Starting dialysis at eGFR >5 ml/min per1.73 m(2): are we barking up the wrong tree?

abstract：:It is unknown whether the association between body mass index (BMI) and chronic kidney disease (CKD) is mediated by genetic confounding or obesity-associated diabetes. We investigated the association between BMI and incident CKD in 29,136 Swedish twins with no history of CKD or diabetes, first using traditional Cox re...

journal_title：Kidney international

authors： Xu H,Kuja-Halkola R,Chen X,Magnusson PKE,Svensson P,Carrero JJ

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:The obstructed kidney in unilateral ureteral obstruction (UUO) is characterized by renal atrophy and tissue loss, which is mediated by renal tubular apoptosis. We sought to determine whether NO is involved in renal tubular apoptosis in vitro and in vivo. METHODS:Rat renal tubular epithelial cells (NRK-52E) ...

journal_title：Kidney international

authors： Miyajima A,Chen J,Poppas DP,Vaughan ED Jr,Felsen D

更新日期：2001-04-01 00:00:00

abstract：:Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal sys...

journal_title：Kidney international

authors： Luciani A,Freedman BS

更新日期：2020-07-01 00:00:00

abstract：:Regardless of the source of injury, an imbalance in the control of mesangial cell proliferation appears to play a direct role in the degree of progressive renal injury and glomerulosclerosis. Some of the regulatory mechanisms include specific soluble or non-soluble extracellular factors and a complex array of receptor...

journal_title：Kidney international

authors： Schöcklmann HO,Lang S,Sterzel RB

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Studies in animal models have shown that the alternative pathway of complement is activated in the kidney after ischemia/reperfusion. In addition, mice deficient in complement factor B, a necessary component of the alternative pathway, are protected from ischemic acute renal failure. The purpose of this stud...

journal_title：Kidney international

authors： Thurman JM,Lucia MS,Ljubanovic D,Holers VM

更新日期：2005-02-01 00:00:00

abstract：:Identifying subjects with progressive chronic kidney disease will be important both in clinical practice and in conducting clinical trials. Pruijm et al. (in this issue) demonstrate for the first time that cortical oxygenation as evaluated by blood oxygenation level-dependent magnetic resonance imaging can predict fut...

journal_title：Kidney international

authors： Prasad PV

更新日期：2018-04-01 00:00:00

abstract：:Hypertension is a well-known complication in children on renal replacement therapy and an important risk factor for cardiovascular disease in later life. In order to define the prevalence of and risk factors for hypertension among children, we enrolled 3337 pediatric patients from 15 countries in the ESPN/ERA-EDTA Reg...

journal_title：Kidney international

authors： Kramer AM,van Stralen KJ,Jager KJ,Schaefer F,Verrina E,Seeman T,Lewis MA,Boehm M,Simonetti GD,Novljan G,Groothoff JW

更新日期：2011-11-01 00:00:00

abstract：:Our genetic hypercalciuric (GH) rats have been selected and inbred for 29 generations to maximize urine calcium (UCa) excretion compared to identical gender controls (Ctl). To determine the effect of the increased UCa on urinary supersaturation and stone formation, we pair fed 15 GH and 15 Ctl rats a standard 1.2% cal...

journal_title：Kidney international

authors： Bushinsky DA,Grynpas MD,Nilsson EL,Nakagawa Y,Coe FL

更新日期：1995-12-01 00:00:00

abstract：:Prior studies reported associations of APOL1 nephropathy risk variants with subclinical atherosclerosis. However, these findings were limited to older individuals with high comorbidities. To evaluate this in younger individuals, we calculated associations of APOL1 risk variants (high risk [2 risk variants] vs. low ris...

journal_title：Kidney international

authors： Gutiérrez OM,Limou S,Lin F,Peralta CA,Kramer HJ,Carr JJ,Bibbins-Domingo K,Winkler CA,Lewis CE,Kopp JB

更新日期：2018-03-01 00:00:00

abstract：:In chronic serum sickness, glomerular immune complexes form, yet C57BL/6 mice do not develop glomerulonephritis unless complement factor H (CfH) is absent, indicating the relevance of complement regulation. Complement receptor 3 (CD11b) and Fcγ receptors on leukocytes, and CfH on platelets, can bind immune complexes. ...

journal_title：Kidney international

authors： Alexander JJ,Chaves LD,Chang A,Jacob A,Ritchie M,Quigg RJ

更新日期：2015-05-01 00:00:00

abstract：:A model of glomerular dynamics has been developed by using network thermodynamics and the SPICE 2 computer program to further explore the determinants of glomerular filtration. The model is designed to be holistic and self-adjusting, taking cognizance of and permitting quantitation of the secondary alterations in indi...

