Abdominal obesity modifies the risk of hypertriglyceridemia for all-cause and cardiovascular mortality in hemodialysis patients.

abstract：:To investigate the direct toxicity of human Bence Jones protein (BJP), individual nephrons of male Sprague-Dawley rats were perfused in vivo at 20 nl/min with an artificial tubule fluid (ATF) that contained no protein, a human kappa BJP (5 g/dl), or bovine serum albumin (5 g/dl), and proximal convoluted tubule functio...

journal_title：Kidney international

authors： Sanders PW,Herrera GA,Galla JH

更新日期：1987-12-01 00:00:00

abstract：:US adults with metabolic syndrome, as defined by National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, have been shown to be at increased risk of chronic kidney disease (CKD), but there is limited information in other populations. The relationship between metabolic syndrome and CKD ...

journal_title：Kidney international

authors： Kitiyakara C,Yamwong S,Cheepudomwit S,Domrongkitchaiporn S,Unkurapinun N,Pakpeankitvatana V,Sritara P

更新日期：2007-04-01 00:00:00

abstract：:Meprins are zinc-dependent metalloproteinases that are highly expressed in the brush-border membranes of both the kidney and the intestines. Meprins are capable of proteolytically degrading extracellular matrix proteins, proteolytically processing bioactive proteins, and play a role in inflammatory processes. In this ...

journal_title：Kidney international

authors： Herzog C,Seth R,Shah SV,Kaushal GP

更新日期：2007-05-01 00:00:00

abstract：:Problems with vascular access are an important cause of morbidity and mortality in hemodialysis patients. We established a rodent model of arteriovenous fistula by anastomosing the end of a lateral vein to the side of the ventral artery of the rat tail. All operations were technically successful and in all animals the...

journal_title：Kidney international

authors： Lin T,Horsfield C,Robson MG

更新日期：2008-08-01 00:00:00

abstract：:The influence of transforming growth factor beta 1 (TGF-beta 1) and of dexamethasone on fibronectin (FN) synthesis of human renal tubular epithelial cells in culture (TEC) was studied. Cocultivation with TGF-beta 1 increased the steady state level of FN RNA within 24 to 48 hours. By PCR and Northern blotting it was fo...

journal_title：Kidney international

authors： Viedt C,Bürger A,Hänsch GM

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:The clinical use of cyclosporine (CsA) is limited by its nephrotoxicity. Apoptosis, perhaps instigated by increased nitric oxide synthase (NOS) activity, may play a role in such toxicity. METHODS:Human mesangial cells, human tubular cells, human umbilical vein endothelial cells, or murine endothelial cells ...

journal_title：Kidney international

authors： Amore A,Emancipator SN,Cirina P,Conti G,Ricotti E,Bagheri N,Coppo R

更新日期：2000-04-01 00:00:00

abstract：:Atherogenic lipoproteins and reactive oxygen species stimulate renin release from isolated juxtaglomerular (JG) cells. Here we assessed whether stimulation of renin release is mediated by formation of superoxide anion (O2-), and whether the effects of oxidized lipoproteins, like in many other biological systems, can b...

journal_title：Kidney international

authors： Galle J,Heinloth A,Schwedler S,Wanner C

更新日期：1997-01-01 00:00:00

abstract：:Polycystic kidney disease progresses more rapidly in men than in women. To investigate the basis for this sexual dimorphism, we exposed Madin-Darby canine kidney (MDCK) cells grown on collagen-coated cell culture inserts to control media, or to estradiol or testosterone (1 nM-1 microM). Compared to control and estradi...

journal_title：Kidney international

authors： Sandhu S,Silbiger SR,Lei J,Neugarten J

更新日期：1997-05-01 00:00:00

abstract：:The sympathetic nervous system modulates renal function through its receptors namely beta1 (cardiac output and renin release), alpha1 (systemic and renovascular constriction), and beta2 renovascular dilation. Sympathetic overactivity is commonly seen in chronic kidney disease (CKD) and is an important contributor to i...

journal_title：Kidney international

authors： Bakris GL,Hart P,Ritz E

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Atherogenic lipoproteins cause injury to the vascular wall in the early phase of atherogenesis. We assessed the effects of native (nLDL) and oxidized (oxLDL) low-density lipoprotein (LDL) and lipoprotein (a) [Lp(a)] on O2- formation and cell death in cultured human umbilical vein endothelial cells (HUVECs) a...

journal_title：Kidney international

authors： Galle J,Schneider R,Heinloth A,Wanner C,Galle PR,Conzelmann E,Dimmeler S,Heermeier K

