Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion.

abstract：BACKGROUND:The aim of this study was to determine the glucose-dependent regulation of the sodium-proton-antiporter (Na+/H+ antiporter) in patients with mild chronic renal failure (CRF). METHODS:We measured plasma glucose concentrations, plasma insulin concentrations, plasma C peptide concentrations, arterial blood pre...

journal_title：Kidney international

authors： Tepel M,van der Giet M,Brukamp K,Weyer J,Zidek W

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7), a member of the transforming growth factor-beta superfamily, has been shown to prevent kidney damage from ischemia/reperfusion injury in rats. The molecular events involved in OP-1 action on kidney are not yet understood. METHODS:In this study,...

journal_title：Kidney international

authors： Bosukonda D,Shih MS,Sampath KT,Vukicevic S

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Hyperoxaluria may be idiopathic, secondary, or due to primary hyperoxaluria (PH). Hepatic alanine:glyoxylate aminotransferase (AGT) or glyoxylate/hydroxypyruvate reductase (GR/HPR) deficiency causes PHI or PHII, respectively. Hepatic glycolate oxidase (GO) is a candidate enzyme for a third form of inherited ...

journal_title：Kidney international

authors： Monico CG,Persson M,Ford GC,Rumsby G,Milliner DS

更新日期：2002-08-01 00:00:00

abstract：:Multiphoton excitation fluorescence microscopy is a state-of-the-art confocal imaging technique ideal for deep optical sectioning of living tissues. It is capable of performing ultrasensitive, quantitative imaging of organ functions in health and disease with high spatial and temporal resolution which other imaging mo...

journal_title：Kidney international

authors： Sipos A,Toma I,Kang JJ,Rosivall L,Peti-Peterdi J

更新日期：2007-11-01 00:00:00

abstract：:Serum calcitriol and the free calcitriol index together with factors considered to regulate calcitriol production were measured in eleven patients with moderate chronic renal failure (MCRF) and eleven age- and sex-matched normal subjects. Although the serum dialysable calcium levels were similar in the two groups, the...

journal_title：Kidney international

authors： Prince RL,Hutchison BG,Kent JC,Kent GN,Retallack RW

更新日期：1988-03-01 00:00:00

abstract：:Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus...

journal_title：Kidney international

authors： Maltzman JS,Haase VH

更新日期：2008-04-01 00:00:00

abstract：:Vitamin D deficiency is common in patients with chronic kidney disease after renal transplantation. Vitamin D, essential for mineral and bone metabolism, also has myriad beneficial autocrine effects on intact immune responses and defense against infection, as well as suppression of malignant changes. Supplementation w...

journal_title：Kidney international

authors： Levi R,Silver J

更新日期：2009-03-01 00:00:00

abstract：:Indomethacin antagonizes the natriuretic and chloruretic response to hydrochlorothiazide in most studies. Neither the mechanism nor nephron site of this antagonism has been determined. To identify sites and potential mechanisms, cortical micropuncture was performed during hydrochlorothiazide treatment in control and i...

journal_title：Kidney international

authors： Kirchner KA,Brandon S,Mueller RA,Smith MJ,Bower JD

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme activated by strand breaks in DNA, plays an important role in the development of ischemia/reperfusion (I/R) injury. The aim of this study was to investigate the effects of a water-soluble and potent PARP inhibitor, 5-aminoisoquinolinone (5-AIQ), on the re...

journal_title：Kidney international

authors： Chatterjee PK,Chatterjee BE,Pedersen H,Sivarajah A,McDonald MC,Mota-Filipe H,Brown PA,Stewart KN,Cuzzocrea S,Threadgill MD,Thiemermann C

更新日期：2004-02-01 00:00:00

abstract：:We examined the role of the plasminogen activator/plasmin system in extracellular matrix (ECM) degradation by human mesangial cells cultured on thin films of 125I-labeled ECM (Matrigel). ECM degradation (release of 125I into the medium) was dependent on exogenous plasminogen, proportional to the number of mesangial ce...

journal_title：Kidney international

authors： Baricos WH,Cortez SL,el-Dahr SS,Schnaper HW

更新日期：1995-04-01 00:00:00

abstract：:Previous studies from our laboratory have demonstrated that metabolic clearance rate (MCR) of calcitriol is decreased in experimental renal failure. In this experiment, we examined the effects of calcitriol, 25-hydroxyvitamin D3 (25(OH)D3) and 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) on the MCR of calcitriol in renal ...

