当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Cyclooxygenase-2 (COX-2) inhibition limits abnormal COX-2 expression and progressive injury in the remnant kidney.

Cyclooxygenase-2 (COX-2) inhibition limits abnormal COX-2 expression and progressive injury in the remnant kidney.

Abstract：

BACKGROUND:The pathogenesis of progressive nephropathies involves hemodynamic and inflammatory factors. In the 5/6 nephrectomy model, a selective increase of cyclooxygenase-2 (COX-2) expression was shown, whereas treatment with a nonsteroidal anti-inflammatory or a specific COX-2 inhibitor was renoprotective. We investigated in the 5/6 nephrectomy model (1) the renal distribution of COX-2; (2) the hemodynamic and cellular mechanisms by which chronic COX-2 inhibition prevents renal injury. METHODS:After 5/6 nephrectomy, adult male Munich-Wistar rats were subdivided in two groups: 5/6 nephrectomy (N=20), receiving vehicle, and 5/6 nephrectomy + celecoxib (N=19), treated orally with the COX-2 inhibitor, celecoxib, 10 mg/kg/day. Untreated and treated (celecoxib) sham-operated rats were also studied. Renal hemodynamics were examined at 4 weeks, whereas renal morphologic/immunohistochemical studies were carried at 8 weeks. RESULTS:At 4 weeks, 5/6 nephrectomy rats exhibited marked systemic and glomerular hypertension. Celecoxib attenuated both systemic and glomerular hypertension, without affecting glomerular filtration rate (GFR). At 8 weeks, glomerulosclerosis and interstitial expansion were evident in 5/6 nephrectomy rats, and markedly attenuated in 5/6 nephrectomy rats given celecoxib. In both sham-operated and 5/6 nephrectomy rats, COX-2 was expressed at the macula densa. The extent of COX-2 expression at the macula densa was nearly tripled by celecoxib, indicating the existence of a feedback mechanism. In 5/6 nephrectomy rats, COX-2 was also expressed in glomeruli, arterioles, and the cortical interstitium, mostly at inflamed or sclerosing areas. Celecoxib markedly attenuated renal injury, inflammation, and ectopic COX-2 expression in 5/6 nephrectomy rats. CONCLUSION:Chronic COX-2 inhibition attenuated progressive nephropathy by reducing glomerular hypertension, renal inflammation, and ectopic COX-2 expression, indicating a complex contribution of COX-2 to progressive renal injury in 5/6 nephrectomy rats.

journal_name

Kidney Int

journal_title

Kidney international

authors

Fujihara CK,Antunes GR,Mattar AL,Andreoli N,Malheiros DM,Noronha IL,Zatz R

doi

10.1046/j.1523-1755.2003.00319.x

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

2172-81

issue

6

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)49586-9

journal_volume

64

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Novel inflammatory mechanisms of accelerated atherosclerosis in kidney disease.

    abstract：:A substantial body of evidence has accumulated linking an increased incidence of cardiovascular disease in patients with acute kidney injury (AKI), chronic kidney disease (CKD), and end-stage renal disease (ESRD). A multitude of novel risk factors related to decreased kidney function might interact with the renal and ...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.2011.178

    authors： Swaminathan S,Shah SV

    更新日期：2011-09-01 00:00:00

  • Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.

    abstract：:Mutations in the complement regulatory proteins are associated with several different diseases. Although these mutations cause dysregulated alternative pathway activation throughout the body, the kidneys are the most common site of injury. The susceptibility of the kidney to alternative pathway-mediated injury may be ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.02.036

    authors： Laskowski J,Renner B,Le Quintrec M,Panzer S,Hannan JP,Ljubanovic D,Ruseva MM,Borza DB,Antonioli AH,Pickering MC,Holers VM,Thurman JM

    更新日期：2016-07-01 00:00:00

  • Expression of a monoclonal antibody (3G5) defined ganglioside antigen in the renal cortex.

    abstract：:The monoclonal antibody (mAb) 3G5 was found, by indirect immunofluorescence, to bind to renal cortical structures in frozen sections of human, rat and calf kidneys. Double indirect immunofluorescence studies on frozen sections of rat kidneys showed that 3G5 stained only the glomerulus and the distribution of the 3G5 a...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1992.236

    authors： Nayak RC,Attawia MA,Cahill CJ,King GL,Ohashi H,Moromisato R

    更新日期：1992-06-01 00:00:00

  • Increased expression of a brain/embryo-type myosin heavy chain isoform (MIIB2) in mesangial proliferative glomerulonephritis.

    abstract：:Proliferation of mesangial cells is frequently found in glomerulonephritis, such as IgA glomerulonephritis. Recent reports suggest that a brain/embryo-type myosin isoform (MIIB2) is involved in cell proliferation. We have studied the expression of MIIB2 in renal biopsy samples from patients with various renal diseases...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.191

    authors： Kishino M,Kimura A,Yamaguchi K,Ohtani H,Yamada Y,Takahashi T,Mune M,Mimura K,Maeda T,Matsumura S,Tsuji T,Yukawa S

