Changing gears in the course of glomerulonephritis by shifting superoxide to nitric oxide-dominated chemistry.

abstract：:The aging process in humans and in the rat is associated with an impairment in renal tubular reabsorption of Pi and renal tubular adaptation to a low Pi diet. The purposes of the present study were to determine whether changes in the abundance of type II Na-Pi contransporter (NaPi-2) protein and/or mRNA play a role in...

journal_title：Kidney international

authors： Sorribas V,Lötscher M,Loffing J,Biber J,Kaissling B,Murer H,Levi M

更新日期：1996-09-01 00:00:00

abstract：:Horvat and coauthors report on trends in living kidney transplantation in 69 countries, having assembled the data from registries, national societies, the medical literature, and direct contact with transplant centers. Assembling worldwide data on live-donor kidney transplants is a commendable accomplishment that serv...

journal_title：Kidney international

authors： Delmonico FL

更新日期：2009-05-01 00:00:00

abstract：:Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare. Current studies of such 'double-positive' cases report small numbers and variable outcomes. To study this further we retrospectively analyzed clinical features and long-term outcomes of a large cohort of 568 contemporary patients ...

journal_title：Kidney international

authors： McAdoo SP,Tanna A,Hrušková Z,Holm L,Weiner M,Arulkumaran N,Kang A,Satrapová V,Levy J,Ohlsson S,Tesar V,Segelmark M,Pusey CD

更新日期：2017-09-01 00:00:00

abstract：:Recent advances have led to a greater appreciation of how mitochondrial dysfunction contributes to diverse acute and chronic pathologies. Indeed, mitochondria have received increasing attention as a therapeutic target in a variety of diseases because they serve as key regulatory hubs uniquely situated at crossroads be...

journal_title：Kidney international

authors： Galvan DL,Green NH,Danesh FR

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:While an understanding of the epidemiology and clinical course of HIV-associated nephropathy (HIVAN) is growing, little is known about the risk factors and clinical course of the other renal diseases that may also occur as a complication of HIV infection. This study was undertaken to compare HIVAN to the spe...

journal_title：Kidney international

authors： Szczech LA,Gupta SK,Habash R,Guasch A,Kalayjian R,Appel R,Fields TA,Svetkey LP,Flanagan KH,Klotman PE,Winston JA

更新日期：2004-09-01 00:00:00

abstract：:A study of dialysis costs in five major dialysis centers throughout the United States was conducted in 1973. When available, home, home training, limited care, satellite and in-hospital-full-care dialysis were included. The study's objective was to determine the cost per dialysis for each separate dialysis modality. A...

journal_title：Kidney international

authors： Hoffstein PA,Krueger KK,Wineman RJ

更新日期：1976-03-01 00:00:00

abstract：:Experimental studies have demonstrated the cardinal role played by the mononuclear phagocyte system in the removal of antigen-antibody complexes. To assess the functional capacity of phagocytes in patients with renal disease, 33 normal subjects, 10 patients with mesangial proliferative glomerulonephritis, 8 patients w...

journal_title：Kidney international

authors： Ooi YM,Ooi BS

更新日期：1983-06-01 00:00:00

abstract：:The pathologic and clinical features of 16 patients with dense intramembranous deposit disease are described. By light microscopy nine patients had membranoproliferative glomerulonephritis, five had focal segmental necrotizing glomerulonephritis with segmental epithelial crescents, four of whom also had a prominent tu...

journal_title：Kidney international

authors： Sibley RK,Kim Y

更新日期：1984-04-01 00:00:00

abstract：:The cellular redox state is altered in a number of pathological conditions, including various forms of glomerular injury and diabetes. For example, glucose, via the pentose phosphate pathway generates NADPH, which maintains glutathione (GSH) (part of a major intracellular reducing system) in its reduced state. GSH in ...

journal_title：Kidney international

authors： Shan Z,Tan D,Satriano J,Silbiger S,Schlondorff D

更新日期：1994-08-01 00:00:00

abstract：:The microvillus brush border on the renal proximal tubule epithelium allows the controlled reabsorption of solutes that are filtered through the glomerulus and thus participates in general body homeostasis. Here, using the lipid 5-phosphatase Ship2 global knockout mice, proximal tubule-specific Ship2 knockout mice, an...

journal_title：Kidney international

authors： Sayyed SG,Jouret F,Vermeersch M,Pérez-Morga D,Schurmans S

更新日期：2017-07-01 00:00:00

abstract：:Recent reports indicate a decreased mortality risk for patients on chronic peritoneal dialysis in the United States. We sought to determine whether a higher use of automated versus continuous ambulatory peritoneal dialysis was associated with this improvement. Analyses were carried out using data from the United State...

