Alloreactive T cells and 'the persistence of memory'.

abstract：:Experiments were performed to study the mechanism of the compensatory increase in the excretion of metabolic acid by residual nephrons after reduction in renal mass. Despite a decrease in nephron population to 20% of control, total excretion of acid remained similar to pair-fed controls due to an increase in nephron e...

journal_title：Kidney international

authors： MacClean AJ,Hayslett JP

更新日期：1980-05-01 00:00:00

abstract：:Determination of serum oxalate concentration is important for the diagnosis and monitoring of hyperoxalurias, and extends to patients with all types of renal disease. Approximately 5 to 10 ml of blood is required for each test by conventional methods, and the test is not adapted for use in children. We developed a hig...

journal_title：Kidney international

authors： Gaulier JM,Cochat P,Lardet G,Vallon JJ

更新日期：1997-12-01 00:00:00

abstract：UNLABELLED:Expression of apoptosis regulatory genes in chronic cyclosporine nephrotoxicity favors apoptosis. BACKGROUND:Chronic cyclosporine (CsA) nephrotoxicity is characterized by interstitial fibrosis, tubular dropout, and loss of cellularity in areas of fibrosis. Apoptosis was found to play a role in CsA-induced f...

journal_title：Kidney international

authors： Shihab FS,Andoh TF,Tanner AM,Yi H,Bennett WM

更新日期：1999-12-01 00:00:00

abstract：:The study by Rieg et al. is the first to examine potassium handling in BK(-/-) mice, thereby addressing many unanswered questions regarding the separate roles of BK and ROMK channels in renal potassium secretion. This Commentary is an interpretation and opinion of their results, by two researchers who have been studyi...

journal_title：Kidney international

authors： Sansom SC,Welling PA

更新日期：2007-09-01 00:00:00

abstract：:The influence of transforming growth factor beta 1 (TGF-beta 1) and of dexamethasone on fibronectin (FN) synthesis of human renal tubular epithelial cells in culture (TEC) was studied. Cocultivation with TGF-beta 1 increased the steady state level of FN RNA within 24 to 48 hours. By PCR and Northern blotting it was fo...

journal_title：Kidney international

authors： Viedt C,Bürger A,Hänsch GM

更新日期：1995-12-01 00:00:00

abstract：:Major features of a long-standing inflammation in the kidney are vascular proliferation, glomerulosclerosis, interstitial fibrosis and tubular atrophy, leading to a gradual deterioration of the renal function. In this study we have investigated the expression of B-type receptors for platelet-derived growth factor (PDG...

journal_title：Kidney international

authors： Fellström B,Klareskog L,Heldin CH,Larsson E,Rönnstrand L,Terracio L,Tufveson G,Wahlberg J,Rubin K

更新日期：1989-12-01 00:00:00

abstract：:Unilateral ureteral obstruction in rabbits leads to an influx of macrophages into the kidney, a proliferation of interstitial cells, and an increase in arachidonic acid metabolism. The role of the macrophage in the metabolic changes of hydronephrosis was investigated by using endotoxin and nitrogen mustard. The in viv...

journal_title：Kidney international

authors： Lefkowith JB,Okegawa T,DeSchryver-Kecskemeti K,Needleman P

更新日期：1984-07-01 00:00:00

abstract：:A major contributor to the development and progression of ischemia-reperfusion (IR)-induced acute renal failure (ARF) is the loss of functioning tubular epithelial cells by means of various cell deletion or death processes. Although the term "acute tubular necrosis" is still used to describe the pathology of ARF, this...

journal_title：Kidney international

authors： Gobé G,Willgoss D,Hogg N,Schoch E,Endre Z

更新日期：1999-10-01 00:00:00

abstract：:Pathologic calcification is a significant cause of increased morbidity and mortality in patients with chronic kidney disease. The precise mechanisms of ectopic calcification are not fully elucidated, but it is known to be caused by an imbalance of procalcific and anticalcific factors. In the chronic kidney disease pop...

journal_title：Kidney international

authors： Paloian NJ,Leaf EM,Giachelli CM

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:While the progression of renal disease to end stage is strongly correlated with tubulointerstitial changes, the control of the fibrotic process within the interstitium is poorly understood. Basic fibroblast growth factor (FGF-2) has been implicated as a major growth factor involved in fibroblast activation a...

journal_title：Kidney international

authors： Clayton A,Thomas J,Thomas GJ,Davies M,Steadman R

更新日期：2001-06-01 00:00:00

abstract：:A cyclical corticosteroid-cyclophosphamide regimen is recommended for patients with primary membranous nephropathy at high risk of progression. We hypothesized that sequential therapy with tacrolimus and rituximab is superior to cyclical alternating treatment with corticosteroids and cyclophosphamide in inducing persi...

