Role of platelet activating factor in kidney transplant rejection in the rat.

abstract：:Recent studies have greatly expanded our knowledge of initial events that lead to epithelial cell polarity. Epithelial polarity is defined, in part, by apical cell-cell tight junctions that separate the plasma membrane into the apical domain and the basolateral domain, as well as the zonula adherens that mediate inter...

journal_title：Kidney international

authors： Wang Q,Margolis B

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:The Banff working formulation of renal transplant pathology is intended to have international application. There remains a need to develop methods to harmonize the application of such grading systems between laboratories. Banff grades do not always permit precise management decisions to be made. Alternative ...

journal_title：Kidney international

authors： Furness PN,Taub N,Convergence of European Renal Transplant Pathology Assessment Procedures (CERTPAP) Project.

更新日期：2001-11-01 00:00:00

abstract：:The mean renal tubular diameters, number of tubules per unit of cross-sectional area, and fraction of the total volume occupied by each medullary structure were determined at various levels of the renal medulla of the rat and rabbit. Statistical estimates of anatomic variables were made using spatial sampling techniqu...

journal_title：Kidney international

authors： Knepper MA,Danielson RA,Saidel GM,Post RS

更新日期：1977-11-01 00:00:00

abstract：:The impacts of IgA nephropathy and pregnancy on each other were evaluated in 118 women who conceived 168 times between 1970 and 1988. Rates of spontaneous abortion, normal delivery, live birth and perinatal death were 9, 66, 87 and 4%, respectively. Infants born to women with glomerular filtration rates (GFR) lower th...

journal_title：Kidney international

authors： Abe S

更新日期：1991-12-01 00:00:00

abstract：:The risk of developing contrast media-induced acute renal failure was studied in 49 randomly selected nonazotemic type 2 adult diabetic patients subjected to IVU. There were 19 men and 30 women in the group whose mean age was 62 +/- 10 years (range, 38 to 82 years). In preparation for IVU, patients were neither dehydr...

journal_title：Kidney international

authors： Shieh SD,Hirsch SR,Boshell BR,Pino JA,Alexander LJ,Witten DM,Friedman EA

更新日期：1982-05-01 00:00:00

abstract：UNLABELLED:Correlation of histology to rejection reversal: A Thymoglobulin Multicenter Trial report BACKGROUND:Histology may provide a link between clinical response to antirejection therapy and graft function. In a subset of centers, renal biopsy was a secondary end point for the Thymoglobulin Multicenter Trial. MET...

journal_title：Kidney international

authors： Gaber LW,Moore LW,Gaber AO,Tesi RJ,Meyer J,Schroeder TJ

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Regular access monitoring is recommended to detect and treat access stenosis in order to prevent access thrombosis and failure. METHODS:In 1999, we instituted monthly access blood flow monitoring using the ultrasound dilution technique (UDT). In a sequential observational trial, 222 patients were studied fo...

journal_title：Kidney international

authors： Shahin H,Reddy G,Sharafuddin M,Katz D,Franzwa BS,Dixon BS

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Peritonitis in peritoneal dialysis patients is accompanied by an enhanced migration of neutrophils (PMNs) and increased protein loss into the peritoneal cavity; however, the role of PMNs in governing increased protein loss during peritonitis associated with peritoneal dialysis is unknown. METHODS:We determi...

journal_title：Kidney international

authors： Luo Q,Cheung AK,Kamerath CD,Reimer LG,Leypoldt JK

更新日期：2000-04-01 00:00:00

abstract：:The presence of CR1 mRNA in podocytes was investigated using a 35S-labeled CR1 cDNA probe and in situ hybridization in sections from fetal and adult human kidneys. CR1 mRNA was only detected in immature podocytes at early stages of glomerular differentiation in the fetal kidney. In contrast, CR1 antigen was abundantly...

journal_title：Kidney international

authors： Appay MD,Kazatchkine MD,Levi-Strauss M,Hinglais N,Bariety J

更新日期：1990-08-01 00:00:00

abstract：:Chronic kidney disease (CKD) has received increased attention as a leading public health problem worldwide. Globally surveillance systems for kidney disease are still lacking, especially in developing countries like China, which constitutes an obstacle to develop effective preventive strategies. China Kidney Disease N...

journal_title：Kidney international

authors： Wang F,Yang C,Long J,Zhao X,Tang W,Zhang D,Bai K,Su Z,Gao B,Chu H,Wang J,Sun X,Wang S,Zuo L,Wang Y,Yu F,Wang H,Zhang L,Zhao MH