journal_title：Kidney international

authors： Oken DE,Thomas SR,Mikulecky DC

更新日期：1981-02-01 00:00:00

abstract：:To determine the effect of an acute load of potassium on potassium reabsorption by the loop of Henle in chronic renal failure, the right kidney was removed and branches of the left renal artery were ligated in 17 rats. One week later and after 2 days of a potassium-free diet, rats were studied before (period 1) and af...

journal_title：Kidney international

authors： Milanes CL,Jamison RL

更新日期：1985-06-01 00:00:00

abstract：:One hundred six patients with terminal renal insufficiency and 29 medical personnel were given three doses of hepatitis B vaccine at an interval of 0, 1, and 6 months (Merck, Sharp and Dohme, West Point, Pennsylvania, part of a joint study no. 649). Chronic hemodialysis patients (N = 99) received 40 micrograms vaccine...

journal_title：Kidney international

authors： Köhler H,Arnold W,Renschin G,Dormeyer HH,Meyer zum Büschenfelde KH

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:C-peptide has been reported to have biological effects on renal function early in the course of diabetes. This investigation was initiated to elucidate and amplify these findings with respect to protein leakage, hyperfiltration and renal functional reserve in diabetic rats. METHODS:Acute effects of 140 minu...

journal_title：Kidney international

authors： Sjöquist M,Huang W,Johansson BL

更新日期：1998-09-01 00:00:00

abstract：:The effects of acidosis on renal function and morphology were examined in the isolated perfused rat kidney (IPK). Kidneys were perfused with oxygenated Krebs-Henseleit-albumin medium for 60 minutes at pH 7.4 or pH 7.0. At the lower pH, GFR was reduced by 25%, TRNa by 32% and oxygen consumption by 41% as compared to pe...

journal_title：Kidney international

authors： Shanley PF,Shapiro JI,Chan L,Burke TJ,Johnson GC

更新日期：1988-12-01 00:00:00

abstract：:The antiproteinuric effect of angiotensin converting enzyme (ACE) inhibition in insulin-dependent diabetes mellitus (IDDM) patients with diabetic nephropathy varies considerably. Therefore, we tested the potential role of an insertion (I)/deletion (D) polymorphism of the ACE gene on this early antiproteinuric responsi...

journal_title：Kidney international

authors： Jacobsen P,Rossing K,Rossing P,Tarnow L,Mallet C,Poirier O,Cambien F,Parving HH

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:The amount of oxalate excreted in urine has a significant impact on calcium oxalate supersaturation and stone formation. Dietary oxalate is believed to make only a minor (10 to 20%) contribution to the amount of oxalate excreted in urine, but the validity of the experimental observations that support this co...

journal_title：Kidney international

authors： Holmes RP,Goodman HO,Assimos DG

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Dialysis efficiency has a great influence on the outcome of patients. Few data are available on the removal of solutes with molecular weights higher than urea and creatinine. The aim of our study was to assess the transport and the removal of substances with molecular weights up to 15 kD and to evaluate the ...

journal_title：Kidney international

authors： Montini G,Amici G,Milan S,Mussap M,Naturale M,Rätsch IM,Ammenti A,Sorino P,Verrina E,Andreetta B,Zacchello G,Italian Registry of Pediatric Peritoneal Dialysis.

更新日期：2002-03-01 00:00:00

abstract：:Disasters result in a substantial number of renal challenges, either by the creation of crush injury in victims trapped in collapsed buildings or by the destruction of existing dialysis facilities, leaving chronic dialysis patients without access to their dialysis units, medications, or medical care. Over the past two...

journal_title：Kidney international

authors： Gibney RT,Sever MS,Vanholder RC

更新日期：2014-05-01 00:00:00

abstract：:Renal iron handling was characterized in three experimental models of the nephrotic syndrome: puromycin aminonucleoside, adriamycin and nephrotoxic serum. In adriamycin-induced nephrotic syndrome, which has previously been shown to result from alterations in pore size of the filtration barrier, the transferrin leak wa...

journal_title：Kidney international

authors： Alfrey AC,Hammond WS

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:In X-linked Alport syndrome, mutations in the COL4A5 gene encoding the alpha 5 chain of type IV collagen result in progressive renal failure. This nephropathy appears to relate to the arrest of a switch from an alpha 1/alpha 2 to an alpha 3/alpha 4/alpha 5 network of type IV collagen in the developing glomer...

