Angiotensin converting enzyme gene polymorphism and ACE inhibition in diabetic nephropathy.

abstract：:The essential role of the glycoprotein hormone erythropoietin (Epo) in the control of red blood cell production is well established. Synthesis of Epo is induced in response to low oxygen (hypoxia). In response to stimulation, increases in serum Epo levels are paralleled by changes in the abundance of Epo mRNA. These c...

journal_title：Kidney international

authors： Göpfert T,Eckardt KU,Geb B,Kurtz A

更新日期：1997-02-01 00:00:00

abstract：:It is known that in rodents recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor (rhIGF-1) increase renal mass. It is uncertain, however, whether renal mass increases in proportion to body growth, or whether renal growth is stimulated selectively. In 120 to 150 g female Sprague-Dawl...

journal_title：Kidney international

authors： Mehls O,Irzynjec T,Ritz E,Eden S,Kovàcs G,Klaus G,Floege J,Mall G

更新日期：1993-12-01 00:00:00

abstract：:Circulating immune complexes (CIC), measured by the solid-phase Clq method, were found to be in abnormal concentration in about half of 39 patients with membranoproliferative glomerulonephritis (MPGN). In contrast, they were present, usually in higher concentration, in nearly all patients with active lupus nephritis. ...

journal_title：Kidney international

authors： Davis CA,Marder H,West CD

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:Peritoneal sclerosis, characterized by collagen accumulation, is a serious complication in continuous ambulatory peritoneal dialysis (CAPD) therapy. Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperon and is closely associated with collagen synthesis. METHODS:We determined the expression...

journal_title：Kidney international

authors： Shioshita K,Miyazaki M,Ozono Y,Abe K,Taura K,Harada T,Koji T,Taguchi T,Kohno S

更新日期：2000-02-01 00:00:00

abstract：:Nephronophthisis is an autosomal recessive kidney disease with high genetic heterogeneity. Understanding the functions of the individual genes contributing to this disease is critical for delineating the pathomechanisms of this disorder. Here, we investigated kidney function of a novel gene associated with nephronopht...

journal_title：Kidney international

authors： Airik R,Airik M,Schueler M,Bates CM,Hildebrandt F

更新日期：2019-08-01 00:00:00

abstract：:Tenascin-C is an extracellular matrix glycoprotein that plays a critical role in kidney fibrosis by orchestrating a fibrogenic niche. Here, we demonstrate that tenascin-C is a biomarker and a mediator of kidney fibrogenesis by impairing tubular integrity. Tenascin-C was found to be increased in kidney biopsies from pa...

journal_title：Kidney international

authors： Zhu H,Liao J,Zhou X,Hong X,Song D,Hou FF,Liu Y,Fu H

更新日期：2020-05-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is an inherited, progressive nephropathy accounting for 4-10% of end stage renal disease worldwide. PKD1 and PKD2 are the most common disease loci, but even accounting for other genetic causes, about 7% of families remain unresolved. Typically, these unsolved cases ...

journal_title：Kidney international

authors： Hopp K,Cornec-Le Gall E,Senum SR,Te Paske IBAW,Raj S,Lavu S,Baheti S,Edwards ME,Madsen CD,Heyer CM,Ong ACM,Bae KT,Fatica R,Steinman TI,Chapman AB,Gitomer B,Perrone RD,Rahbari-Oskoui FF,Torres VE,HALT Progression of

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] in the alveolar and glomerular basement membrane. These antibodies are associated with the development of a rapidly progressive ...

journal_title：Kidney international

authors： Hellmark T,Segelmark M,Unger C,Burkhardt H,Saus J,Wieslander J

更新日期：1999-03-01 00:00:00

abstract：:Hypertension is a well-known complication in children on renal replacement therapy and an important risk factor for cardiovascular disease in later life. In order to define the prevalence of and risk factors for hypertension among children, we enrolled 3337 pediatric patients from 15 countries in the ESPN/ERA-EDTA Reg...

journal_title：Kidney international

authors： Kramer AM,van Stralen KJ,Jager KJ,Schaefer F,Verrina E,Seeman T,Lewis MA,Boehm M,Simonetti GD,Novljan G,Groothoff JW

更新日期：2011-11-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia emerged in Wuhan, China in December 2019. Unfortunately, there is a lack of evidence about the optimal management of novel coronavirus disease 2019 (COVID-19), and even less is available in patients on maintenance hemodialysis therapy than in the g...

journal_title：Kidney international

authors： Goicoechea M,Sánchez Cámara LA,Macías N,Muñoz de Morales A,Rojas ÁG,Bascuñana A,Arroyo D,Vega A,Abad S,Verde E,García Prieto AM,Verdalles Ú,Barbieri D,Delgado AF,Carbayo J,Mijaylova A,Acosta A,Melero R,Tejedor A,Ben