    更新日期：1996-05-01 00:00:00

  • Epidemiology of atherosclerotic renal artery stenosis as a mirror of prospective trials.

    abstract：:Diagnosis and treatment of atherosclerotic renal artery stenosis (ARAS) in the elderly is a never-ending challenge for every nephrologist. Kalra et al. report that adjusted hazard ratios for ARAS increased threefold from 1992 to 2004 in 16 million United States Renal Data System participants aged 66 years or older. Ho...

    journal_title：Kidney international

    pub_type： 信件

    doi：10.1038/ki.2009.326

    authors： Krumme B

    更新日期：2010-01-01 00:00:00

  • Gene therapy in renal diseases.

    abstract：:Kidney-targeted gene therapy could be an ideal treatment for renal diseases since the therapeutic molecule is limited in the kidney and the systemic effect may be minimized. The technical development of the gene delivery to kidney and the identification of the responsive gene for a particular disease encourage the cha...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1111/j.1523-1755.2004.05409.x

    authors： Imai E,Takabatake Y,Mizui M,Isaka Y

    更新日期：2004-05-01 00:00:00

  • The podocyte's response to injury: role in proteinuria and glomerulosclerosis.

    abstract：:The terminally differentiated podocyte, also called glomerular visceral epithelial cell, are highly specialized cells. They function as a critical size and charge barrier to prevent proteinuria. Podocytes are injured in diabetic and non-diabetic renal diseases. The clinical signature of podocyte injury is proteinuria,...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/sj.ki.5000410

    authors： Shankland SJ

    更新日期：2006-06-01 00:00:00

  • Binding inhibitors restore furosemide potency in tubule fluid containing albumin.

    abstract：:We have previously suggested that albumin in tubule fluid at concentrations found in the nephrotic syndrome (NS) binds furosemide, thereby diminishing diuretic effect. This mechanism may contribute to diuretic resistance in NS. If this hypothesis is correct, displacement of albumin from furosemide should restore diure...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1991.228

    authors： Kirchner KA,Voelker JR,Brater DC

    更新日期：1991-09-01 00:00:00

  • Role of an improvement in acid-base status and nutrition in CAPD patients.

    abstract：:Short-term correction of metabolic acidosis in normal and uremic subjects has been shown to decrease protein degradation, but the long-term effects of better correction of acidosis on nutrition in ESRF are unknown. The aim of this study was to assess the possible benefits, in the nutritional state and morbidity, of im...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/ki.1997.433

    authors： Stein A,Moorhouse J,Iles-Smith H,Baker F,Johnstone J,James G,Troughton J,Bircher G,Walls J

    更新日期：1997-10-01 00:00:00

  • Differential expression of transforming growth factor-beta isoforms and receptors in experimental membranous nephropathy.

    abstract：:In membranous nephropathy (MN) overproduction of matrix by glomerular epithelial cells (GEC) is believed to be responsible for glomerular basement membrane thickening and spikes. We studied experimental MN in rats (passive Heymann nephritis, PHN) at 5, 10 and 30 days. PHN rats exhibited a marked increase in GEC immuno...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.294

    authors： Shankland SJ,Pippin J,Pichler RH,Gordon KL,Friedman S,Gold LI,Johnson RJ,Couser WG

    更新日期：1996-07-01 00:00:00

  • Sarcopenia and its individual criteria are associated, in part, with mortality among patients on hemodialysis.

    abstract：:The relative importance of sarcopenia and its individual components as independent predictors of mortality in the dialysis population has not been determined. We estimated whole-body muscle mass using pre-dialysis bioimpedance spectroscopy measurements in 645 ACTIVE/ADIPOSE-enrolled prevalent hemodialysis patients fro...

    journal_title：Kidney international

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.kint.2017.01.024

    authors： Kittiskulnam P,Chertow GM,Carrero JJ,Delgado C,Kaysen GA,Johansen KL

    更新日期：2017-07-01 00:00:00

  • Distribution of pyruvate carboxylase along the rat nephron: an immunological and enzymatic study.

    abstract：:Antibodies against purified rat-kidney-cortex pyruvate carboxylase were raised in rabbits. These polyspecific antibodies recognize pyruvate carboxylase enzymes alone without cross reactivity with other carboxylases as detected by immunoblotting. The abundance of pyruvate carboxylase in the various renal fractions was ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1991.147

    authors： Salto R,Oliver J,del Mar Sola M,Vargas AM

    更新日期：1991-06-01 00:00:00

  • Characterization of receptors for osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7) in rat kidneys.