journal_title：Kidney international

authors： Harvey SJ,Zheng K,Sado Y,Naito I,Ninomiya Y,Jacobs RM,Hudson BG,Thorner PS

更新日期：1998-12-01 00:00:00

abstract：:In seven patients on maintenance hemodialysis, de novo recurrent renal stone formation was observed. In all patients, the underlying disease was glomerulonephritis, with or without the nephrotic syndrome. All patients had considerable persistent proteinuria. The stones consisted predominantly of protein, as revealed b...

journal_title：Kidney international

authors： Bommer J,Ritz E,Tschöpe W,Waldherr R,Gebhardt M

更新日期：1979-12-01 00:00:00

abstract：:Nephropathia epidemica (NE) caused by Puumala hantavirus is one type of hemorrhagic fever with renal syndrome (HFRS). There is considerable variability in the clinical severity of NE. Many infections are subclinical but the disease can even be fatal. We questioned whether the wide spectrum in the outcome of NE is depe...

journal_title：Kidney international

authors： Mustonen J,Partanen J,Kanerva M,Pietilä K,Vapalahti O,Pasternack A,Vaheri A

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:The fluid filling renal cysts in human polycystic kidneys is secreted chiefly by the tubular epithelium lining the cysts via secondary chloride transport. Inhibiting this process by somatostatin therapy should induce shrinking of renal cysts. METHODS:In this randomized, cross-over, placebo-controlled trial ...

journal_title：Kidney international

authors： Ruggenenti P,Remuzzi A,Ondei P,Fasolini G,Antiga L,Ene-Iordache B,Remuzzi G,Epstein FH

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:The beneficial effect of blood transfusions before cadaveric renal transplantation on allograft survival, although previously well documented, has become controversial in light of their adverse effects. Recently, it has been suggested that their clinical benefits are due to HLA-DR sharing between the blood d...

journal_title：Kidney international

authors： Hiesse C,Busson M,Buisson C,Farahmand H,Bierling P,Benbunan M,Bedrossian J,Aubert P,Glotz D,Loirat C,Rondeau E,Viron B,Bleux H,Lang P

更新日期：2001-07-01 00:00:00

abstract：:Cells from RCCT-28A cell line, which exhibited the highest peanut-lectin binding capacity [RCCT-28A(P+)] were separated and cultured attempting to obtain a population of HCO3- secreting cells. The mechanisms of apical solution acid or base extrusion were studied in confluent monolayers. In RCCT-28A (P+) cells net H+ f...

journal_title：Kidney international

authors： Bello-Reuss E

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Angiotensin II type 2 receptor-deficient mice (AT(2)-/y) provide an opportunity to study the relationship between the angiotensin II type 1 receptor (AT(1)) and nitric oxide synthase (NOS) isoforms without concomitant AT(2) receptor-related effects. To test this relationship, the expression of renal NOS isof...

journal_title：Kidney international

authors： Obst M,Gross V,Bonartsev A,Janke J,Müller DN,Park JK,Kärgel E,Luft FC

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:The induction of stress response (heat shock) proteins (HSPs) is a highly conserved response that protects many cell types from diverse physiological and environmental stressors. We tested the hypothesis that the induction of HSPs is protective in experimental renal ischemia/reperfusion injury. METHODS:The ...

journal_title：Kidney international

authors： Kelly KJ,Baird NR,Greene AL

更新日期：2001-05-01 00:00:00

abstract：:Tenascin-C is an extracellular matrix glycoprotein that plays a critical role in kidney fibrosis by orchestrating a fibrogenic niche. Here, we demonstrate that tenascin-C is a biomarker and a mediator of kidney fibrogenesis by impairing tubular integrity. Tenascin-C was found to be increased in kidney biopsies from pa...

journal_title：Kidney international

authors： Zhu H,Liao J,Zhou X,Hong X,Song D,Hou FF,Liu Y,Fu H

更新日期：2020-05-01 00:00:00

abstract：:Chronic metabolic acidosis (CMA) is a major cause of growth defect, implying disturbances of protein metabolism. Previously, in vivo studies performed in the fasting state showed enhanced whole body protein turnover, whereas in vitro studies showed unchanged muscle protein synthesis. The present study is the first to ...

journal_title：Kidney international

authors： Maniar S,Laouari D,Dechaux M,Motel V,Yvert JP,Mathian B,Kleinknecht C

更新日期：1994-12-01 00:00:00