Aboriginal patients on the road to kidney transplantation: is residence location a barrier?

abstract：:In rats undergoing renal mass reduction (RMR) oral supplementation with the nitric oxide (NO) precursor L-arginine increases glomerular filtration rate and ameliorates signs of glomerular injury, suggesting that chronic renal failure in the rats is a condition of low NO formation in the kidney. On the contrary, data a...

journal_title：Kidney international

authors： Aiello S,Noris M,Todeschini M,Zappella S,Foglieni C,Benigni A,Corna D,Zoja C,Cavallotti D,Remuzzi G

更新日期：1997-07-01 00:00:00

abstract：:Cholesterol conversion to and biliary excretion of bile acids represents the principal pathway of cholesterol catabolism in mammals. Cholesterol 7 alpha-hydroxylase (Ch-7 alpha-H) is the first and the rate limiting step in bile acid production. Recently, Ch-7 alpha-H enzymatic activity has been shown to be normal in r...

journal_title：Kidney international

authors： Liang KH,Oveisi F,Vaziri ND

更新日期：1996-03-01 00:00:00

abstract：:Chronic kidney disease is characterized as impaired renal function along with the imbalance and dysregulation of mineral metabolism; recognized as chronic kidney disease-mineral and bone disorder. Hyperphosphatemia, characterized by altered phosphate homeostasis along with elevated fibroblast growth factor-23 and inta...

journal_title：Kidney international

authors： Tsuboi Y,Ohtomo S,Ichida Y,Hagita H,Ozawa K,Iida M,Nagao S,Ikegami H,Takahashi T,Horiba N

更新日期：2020-08-01 00:00:00

abstract：:Congenital chloride diarrhea is due to mutations in the intestinal Cl(-)/HCO(3)(-) exchange (SLC26A3) which results in sodium chloride and fluid depletion leading to hypochloremic and hypokalemic metabolic alkalosis. Although treatment with sodium and potassium chloride offers protection from renal involvement in chil...

journal_title：Kidney international

authors： Wedenoja S,Ormälä T,Berg UB,Halling SF,Jalanko H,Karikoski R,Kere J,Holmberg C,Höglund P

更新日期：2008-10-01 00:00:00

abstract：:Kinetic parameters were studied to determine the effectiveness of hemoperfusion in removing ethychlorvynol from the plasma and red blood cells (RBC) of intoxicated dogs. Perfusion columns contained polystyrene/divinyl benzene resin (XAD-4 Amberlite. Column clearances of ethchlorvynol averaged 96.5 +/- 0.4% of the plas...

journal_title：Kidney international

authors： Zmuda MJ

更新日期：1980-03-01 00:00:00

abstract：BACKGROUND:Chronic cyclosporine (CsA) nephrotoxicity is characterized by interstitial fibrosis and afferent arteriolar hyalinosis. L-arginine (L-Arg), the substrate for nitric oxide (NO) synthase and N-nitro-L-arginine-methyl ester (L-NAME), the NO synthase inhibitor, were shown to modulate acute CsA nephrotoxicity. Ho...

journal_title：Kidney international

authors： Shihab FS,Yi H,Bennett WM,Andoh TF

更新日期：2000-09-01 00:00:00

abstract：:The normal pattern of mRNA metabolism almost certainly becomes altered after uninephrectomy, especially during the first day when ribosomes accumulate in the proximal tubular cells of the remaining kidney. For example, within the first hour after nephrectomy, the fraction of newly synthesized poly(A)-deficient mRNA in...

journal_title：Kidney international

authors： Ouellette AJ

更新日期：1983-04-01 00:00:00

abstract：:Our findings indicate that hypoaldosteronism occurs commonly (23/31 patients) in hyperkalemic patients with chronic renal insufficiency and that the deficiency of aldosterone contributes to the pathogenesis of the hyperkalemia. In most patients (83%), hypoaldosteronism could be accounted for by deficient renal secreti...

journal_title：Kidney international

authors： Schambelan M,Sebastian A,Biglieri EG

更新日期：1980-01-01 00:00:00

abstract：:Vitamin D deficiency is common in patients with chronic kidney disease after renal transplantation. Vitamin D, essential for mineral and bone metabolism, also has myriad beneficial autocrine effects on intact immune responses and defense against infection, as well as suppression of malignant changes. Supplementation w...

journal_title：Kidney international

authors： Levi R,Silver J

更新日期：2009-03-01 00:00:00

abstract：:The influence of transforming growth factor beta 1 (TGF-beta 1) and of dexamethasone on fibronectin (FN) synthesis of human renal tubular epithelial cells in culture (TEC) was studied. Cocultivation with TGF-beta 1 increased the steady state level of FN RNA within 24 to 48 hours. By PCR and Northern blotting it was fo...

journal_title：Kidney international

authors： Viedt C,Bürger A,Hänsch GM

更新日期：1995-12-01 00:00:00

abstract：:As the worldwide prevalence of end-stage renal disease increases it is important to evaluate the rate of living kidney donation in various countries; however there is no comprehensive global assessment of these rates. To measure this, we compiled data from representatives, renal registries, transplant networks, publis...

journal_title：Kidney international

authors： Horvat LD,Shariff SZ,Garg AX,Donor Nephrectomy Outcomes Research (DONOR) Network.

