Distribution of pyruvate carboxylase along the rat nephron: an immunological and enzymatic study.

abstract：BACKGROUND:Decreased red blood cell survival contributes to the anemia of chronic renal failure patients. Because patients on chronic dialysis therapy are frequently exposed to excessive complement activation, we investigated the susceptibility of this patient population to erythrocyte C5b-9 deposition, complement-medi...

journal_title：Kidney international

authors： Himmelfarb J,McMonagle E,Holbrook D,Hakim R

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Cadaveric renal transplantation is associated with a survival advantage compared with dialysis patients remaining on the renal transplantation waiting list, but this advantage has not been confirmed in obese end-stage renal disease (ESRD) patients. METHODS:Using data from the USRDS, we studied 7521 patients...

journal_title：Kidney international

authors： Glanton CW,Kao TC,Cruess D,Agodoa LY,Abbott KC

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Among the members of the small leucine-rich proteoglycan family, decorin, biglycan, and fibromodulin have been proposed to be potent modulators of transforming growth factor-beta (TGF-beta) activity, thereby playing an important role in the pathogenesis of fibrotic kidney diseases. Furthermore, decorin expre...

journal_title：Kidney international

authors： Schaefer L,Gröne HJ,Raslik I,Robenek H,Ugorcakova J,Budny S,Schaefer RM,Kresse H

更新日期：2000-10-01 00:00:00

abstract：:The present study was undertaken to evaluate some pathophysiological mechanisms of edema formation in diabetic nephropathy. Sixty-three subjects were investigated: 9 normal subjects (I), 9 normoalbuminuric Type 1 (insulin-dependent) diabetic patients (II), 15 microalbuminuric Type 1 diabetic patients (III), 16 Type 1 ...

journal_title：Kidney international

authors： Hommel E,Mathiesen ER,Aukland K,Parving HH

更新日期：1990-12-01 00:00:00

abstract：:The aging process in humans and in the rat is associated with an impairment in renal tubular reabsorption of Pi and renal tubular adaptation to a low Pi diet. The purposes of the present study were to determine whether changes in the abundance of type II Na-Pi contransporter (NaPi-2) protein and/or mRNA play a role in...

journal_title：Kidney international

authors： Sorribas V,Lötscher M,Loffing J,Biber J,Kaissling B,Murer H,Levi M

更新日期：1996-09-01 00:00:00

abstract：:The effect of glycine on hypoxia- and ionomycin-induced increases in calpain activity in rat proximal tubules was determined. Calpain activity was determined both in vitro and in the intact cell using the fluorescent substrate N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methyl coumarin (N-succinyl-Leu-Leu-Val-Tyr-AMC) and We...

journal_title：Kidney international

authors： Edelstein CL,Ling H,Gengaro PE,Nemenoff RA,Bahr BA,Schrier RW

更新日期：1997-11-01 00:00:00

abstract：:Progressive renal vascular sclerosis is a key feature of chronic kidney disease (CKD). Adiponectin, an adipokine with potent anti-inflammatory and antiatherosclerotic properties, is associated with insulin resistance, type II diabetes and cardiovascular disease. In this study, we evaluated the predictive value of adip...

journal_title：Kidney international

authors： Kollerits B,Fliser D,Heid IM,Ritz E,Kronenberg F,MMKD Study Group.

更新日期：2007-06-01 00:00:00

abstract：:Healthy male rats were exposed to a chronic ingesta of an isotonic NaCl solution during a period of four months. Two different preparations were utilized to study the effect of this treatment on the active mechanisms of Na+ reabsorption of kidney proximal tubular cells: outermost kidney cortex slices (rich in proximal...

journal_title：Kidney international

authors： Marín R,Obando MA,Proverbio T,Proverbio F

更新日期：1986-10-01 00:00:00

abstract：:Intravenous conjugated estrogens reduce the prolonged bleeding time in uremic patients and in a rat model of uremia. However, estrogens have major side effects related to their hormonal activity. We investigated whether a beta-resorcylic acid lactone, zeranol (a compound with close spatial similarity to estrogens but ...

journal_title：Kidney international

authors： Zoja C,Viganò G,Corna D,Salmona M,Remuzzi G,Garattini S

更新日期：1990-07-01 00:00:00

abstract：:Initiation of dialysis is associated with increased morbidity and mortality. However, a question could be asked whether these events are caused by initiation of dialysis or whether dialysis serves as a trigger unveiling or worsening underlying preexisting cardiovascular comorbidities that could be pre-treated. ...