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] in the alveolar and glomerular basement membrane. These antibodies are associated with the development of a rapidly progressive ...

journal_title：Kidney international

authors： Hellmark T,Segelmark M,Unger C,Burkhardt H,Saus J,Wieslander J

更新日期：1999-03-01 00:00:00

abstract：:As the worldwide prevalence of end-stage renal disease increases it is important to evaluate the rate of living kidney donation in various countries; however there is no comprehensive global assessment of these rates. To measure this, we compiled data from representatives, renal registries, transplant networks, publis...

journal_title：Kidney international

authors： Horvat LD,Shariff SZ,Garg AX,Donor Nephrectomy Outcomes Research (DONOR) Network.

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Patients with thin basement membrane disease (TBMD) are often from families where hematuria segregates with the COL4A3 and COL4A4 genes. These genes also are affected in autosomal recessive Alport syndrome. The aim of this study was to demonstrate COL4A4 mutations in TBMD. METHODS:Forty-eight unrelated indi...

journal_title：Kidney international

authors： Buzza M,Dagher H,Wang YY,Wilson D,Babon JJ,Cotton RG,Savige J

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Decay accelerating factor (DAF), a product of mesangial cells in vitro, is expressed on the surface of cells and is a candidate for the focal suppression of complement activation. It is not clear at present whether the levels of expression of DAF and intrarenal C3 synthesis correlate with the level of tissue...

journal_title：Kidney international

authors： Abe K,Miyazaki M,Koji T,Furusu A,Ozono Y,Harada T,Sakai H,Nakane PK,Kohno S

更新日期：1998-07-01 00:00:00

abstract：:Cell-cycle proteins influence almost all aspects of embryogenesis and differentiation. In adults, these proteins control cell division and regeneration after injury. During the past several years, their roles in controlling reaction to stress have been demonstrated in several organ systems. In the kidney, the cell typ...

journal_title：Kidney international

authors： Price PM

更新日期：2010-04-01 00:00:00

abstract：:Primary distal renal tubular acidosis is a rare genetic disease. Mutations in SLC4A1, ATP6V0A4, and ATP6V1B1 genes have been described as the cause of the disease, transmitted as either an autosomal dominant or recessive trait. Particular clinical features, such as sensorineural hearing loss, have been mainly describe...

journal_title：Kidney international

authors： Palazzo V,Provenzano A,Becherucci F,Sansavini G,Mazzinghi B,Orlandini V,Giunti L,Roperto RM,Pantaleo M,Artuso R,Andreucci E,Bargiacchi S,Traficante G,Stagi S,Murer L,Benetti E,Emma F,Giordano M,Rivieri F,Colussi G,

更新日期：2017-05-01 00:00:00

abstract：:Isotomic fluid reabsorption (JV) of rat renal proximal tubules was examined by the shrinking droplet method in combination with simulatneous perfusion of blood capillaries. Sensitivity of JV measurement was improved by using each punctured tubule for control measurements: 1) Parathyroid hormoen (PTH) on the contralumi...

journal_title：Kidney international

authors： Baumann K,Chan YL,Bode F,Papavassiliou F

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:The parathyroid (PT) hyperplasia induced by renal failure can be further enhanced by high dietary phosphate (P) or completely abolished by P restriction. To identify potential mechanisms mediating these opposing effects of dietary P on PT growth, this study first focused on p21(WAF1) (p21) because high P red...

journal_title：Kidney international

authors： Dusso AS,Pavlopoulos T,Naumovich L,Lu Y,Finch J,Brown AJ,Morrissey J,Slatopolsky E

更新日期：2001-03-01 00:00:00

abstract：:The soluble receptor of advanced glycation end product (sRAGE) prevents vascular damage in experimental animal models, and observational studies in the general population support the hypothesis that sRAGE may exert a protective role on the vasculature. To test this in patients with chronic kidney disease, we determine...

journal_title：Kidney international

authors： Basta G,Leonardis D,Mallamaci F,Cutrupi S,Pizzini P,Gaetano L,Tripepi R,Tripepi G,De Caterina R,Zoccali C

更新日期：2010-02-01 00:00:00

abstract：:Metabolic changes due to chronic renal failure (CRF) were studied in isolated liver cells. In 14 CRF and 14 sham-operated rats, liver cells were isolated by the Berry and Friend method and incubated with various substrates in order to study gluconeogenesis, ureagenesis, ketogenesis, oxygen consumption as well as cytos...