更新日期：2009-05-01 00:00:00

abstract：:Genetic variation at the MYH9 locus is linked to the high incidence of focal segmental glomerulosclerosis (FSGS) and non-diabetic end-stage renal disease among African Americans. To further define risk alleles with FSGS we performed a genome-wide association analysis using more than one million single-nucleotide polym...

journal_title：Kidney international

authors： Genovese G,Tonna SJ,Knob AU,Appel GB,Katz A,Bernhardy AJ,Needham AW,Lazarus R,Pollak MR

更新日期：2010-10-01 00:00:00

abstract：:Severe sepsis is often accompanied by acute kidney injury (AKI) and albuminuria. Here we studied whether the AKI and albuminuria associated with lipopolysaccharide (LPS) treatment in mice reflects impairment of the glomerular endothelium with its associated endothelial surface layer. LPS treatment decreased the abunda...

journal_title：Kidney international

authors： Xu C,Chang A,Hack BK,Eadon MT,Alper SL,Cunningham PN

更新日期：2014-01-01 00:00:00

abstract：:Recent reports indicate a decreased mortality risk for patients on chronic peritoneal dialysis in the United States. We sought to determine whether a higher use of automated versus continuous ambulatory peritoneal dialysis was associated with this improvement. Analyses were carried out using data from the United State...

journal_title：Kidney international

authors： Mehrotra R,Chiu YW,Kalantar-Zadeh K,Vonesh E

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Hypercholesterolemia may affect both endothelial function and arterial distensibility (DC). Renal transplant recipients (NTX) exhibit advanced structural and functional alterations of arterial vessel walls. The aim of this double-blind, randomized trial was to evaluate the effects of fluvastatin (FLU) on bra...

journal_title：Kidney international

authors： Hausberg M,Kosch M,Stam F,Heidenreich S,Kisters K,Rahn KH,Barenbrock M

更新日期：2001-04-01 00:00:00

abstract：:The soluble urokinase receptor (suPAR) promotes proteinuria and induces focal segmental glomerulosclerosis (FSGS)-like lesions in mice. A serum suPAR concentration cutoff of 3000 pg/ml has been proposed as a clinical biomarker for patients with FSGS. Interestingly, several studies in patients with glomerulopathy found...

journal_title：Kidney international

authors： Meijers B,Maas RJ,Sprangers B,Claes K,Poesen R,Bammens B,Naesens M,Deegens JK,Dietrich R,Storr M,Wetzels JF,Evenepoel P,Kuypers D

更新日期：2014-03-01 00:00:00

abstract：:Emerging evidence of crosstalk between glomerular cells in pathological settings provides opportunities for novel therapeutic discovery. Here we investigated underlying mechanisms of early events leading to filtration barrier defects of podocyte and glomerular endothelial cell crosstalk in the mouse models of primary ...

journal_title：Kidney international

authors： Ebefors K,Wiener RJ,Yu L,Azeloglu EU,Yi Z,Jia F,Zhang W,Baron MH,He JC,Haraldsson B,Daehn I

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Rats that recover from acute puromycin nephrosis later develop widespread glomerular and tubulointerstitial injury. The current study sought to identify structural changes present in the recovery phase that could precipitate progressive renal disease. METHODS:Stereologic studies were performed 10 weeks afte...

journal_title：Kidney international

authors： Rasch R,Nyengaard JR,Marcussen N,Meyer TW

更新日期：2002-08-01 00:00:00

abstract：:Defective cholesterol metabolism primarily linked to reduced ATP-binding cassette transporter A1 (ABCA1) expression is closely associated with the pathogenesis and progression of kidney diseases, including diabetic kidney disease and Alport Syndrome. However, whether the accumulation of free or esterified cholesterol ...

journal_title：Kidney international

authors： Liu X,Ducasa GM,Mallela SK,Kim JJ,Molina J,Mitrofanova A,Wilbon SS,Ge M,Fontanella A,Pedigo C,Santos JV,Nelson RG,Drexler Y,Contreras G,Al-Ali H,Merscher S,Fornoni A

