Colfibrate attenuates blood pressure and sodium retention in DOCA-salt hypertension.

abstract：:Transforming growth factor-β1 (TGF-β1) upregulation occurs in virtually all chronic kidney diseases and is associated with podocyte injury and proteinuria; however, the mechanisms contributing to this in vivo are ambiguous. In vitro, incubation of podocytes with TGF-β1 induced Wnt1 expression, β-catenin activation, an...

journal_title：Kidney international

authors： Wang D,Dai C,Li Y,Liu Y

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The development of strategies to enhance the survival of transplanted organs and to potentially lower or even discontinue immunosuppressive therapy would represent a significant advancement in post-transplant patient care. METHODS:We studied the effect of pretransplant infusion of donor leukocytes alone or ...

journal_title：Kidney international

authors： Noris M,Azzollini N,Mister M,Pezzotta A,Piccinini G,Casiraghi F,Cugini D,Perico N,Orisio S,Remuzzi G

更新日期：1999-09-01 00:00:00

abstract：:Tenofovir, a widely prescribed antiretroviral medication for treatment of HIV-1 infection, is infrequently associated with renal dysfunction and biopsy findings of acute tubular necrosis. We examined the clinical and pathological findings in 13 cases of tenofovir nephrotoxicity (7 men and 6 women, mean age of 51.1±9.6...

journal_title：Kidney international

authors： Herlitz LC,Mohan S,Stokes MB,Radhakrishnan J,D'Agati VD,Markowitz GS

更新日期：2010-12-01 00:00:00

abstract：:The loss of interstitial capillaries is a feature of several experimental models of renal disease and this contributes to secondary kidney injury. Angiopoietin-1 is a secreted growth factor which binds to Tie-2 present on endothelia to enhance cell survival thereby stabilizing capillary architecture in-vitro. Previous...

journal_title：Kidney international

authors： Long DA,Price KL,Ioffe E,Gannon CM,Gnudi L,White KE,Yancopoulos GD,Rudge JS,Woolf AS

更新日期：2008-08-01 00:00:00

abstract：:Nitric oxide is synthesized in experimental immune complex glomerulonephritis due to local induction of type 2 nitric oxide synthase (NOS2). To determine the role of NOS2, the course of accelerated anti-glomerular basement membrane glomerulonephritis (anti-GBM) was examined in mice homozygous for disruption of the NOS...

journal_title：Kidney international

authors： Cattell V,Cook HT,Ebrahim H,Waddington SN,Wei XQ,Assmann KJ,Liew FY

更新日期：1998-04-01 00:00:00

abstract：:Gene expression differs substantially among individual cells of the same type. We speculate that genes that are expressed in all but a portion of cells of a given cell type would be likely essential and required for either the cell survival (housekeeping) or for the cell type's unique structure and function, enabling ...

journal_title：Kidney international

authors： Lu Y,Ye Y,Bao W,Yang Q,Wang J,Liu Z,Shi S

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The renal 11beta-hydroxysteroid dehydrogenase type 2 (11beta HSD2) enzyme inactivates 11-hydroxy steroids in the kidney, thereby protecting the nonselective mineralocorticoid (MR) receptor from occupation by glucocorticoids. Loss-of-function mutations in the gene encoding 11beta HSD2 (HSD11B2) result in over...

journal_title：Kidney international

authors： Williams TA,Mulatero P,Filigheddu F,Troffa C,Milan A,Argiolas G,Parpaglia PP,Veglio F,Glorioso N

更新日期：2005-02-01 00:00:00

abstract：:Germ free rats provide a unique model in which to assess biological response to environment. In 48 germ-free male, Sprague-Dawley rats we examined the consequences of oral exposure to nordihydroguaiaretic acid (NDGA), a nephrotoxin; to Staphylococcus epidermidis and bacillus species, non-endotoxin-containing bacteria;...

journal_title：Kidney international

authors： Gardner KD Jr,Reed WP,Evan AP,Zedalis J,Hylarides MD,Leon AA

更新日期：1987-09-01 00:00:00

abstract：:Osteocytes within the mineralized bone matrix control bone remodeling by regulating osteoblast and osteoclast activity. Osteocytes express the aging suppressor Klotho, but the functional role of this protein in skeletal homeostasis is unknown. Here we identify Klotho expression in osteocytes as a potent regulator of b...

journal_title：Kidney international

authors： Komaba H,Kaludjerovic J,Hu DZ,Nagano K,Amano K,Ide N,Sato T,Densmore MJ,Hanai JI,Olauson H,Bellido T,Larsson TE,Baron R,Lanske B