    abstract：BACKGROUND:Osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7), a member of the transforming growth factor-beta superfamily, has been shown to prevent kidney damage from ischemia/reperfusion injury in rats. The molecular events involved in OP-1 action on kidney are not yet understood. METHODS:In this study,...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2000.00362.x

    authors： Bosukonda D,Shih MS,Sampath KT,Vukicevic S

    更新日期：2000-11-01 00:00:00

  • Predicting renal survival in primary focal glomerulosclerosis from the time of presentation.

    abstract：UNLABELLED:Predicting renal survival in primary focal glomerulosclerosis from the time of presentation. BACKGROUND:To predict the risk of developing chronic renal failure in patients with primary focal glomerulosclerosis (FGS) using predictors available at the time of presentation, a retrospective analysis was perform...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.4491164

    authors： Chitalia VC,Wells JE,Robson RA,Searle M,Lynn KL

    更新日期：1999-12-01 00:00:00

  • A common-source outbreak of fulminant hepatitis B in hemodialysis patients induced by precore mutant.

    abstract：:From September 9 to October 3, 1994, five patients on maintenance hemodialysis in a dialysis unit in Tokyo contracted hepatitis B virus (HBV) infection successively, and four of them died of fulminant hepatitis. The unit treated 181 patients three times a week on eight shifts, and all five afflicted patients were on t...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.499

    authors： Tanaka S,Yoshiba M,Iino S,Fukuda M,Nakao H,Tsuda F,Okamoto H,Miyakawa Y,Mayumi M

    更新日期：1995-12-01 00:00:00

  • Youthful systemic milieu alleviates renal ischemia-reperfusion injury in elderly mice.

    abstract：:The incidence of acute kidney injury (AKI) is high in elderly people, and is difficult to prevent and treat. One of its major causes is renal ischemia-reperfusion injury (IRI). A young systemic environment may prevent the senescence of old organs. However, it is unknown whether a young milieu may reduce renal IRI in t...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2018.03.019

    authors： Liu D,Lun L,Huang Q,Ning Y,Zhang Y,Wang L,Yin Z,Zhang Y,Xia L,Yin Z,Fu B,Cai G,Sun X,Chen X

    更新日期：2018-08-01 00:00:00

  • Graft survival after renal transplantation: agenda for analysis.

    abstract：:Simple life-table analyses have not identified the reasons for the steady improvement over the years in graft survival. The use of more sophisticated multifactorial statistical techniques is indicated to identify prognostic factors and to explore the "center effect" on graft survival. An agenda for retrospective analy...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1983.188

    authors： Gore SM

    更新日期：1983-10-01 00:00:00

  • Coronary artery stenosis: a new risk factor for chronic kidney injury?

    abstract：:Coronary artery stenosis induces renal inflammation and kidney injury in pigs even in the absence of myocardial infarction or clinically significant heart failure. This effect is aggravated by experimentally induced renovascular hypertension. Interestingly, oxidative stress originating from the ischemic myocardium was...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2014.431

    authors： Rump LC,Stegbauer J

    更新日期：2015-04-01 00:00:00

  • Stimulation of renin secretion by non-diuretic sulfhydryl reagents.

    abstract：:Organomercurial diuretics stimulate renin secretion although the underlying cellular mechanisms remain undefined. Since organomercurials are also known to react with sulfhydryl groups, the present studies determined the effects of sulfhydryl reagents on renin secretion. The effects of the non-diuretic mercurial agent,...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.57

    authors： Lee DY,Cho KW,Lee JS,Honeyman TW,Park CS

    更新日期：1989-03-01 00:00:00

  • Antineutrophil cytoplasm antibody-induced neutrophil nitric oxide production is nitric oxide synthase independent.

    abstract：BACKGROUND:Antineutrophil cytoplasm antibodies (ANCAs) are implicated in the pathogenesis of systemic vasculitis. We asked whether ANCA could induce nitric oxide (NO) release from human neutrophils and, if so, whether this NO production was dependent on NO synthase (NOS) activity. METHODS:Neutrophil NO production was ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.059002593.x

    authors： Tse WY,Williams J,Pall A,Wilkes M,Savage CO,Adu D

    更新日期：2001-02-01 00:00:00

  • Recombinant human growth hormone exacerbates chronic puromycin aminonucleoside nephropathy in rats.

    abstract：:Growth failure is a cardinal feature of chronic renal failure in children. Administration of recombinant human growth hormone (rhGH) ameliorates this problem but may adversely affect the kidney and hasten the progression to end-stage renal disease. We conducted experiments to examine the impact of rhGH on the severity...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1993.380

    authors： Trachtman H,Futterweit S,Schwob N,Maesaka J,Valderrama E

    更新日期：1993-12-01 00:00:00

  • Enhanced renoprotective effects of ultrahigh doses of irbesartan in patients with type 2 diabetes and microalbuminuria.