journal_title：Kidney international

authors： Mehrotra R,Chiu YW,Kalantar-Zadeh K,Vonesh E

更新日期：2009-07-01 00:00:00

abstract：:Impaired olfactory function is a marker of neurologic dysfunction in the uremic state. Retained uremic toxins not adequately cleared with dialysis may undermine the integrity of the olfactory epithelium and olfactory bulb and malign central olfactory processing. The evidence suggests that only renal transplantation, w...

journal_title：Kidney international

authors： Bomback AS,Raff AC

更新日期：2011-10-01 00:00:00

abstract：UNLABELLED:Predicting renal survival in primary focal glomerulosclerosis from the time of presentation. BACKGROUND:To predict the risk of developing chronic renal failure in patients with primary focal glomerulosclerosis (FGS) using predictors available at the time of presentation, a retrospective analysis was perform...

journal_title：Kidney international

authors： Chitalia VC,Wells JE,Robson RA,Searle M,Lynn KL

更新日期：1999-12-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase. Its activation results in beneficial or detrimental consequences, depending on the particular setting. Earlier studies in the animal model of acute kidney injury showed that EGFR activation promotes renal tubular cell proliferation. Activation of E...

journal_title：Kidney international

authors： Tang J,Liu N,Zhuang S

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:It is known that chronic renal insufficiency (CRI) patients with gout may have subtle lead poisoning. In addition, gout episodes frequently aggravate progressive renal insufficiency because of the use of nephrotoxic drugs and urate deposition. Our study was arranged to evaluate the causal effect of environme...

journal_title：Kidney international

authors： Lin JL,Yu CC,Lin-Tan DT,Ho HH

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:It is not known to what extent intravascular phenotypic alterations in adhesion molecule expression induced by hemodialysis influence the recruitment of monocytes and their ability to up-regulate CD11b at the local site of inflammation in the interstitium. Using a skin suction chamber technique, we addressed...

journal_title：Kidney international

authors： Thylén P,Lundahl J,Fernvik E,Grönneberg R,Halldén G,Jacobson SH

更新日期：2000-05-01 00:00:00

abstract：:Chronic kidney disease (CKD) promotes development of cardiac abnormalities and is highly prevalent in patients with heart failure, particularly in those with preserved ejection fraction. CKD is associated with endothelial dysfunction, however, whether CKD can induce impairment of endothelium-to-cardiomyocyte crosstalk...

journal_title：Kidney international

authors： Juni RP,Al-Shama R,Kuster DWD,van der Velden J,Hamer HM,Vervloet MG,Eringa EC,Koolwijk P,van Hinsbergh VWM

更新日期：2020-12-22 00:00:00

abstract：:The renal growth hormone--insulin-like growth factor-I system in acute ischemic renal failure. Recovery from acute tubular necrosis (ATN) is accelerated by IGF-I therapy. Furthermore, the local renal growth hormone-IGF-I system may participate in the natural repair. We examined the IGF-I system in rat kidneys subjecte...

journal_title：Kidney international

authors： Tsao T,Wang J,Fervenza FC,Vu TH,Jin IH,Hoffman AR,Rabkin R

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Cold ischemia and reperfusion during kidney transplantation are associated with release of free oxygen radicals and damage of renal tubular cells. Bioflavonoids may diminish cold storage-induced injury due to antioxidant and iron chelating activities. This study was designed to delineate the renoprotective m...

journal_title：Kidney international

authors： Ahlenstiel T,Burkhardt G,Köhler H,Kuhlmann MK

更新日期：2003-02-01 00:00:00

abstract：:The mean renal tubular diameters, number of tubules per unit of cross-sectional area, and fraction of the total volume occupied by each medullary structure were determined at various levels of the renal medulla of the rat and rabbit. Statistical estimates of anatomic variables were made using spatial sampling techniqu...

journal_title：Kidney international

authors： Knepper MA,Danielson RA,Saidel GM,Post RS

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:Controversy exists regarding the possible associations between a single nucleotide polymorphism of the transcobalamin II encoding gene (TCN2 776C>G) and plasma levels of vitamin B(12), folate, or total homocysteine. METHODS:In a cross-sectional study of 732 kidney allograft recipients, patients were categor...