更新日期：2020-11-01 00:00:00

abstract：:Previous work has documented an acceleration of proteolysis and branched-chain amino acid oxidation when muscles from rats with chronic metabolic acidosis were incubated in vitro. The present study examines the impact of chronic metabolic acidosis on whole body amino acid turnover and oxidation in chronically catheter...

journal_title：Kidney international

authors： May RC,Masud T,Logue B,Bailey J,England B

更新日期：1992-06-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with an increased risk of acute kidney injury (AKI) when used in triple combination with renin-angiotensin system inhibitors and diuretics, but previous research reported that NSAIDs in dual combinations with either renin-angiotensin system inhibitors or diu...

journal_title：Kidney international

authors： Dreischulte T,Morales DR,Bell S,Guthrie B

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The National Kidney Foundation Dialysis Outcomes Quality Initiative (DOQI) clinical practice guidelines have suggested minimal weekly Kt/V urea and creatinine clearance goals for peritoneal dialysis patients maintained on continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD...

journal_title：Kidney international

authors： Juergensen PH,Murphy AL,Pherson KA,Kliger AS,Finkelstein FO

更新日期：2000-06-01 00:00:00

abstract：:Renal iron handling was characterized in three experimental models of the nephrotic syndrome: puromycin aminonucleoside, adriamycin and nephrotoxic serum. In adriamycin-induced nephrotic syndrome, which has previously been shown to result from alterations in pore size of the filtration barrier, the transferrin leak wa...

journal_title：Kidney international

authors： Alfrey AC,Hammond WS

更新日期：1990-06-01 00:00:00

abstract：:Absorption of amino acids by the necturus proximal tubules was measured under free-flow conditions The coexistence of proximal tubular amino acid influx was determined by infusing saline into tubular lumens by the stopped-flow microperfusion technique. Under free-flow conditions, fractional absorption of individual am...

journal_title：Kidney international

authors： Oken DE,Weise M

更新日期：1978-06-01 00:00:00

abstract：INTRODUCTION:Monocyte chemoattractant protein-1 (MCP-1) promotes renal inflammation, thereby contributing to acute and chronic nephropathies. Its production is stimulated by oxidative stress. Thus, this study tested whether pro-oxidant iron/carbohydrate complexes, used to treat iron deficiency, induce MCP-1 in renal/ex...

journal_title：Kidney international

authors： Zager RA

更新日期：2005-10-01 00:00:00

abstract：:Platelet activating factor (PAF) is a potent lipid mediator with a broad range of biologic activities. Experimental evidence suggests that PAF plays a role in the pathogenesis of a variety of inflammatory processes including allograft rejection. In this study, we evaluated the effects of the PAF antagonist BN52021 on ...

journal_title：Kidney international

authors： Butterly DW,Spurney RF,Ruiz P,Pirotzky E,Braquet P,Coffman TM

更新日期：1995-08-01 00:00:00

abstract：:Severe segmental glomerulonephritis (Seg GN) (greater than or equal to 50% involvement) in systemic lupus erythematosus (SLE) is classified as diffuse GN (DPGN) in the WHO classification. We tested the validity of the assumption that severe Seg GN and DPGN have the same prognosis by determining the proportion of glome...

journal_title：Kidney international

authors： Schwartz MM,Kawala KS,Corwin HL,Lewis EJ

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:The ontogeny of the renal mineralocorticoid (MR) and glucocorticoid (GR) receptors in the ovine fetus, and the effects of early exposure to synthetic or natural glucocorticoids on the expression of these genes in late gestation were examined. METHODS:A partial cDNA sequence for the ovine MR was cloned and u...

journal_title：Kidney international

authors： Hantzis V,Albiston A,Matsacos D,Wintour EM,Peers A,Koukoulas I,Myles K,Moritz K,Dodic M

更新日期：2002-02-01 00:00:00

abstract：:Tubulointerstitial nephritis (TIN) is a disease pattern with heterogeneous causes. Recently a specific subtype of autoimmune TIN, IgG4-related TIN, has been identified that is part of systemic IgG4-related disease/ autoimmune pancreatitis. On biopsy, this TIN shows an IgG4+ plasma cell-rich infiltrate, akin to the pan...

journal_title：Kidney international

authors： Cornell LD

更新日期：2010-11-01 00:00:00

abstract：:Chronic cyclosporine (CsA) nephrotoxicity is a major complication of heart, bone marrow, and renal transplantation, and is characterized in humans by striped interstitial fibrosis, tubular dilatation and atrophy, and hyalinization of hilar arterioles. This last feature is highly specific for cyclosporine injury and ha...

journal_title：Kidney international

authors： Young BA,Burdmann EA,Johnson RJ,Andoh T,Bennett WM,Couser WG,Alpers CE

更新日期：1995-08-01 00:00:00