当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Transplant approach establishes that kidneys are responsible for serum CSF-1 but require a stimulus in MRL-lpr mice.

Transplant approach establishes that kidneys are responsible for serum CSF-1 but require a stimulus in MRL-lpr mice.

Abstract：

:Colony stimulating factor-1 (CSF-1) is a chemoattractant and growth factor for macrophages. In autoimmune MRL-lpr mice, CSF-1 is detected in the circulation and there is an increase in CSF-1 transcripts and macrophages in the kidney. The purpose of this study was to establish whether the MRL-lpr kidney is responsible for increasing serum CSF-1, and to determine if the expression of CSF-1 requires a circulating component in MRL-lpr mice. We transplanted a MRL-lpr kidney with nephritis [serum CSF-1 = 32.6 +/- 5.1 colony forming units (CFU)] into a bilaterally nephrectomized normal MRL-++ recipient. Circulating CSF-1 increased from 1.2 +/- CFU to 14.1 +/_ 5.6 CFU in recipients by one week. Continuous production of CSF-1 required a stimulating component since: (1) CSF-1 in the kidney and circulation disappeared several weeks after engraftment into MRL-++ mice and (2) isolated glomeruli from MRL-lpr required stimulation to express CSF-1. In the transplanted MRL-lpr kidney, hypercellularity in the glomerulus and interstitium (predominantly macrophages) returned to normal as rapidly as two weeks after engraftment into MRL-++. Thus, this study establishes that the kidney is responsible for circulating CSF-1 in MRL-lpr mice. Without the autoimmune environment CSF-1, macrophages, but not T cells, disappear and nephritis resolves.

journal_name

Kidney Int

journal_title

Kidney international

authors

Naito T,Griffiths RC,Coffman TM,Kelley VR

doi

10.1038/ki.1996.9

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

67-74

issue

1

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)59339-3

journal_volume

49

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Mortality prediction in stable hemodialysis patients is refined by YKL-40, a 40-kDa glycoprotein associated with inflammation.

    abstract：:Chronic inflammation contributes to increased mortality in hemodialysis (HD) patients. YKL-40 is a novel marker of inflammation, tissue remodeling, and highly expressed in macrophages inside vascular lesions. Elevated levels of YKL-40 have been reported for HD patients but how it integrates into the proinflammatory me...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2017.07.010

    authors： Lorenz G,Schmalenberg M,Kemmner S,Haller B,Steubl D,Pham D,Schreiegg A,Bachmann Q,Schmidt A,Haderer S,Huber M,Angermann S,Günthner R,Braunisch M,Hauser C,Reichelt AL,Matschkal J,Suttmann Y,Moog P,Stock K,Küchle C

    更新日期：2018-01-01 00:00:00

  • Glomerular platelet-activating factor levels and origin in experimental glomerulonephritis.

    abstract：:The content of platelet activating factor (PAF) in glomeruli isolated from rats with nephrotoxic serum glomerulonephritis (NSGN) was quantified at various stages of the disease and the role of complement, platelets and neutrophils in mediating changes in glomerular PAF levels was evaluated. PAF content was assessed fo...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.40

    authors： Lianos EA,Zanglis A

    更新日期：1990-02-01 00:00:00

  • Crystalluria: a clinically useful investigation in children with primary hyperoxaluria post-transplantation.

    abstract：:Primary hyperoxaluria type I (PH I) is a congenital error of metabolism that can be manifested by an increased oxalate production, and ultimately result in kidney failure. After a combined liver/kidney transplantation, children with PH I have persistent excretion of oxalate that causes crystal formation in the urinary...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00876.x

    authors： Jouvet P,Priqueler L,Gagnadoux MF,Jan D,Beringer A,Lacaille F,Revillon Y,Broyer M,Daudon M

    更新日期：1998-05-01 00:00:00

  • Alloreactive T cells and 'the persistence of memory'.

    abstract：:Circulating donor-reactive effector memory T cells have been associated with allograft injury in humans. The next step to translate this observation into clinical practice is the design of clinical trials aimed at individualization of T cell-targeted therapy. The administration of immunosuppressive therapy based on th...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2013.295

    authors： Poggio ED,Augustine JJ

    更新日期：2013-12-01 00:00:00

  • The role of the collecting duct in urinary concentration.

    abstract：:In summary, the three major segments of the collecting duct subserve three different functions in the urinary concentrating mechanism. The main function of the cortical collecting tubule is to raise the fractional solute contribution and absolute concentration of urea in fluid that it delivers to the outer medullary c...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.1987.41

    authors： Kokko JP

    更新日期：1987-02-01 00:00:00

  • A non-nucleotide-bridged DNA decoy inhibits renal epithelial nitric oxide synthase expression.