更新日期：1999-04-01 00:00:00

abstract：:Hypertension is associated with an accelerated rate of decline in renal function in patients with chronic renal disease. To identify factors that might alter the rate of decline in renal function, we reviewed records of 200 patients from the Nephrology Clinic of the Durham VA Medical Center who had chronic progressive...

journal_title：Kidney international

authors： Brazy PC,Fitzwilliam JF

更新日期：1990-04-01 00:00:00

abstract：:One hundred six patients with terminal renal insufficiency and 29 medical personnel were given three doses of hepatitis B vaccine at an interval of 0, 1, and 6 months (Merck, Sharp and Dohme, West Point, Pennsylvania, part of a joint study no. 649). Chronic hemodialysis patients (N = 99) received 40 micrograms vaccine...

journal_title：Kidney international

authors： Köhler H,Arnold W,Renschin G,Dormeyer HH,Meyer zum Büschenfelde KH

更新日期：1984-01-01 00:00:00

abstract：:The renal effects of a single intravenous dose of two different E. coli lipopolysaccharides (LPS 0111:B4 and LPS 0127:B8), at the same dose of 100 micrograms/kg, were evaluated in euvolemic Munich-Wistar (MW) rats by whole kidney clearance techniques and micropuncture studies. Following LPS infusion, a significant dec...

journal_title：Kidney international

authors： Lugon JR,Boim MA,Ramos OL,Ajzen H,Schor N

更新日期：1989-10-01 00:00:00

abstract：:The relationship of protein intake to urinary oxalate and glycolate excretion was examined in a large cohort (N = 101) of normal individuals on self-selected diets and in 11 individuals on controlled protein diets. On self-selected diets no correlation was detected between protein intake and urinary oxalate or glycola...

journal_title：Kidney international

authors： Holmes RP,Goodman HO,Hart LJ,Assimos DG

更新日期：1993-08-01 00:00:00

abstract：:Zhang and co-workers report on the renoprotective role of the vitamin D receptor (VDR) in diabetic nephropathy using the method of streptozotocin-induced hyperglycemia in wild-type and VDR(-/-) mice. Also, experiments with cultured mesangial cells and podocytes confirm the effect of the active vitamin D metabolite 1,2...

journal_title：Kidney international

authors： Klaus G

更新日期：2008-01-01 00:00:00

abstract：:Angiotensinase A (aminopeptidase A; ATA) is an angiotensin II splitting exopeptidase, which is localized in endothelial and epithelial cells of the glomerular tuft. In order to investigate the influence of a reduction in renal mass on enzyme activity, ATA activity was measured in isolated rat glomeruli five and 14 wee...

journal_title：Kidney international

authors： Wolf G,Thaiss F,Scherberich JE,Schoeppe W,Stahl RA

更新日期：1990-11-01 00:00:00

abstract：:From August 1987 through February 1995 we performed 42 surgical procedures in 29 patients with occluded or stenotic radiocephalic arteriovenous fistulae. Operations were designed to preserve native veins for cannulation (Group I) or to preserve access in the same forearm, bypassing the failed fistula (Group II). For 2...

journal_title：Kidney international

authors： Oakes DD,Sherck JP,Cobb LF

更新日期：1998-02-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of kidney cysts leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Identification of an early biomarker that can predict progression of CKD is urgently needed. In an earlier Consortium for Radiolog...

journal_title：Kidney international

authors： Yu ASL,Shen C,Landsittel DP,Harris PC,Torres VE,Mrug M,Bae KT,Grantham JJ,Rahbari-Oskoui FF,Flessner MF,Bennett WM,Chapman AB,Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP).

更新日期：2018-03-01 00:00:00

abstract：:Long-term treatment (8 and 13 weeks) of rats with FGF-2 led to albuminuria and to increase in serum creatinine indicating the development of chronic renal failure. Histologically, the classic picture of focal segmental glomerulosclerosis (FSGS) was found; males were more severely affected than females. Among the early...

journal_title：Kidney international

authors： Kriz W,Hähnel B,Rösener S,Elger M

更新日期：1995-11-01 00:00:00

abstract：:Lipid abnormalities have been suggested as a major cause of the accelerated atherosclerosis and the high incidence of coronary heart disease in chronic renal failure patients. In the present work the postprandial lipoprotein metabolism was studied in chronic dialysis patients with or without fasting hypertriglyceridem...

journal_title：Kidney international

authors： Weintraub M,Burstein A,Rassin T,Liron M,Ringel Y,Cabili S,Blum M,Peer G,Iaina A