更新日期：2017-09-01 00:00:00

abstract：:Angiotensinase A (aminopeptidase A; ATA) is an angiotensin II splitting exopeptidase, which is localized in endothelial and epithelial cells of the glomerular tuft. In order to investigate the influence of a reduction in renal mass on enzyme activity, ATA activity was measured in isolated rat glomeruli five and 14 wee...

journal_title：Kidney international

authors： Wolf G,Thaiss F,Scherberich JE,Schoeppe W,Stahl RA

更新日期：1990-11-01 00:00:00

abstract：:Clinical studies have demonstrated a poor correlation between localization tests, which are designed to determine the site of urinary tract infection, and symptoms of upper urinary tract infection. One explanation is that microorganisms may be present in the kidney but not initiate an inflammatory response with associ...

journal_title：Kidney international

authors： Miller TE,Findon G,Rainer SP,Gavin JB

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Tacrolimus is a relatively new calcineurin inhibitor that has been increasingly used in transplant medicine. The objective of the current work is to report our preliminary experience with tacrolimus in the treatment of diffuse proliferative glomerulonephritis in systemic lupus erythematosus (SLE). METHODS:N...

journal_title：Kidney international

authors： Mok CC,Tong KH,To CH,Siu YP,Au TC

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Nephrotoxic glomerulonephritis is induced by the administration of antibody against the glomerular basement membrane (GBM). We demonstrated previously that Fc receptors for immunoglobulin G (IgG) (FcgammaR) play crucial roles in the induction of accelerated nephrotoxic glomerulonephritis by using FcRgamma-de...

journal_title：Kidney international

authors： Fujii T,Hamano Y,Ueda S,Akikusa B,Yamasaki S,Ogawa M,Saisho H,Verbeek JS,Taki S,Saito T

更新日期：2003-10-01 00:00:00

abstract：:An effective therapeutic means to remove relatively large polypeptide uremic toxins seems to be a hemofiltration (HF) or hemodiafiltration (HDF) employing a larger-pore membrane, that is, a protein-permeable membrane. With either method, however, a significant amount of albumin will be lost into the ultrafiltrate or d...

journal_title：Kidney international

authors： Shinzato T,Miwa M,Nakai S,Takai I,Matsumoto Y,Morita H,Miyata T,Maeda K

更新日期：1996-08-01 00:00:00

abstract：INTRODUCTION:Transforming growth factor-beta (TGF-beta) is known to play a pivotal role in the regulation of extracellular matrix (ECM) accumulation. Since diabetic nephropathy (DMN) is characterized by basement membrane thickening and mesangial expansion, control of ECM deposition is believed to be important in the pa...

journal_title：Kidney international

authors： Wong TY,Poon P,Chow KM,Szeto CC,Cheung MK,Li PK

更新日期：2003-05-01 00:00:00

abstract：:In adults on chronic hemodialysis, achieving a hemoglobin concentration of 12g/dl and above with erythropoiesis stimulating agents leads to increased cardiovascular events and mortality, but this may not be true in children. Therefore, we conducted a retrospective cohort study of pediatric patients (under 18) from the...

journal_title：Kidney international

authors： Rheault MN,Molony JT,Nevins T,Herzog CA,Chavers BM

更新日期：2017-01-01 00:00:00

abstract：:Experiments were performed to study the mechanism of the compensatory increase in the excretion of metabolic acid by residual nephrons after reduction in renal mass. Despite a decrease in nephron population to 20% of control, total excretion of acid remained similar to pair-fed controls due to an increase in nephron e...

journal_title：Kidney international

authors： MacClean AJ,Hayslett JP

更新日期：1980-05-01 00:00:00

abstract：:Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) are exposed to a continuous infusion of glucose via their peritoneal cavity. We performed studies to quantitate the amount of energy derived from dialysate glucose. Net glucose absorption averaged 182 +/- (SD) 61 g/day in 19 studies with a dialysate ...

journal_title：Kidney international

authors： Grodstein GP,Blumenkrantz MJ,Kopple JD,Moran JK,Coburn JW

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND:The prevalence of cardiovascular disease (CVD) and inflammation is high in patients with end-stage renal disease (ESRD). Adiponectin is an adipocytokine that may have significant anti-inflammatory and anti-atherosclerotic effects. Low adiponectin levels have previously been found in patients with high risk f...

journal_title：Kidney international

authors： Stenvinkel P,Marchlewska A,Pecoits-Filho R,Heimbürger O,Zhang Z,Hoff C,Holmes C,Axelsson J,Arvidsson S,Schalling M,Barany P,Lindholm B,Nordfors L