journal_title：Kidney international

authors： Zareba W

更新日期：2015-11-01 00:00:00

abstract：:We have developed an immunological procedure for measuring advanced glycosylation end-products (AGEs) in serum. Using this method, we measured AGEs in healthy volunteers, patients with diabetes, renal failure without treatment and in patients with renal failure, treated with hemodialysis (HD) or continuous ambulatory ...

journal_title：Kidney international

authors： Papanastasiou P,Grass L,Rodela H,Patrikarea A,Oreopoulos D,Diamandis EP

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Variant forms of lysozyme, a ubiquitous bacteriolytic enzyme, are known to lead to hereditary non-neuropathic renal amyloidosis and, so far, three different mutations of the lysozyme gene have been reported. In this study, we report a novel lysozyme variant, Phe57Ile, associated with renal amyloidosis in thr...

journal_title：Kidney international

authors： Yazaki M,Farrell SA,Benson MD

更新日期：2003-05-01 00:00:00

abstract：:We analyzed clinical and pathologic data from 36 recipients of 38 renal allografts who developed nephrotic syndrome following transplantation. Three groups were identified on the basis of histologic changes in the graft, and each group had a distinct clinical course. Nine grafts (23.7%) had recurrent glomerulonephriti...

journal_title：Kidney international

authors： Cheigh JS,Mouradian J,Susin M,Stubenbord WT,Tapia L,Riggio RR,Stenzel KH,Rubin AL

更新日期：1980-09-01 00:00:00

abstract：:Tubulointerstitial fibrosis is one of the most important histologic features that predicts progression in kidney disease. Thrombospondin 1 is an extracellular matrix protein that can activate latent TGF-beta, a cytokine implicated in the pathogenesis of tubulointerstitial fibrosis. We examined the expression of thromb...

journal_title：Kidney international

authors： Hugo C,Shankland SJ,Pichler RH,Couser WG,Johnson RJ

更新日期：1998-02-01 00:00:00

abstract：:Neuropilin1 (Nrp1) is a co-receptor best known to regulate the development of endothelial cells and is a target of anticancer therapies. However, its role in other vascular cells including pericytes is emergent. The kidney is an organ with high pericyte density and cancer patients develop severe proteinuria following ...

journal_title：Kidney international

authors： Wnuk M,Anderegg MA,Graber WA,Buergy R,Fuster DG,Djonov V

更新日期：2017-04-01 00:00:00

abstract：:Recent linkage analyses of nondiabetic African-American patients with focal segmental glomerulosclerosis (FSGS) have identified MYH9, encoding nonmuscle myosin heavy chain IIA (NMMHC-IIA), as a gene having a critical role in this disease. Abnormalities of the MYH9 locus also underlie rare autosomal dominant diseases s...

journal_title：Kidney international

authors： Sekine T,Konno M,Sasaki S,Moritani S,Miura T,Wong WS,Nishio H,Nishiguchi T,Ohuchi MY,Tsuchiya S,Matsuyama T,Kanegane H,Ida K,Miura K,Harita Y,Hattori M,Horita S,Igarashi T,Saito H,Kunishima S

更新日期：2010-07-01 00:00:00

abstract：:Tremendous progress has been made over recent years in the understanding of the mechanisms regulating calcium, phosphorus, vitamin D, and parathyroid hormone homeostasis in the normal human body and in patients with different degrees of renal failure. In addition, some of these findings have been translated into clini...

journal_title：Kidney international

authors： De Broe ME

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Lipoprotein glomerulopathy (LPG) is characterized by intraglomerular lipoprotein thrombosis and high plasma concentrations of apolipoprotein (apo) E. An apo E variant, apo E2 (Arg145Pro) Sendai, was recently identified in three patients with LPG. We detected a novel point mutation in the apo E gene in a pati...

journal_title：Kidney international

authors： Matsunaga A,Sasaki J,Komatsu T,Kanatsu K,Tsuji E,Moriyama K,Koga T,Arakawa K,Oikawa S,Saito T,Kita T,Doi T

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:The growth hormone (GH)/insulin-like growth factor (IGF) system is thought to participate in the glomerulosclerosis process. Because IGF-binding proteins (IGFBPs) modulate IGF actions and hence GH secretion, this study assessed whether mice transgenic for human IGFBP-1 have altered susceptibility to glomerul...

journal_title：Kidney international

authors： Doublier S,Seurin D,Fouqueray B,Verpont MC,Callard P,Striker LJ,Striker GE,Binoux M,Baud L

更新日期：2000-06-01 00:00:00

abstract：:Aboriginal dialysis patients have reduced access to kidney transplantation. The reasons for this disparity are unknown. Tonelli et al. show that in Canada, residence location does not significantly impact on an Aboriginal dialysis patient's likelihood of receiving kidney transplantation. This Commentary explores the i...