journal_title：Kidney international

authors： Cano N,Catelloni F,Fontaine E,Novaretti R,di Costanzo-Dufetel J,Reynier JP,Leverve XM

更新日期：1995-06-01 00:00:00

abstract：:A newly described glomerulotubular feedback loop may explain the relationship between glomerular damage, epitope spreading, tubulointerstitial nephritis, proteinuria as a progression factor, and the importance of the local milieu in kidney damage. It also opens the horizons for exciting innovative approaches to therap...

journal_title：Kidney international

authors： Sung SS,Bolton WK

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:We have recently found evidence for increased reactive oxygen species (ROS) in rats with lead-induced hypertension. We hypothesized that increased ROS activity may contribute to hypertension by enhancing inactivation of nitric oxide (NO) in this model. METHODS:Rats were treated for 12 weeks with either lead...

journal_title：Kidney international

authors： Vaziri ND,Liang K,Ding Y

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Diabetic nephropathy is commonly associated with renal salt and water retention and hypertension. The molecular mechanisms involved and how the kidney responds to this volume expansion, in terms of renal transporter regulation, are not understood. METHODS:Targeted proteomics employing semiquantitative immun...

journal_title：Kidney international

authors： Bickel CA,Knepper MA,Verbalis JG,Ecelbarger CA

更新日期：2002-06-01 00:00:00

abstract：:Tuberous sclerosis complex is a genetic disorder characterized by hamartomatous lesions in multiple organs, frequently involving the kidney. We conducted a retrospective review of the clinical and radiographic records of 167 patients with tuberous sclerosis to determine the frequency of renal disease, the likelihood o...

journal_title：Kidney international

authors： Rakowski SK,Winterkorn EB,Paul E,Steele DJ,Halpern EF,Thiele EA

更新日期：2006-11-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) upregulation occurs in virtually all chronic kidney diseases and is associated with podocyte injury and proteinuria; however, the mechanisms contributing to this in vivo are ambiguous. In vitro, incubation of podocytes with TGF-β1 induced Wnt1 expression, β-catenin activation, an...

journal_title：Kidney international

authors： Wang D,Dai C,Li Y,Liu Y

更新日期：2011-12-01 00:00:00

abstract：:Nephrons possess a segmental organization where each segment is specialized for the secretion and reabsorption of particular solutes. The developmental control of nephron segment patterning remains one of the enigmas within the field of renal biology. Achieving an understanding of the mechanisms that direct nephron se...

journal_title：Kidney international

authors： Wingert RA,Davidson AJ

更新日期：2008-05-01 00:00:00

abstract：:The role of peritoneal dialysis (PD) in renal replacement therapy (RRT) remains unclear. There are no controlled trials to provide hard evidence of its efficacy. Comparative studies with haemodialysis from different centres and countries have given conflicting results even when allowing for case mix. Data from the Uni...

journal_title：Kidney international

authors： Coles GA,Williams JD

更新日期：1998-12-01 00:00:00

abstract：:Mutations in the NPHS2 gene, encoding podocin, are responsible for familial autosomal recessive and sporadic cases of steroid-resistant nephrotic syndrome. We have successfully generated a mouse model in which the common p.R138Q mutation found in nephrotic patients is expressed in the kidney. Homozygous mice express t...

journal_title：Kidney international

authors： Philippe A,Weber S,Esquivel EL,Houbron C,Hamard G,Ratelade J,Kriz W,Schaefer F,Gubler MC,Antignac C

更新日期：2008-05-01 00:00:00

abstract：:Hypercalciuria is one of the early manifestations of diabetic nephropathy. We explored here the role of α-Klotho, a protein expressed predominantly in distal convoluted tubules that has a role in calcium reabsorption. We studied 31 patients with early diabetic nephropathy and compared them with 31 patients with IgA ne...

journal_title：Kidney international

authors： Asai O,Nakatani K,Tanaka T,Sakan H,Imura A,Yoshimoto S,Samejima K,Yamaguchi Y,Matsui M,Akai Y,Konishi N,Iwano M,Nabeshima Y,Saito Y

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:We have previously reported that the serum concentration of 2-(alpha-mannopyranosyl)-L-tryptophan (MPT), tryptophan glycoconjugate, is a more accurate measure of renal function than that of serum creatinine concentration. The aim of the present study was to compare the diagnostic value of serum concentration...

journal_title：Kidney international

authors： Yonemura K,Takahira R,Yonekawa O,Wada N,Hishida A

更新日期：2004-04-01 00:00:00