    abstract：BACKGROUND:The purpose of this study was to evaluate the renoprotective effect as reflected by short-term changes in albuminuria of ultrahigh doses of irbesartan in type 2 diabetic patients with microalbuminuria. METHODS:This double-masked randomized crossover trial included 52 (41 males) hypertensive type 2 diabetic ...

    journal_title：Kidney international

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1523-1755.2005.00511.x

    authors： Rossing K,Schjoedt KJ,Jensen BR,Boomsma F,Parving HH

    更新日期：2005-09-01 00:00:00

  • Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management.

    abstract：:Steroid Resistant Nephrotic Syndrome (SRNS) in children and young adults has differing etiologies with monogenic disease accounting for 2.9-30% in selected series. Using whole exome sequencing we sought to stratify a national population of children with SRNS into monogenic and non-monogenic forms, and further define t...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.10.013

    authors： Bierzynska A,McCarthy HJ,Soderquest K,Sen ES,Colby E,Ding WY,Nabhan MM,Kerecuk L,Hegde S,Hughes D,Marks S,Feather S,Jones C,Webb NJ,Ognjanovic M,Christian M,Gilbert RD,Sinha MD,Lord GM,Simpson M,Koziell AB,Welsh

    更新日期：2017-04-01 00:00:00

  • Circulating immune complexes in membranoproliferative glomerulonephritis.

    abstract：:Circulating immune complexes (CIC), measured by the solid-phase Clq method, were found to be in abnormal concentration in about half of 39 patients with membranoproliferative glomerulonephritis (MPGN). In contrast, they were present, usually in higher concentration, in nearly all patients with active lupus nephritis. ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1981.203

    authors： Davis CA,Marder H,West CD

    更新日期：1981-12-01 00:00:00

  • Endothelial nitric oxide synthase: from structure to function in one aspartic substitution.

    abstract：:Cherney and co-workers examine the functional phenotype of the G894T eNOS polymorphism in a selected group of apparently healthy subjects. The investigators used L-arginine infusion and induced changes in renal hemodynamics. While L-arginine increased effective plasma flow and glomerular filtration rate in GG subjects...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2008.605

    authors： Goligorsky MS

    更新日期：2009-02-01 00:00:00

  • Coordinate regulation of canine glomeruli and adrenal angiotensin receptors by dietary sodium manipulation.

    abstract：BACKGROUND:This study evaluated the effects of dietary sodium manipulation in dogs on the regulation of canine angiotensin receptors (cAT1 and cAT2) in the kidney and adrenal. METHODS:Isolated glomeruli and membranes from renal medulla and the adrenal gland were used in radioligand binding assays from two groups of do...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.0590051881.x

    authors： Zheng W,Ji H,Szabo Z,Brown PR,Yoo SE,Sandberg K

    更新日期：2001-05-01 00:00:00

  • The risks and benefits of a low protein-essential amino acid-keto acid diet.

    abstract：:Twelve patients with progressive renal failure were placed on a very low protein diet supplemented by an essential amino acid-keto acid mixture for six to twelve months. Total daily intake was 0.04 g nitrogen/kg and 50 kcal/kg. Eight subjects had a significant change in the slope of reciprocal plasma creatinine, becom...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1986.99

    authors： Lucas PA,Meadows JH,Roberts DE,Coles GA

    更新日期：1986-05-01 00:00:00

  • Transcriptome analysis of a rat PKD model: Importance of genes involved in extracellular matrix metabolism.

    abstract：:Transcriptome analysis of a rat polycystic kidney disease (PKD) model: importance of genes involved in extracellular matrix metabolism. PKD is a common genetic cause of chronic renal failure, and is characterized by the accumulation of fluid-filled cysts in the kidneys and other organs. Abnormalities in the expression...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000309

    authors： Riera M,Burtey S,Fontés M

    更新日期：2006-05-01 00:00:00

  • Mineralocorticoid activity and the excretion of an oral potassium load in normal man.

    abstract：:In six healthy males on a fixed sodium/potassium (Na/K) intake, we studied the relation between plasma K and urine K and Na excretion after an oral K load. Studies were repeated during fludrocortisone (0.5 mg bid) or spironolactone (50 mg qid), that is, after escape from the Na-retaining and Na-excreting effects of th...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.235

    authors： Hené RJ,Koomans HA,Rabelink AJ,Boer P,Dorhout Mees EJ

    更新日期：1988-11-01 00:00:00

  • LECT2 amyloidosis.

    abstract：:LECT2 amyloidosis is the latest systemic type of amyloidosis to be described. It was discovered in patients with nephrotic syndrome and renal failure and is characterized by amyloid deposition in glomeruli, renal vessels, and interstitium. Clinical and pathological features of earlier phases of this type of amyloidosi...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2010.18

    authors： Benson MD

    更新日期：2010-05-01 00:00:00