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the relationship between glomerular filtration rate (GFR) measured at 5 years' diabetes duration and annual urine albumin excretion in a prospective cohort of children with type 1 diabetes (T1DM). METHODS:Three hundred and eight children were followed from diagnosis ...

journal_title：Kidney international

authors： Amin R,Turner C,van Aken S,Bahu TK,Watts A,Lindsell DR,Dalton RN,Dunger DB

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Nitric oxide inactivation by superoxide impairs endothelium-dependent vasodilation and plays a role in various forms of hypertension. Almost no data exist regarding hypertension secondary to chronic renal failure. Previous studies have shown that endothelium-related relaxations, secondary to decreased nitric...

journal_title：Kidney international

authors： Hasdan G,Benchetrit S,Rashid G,Green J,Bernheim J,Rathaus M

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Both high glucose (HG) and angiotensin II (Ang II) causes glomerular mesangial cell (GMC) growth and increased synthesis of matrix proteins like collagen IV contributing to diabetic nephropathy. We have recently found that exposure of vascular smooth muscle cells to HG augments the Ang II activation of the g...

journal_title：Kidney international

authors： Amiri F,Shaw S,Wang X,Tang J,Waller JL,Eaton DC,Marrero MB

更新日期：2002-05-01 00:00:00

abstract：:The existence of a tissue renin-angiotensin (RAS) system independent of the circulating RAS has prompted the search for cellular binding sites for angiotensinogen and for renin in order to explain their tissue uptake. Two receptors that bind with similar affinity mature renin and prorenin were identified, the mannose-...

journal_title：Kidney international

authors： Nguyen G

更新日期：2006-05-01 00:00:00

abstract：:Renal dysfunction is a common and serious complication in multiple myeloma (MM) patients. Renal proximal tubule injury is characteristic in MM, and may result in disturbed renal handling of various vitamins. The abnormal excretion of vitamins in urine may result in their low serum levels. The goal of this study was to...

journal_title：Kidney international

authors： Gavrilov V,Yermiahu T,Gorodischer R

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Nephrotic syndrome is associated with abnormal lipoprotein metabolism and increased risk of coronary heart disease. Endothelial dysfunction, an early phase of atherogenesis that manifests as impaired flow-mediated dilation (FMD) of the peripheral circulation, may link these associations. METHODS:We examined...

journal_title：Kidney international

authors： Watts GF,Herrmann S,Dogra GK,Playford DA,Best JD,Thomas MA,Irish A

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:The p21 protein is found in the nucleus of most cells where it modulates cell cycle activity. At low levels, p21 stabilizes interactions between D cyclins and their cyclin-dependent kinases (cdks), but at high levels after induction by several different stress pathways, it causes cell cycle arrest. The p21 m...

journal_title：Kidney international

authors： Megyesi J,Andrade L,Vieira JM Jr,Safirstein RL,Price PM

更新日期：2001-12-01 00:00:00

abstract：:We studied the glomerular architecture in renal biopsies of 95 patients undergoing bariatric surgery for extreme obesity but whose renal function was normal. The comparison group was 40 control patients having protocol biopsies. These latter patients had normal weight and renal function, were non-diabetic, non-hyperte...

journal_title：Kidney international

authors： Serra A,Romero R,Lopez D,Navarro M,Esteve A,Perez N,Alastrue A,Ariza A

更新日期：2008-04-01 00:00:00

abstract：:Pathogenesis of vascular calcification in chronic kidney disease. Background. Hyperphosphatemia and hypercalcemia are independent risk factors for higher incidence of cardiovascular events in patients with chronic kidney disease. In addition to increased calcium-phosphate product, hyperphosphatemia accelerates the pro...

journal_title：Kidney international

authors： Cozzolino M,Brancaccio D,Gallieni M,Slatopolsky E

更新日期：2005-08-01 00:00:00

abstract：:Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results...

journal_title：Kidney international

authors： Ooi YM,Vallota EH,West CD

更新日期：1976-01-01 00:00:00

abstract：:Recent studies have shown renoprotective effects of the peroxisome proliferator-activated receptor-α (PPAR-α), but its role in kidney fibrosis is unknown. In order to gain insight into this, we examined the effect of a novel PPAR-α agonist, BAY PP1, in two rat models of renal fibrosis: unilateral ureteral obstruction ...

journal_title：Kidney international

authors： Boor P,Celec P,Martin IV,Villa L,Hodosy J,Klenovicsová K,Esposito C,Schäfer S,Albrecht-Küpper B,Ostendorf T,Heidland A,Šebeková K

更新日期：2011-12-01 00:00:00