Abstract：
:Problems with vascular access are an important cause of morbidity and mortality in hemodialysis patients. We established a rodent model of arteriovenous fistula by anastomosing the end of a lateral vein to the side of the ventral artery of the rat tail. All operations were technically successful and in all animals the fistula was patent with a dilated fistula vein clearly visible after 28 days. Neointimal hyperplasia was found in 4 out of 5 fistulae with varied pathology from immature to more mature lesions seen both proximal and distal to the anastomosis. There was no particular pattern to the presence of or type of lesion found at any particular site of the fistulae. This fistula promises to be useful in analyzing pathologic processes that occur in native arteriovenous fistulae since the vein is accessible to functional studies and to test new subcutaneous or intravascular treatments.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Lin T,Horsfield C,Robson MGdoi
10.1038/ki.2008.207subject
Has Abstractpub_date
2008-08-01 00:00:00pages
528-31issue
4eissn
0085-2538issn
1523-1755pii
S0085-2538(15)53344-9journal_volume
74pub_type
杂志文章abstract：:It is unknown whether the association between body mass index (BMI) and chronic kidney disease (CKD) is mediated by genetic confounding or obesity-associated diabetes. We investigated the association between BMI and incident CKD in 29,136 Swedish twins with no history of CKD or diabetes, first using traditional Cox re...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2018.12.019
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Rats that recover from acute puromycin nephrosis later develop widespread glomerular and tubulointerstitial injury. The current study sought to identify structural changes present in the recovery phase that could precipitate progressive renal disease. METHODS:Stereologic studies were performed 10 weeks afte...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2002.00481.x
更新日期：2002-08-01 00:00:00
abstract：:Antibody responses to antigens are impaired in humans and animals with chronic renal failure (CRF), and parathyroid hormone (PTH) inhibits Staphylococcus aureus Cowan I (SAC) or pokeweed mitogen (PWM)-induced antibody production by B cells from normal subjects. Since CRF is associated with secondary hyperparathyroidis...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1991.286
更新日期：1991-11-01 00:00:00
abstract：:Intravascular hemolysis is relatively rare but can lead to acute kidney injury (AKI), from increased destruction of erythrocytes and release of free hemoglobin. Since hemolysis and hemoglobinuria are known causes of acute kidney injury we sought to define clinicopathologic findings and outcomes of patients with hemoly...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2019.08.026
更新日期：2019-12-01 00:00:00
abstract：:Unilateral ureteral obstruction in rabbits leads to an influx of macrophages into the kidney, a proliferation of interstitial cells, and an increase in arachidonic acid metabolism. The role of the macrophage in the metabolic changes of hydronephrosis was investigated by using endotoxin and nitrogen mustard. The in viv...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1984.127
更新日期：1984-07-01 00:00:00
abstract：:Low-density lipoprotein was derived from carbamyl (carbamyl-LDL) by incubating LDL in potassium cyanate (KCNO). The proportion of free amino groups in the carbamyl-LDL was negatively correlated (r = -0.95) with the time of incubation in potassium cyanate (ranged from 5 to 360 min). The carbamylation did not change the...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1992.179
更新日期：1992-05-01 00:00:00
abstract：:The selective vasopressin V2-receptor antagonist tolvaptan is eliminated almost exclusively by non-renal mechanisms. As renal impairment can influence the pharmacokinetics of drugs even when eliminated by non-renal mechanisms, we evaluated the effect of renal insufficiency on the pharmacokinetics/pharmacodynamics of t...
journal_title：Kidney international
pub_type： 临床试验,杂志文章
doi：10.1038/ki.2013.350
更新日期：2014-04-01 00:00:00
abstract：:Germ free rats provide a unique model in which to assess biological response to environment. In 48 germ-free male, Sprague-Dawley rats we examined the consequences of oral exposure to nordihydroguaiaretic acid (NDGA), a nephrotoxin; to Staphylococcus epidermidis and bacillus species, non-endotoxin-containing bacteria;...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1987.213
更新日期：1987-09-01 00:00:00
abstract：:Multiple-relapsing minimal-change disease (MCD) often requires exposure to potentially toxic agents in an attempt to achieve a lasting remission of nephrotic syndrome. Munyentwali and co-workers describe an experience using rituximab in adults with multiple-relapsing MCD that supports both efficacy and safety of this ...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2012.412
更新日期：2013-03-01 00:00:00
abstract：:The natural course of idiopathic membranous nephropathy is variable, with some patients slowly progressing to renal failure while others maintain normal renal function over the entire time. Whether to treat this disease or not is controversial due to the lack of controlled data about the long-term effects of treatment...