journal_title：Kidney international

authors： Patel S,Simpson RU,Hsu CH

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Renal inflammation is regulated by a network of local and systemic mediators. Of them, transforming growth factor-beta1 (TGF-beta 1) and glucocorticoids play an important role in deactivating monocytes/macrophages. We examined the hypothesis that TGF-beta 1 effects may be partially achieved through modulatio...

journal_title：Kidney international

authors： Peltier J,Perez J,Bellocq A,Escoubet B,Fouqueray B,Baud L

更新日期：2003-06-01 00:00:00

abstract：:Colony stimulating factor-1 (CSF-1) is a chemoattractant and growth factor for macrophages. In autoimmune MRL-lpr mice, CSF-1 is detected in the circulation and there is an increase in CSF-1 transcripts and macrophages in the kidney. The purpose of this study was to establish whether the MRL-lpr kidney is responsible ...

journal_title：Kidney international

authors： Naito T,Griffiths RC,Coffman TM,Kelley VR

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Tubular transepithelial reabsorption of chloride along the nephron is a major determinant of body salt and water homeostasis and blood pressure regulation. About 40% of the glomerulary filtered sodium chloride are reabsorbed in the distal nephrons. Vectorial transepithelial sodium chloride transport is criti...

journal_title：Kidney international

authors： Jeck N,Waldegger P,Doroszewicz J,Seyberth H,Waldegger S

更新日期：2004-01-01 00:00:00

abstract：:To determine the prognosis and risk factors for ischemic heart disease in chronic uremia, a cohort of 432 dialysis patients were followed prospectively from start of dialysis therapy until death or renal transplantation. Baseline demographic, clinical and echocardiographic data were obtained. After the initiation of d...

journal_title：Kidney international

authors： Parfrey PS,Foley RN,Harnett JD,Kent GM,Murray D,Barre PE

更新日期：1996-05-01 00:00:00

abstract：:Hemodynamic studies were performed at two levels of dietary sodium intake (10 mmoles/day and 100 mmoles/day for 14 days) in a group of patients (with retained kidneys) on chronic hemodialysis. Plasma renin activity and aldosterone, plasma, and extracellular fluid (ECF) volumes were measured while the patient were at r...

journal_title：Kidney international

authors： McGrath BP,Tiller DJ,Bune A,Chalmers JP,Korner PI,Uther JB

更新日期：1977-10-01 00:00:00

abstract：:Reducing proteinuria and blood pressure in chronic kidney disease (CKD) decreases rate of progression. Inhibition of the renin-angiotensin system by angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers is beneficial in reducing proteinuria but incomplete in suppressing aldosterone production a...

journal_title：Kidney international

authors： Weinberger MH,Luft FC

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Dopamine (DA) is thought to regulate renal proximal transport through the inhibition of the Na+,K+-ATPase and/or Na+/H+ exchanger. Defects in this dopaminergic system are proposed to be a pathogenic factor of genetic hypertension. However, microperfusion studies have not consistently confirmed direct tubular...

journal_title：Kidney international

authors： Kunimi M,Seki G,Hara C,Taniguchi S,Uwatoko S,Goto A,Kimura S,Fujita T

更新日期：2000-02-01 00:00:00

abstract：:Fifty-one adults with HIV infection, including 20 chronic hemodialysis patients with superimposed HIV infection and 31 patients with HIV-associated nephropathy requiring chronic maintenance hemodialysis were followed to evaluate survival on outpatient dialysis in relation to the clinical stage of the HIV infection. Re...

journal_title：Kidney international

authors： Ortiz C,Meneses R,Jaffe D,Fernandez JA,Perez G,Bourgoignie JJ

更新日期：1988-08-01 00:00:00

abstract：:Mutations in the MYH9 gene, coding for the non-muscle myosin heavy chain IIA (NMHC-IIA), are responsible for syndromes characterized by macrothrombocytopenia associated with deafness, cataracts, and severe glomerular disease. Electron microscopy of renal biopsies from these patients found glomerular abnormalities char...

journal_title：Kidney international

authors： Müller T,Rumpel E,Hradetzky S,Bollig F,Wegner H,Blumenthal A,Greinacher A,Endlich K,Endlich N

更新日期：2011-11-01 00:00:00

abstract：:Early identification of kidney transplant recipients at risk of progressive allograft dysfunction may allow clinicians to provide closer monitoring and more aggressive risk factor modification. In this issue, Raynaud et al. presented a latent class model that clustered kidney transplant recipients into 8 risk categori...