    abstract：UNLABELLED:A non-nucleotide-bridged DNA decoy inhibits renal epithelial nitric oxide synthase expression. BACKGROUND:The expression of inducible nitric oxide synthase (iNOS) is subject to strict tissue-specific transcriptional control. In mouse renal epithelium, an interferon-gamma (IFN-gamma)-induced signaling protei...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00809.x

    authors： Amoah-Apraku B,Fang MZ,Guzman NJ

    更新日期：2000-01-01 00:00:00

  • Factors in the dialysis regimen which contribute to alterations in the abnormalities of uremia.

    abstract：:While hemodialysis therapy in its present form is capable of sustaining life, dialysis patients are not metabolically normal and we are unable to say what technical factors contribute adequate therapy. Recent efforts to resolve these problems have led to the assumption that substances in the molecular weight range of ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1976.126

    authors： Lowrie EG,Steinberg SM,Galen MA,Gagneux SA,Lazarus JM,Gottlieb MN,Merrill JP

    更新日期：1976-11-01 00:00:00

  • Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release.

    abstract：:Autophagy is a dynamic and highly regulated process of self-digestion responsible for cell survival and reaction to oxidative stress. As oxidative stress is increased in uremia and is associated with vascular calcification, we studied the role of autophagy in vascular calcification induced by phosphate. In an in vitro...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2012.482

    authors： Dai XY,Zhao MM,Cai Y,Guan QC,Zhao Y,Guan Y,Kong W,Zhu WG,Xu MJ,Wang X

    更新日期：2013-06-01 00:00:00

  • Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis.

    abstract：BACKGROUND:Microarray technology is a powerful tool that can probe the molecular pathogenesis of renal injury. In this present study microarray analysis was used to monitor serial changes in the renal transcriptome of a rat model of mesangial proliferative glomerulonephritis. Administration of anti-Thy1 antibody result...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00661.x

    authors： Sadlier DM,Ouyang X,McMahon B,Mu W,Ohashi R,Rodgers K,Murray D,Nakagawa T,Godson C,Doran P,Brady HR,Johnson RJ

    更新日期：2005-12-01 00:00:00

  • Association of short sleep duration and rapid decline in renal function.

    abstract：:The kidney is influenced by circadian rhythms and is entrained to the sleep-wake cycle allowing anticipation of the metabolic and physiological demands of the kidney throughout a 24-hour cycle. Although sleep disruption has been studied extensively in cardiovascular and metabolic disease, its association with chronic ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2015.12.048

    authors： McMullan CJ,Curhan GC,Forman JP

    更新日期：2016-06-01 00:00:00

  • Advances in renal (patho)physiology using multiphoton microscopy.

    abstract：:Multiphoton excitation fluorescence microscopy is a state-of-the-art confocal imaging technique ideal for deep optical sectioning of living tissues. It is capable of performing ultrasensitive, quantitative imaging of organ functions in health and disease with high spatial and temporal resolution which other imaging mo...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/sj.ki.5002461

    authors： Sipos A,Toma I,Kang JJ,Rosivall L,Peti-Peterdi J

    更新日期：2007-11-01 00:00:00

  • Mesangial cell signaling cascades in response to mechanical strain and glucose.

    abstract：BACKGROUND:Elevated glucose levels and glomerular hypertension (Pgc) are considered to contribute to the elaboration of matrix protein by mesangial cells (MCs) in diabetic glomeruli. MCs grown in 30 mM of glucose produce excessive matrix protein, as do MCs exposed to cyclic strain, and the combination of the two exacer...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00743.x

    authors： Ingram AJ,Ly H,Thai K,Kang MJ,Scholey JW

    更新日期：1999-11-01 00:00:00

  • Dietary salt regulates expression of Tamm-Horsfall glycoprotein in rats.

    abstract：BACKGROUND:Tamm-Horsfall glycoprotein (THP) is a unique protein that is produced exclusively by cells of the thick ascending limb of Henle's loop (TALH). This study examined whether dietary salt altered renal THP production. METHODS:Male Sprague-Dawley rats were examined on days 1, 4, and 15 following placement in met...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00117.x

    authors： Ying WZ,Sanders PW

    更新日期：1998-10-01 00:00:00

  • Autonomic blockade and the Valsalva maneuver in patients on maintenance hemodialysis: a hemodynamic study.