journal_title：Kidney international

authors： Fernández-Juárez G,Rojas-Rivera J,Logt AV,Justino J,Sevillano A,Caravaca-Fontán F,Ávila A,Rabasco C,Cabello V,Varela A,Díez M,Martín-Reyes G,Diezhandino MG,Quintana LF,Agraz I,Gómez-Martino JR,Cao M,Rodríguez-Moreno A,

更新日期：2020-11-07 00:00:00

abstract：:Prostaglandin E2 (PGE2) may be an important negative feedback modulator of endothelin-1 (ET-1)-stimulated mesangial cell proliferation and contraction. Recent studies suggest that ET-1 may induce prolonged mesangial cell PGE2 production, however the mechanism of this effect is unknown. The current study was undertaken...

journal_title：Kidney international

authors： Hughes AK,Padilla E,Kutchera WA,Michael JR,Kohan DE

更新日期：1995-01-01 00:00:00

abstract：:Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), is a potent microvascular permeability-enhancing mediator as well as a selective mitogen for vascular endothelium. In this study, in situ hybridization and immunohistochemistry co-localized VPF mRNA and protein to glomerular v...

journal_title：Kidney international

authors： Brown LF,Berse B,Tognazzi K,Manseau EJ,Van de Water L,Senger DR,Dvorak HF,Rosen S

更新日期：1992-12-01 00:00:00

abstract：:Inflammation is a protective response to remove dangerous stimuli from the body. The multiprotein complex called the inflammasome regulates inflammation through the cleavage of proinflammatory cytokines into mature forms. Shahzad et al. unravel the importance of the Nlrp3 inflammasome, especially activated in glomerul...

journal_title：Kidney international

authors： Sakai N,Wada T

更新日期：2015-01-01 00:00:00

abstract：:Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), an enzyme that exists in several isoforms. Some studies found that a polymorphism (G894T) in the endothelial NOS gene was associated with decreased nitric oxide bioactivity and vascular complications. However, it is not known whether the enzyme ...

journal_title：Kidney international

authors： Cherney DZ,Scholey JW,Zhou J,Zimpelmann J,Kennedy C,Burns KD,Lai V,Miller JA

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Diabetic nephropathy is commonly associated with renal salt and water retention and hypertension. The molecular mechanisms involved and how the kidney responds to this volume expansion, in terms of renal transporter regulation, are not understood. METHODS:Targeted proteomics employing semiquantitative immun...

journal_title：Kidney international

authors： Bickel CA,Knepper MA,Verbalis JG,Ecelbarger CA

更新日期：2002-06-01 00:00:00

abstract：:Bone-derived fibroblast growth factor-23 (FGF23) plays an important role in systemic phosphate turnover. Increased FGF23 activity results in hypophosphatemic disorders, while reduced activity is linked to hyperphosphatemic disorders. FGF23, together with klotho as co-factor, can activate FGF receptors in its target ti...

journal_title：Kidney international

authors： Lanske B,Razzaque MS

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Fabry disease is an X-linked generalized progressive debilitating lysosomal storage disorder. The disease usually manifests in childhood, but the diagnosis is often made following the occurrence of late-stage complications such as progressive kidney failure. In order to identify key novel renal diagnostic im...

journal_title：Kidney international

authors： Ries M,Bettis KE,Choyke P,Kopp JB,Austin HA 3rd,Brady RO,Schiffmann R

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Lipid peroxidation impairs renal function. Aldosterone contributes to renal injury in the remnant kidney model. This study aimed to determine the effects of the antioxidant N-acetylcysteine (NAC) on renal function and aldosterone levels in chronic renal failure. METHODS:Adult male Wistar rats were submitted...

journal_title：Kidney international

authors： Shimizu MH,Coimbra TM,de Araujo M,Menezes LF,Seguro AC

更新日期：2005-11-01 00:00:00

abstract：:In vitro metabolic acidosis (Met) induces greater bone mineral resorption than respiratory acidosis (Resp). Met, but not Resp, inhibits osteoblasts which control many aspects of osteoclastic function. To determine whether at a similar decrement in extracellular pH, Met and Resp would induce different changes in intrac...

journal_title：Kidney international

authors： Ori Y,Lee SG,Krieger NS,Bushinsky DA

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Hyperhomocysteinemia is a risk factor for atherosclerosis that is common in chronic renal failure (CRF), but its cause is unknown. Homocysteine metabolism is linked to betaine-homocysteine methyl transferase (BHMT), a zinc metalloenzyme that converts glycine betaine (GB) to N,N dimethylglycine (DMG). DMG is ...