更新日期：1992-11-01 00:00:00

abstract：INTRODUCTION:Transforming growth factor-beta (TGF-beta) is known to play a pivotal role in the regulation of extracellular matrix (ECM) accumulation. Since diabetic nephropathy (DMN) is characterized by basement membrane thickening and mesangial expansion, control of ECM deposition is believed to be important in the pa...

journal_title：Kidney international

authors： Wong TY,Poon P,Chow KM,Szeto CC,Cheung MK,Li PK

更新日期：2003-05-01 00:00:00

abstract：:Pulse wave velocity (PWV) was measured in the aorta, right leg and arm of 90 control subjects (CS) and 92 hemodialysis patients (HD) of the same age and mean arterial pressure (MAP). Blood chemistry, including blood lipids, and echographic dimensions of the aorta, were measured in all subjects. Presence of aortic calc...

journal_title：Kidney international

authors： London GM,Marchais SJ,Safar ME,Genest AF,Guerin AP,Metivier F,Chedid K,London AM

更新日期：1990-01-01 00:00:00

abstract：:Recent evidence suggests that glomerular hypertrophy is a key event in the development of focal and segmental glomerulosclerosis and hyalinosis (FSGS) in humans and in many experimental models of FSGS. The initial aim of the present study was to determine if glomerular hypertrophy occurs in a puromycin aminonucleoside...

journal_title：Kidney international

authors： Cahill MM,Ryan GB,Bertram JF

更新日期：1996-09-01 00:00:00

abstract：:To test the contribution of bicarbonate (Bi) to hemodynamic stability during hemodialysis (HD), we compared the effects of ultrafiltration dialysis with bicarbonate and with acetate under conditions of high-sodium (141 mEq/liter) and low-sodium (130 mEq/liter) dialysate concentrations in 12 stable HD patients. Group 1...

journal_title：Kidney international

authors： Velez RL,Woodard TD,Henrich WL

更新日期：1984-07-01 00:00:00

abstract：:Transport and metabolism of adenosine were studied in the S1, S2, and S3 segments of the rabbit proximal renal tubule. Isolated segments were perfused in vitro with uniformly labelled 14C-adenosine to measure the lumen-to-bath flux of adenosine. This flux rate was measured by the disappearance of 14C from the luminal ...

journal_title：Kidney international

authors： Barfuss DW,McCann WP,Katholi RE

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Protein-calorie malnutrition is common in chronic hemodialysis (CHD) patients and correlates with morbidity and mortality in these patients. There are limited trials evaluating the efficacy of oral nutritional supplementation in malnourished CHD patients. METHODS:Eighty-five CHD patients with evidence of ma...

journal_title：Kidney international

authors： Caglar K,Fedje L,Dimmitt R,Hakim RM,Shyr Y,Ikizler TA

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Nephrotic syndrome is associated with abnormal lipoprotein metabolism and increased risk of coronary heart disease. Endothelial dysfunction, an early phase of atherogenesis that manifests as impaired flow-mediated dilation (FMD) of the peripheral circulation, may link these associations. METHODS:We examined...

journal_title：Kidney international

authors： Watts GF,Herrmann S,Dogra GK,Playford DA,Best JD,Thomas MA,Irish A

更新日期：2001-07-01 00:00:00

abstract：:Adynamic bone disease (ABD) is increasingly recognized, especially in dialysis patients treated with oral calcium carbonate, vitamin D supplements, or supraphysiological dialysate calcium. We undertook this study to assess the effect of lowering dialysate calcium on episodes of hypercalcemia, serum parathyroid hormone...

journal_title：Kidney international

authors： Haris A,Sherrard DJ,Hercz G

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:We evaluated the effects of different concentrations of iron dextran administered through the intraperitoneal route, in iron-deficient rats, on hematocrit (Hct in percentage), serum iron (mg/dL), total iron binding capacity (TIBC in mg/dL), and the function and histology of the peritoneal membrane. METHODS:...

journal_title：Kidney international

authors： Reddy DK,Moore HL,Lee JH,Saran R,Nolph KD,Khanna R,Twardowski ZJ

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:The genetic dissection of a polygenic, multifactorial, quantitative disease such as arterial hypertension is hampered by a large environmental variance and by genetic heterogeneity. METHODS:To reduce the environmental variance, we measured the pressor response to a saline load (PRSL) and the basal plasma re...

journal_title：Kidney international

authors： Barlassina C,Schork NJ,Manunta P,Citterio L,Sciarrone M,Lanella G,Bianchi G,Cusi D

更新日期：2000-03-01 00:00:00