    abstract：:Hemodynamic studies were performed at two levels of dietary sodium intake (10 mmoles/day and 100 mmoles/day for 14 days) in a group of patients (with retained kidneys) on chronic hemodialysis. Plasma renin activity and aldosterone, plasma, and extracellular fluid (ECF) volumes were measured while the patient were at r...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1977.114

    authors： McGrath BP,Tiller DJ,Bune A,Chalmers JP,Korner PI,Uther JB

    更新日期：1977-10-01 00:00:00

  • Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport syndrome.

    abstract：:Defective cholesterol metabolism primarily linked to reduced ATP-binding cassette transporter A1 (ABCA1) expression is closely associated with the pathogenesis and progression of kidney diseases, including diabetic kidney disease and Alport Syndrome. However, whether the accumulation of free or esterified cholesterol ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2020.06.040

    authors： Liu X,Ducasa GM,Mallela SK,Kim JJ,Molina J,Mitrofanova A,Wilbon SS,Ge M,Fontanella A,Pedigo C,Santos JV,Nelson RG,Drexler Y,Contreras G,Al-Ali H,Merscher S,Fornoni A

    更新日期：2020-11-01 00:00:00

  • Changing gears in the course of glomerulonephritis by shifting superoxide to nitric oxide-dominated chemistry.

    abstract：:The glomerular response to injury displays astonishingly uniform features that include infiltration with professional immune cells, activation and proliferation of resident glomerular cells and matrix expansion. Cross-communication of intrinsic mesangial cells with invading immune cells is crucial for the fate of glom...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1046/j.1523-1755.2002.00225.x

    authors： Pfeilschifter J,Beck KF,Eberhardt W,Huwiler A

    更新日期：2002-03-01 00:00:00

  • Identification of a clinically relevant immunodominant region of collagen IV in Goodpasture disease.

    abstract：BACKGROUND:The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] in the alveolar and glomerular basement membrane. These antibodies are associated with the development of a rapidly progressive ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.055003936.x

    authors： Hellmark T,Segelmark M,Unger C,Burkhardt H,Saus J,Wieslander J

    更新日期：1999-03-01 00:00:00

  • Preserved leukocyte CD11b expression at the site of interstitial inflammation in patients with high-flux hemodiafiltration.

    abstract：:The impact of high-flux hemodialysis on clinical outcomes remains controversial. We have previously shown that in vivo transmigrated leukocytes from patients with low-flux bioincompatible hemodialysis have an impaired capacity to upregulate CD11b at the site of interstitial inflammation. In the present study, we inves...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5002090

    authors： Olsson J,Dadfar E,Paulsson J,Lundahl J,Moshfegh A,Jacobson SH

    更新日期：2007-03-01 00:00:00

  • The hypoxia-inducible factor-1 DNA recognition site is cAMP-responsive.

    abstract：:The hypoxia-inducible factor-1 (HIF-1) was first described as a DNA binding activity that specifically recognizes an 8 bp hypoxia response element (HRE) known to be essential for oxygen-regulated erythropoietin gene expression. In electrophoretic mobility shift assays (EMSAs) HIF-1 DNA binding activity is only detecta...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.80

    authors： Kvietikova I,Wenger RH,Marti HH,Gassmann M

    更新日期：1997-02-01 00:00:00

  • Acute renal failure independently predicts mortality after myeloablative allogeneic hematopoietic cell transplant.

    abstract：BACKGROUND:Patients undergoing myeloablative allogeneic hematopoietic cell transplantation (HCT) have a high incidence of acute renal failure (ARF). However, it is unclear if ARF is independently associated with mortality after this procedure. METHODS:We performed meta-analysis of published reports on ARF after myeloa...

    journal_title：Kidney international

    pub_type： 杂志文章,meta分析

    doi：10.1111/j.1523-1755.2005.00301.x

    authors： Parikh CR,McSweeney P,Schrier RW

    更新日期：2005-05-01 00:00:00

  • Diabetic nephropathy in the uninephrectomized dog: microscopic lesions after one year.

    abstract：:Carefully age-matched, purebred male beagle dogs that underwent uninephrectomy one month after they were made diabetic with alloxan were used to establish a model of rapidly developing diabetic nephropathy in a large animal. The diabetic animals, all requiring insulin, were divided into two groups: one group with cont...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1982.88

    authors： Steffes MW,Buchwald H,Wigness BD,Groppoli TJ,Rupp WM,Rohde TD,Blackshear PJ,Mauer SM

    更新日期：1982-05-01 00:00:00

  • High glomerular permeability of bikunin despite similarity in charge and hydrodynamic size to serum albumin.