更新日期：2020-07-01 00:00:00

abstract：:Hypertension is associated with an accelerated rate of decline in renal function in patients with chronic renal disease. To identify factors that might alter the rate of decline in renal function, we reviewed records of 200 patients from the Nephrology Clinic of the Durham VA Medical Center who had chronic progressive...

journal_title：Kidney international

authors： Brazy PC,Fitzwilliam JF

更新日期：1990-04-01 00:00:00

abstract：:Acute elevations in intracellular adenosine 3',5'-cyclic monophosphate (cAMP) concentrations are known to increase ionic chloride permeability in diverse tissues. To determine if chronic endogenous increases in cAMP are associated with sustained alterations in membrane ionic permeabilities, renal cortical brush border...

journal_title：Kidney international

authors： London RD,Lipkowitz MS,Abramson RG

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Renal tract malformations are, on occasion, associated with uterine malformations. The transcription factor hepatocyte nuclear factor (HNF)-1beta is expressed from the earliest stages of development of the Wolffian duct, the mesonephros and metanephros, and the Müllerian ducts in the mouse. In adult mice HNF...

journal_title：Kidney international

authors： Bingham C,Ellard S,Cole TR,Jones KE,Allen LI,Goodship JA,Goodship TH,Bakalinova-Pugh D,Russell GI,Woolf AS,Nicholls AJ,Hattersley AT

更新日期：2002-04-01 00:00:00

abstract：:The addition of spironolactone or hydrochlorothiazide enhances the antialbuminuric effect of renin-angiotensin blockers. However, comparative studies on the effect of different diuretics are lacking. We conducted a prospective randomized crossover study to compare the effects of spironolactone (25 mg/day), hydrochloro...

journal_title：Kidney international

authors： Morales E,Caro J,Gutierrez E,Sevillano A,Auñón P,Fernandez C,Praga M

更新日期：2015-12-01 00:00:00

abstract：:Sodium thiosulfate, a reversible oxidation product of hydrogen sulfide, has vasodilating and anti-oxidative properties, making it an attractive agent to alleviate damaging effects of hypertension. In experimental settings, inhibition of nitric oxide synthase causes hypertension, renal dysfunction and damage. We hypoth...

journal_title：Kidney international

authors： Nguyen ITN,Klooster A,Minnion M,Feelisch M,Verhaar MC,van Goor H,Joles JA

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Wegener's granulomatosis (WG) is characterized by systemic vasculitis with crescentic glomerulonephritis (CGN) and circulating autoantibodies directed against neutrophil cytoplasmic antigens (ANCA). Proteinase 3 (PR-3), a neutral serine proteinase in neutrophils implicated in the growth control of myeloid ce...

journal_title：Kidney international

authors： Schwarting A,Hagen D,Odenthal M,Brockmann H,Dienes HP,Wandel E,Rumpelt HJ,Zum Büschenfelde KH,Galle PR,Mayet W

更新日期：2000-06-01 00:00:00

abstract：:Acute kidney injury (AKI) increases the risk for chronic kidney disease (CKD). However, there are few tools to detect microstructural changes after AKI. Here, cationic ferritin-enhanced magnetic resonance imaging (CFE-MRI) was applied to examine the heterogeneity of kidney pathology in the transition from AKI to CKD. ...

journal_title：Kidney international

authors： Charlton JR,Xu Y,Wu T,deRonde KA,Hughes JL,Dutta S,Oxley GT,Cwiek A,Cathro HP,Charlton NP,Conaway MR,Baldelomar EJ,Parvin N,Bennett KM

更新日期：2021-01-01 00:00:00

abstract：:Human mesangial cells (MC) in culture, when stimulated by interleukin 1 alpha(IL-1 alpha) or tumour necrosis factor (TNF alpha), but not with lipopolysaccharide (LPS), express interleukin 8 (IL-8) mRNA, and both cell associated and extracellular IL-8. Dexamethasone treatment of mesangial cells induced partial inhibiti...

journal_title：Kidney international

authors： Brown Z,Strieter RM,Chensue SW,Ceska M,Lindley I,Neild GH,Kunkel SL,Westwick J

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:We aimed to identify genes with kidney specific, developmentally regulated expression. Here we report the cDNA sequence and expression pattern of KS, a novel kidney-specific rat gene. METHODS:A partial cDNA was identified by differential display polymerase chain reaction (PCR) of a renal cell fraction enric...

journal_title：Kidney international

authors： Hilgers KF,Nagaraj SK,Karginova EA,Kazakova IG,Chevalier RL,Carey RM,Pentz ES,Gomez RA

更新日期：1998-11-01 00:00:00

abstract：INTRODUCTION:Monocyte chemoattractant protein-1 (MCP-1) promotes renal inflammation, thereby contributing to acute and chronic nephropathies. Its production is stimulated by oxidative stress. Thus, this study tested whether pro-oxidant iron/carbohydrate complexes, used to treat iron deficiency, induce MCP-1 in renal/ex...