journal_title：Kidney international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/ki.1995.453
更新日期：1995-11-01 00:00:00
abstract：:Plasma lipid and lipoprotein concentration and high density lipoprotein (HDL) kinetics were determined in control subjects and patients with chronic renal failure (CRF). Results demonstrated that plasma triglyceride (TG) concentration was significantly higher (P less than 0.001) in patients with CRF, associated with a...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1990.114
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND:Rho proteins are small guanine 5'-triphosphate (GTP)-binding proteins felt to be important regulators of several aspects of cell function, including the organization of the actin cytoskeleton. The effects of Rho proteins on the regulation of renal tubular epithelial cell function are not known. METHODS:Sele...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2000.00372.x
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:Chemokine receptor 5 (CCR5) plays an important role in the recruitment of monocytes and T cells in inflammation and experimental studies suggest that CCR5 might be involved in the pathogenesis of IgA nephropathy. A mutation in the CCR5 gene (CCR5 Delta32), leading to a nonfunctional receptor, was recently de...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.00057.x
更新日期：2005-01-01 00:00:00
abstract：:To determine the prognosis and risk factors for ischemic heart disease in chronic uremia, a cohort of 432 dialysis patients were followed prospectively from start of dialysis therapy until death or renal transplantation. Baseline demographic, clinical and echocardiographic data were obtained. After the initiation of d...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1996.201
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND:The use of renal Kt/V (r-Kt/V) as an indicator for the need of dialysis initiation has been recommended in the NKF-DOQI guidelines. In analogy to clinical practice in peritoneal dialysis, a fall of r-Kt/V below a threshold of 2.0 per week may indicate inadequate renal toxin elimination. However, there are no...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.00957.x
更新日期：2001-10-01 00:00:00
abstract：:The possibility that the rabbit collecting tubule is heterogeneous with respect to electrical and morphologic properties was examined in isolated segments. Collecting tubules from rabbits treated with desoxycorticosterone acetate were dissected from various locations within the cortex and outer medulla, and the transe...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1978.167
更新日期：1978-12-01 00:00:00
abstract：:Vascular calcification is a recognized risk factor for cardiovascular mortality in patients with end-stage renal disease. The aim of this study was to identify risk factors for vascular access calcification and to determine if patients with this disorder are at increased risk of death. Vascular access calcification wa...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2008.458
更新日期：2008-12-01 00:00:00
abstract：:Modern dietary habits are characterized by high-sodium and low-potassium intakes, each of which was correlated with a higher risk for hypertension. In this study, we examined whether long-term variations in the intake of sodium and potassium induce lasting changes in the plasma concentration of circulating steroids by...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2011.15
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:The parathyroid (PT) hyperplasia induced by renal failure can be further enhanced by high dietary phosphate (P) or completely abolished by P restriction. To identify potential mechanisms mediating these opposing effects of dietary P on PT growth, this study first focused on p21(WAF1) (p21) because high P red...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.059003855.x
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:Gene expression analysis is an invaluable tool in the study of diabetic glomerulosclerosis. The necessary denominator for the quantitative expression of a specific gene is the expression level of a second gene that is presumed to remain unchanged. Thus, it is critical that the stability of this housekeeping ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2004.66016.x
更新日期：2004-12-01 00:00:00
abstract：:Here we studied a possible association between low parathyroid hormone (PTH) status and mortality in incident patients undergoing hemodialysis . A total of 1983 patients were included at baseline and prospectively followed for 24 months. Patients were classified according to their Kidney Disease: Improving Global Outc...
journal_title：Kidney international
pub_type： 杂志文章,多中心研究
doi：10.1016/j.kint.2015.12.001
更新日期：2016-03-01 00:00:00
abstract：:Because the size of renal cysts in the native kidneys of patients with ADPKD who have been transplanted was found to be reduced when rapamycin was the immunosuppressant, we tested the involvement of the mTOR pathway in cyst enlargement. Here, male pcy mice, with mutation in one of the nephronophthisis genes, were trea...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2009.147
更新日期：2009-07-01 00:00:00
abstract：:In six healthy males on a fixed sodium/potassium (Na/K) intake, we studied the relation between plasma K and urine K and Na excretion after an oral K load. Studies were repeated during fludrocortisone (0.5 mg bid) or spironolactone (50 mg qid), that is, after escape from the Na-retaining and Na-excreting effects of th...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1988.235
更新日期：1988-11-01 00:00:00
abstract：BACKGROUND:Bone marrow reconstitution using genetically-modified hematopoietic stem cells has been reported to confer resistance to inflammation and prevent renal injury in glomerulonephritis. Although this strategy has potentials for clinical use, taking hematopoietic stem cells from bone marrow is highly stressful fo...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2003.00046.x
更新日期：2003-07-01 00:00:00
abstract：:Long-term outcomes of kidney allografts have shown only marginal improvement over the last three decades, despite the remarkable improvement in acute rejection and one-year graft survival. Novel biomarkers of tubular injury may prevent irreversible damage to the tubulointerstitial compartment and improve allograft sur...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/sj.ki.5002772
更新日期：2008-03-01 00:00:00
abstract：:Experimental studies have demonstrated the cardinal role played by the mononuclear phagocyte system in the removal of antigen-antibody complexes. To assess the functional capacity of phagocytes in patients with renal disease, 33 normal subjects, 10 patients with mesangial proliferative glomerulonephritis, 8 patients w...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1983.105
更新日期：1983-06-01 00:00:00
abstract：:The relationship between commonly occurring genetic variants (G1 and G2) in the APOL1 gene in African Americans and different disease traits, such as kidney disease, cardiovascular disease, and pre-eclampsia, remains the subject of controversy. Here we took a genotype-first approach, a phenome-wide association study, ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.01.027
更新日期：2020-05-01 00:00:00
abstract：:This report describes the occurrence of immune complex glomerulonephritis in a patient with eosinophilic gastroenteritis and food hypersensitivity. A coincident allergen injection may have been a contributing factor in the sudden development of the nephrotic syndrome. Markedly elevated levels of circulating immune com...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1986.226
更新日期：1986-10-01 00:00:00
abstract：BACKGROUND:Regular access monitoring is recommended to detect and treat access stenosis in order to prevent access thrombosis and failure. METHODS:In 1999, we instituted monthly access blood flow monitoring using the ultrasound dilution technique (UDT). In a sequential observational trial, 222 patients were studied fo...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.00697.x
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:Hyperlipidemia is a risk factor for long-term renal transplant dysfunction, but no prospective clinical trials have investigated the effects of statin treatment on graft function in renal transplant recipients. The aim of the present study was to evaluate the effect of fluvastatin on long-term renal transpla...
journal_title：Kidney international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1523-1755.2004.00919.x
更新日期：2004-10-01 00:00:00