    abstract：:Bikunin is a chondroitin-sulphate containing serum protein with a Stokes-Einstein radius and a negative net charge close to those of serum albumin. The plasma half life of bikunin is about 10 minutes, and approximately half of its clearance occurs in the kidneys. The quantitative role of glomerular filtration in the r...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.147

    authors： Lindström KE,Blom A,Johnsson E,Haraldsson B,Fries E

    更新日期：1997-04-01 00:00:00

  • Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. I. Immunohistochemical studies.

    abstract：:IgA nephropathy (IgAN) often shows lesions morphologically identical with those of focal segmental glomerulosclerosis (FSGS). In order to determine the possible role of FSGS in IgAN lesions, we measured glomerular capsular adhesions, often the first step toward FSGS, in biopsies from 127 patients with IgAN, 100 with l...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2010.466

    authors： Hill GS,Karoui KE,Karras A,Mandet C,Van Huyen JD,Nochy D,Bruneval P

    更新日期：2011-03-01 00:00:00

  • Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in Autosomal Dominant Polycystic Kidney Disease.

    abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of kidney cysts leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Identification of an early biomarker that can predict progression of CKD is urgently needed. In an earlier Consortium for Radiolog...

    journal_title：Kidney international

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.kint.2017.09.027

    authors： Yu ASL,Shen C,Landsittel DP,Harris PC,Torres VE,Mrug M,Bae KT,Grantham JJ,Rahbari-Oskoui FF,Flessner MF,Bennett WM,Chapman AB,Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP).

    更新日期：2018-03-01 00:00:00

  • Apolipoproteins and lipoprotein receptors in glomeruli in human kidney diseases.

    abstract：:This study offers morphological evidence of the involvement of lipid abnormalities in human glomerular injury. Renal biopsy tissues from patients with several types of glomerular diseases were immunocytochemically examined using antibodies to apolipoproteins (apo) A-I, B-100, and E, and antibodies to low density lipop...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1993.129

    authors： Takemura T,Yoshioka K,Aya N,Murakami K,Matumoto A,Itakura H,Kodama T,Suzuki H,Maki S

    更新日期：1993-04-01 00:00:00

  • Renal pathology and retinol status in multiple myeloma patients.

    abstract：:Renal dysfunction is a common and serious complication in multiple myeloma (MM) patients. Renal proximal tubule injury is characteristic in MM, and may result in disturbed renal handling of various vitamins. The abnormal excretion of vitamins in urine may result in their low serum levels. The goal of this study was to...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000024

    authors： Gavrilov V,Yermiahu T,Gorodischer R

    更新日期：2006-01-01 00:00:00

  • Subcellular localization of renal kallikrein by ultrastructural immunocytochemistry.

    abstract：:The subcellular distribution of immunoreactive kallikrein was described in the rat nephron using ultrastructural immunocytochemistry. The renal tissue was fixed with a mixture of buffered picric acid-paraformaldehyde-glutaraldehyde and immunostained with the peroxidase-antiperoxidase method for the electron microscope...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1985.115

    authors： Vío CP,Figueroa CD

    更新日期：1985-07-01 00:00:00

  • AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medulla.

    abstract：:Angiotensin II plays an important role in the regulation of blood pressure, body salt and fluid balance, and urine concentration. Mice with deletion of the AT(1a) receptor develop polyuria and urine concentration defects. We studied the mechanisms of these urine concentration defects by treating wild-type and AT(1a)-k...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.134

    authors： Li XC,Shao Y,Zhuo JL

    更新日期：2009-07-01 00:00:00

  • Myeloproliferative neoplasms cause glomerulopathy.

    abstract：:Myeloproliferative neoplasms are clonal hematopoietic stem cell disorders that can produce an undefined glomerulopathy. To better characterize the glomerular disease associated with myeloproliferative neoplasms, we evaluated features of 11 patients with myeloproliferative neoplasm-related glomerulopathy that included ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2011.147

    authors： Said SM,Leung N,Sethi S,Cornell LD,Fidler ME,Grande JP,Herrmann S,Tefferi A,D'Agati VD,Nasr SH

    更新日期：2011-10-01 00:00:00

  • Effect of dithiothreitol on mercuric chloride- and uranyl nitrate-induced acute renal failure in the rat.

    abstract：:The current study was undertaken to examine the effects of dithiothreitol (DDT), a sulfhydryl-reducing agent and heavy metal chelator, on the course of heavy metal-induced acute renal failure in the rat. Groups of rats in metabolic cages received uranyl nitrate (UN) alone, UN plus DTT, mercuric chloride (HgCl2) alone,...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1977.88

    authors： Kleinman JG,McNeil JS,Schwartz JH,Hamburger RJ,Flamenbaum W

    更新日期：1977-08-01 00:00:00