journal_title：Kidney international

authors： McGregor DO,Dellow WJ,Lever M,George PM,Robson RA,Chambers ST

更新日期：2001-06-01 00:00:00

abstract：UNLABELLED:Compensatory renal growth in uninephrectomized adult mice is growth hormone dependent. BACKGROUND:Growth hormone (GH) and insulin-like growth factors (IGFs) have been implicated as pathogenic factors in compensatory renal growth (CRG) following unilateral nephrectomy in rodents. CRG in adult rats has been s...

journal_title：Kidney international

authors： Flyvbjerg A,Bennett WF,Rasch R,van Neck JW,Groffen CA,Kopchick JJ,Scarlett JA

更新日期：1999-12-01 00:00:00

abstract：:Acid (H+) retention appears to contribute to progressive decline in glomerular filtration rate (GFR) in patients with chronic kidney disease (CKD), including some patients without metabolic acidosis. Identification of patients with H+ retention but without metabolic acidosis could facilitate targeted alkali therapy; h...

journal_title：Kidney international

authors： Goraya N,Simoni J,Sager LN,Madias NE,Wesson DE

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:The T allele of the G protein beta3 subunit (GNB3) C825T polymorphism has been associated with increased signal transduction, increased activity of the kidney Na+/H+ exchanger, and also with late-onset essential hypertension. Hypertension is a strong independent risk factor for progression in IgA nephropathy...

journal_title：Kidney international

authors： Thibaudin L,Berthoux P,Thibaudin D,Mariat C,Berthoux F

更新日期：2004-07-01 00:00:00

abstract：:From September 9 to October 3, 1994, five patients on maintenance hemodialysis in a dialysis unit in Tokyo contracted hepatitis B virus (HBV) infection successively, and four of them died of fulminant hepatitis. The unit treated 181 patients three times a week on eight shifts, and all five afflicted patients were on t...

journal_title：Kidney international

authors： Tanaka S,Yoshiba M,Iino S,Fukuda M,Nakao H,Tsuda F,Okamoto H,Miyakawa Y,Mayumi M

更新日期：1995-12-01 00:00:00

abstract：:Clofibrate, a peroxisome proliferator-activated receptor-alpha (PPAR alpha) agonist, increases renal tubular cytochrome P450 4a (Cyp4a) expression thereby increasing 20-hydroxyeicosatetraenoic acid (20-HETE) production. To determine if clofibrate affects blood pressure regulation we studied mice with DOCA-salt induced...

journal_title：Kidney international

authors： Zhou Y,Luo P,Chang HH,Huang H,Yang T,Dong Z,Wang CY,Wang MH

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Glucose degradation products (GDPs) are cytotoxic in vitro and potentially toxic in vivo during peritoneal dialysis (PD). We are presenting the results of a two-year randomized clinical trial of a new PD fluid, produced in a two-compartment bag and designed to minimize heat-induced glucose degradation while ...

journal_title：Kidney international

authors： Rippe B,Simonsen O,Heimbürger O,Christensson A,Haraldsson B,Stelin G,Weiss L,Nielsen FD,Bro S,Friedberg M,Wieslander A

更新日期：2001-01-01 00:00:00

abstract：:Adoptive immunotherapy in patients with advanced cancer produces significant regression of metastatic disease in selected patients, but it is complicated by severe side effects. Prevention of these complications is still limited because their precise mechanisms remain unknown. For this reason we have investigated rena...

journal_title：Kidney international

authors： Mercatello A,Hadj-Aïssa A,Négrier S,Allaouchiche B,Coronel B,Tognet E,Bret M,Favrot M,Pozet N,Moskovtchenko JF

更新日期：1991-08-01 00:00:00

abstract：:Many renal diseases are associated with fibrin deposition in the glomeruli, a situation that reflects an abnormality in the balance between the coagulation and fibrinolytic systems. We recently demonstrated that normal mouse kidney contains very low levels of type 1 plasminogen activator inhibitor (PAI-1), a potent an...

journal_title：Kidney international

authors： Keeton M,Ahn C,Eguchi Y,Burlingame R,Loskutoff DJ

更新日期：1995-01-01 00:00:00

abstract：:Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare. Current studies of such 'double-positive' cases report small numbers and variable outcomes. To study this further we retrospectively analyzed clinical features and long-term outcomes of a large cohort of 568 contemporary patients ...

journal_title：Kidney international

authors： McAdoo SP,Tanna A,Hrušková Z,Holm L,Weiner M,Arulkumaran N,Kang A,Satrapová V,Levy J,Ohlsson S,Tesar V,Segelmark M,Pusey CD

更新日期：2017-09-01 00:00:00