journal_title：Kidney international

authors： Dinh A,McCulloch CE,Ku E

更新日期：2021-01-01 00:00:00

abstract：:Cyclosporine A (CsA) is a potent immunosuppressive drug that inhibits the transcription of several proinflammatory cytokines including interleukin-2. In contrast, CsA stimulates transcription of the pleuripotent cytokine, transforming growth factor-beta (TGF beta). Since the effect of CsA in transplant recipients is u...

journal_title：Kidney international

authors： Pankewycz OG,Miao L,Isaacs R,Guan J,Pruett T,Haussmann G,Sturgill BC

更新日期：1996-11-01 00:00:00

abstract：:The natural course of idiopathic membranous nephropathy is variable, with some patients slowly progressing to renal failure while others maintain normal renal function over the entire time. Whether to treat this disease or not is controversial due to the lack of controlled data about the long-term effects of treatment...

journal_title：Kidney international

authors： Ponticelli C,Zucchelli P,Passerini P,Cesana B,Locatelli F,Pasquali S,Sasdelli M,Redaelli B,Grassi C,Pozzi C

更新日期：1995-11-01 00:00:00

abstract：:Reliable estimates of the long-term outcomes of acute kidney injury (AKI) are needed to inform clinical practice and guide allocation of health care resources. This systematic review and meta-analysis aimed to quantify the association between AKI and chronic kidney disease (CKD), end-stage kidney disease (ESKD), and d...

journal_title：Kidney international

authors： See EJ,Jayasinghe K,Glassford N,Bailey M,Johnson DW,Polkinghorne KR,Toussaint ND,Bellomo R

更新日期：2019-01-01 00:00:00

abstract：:Long-term treatment (8 and 13 weeks) of rats with FGF-2 led to albuminuria and to increase in serum creatinine indicating the development of chronic renal failure. Histologically, the classic picture of focal segmental glomerulosclerosis (FSGS) was found; males were more severely affected than females. Among the early...

journal_title：Kidney international

authors： Kriz W,Hähnel B,Rösener S,Elger M

更新日期：1995-11-01 00:00:00

abstract：:Because the size of renal cysts in the native kidneys of patients with ADPKD who have been transplanted was found to be reduced when rapamycin was the immunosuppressant, we tested the involvement of the mTOR pathway in cyst enlargement. Here, male pcy mice, with mutation in one of the nephronophthisis genes, were trea...

journal_title：Kidney international

authors： Gattone VH 2nd,Sinders RM,Hornberger TA,Robling AG

更新日期：2009-07-01 00:00:00

abstract：:The kidney is influenced by circadian rhythms and is entrained to the sleep-wake cycle allowing anticipation of the metabolic and physiological demands of the kidney throughout a 24-hour cycle. Although sleep disruption has been studied extensively in cardiovascular and metabolic disease, its association with chronic ...

journal_title：Kidney international

authors： McMullan CJ,Curhan GC,Forman JP

更新日期：2016-06-01 00:00:00

abstract：:Although the goal glomerular filtration rate (GFR) for chronic dialysis initiation is currently above 5 ml/min per 1.73 m(2), there is no convincing evidence that patients will benefit from this approach. With close follow-up of advanced chronic kidney disease patients, aiming to start dialysis at an estimated GFR (eG...

journal_title：Kidney international

authors： Rosansky SJ,Durkin MW

更新日期：2014-10-01 00:00:00

abstract：:Incompatible donor/recipient pairs with broadly sensitized recipients have difficulty finding a crossmatch-compatible match, despite a large kidney paired donation pool. One approach to this problem is to combine kidney paired donation with lower-risk crossmatch-incompatible transplantation with intravenous immunoglob...

journal_title：Kidney international

authors： Blumberg JM,Gritsch HA,Reed EF,Cecka JM,Lipshutz GS,Danovitch GM,McGuire S,Gjertson DW,Veale JL

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Many studies have reported that blocking the renin-angiotensin-system (RAS) with an angiotensin-converting enzyme (ACE) inhibitor or an angiotensin receptor blocker in the patient with diabetes mellitus leads to an increase in renal plasma flow (RPF), no change in glomerular filtration rate (GFR), and a fall...

journal_title：Kidney international

authors： Hollenberg NK,Price DA,Fisher ND,Lansang MC,Perkins B,Gordon MS,Williams GH,Laffel LM

更新日期：2003-01-01 00:00:00