urinary tract stones in the Japanese. It succeeded previous studies done in 1955, 1966, 1979, and 1990. METHODS:All outpatient visits to urologists that resulted in a diagnosis of first-episode upper ...

journal_title：Kidney international

authors： Yoshida O,Terai A,Ohkawa T,Okada Y

更新日期：1999-11-01 00:00:00

abstract：:Measures related to red cell oxygen transport were evaluated in 17 hemodialysis patients receiving androgen therapy, 15 untreated hemodialysis patients and 15 normal subjects. Hemoglobin levels were higher in androgen-treated patients than in the untreated population and were directly related to the reticulocyte index...

journal_title：Kidney international

authors： Hendler ED,Solomon L

更新日期：1987-01-01 00:00:00

abstract：:Simple life-table analyses have not identified the reasons for the steady improvement over the years in graft survival. The use of more sophisticated multifactorial statistical techniques is indicated to identify prognostic factors and to explore the "center effect" on graft survival. An agenda for retrospective analy...

journal_title：Kidney international

authors： Gore SM

更新日期：1983-10-01 00:00:00

abstract：:Starting from observations in intact cells and extending to studies in native membranes and solubilized membrane proteins, a significant body of evidence has been accumulated to indicate that some of the short-term regulatory influences on the Na+-H+ exchanger in the apical membrane of the proximal convoluted tubule a...

journal_title：Kidney international

authors： Weinman EJ,Dubinsky W,Shenolikar S

更新日期：1989-10-01 00:00:00

abstract：:The impact of high-flux hemodialysis on clinical outcomes remains controversial. We have previously shown that in vivo transmigrated leukocytes from patients with low-flux bioincompatible hemodialysis have an impaired capacity to upregulate CD11b at the site of interstitial inflammation. In the present study, we inves...

journal_title：Kidney international

authors： Olsson J,Dadfar E,Paulsson J,Lundahl J,Moshfegh A,Jacobson SH

更新日期：2007-03-01 00:00:00

abstract：:Amylin (islet amyloid peptide) plays a critical role in islet amyloidosis and in the development of beta-cell dysfunction in patients with diabetes; however, the involvement of amylin in renal amyloidosis has not been studied. For this reason, we surveyed 149 patients with biopsy-proven diabetic nephropathy (DN). The ...

journal_title：Kidney international

authors： Gong W,Liu ZH,Zeng CH,Peng A,Chen HP,Zhou H,Li LS

更新日期：2007-07-01 00:00:00

abstract：:Serum calcitriol and the free calcitriol index together with factors considered to regulate calcitriol production were measured in eleven patients with moderate chronic renal failure (MCRF) and eleven age- and sex-matched normal subjects. Although the serum dialysable calcium levels were similar in the two groups, the...

journal_title：Kidney international

authors： Prince RL,Hutchison BG,Kent JC,Kent GN,Retallack RW

更新日期：1988-03-01 00:00:00

abstract：:Congenital chloride diarrhea is due to mutations in the intestinal Cl(-)/HCO(3)(-) exchange (SLC26A3) which results in sodium chloride and fluid depletion leading to hypochloremic and hypokalemic metabolic alkalosis. Although treatment with sodium and potassium chloride offers protection from renal involvement in chil...

journal_title：Kidney international

authors： Wedenoja S,Ormälä T,Berg UB,Halling SF,Jalanko H,Karikoski R,Kere J,Holmberg C,Höglund P

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus-associated nephropathy (HIVAN) has become the third leading cause of end-stage renal disease (ESRD) in African Americans, and is expected to grow exponentially. Highly active antiretroviral therapy (HAART) has significantly prolonged the survival of patients with HIV infection. D...

journal_title：Kidney international

authors： Kumar MS,Sierka DR,Damask AM,Fyfe B,McAlack RF,Heifets M,Moritz MJ,Alvarez D,Kumar A

更新日期：2005-04-01 00:00:00

abstract：:The present experiments were performed to examine the effect of variation in protein intake on renal function and morphology in the non-clipped kidneys of Goldblatt hypertensive rats. After renal artery clipping, rats were put on diets containing 5 (LP), 17.5 (NP), or 51% (HP) protein. After 4 to 5 weeks, all rats had...

journal_title：Kidney international

authors： Schnermann J,Gokel M,Weber PC,Schubert G,Briggs JP

更新日期：1986-02-01 00:00:00

abstract：:Among Canadians starting dialysis, patients of East Asian and Indo Asian background are less likely than whites to receive a renal allograft. Although the reasons for such variation are complex, less living donation may contribute significantly. More studies are needed to confirm these differences and to evaluate stra...

journal_title：Kidney international

authors： Prasad GV

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Antineutrophil cytoplasm antibodies (ANCAs) are implicated in the pathogenesis of systemic vasculitis. We asked whether ANCA could induce nitric oxide (NO) release from human neutrophils and, if so, whether this NO production was dependent on NO synthase (NOS) activity. METHODS:Neutrophil NO production was ...

journal_title：Kidney international

authors： Tse WY,Williams J,Pall A,Wilkes M,Savage CO,Adu D

更新日期：2001-02-01 00:00:00

abstract：:In summary, the three major segments of the collecting duct subserve three different functions in the urinary concentrating mechanism. The main function of the cortical collecting tubule is to raise the fractional solute contribution and absolute concentration of urea in fluid that it delivers to the outer medullary c...

journal_title：Kidney international

authors： Kokko JP

更新日期：1987-02-01 00:00:00

abstract：:The release of cytokines and prostaglandins (PG) by peritoneal macrophages (PM luminal diameter of) may influence the cytokine network controlling peritoneal inflammation and in the long-term the function of the peritoneum as a dialysis membrane. In the present study, an evaluation of the long-term effects of peritone...

journal_title：Kidney international

authors： McGregor SJ,Topley N,Jörres A,Speekenbrink AB,Gordon A,Gahl GM,Junor BJ,Briggs JD,Brock JH

更新日期：1996-02-01 00:00:00

abstract：:The involvement of sodium/potassium-ATPase in regulating parathyroid hormone (PTH) secretion is inferred from in vitro studies. Recently, the α-klotho-dependent rapid recruitment of this ATPase to the parathyroid cell plasma membrane in response to low extracellular calcium ion was suggested to be linked to increased ...

journal_title：Kidney international

authors： Martuseviciene G,Hofman-Bang J,Clausen T,Olgaard K,Lewin E

更新日期：2011-04-01 00:00:00