journal_title：Kidney international

authors： Yeates KE

更新日期：2006-09-01 00:00:00

abstract：:Growth failure is a cardinal feature of chronic renal failure in children. Administration of recombinant human growth hormone (rhGH) ameliorates this problem but may adversely affect the kidney and hasten the progression to end-stage renal disease. We conducted experiments to examine the impact of rhGH on the severity...

journal_title：Kidney international

authors： Trachtman H,Futterweit S,Schwob N,Maesaka J,Valderrama E

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:There is growing evidence pointing to an involvement of cytokines and growth factors in renal osteodystrophy. In this study, the expression of interleukin-l beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), and basic fibroblast growth factor (bFGF) in bone...

journal_title：Kidney international

authors： Santos FR,Moysés RM,Montenegro FL,Jorgetti V,Noronha IL

更新日期：2003-03-01 00:00:00

abstract：:Gap junctions are present in the juxtaglomerular apparatus enabling intercellular communication. Our study determined the location of different connexin subtypes within the juxtaglomerular apparatus of the rat, and the role of these subtypes in renal hemodynamics through the use of specific mimetic peptides. Immunohis...

journal_title：Kidney international

authors： Takenaka T,Inoue T,Kanno Y,Okada H,Meaney KR,Hill CE,Suzuki H

更新日期：2008-02-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) is known to suppress platelet-derived growth factor (PDGF)-stimulated proliferation of rat cultured vascular smooth muscle cells. The present study examined whether ANP inhibits the PDGF receptor (PDGFR) tyrosine kinase activation, an initial event for PDGF cellular signaling. ANP redu...

journal_title：Kidney international

authors： Awazu M

更新日期：1997-08-01 00:00:00

abstract：:Apoptosis mediated by verotoxins (VTs) has been identified in a renal carcinoma cell line, ACHN cells, which are an in vitro model of renal tubular epithelial cells. ACHN cells express the renal tubular marker CD24 as well as globotriaosyl ceramide/CD77, the receptor for VTs. VT binding to the ACHN cell surface was co...

journal_title：Kidney international

authors： Taguchi T,Uchida H,Kiyokawa N,Mori T,Sato N,Horie H,Takeda T,Fujimoto J

更新日期：1998-06-01 00:00:00

abstract：:The purpose of this prospective, angiographically controlled study was to determine the diagnostic value of color Doppler sonography with two differing approaches of scanning in patients with clinical clues for renal artery stenosis (RAS). In 135 hypertensive patients peak systolic velocity in the main renal arteries ...

journal_title：Kidney international

authors： Krumme B,Blum U,Schwertfeger E,Flügel P,Höllstin F,Schollmeyer P,Rump LC

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Antineutrophil cytoplasm antibodies (ANCAs) are implicated in the pathogenesis of systemic vasculitis. We asked whether ANCA could induce nitric oxide (NO) release from human neutrophils and, if so, whether this NO production was dependent on NO synthase (NOS) activity. METHODS:Neutrophil NO production was ...

journal_title：Kidney international

authors： Tse WY,Williams J,Pall A,Wilkes M,Savage CO,Adu D

更新日期：2001-02-01 00:00:00

abstract：:To test the contribution of bicarbonate (Bi) to hemodynamic stability during hemodialysis (HD), we compared the effects of ultrafiltration dialysis with bicarbonate and with acetate under conditions of high-sodium (141 mEq/liter) and low-sodium (130 mEq/liter) dialysate concentrations in 12 stable HD patients. Group 1...

journal_title：Kidney international

authors： Velez RL,Woodard TD,Henrich WL

更新日期：1984-07-01 00:00:00

abstract：:To maintain nitrogen equilibrium when prescribed a low protein diet (LPD), metabolic adaptations occur involving a reduction protein turnover, principally decreased muscle protein degradation. Studies suggest that in patients with chronic renal failure (CRF) uncomplicated by metabolic acidosis (MA), these adaptive res...

journal_title：Kidney international

authors： Williams B,Hattersley J,Layward E,Walls J

更新日期：1991-10-01 00:00:00

abstract：:A new study in dialysis patients demonstrates that more than one-third of rehospitalizations within 30 days of discharge occur within the first week, and these rehospitalizations are associated with worse survival. Imposing a penalty on the dialysis provider for these rehospitalizations, as mandated by the Hospital Re...

journal_title：Kidney international

authors： Streja E

更新日期：2017-10-01 00:00:00