journal_title：Kidney international

authors： Zager RA

更新日期：2005-10-01 00:00:00

abstract：:Severe segmental glomerulonephritis (Seg GN) (greater than or equal to 50% involvement) in systemic lupus erythematosus (SLE) is classified as diffuse GN (DPGN) in the WHO classification. We tested the validity of the assumption that severe Seg GN and DPGN have the same prognosis by determining the proportion of glome...

journal_title：Kidney international

authors： Schwartz MM,Kawala KS,Corwin HL,Lewis EJ

更新日期：1987-08-01 00:00:00

abstract：:Primary distal renal tubular acidosis is a rare genetic disease. Mutations in SLC4A1, ATP6V0A4, and ATP6V1B1 genes have been described as the cause of the disease, transmitted as either an autosomal dominant or recessive trait. Particular clinical features, such as sensorineural hearing loss, have been mainly describe...

journal_title：Kidney international

authors： Palazzo V,Provenzano A,Becherucci F,Sansavini G,Mazzinghi B,Orlandini V,Giunti L,Roperto RM,Pantaleo M,Artuso R,Andreucci E,Bargiacchi S,Traficante G,Stagi S,Murer L,Benetti E,Emma F,Giordano M,Rivieri F,Colussi G,

更新日期：2017-05-01 00:00:00

abstract：:Ischemia-reperfusion injury is an important cause of graft failure. Because carnitine regulates substrate flux and energy balance across membranes which may be deranged in ischemia we determined whether its use was effective in preventing kidney injury in an allogeneic transplant model. Brown Norway rats received a Le...

journal_title：Kidney international

authors： Azzollini N,Cugini D,Cassis P,Pezzotta A,Gagliardini E,Abbate M,Arduini A,Peschechera A,Remuzzi G,Noris M

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Hyperhomocysteinemia is a risk factor for atherosclerosis that is common in chronic renal failure (CRF), but its cause is unknown. Homocysteine metabolism is linked to betaine-homocysteine methyl transferase (BHMT), a zinc metalloenzyme that converts glycine betaine (GB) to N,N dimethylglycine (DMG). DMG is ...

journal_title：Kidney international

authors： McGregor DO,Dellow WJ,Lever M,George PM,Robson RA,Chambers ST

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Low dietary phosphorus (P) prevents parathyroid gland (PTG) hyperplasia and the development of secondary hyperparathyroidism (SH) in uremic rats. The present study explores the effects of P restriction on parathyroid hormone (PTH) synthesis and secretion and PT cell growth in rats with established SH and PTG...

journal_title：Kidney international

authors： Takahashi F,Denda M,Finch JL,Brown AJ,Slatopolsky E

更新日期：2002-04-01 00:00:00

abstract：:Hemodynamic pressure in glomerular capillaries (GCP) and in first order peritubular capillaries (EAP) in superficial nephrons of mutant Wistar rats with surface glomeruli was measured by micropuncture with a servo-nulling device in the following conditions: 1) control;2) norepinephrine infusion (NE); 3) epinephrine in...

journal_title：Kidney international

authors： Andreucci VE,Dal Canton A,Corradi A,Stanziale R,Migone L

更新日期：1976-06-01 00:00:00

abstract：:Hypoalbuminemia is the most powerful predictor of mortality in end-stage renal disease. Since protein-calorie malnutrition can decrease albumin synthesis it is assumed that hypoalbuminemia results principally from malnutrition in these patients, but albumin synthesis may also be decreased as part of the acute-phase re...

journal_title：Kidney international

authors： Kaysen GA,Rathore V,Shearer GC,Depner TA

更新日期：1995-08-01 00:00:00

abstract：:Zhang et al. found that plasma concentrations of the thiamine antimetabolite oxythiamine are significantly increased in patients with end-stage renal disease. These investigators discuss the potential sources of oxythiamine and the consequences of its plasma elevation. This commentary addresses the significance of the...

journal_title：Kidney international

authors： Moradi H,Said HM

更新日期：2016-08-01 00:00:00

abstract：:Unilateral ureteral obstruction in rabbits leads to an influx of macrophages into the kidney, a proliferation of interstitial cells, and an increase in arachidonic acid metabolism. The role of the macrophage in the metabolic changes of hydronephrosis was investigated by using endotoxin and nitrogen mustard. The in viv...

journal_title：Kidney international

authors： Lefkowith JB,Okegawa T,DeSchryver-Kecskemeti K,Needleman P

更新日期：1984-07-01 00:00:00

abstract：:Incretin-based drugs, i.e., glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors, are widely used for the treatment of type 2 diabetes. In addition to the primary role of incretins in stimulating insulin secretion from pancreatic β-cells, they have extra pancreatic functions ...

journal_title：Kidney international

authors： Tanaka T,Higashijima Y,Wada T,Nangaku M

更新日期：2014-10-01 00:00:00