journal_title：Kidney international

authors： Winkelmayer WC,Skoupy S,Eberle C,Födinger M,Sunder-Plassmann G

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Nephrotoxic glomerulonephritis is induced by the administration of antibody against the glomerular basement membrane (GBM). We demonstrated previously that Fc receptors for immunoglobulin G (IgG) (FcgammaR) play crucial roles in the induction of accelerated nephrotoxic glomerulonephritis by using FcRgamma-de...

journal_title：Kidney international

authors： Fujii T,Hamano Y,Ueda S,Akikusa B,Yamasaki S,Ogawa M,Saisho H,Verbeek JS,Taki S,Saito T

更新日期：2003-10-01 00:00:00

abstract：:Nephropathy is among the most frequent complications of diabetes and the leading cause of end-stage renal disease. Despite the success of novel drugs in animal models, the majority of the subsequent clinical trials employing those drugs targeting diabetic nephropathy failed. This lack of translational value may in par...

journal_title：Kidney international

authors： Klein J,Ramirez-Torres A,Ericsson A,Huang Y,Breuil B,Siwy J,Mischak H,Peng XR,Bascands JL,Schanstra JP

更新日期：2016-11-01 00:00:00

abstract：:We investigated the effects of epidermal growth factor (EGF) and arginine vasopressin (AVP) on Raf-1-MAP kinase cascade, including Raf-1-kinase (Raf-1-K), MAP kinase kinase (MAPKK), MAP kinase (MAPK) and S6 kinase (S6K) in Madin-Darby canine kidney (MDCK) cells. In a dose-dependent manner (10(-10) M to 10(-6) M), EGF ...

journal_title：Kidney international

authors： Yamada T,Terada Y,Homma MK,Nonoguchi H,Sasaki S,Yuasa Y,Tomita K,Marumo F

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Wegener's granulomatosis (WG) is a rare systemic autoimmune disease characterized by small-vessel vasculitis leading to organ damage and the presence of antineutrophil cytoplasmic autoantibodies (ANCAs). ANCAs were shown to be involved in the pathogenesis of the disease by increasing adhesion of polymorphonu...

journal_title：Kidney international

authors： Gencik M,Meller S,Borgmann S,Fricke H

更新日期：2000-12-01 00:00:00

abstract：:Plasma lipid and lipoprotein concentration and high density lipoprotein (HDL) kinetics were determined in control subjects and patients with chronic renal failure (CRF). Results demonstrated that plasma triglyceride (TG) concentration was significantly higher (P less than 0.001) in patients with CRF, associated with a...

journal_title：Kidney international

authors： Fuh MM,Lee CM,Jeng CY,Shen DC,Shieh SM,Reaven GM,Chen YD

更新日期：1990-05-01 00:00:00

abstract：:In a double-blind, randomized, placebo-controlled cross-over study, we investigated in seven patients with chronic renal failure the effect of conjugated estrogens (0.6 mg/kg/day for 5 days) on template bleeding time and on thromboxane A2 (TxA2), beta-thromboglobulin (beta-TG) and prostacyclin (PGI2) concentrations in...

journal_title：Kidney international

authors： Heistinger M,Stockenhuber F,Schneider B,Pabinger I,Brenner B,Wagner B,Balcke P,Lechner K,Kyrle PA

更新日期：1990-12-01 00:00:00

abstract：:Severe segmental glomerulonephritis (Seg GN) (greater than or equal to 50% involvement) in systemic lupus erythematosus (SLE) is classified as diffuse GN (DPGN) in the WHO classification. We tested the validity of the assumption that severe Seg GN and DPGN have the same prognosis by determining the proportion of glome...

journal_title：Kidney international

authors： Schwartz MM,Kawala KS,Corwin HL,Lewis EJ

更新日期：1987-08-01 00:00:00

abstract：UNLABELLED:Comparison of treatments for mild secondary hyperparathyroidism in hemodialysis patients. BACKGROUND:In the management of patients with mild secondary hyperparathyroidism, it is not known whether calcium supplementation alone is sufficient to correct abnormalities in bone and mineral metabolism or if calcit...

journal_title：Kidney international

authors： Indridason OS,Quarles LD

更新日期：2000-01-01 00:00:00

abstract：:Enalapril effectively decreases hematocrits in patients with postrenal transplant erythrocytosis (PTE). We studied the effect of enalapril withdrawal on erythropoiesis in 18 patients with PTE who had been treated for 13 +/- 8 months. Hematocrit, reticulocyte count, plasma erythropoietin, and plasma insulin-like growth...

journal_title：Kidney international

authors： Julian BA,Gaston RS,Barker CV,Krystal G,Diethelm AG,Curtis JJ

更新日期：1994-11-01 00:00:00