Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria.

abstract：:Mutations in the inverted formin 2 gene (INF2) have recently been identified as the most common cause of autosomal dominant focal and segmental glomerulosclerosis (FSGS). To quantify the contribution of various genes contributing to FSGS, we sequenced INF2 where all mutations have previously been described (exons 2 to...

journal_title：Kidney international

authors： Barua M,Brown EJ,Charoonratana VT,Genovese G,Sun H,Pollak MR

更新日期：2013-02-01 00:00:00

abstract：:We have previously suggested that albumin in tubule fluid at concentrations found in the nephrotic syndrome (NS) binds furosemide, thereby diminishing diuretic effect. This mechanism may contribute to diuretic resistance in NS. If this hypothesis is correct, displacement of albumin from furosemide should restore diure...

journal_title：Kidney international

authors： Kirchner KA,Voelker JR,Brater DC

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Chronic oversecretion of parathyroid hormone (PTH) is associated with parathyroid hyperplasia, reflecting a disturbed balance between cell proliferation and apoptosis. This study addressed the unsolved issue of apoptosis in hyperparathyroidism. METHODS:Parathyroid glands from 19 patients with primary (1 deg...

journal_title：Kidney international

authors： Zhang P,Duchambon P,Gogusev J,Nabarra B,Sarfati E,Bourdeau A,Drüeke TB

更新日期：2000-02-01 00:00:00

abstract：:Intrarenal artery infusions of hypertonic saline can activate tubuloglomerular feedback (TGF), decreasing renal blood flow (RBF) and glomerular filtration rate (GFR). The response to infusion of hypertonic saline is enhanced by salt depletion and attenuated by salt loading, but has not previously been investigated in ...

journal_title：Kidney international

authors： Heidemann HT,Jackson EK,Gerkens JF,Branch RA

更新日期：1987-10-01 00:00:00

abstract：:The OSCAR study was a multicenter, prospective randomized open-label blinded end-point study of 1164 Japanese elderly hypertensive patients comparing the efficacy of angiotensin II receptor blocker (ARB) uptitration to an ARB plus calcium channel blocker (CCB) combination. In this prospective study, we performed presp...

journal_title：Kidney international

authors： Kim-Mitsuyama S,Ogawa H,Matsui K,Jinnouchi T,Jinnouchi H,Arakawa K

更新日期：2013-01-01 00:00:00

abstract：:Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal sys...

journal_title：Kidney international

authors： Luciani A,Freedman BS

更新日期：2020-07-01 00:00:00

abstract：:The cannabinoid receptor type 2 (CB2) is a G protein-coupled seven transmembrane receptor that transmits endogenous cannabinoid signaling. The role of CB2 in the pathogenesis of kidney injury and fibrosis remains poorly understood. Here we demonstrate that CB2 was induced, predominantly in kidney tubular epithelium, i...

journal_title：Kidney international

authors： Zhou L,Zhou S,Yang P,Tian Y,Feng Z,Xie XQ,Liu Y

更新日期：2018-10-01 00:00:00

abstract：:Many features of chronic kidney disease may be reversed, but it is unclear whether advanced lesions, such as adhesions of sclerotic glomerular tufts to Bowman's capsule (synechiae), can resolve during treatment. We previously showed, using a renal ablation model, that the renoprotective effect of the AT-1 receptor blo...

journal_title：Kidney international

authors： Teles F,Machado FG,Ventura BH,Malheiros DM,Fujihara CK,Silva LF,Zatz R

更新日期：2009-01-01 00:00:00

abstract：:Kidney fibrosis is the common consequence of chronic kidney diseases that inexorably progresses to end-stage kidney disease with organ failure treatable only with replacement therapy. Since transforming growth factor-β1 is the main player in the pathogenesis of kidney fibrosis, we posed the hypothesis that recombinant...

journal_title：Kidney international

authors： Takeshita A,Yasuma T,Nishihama K,D'Alessandro-Gabazza CN,Toda M,Totoki T,Okano Y,Uchida A,Inoue R,Qin L,Wang S,D'Alessandro VF,Kobayashi T,Takei Y,Mizoguchi A,Yano Y,Gabazza EC

更新日期：2020-11-01 00:00:00

abstract：:Scavenger receptor A (SR-A) is a key transmembrane receptor in the endocytosis of lipids and contributes to the pathogenesis of atherosclerosis. To assess its role in hyperlipidemic chronic kidney disease, wild-type and SR-A-deficient (knockout) mice underwent uninephrectomy followed by either normal or high-fat diet....

journal_title：Kidney international

authors： Wang W,He B,Shi W,Liang X,Ma J,Shan Z,Hu Z,Danesh FR

更新日期：2012-05-01 00:00:00

abstract：:Precise immunofluorescence criteria for C3 glomerulopathy remain to be defined. Here we tested hierarchical immunofluorescence criteria with varying stringency for C3 glomerulopathy in a cohort with dense deposit disease as the gold standard and then applied these criteria to analyze the incidence of C3 glomerulopathy...

journal_title：Kidney international

authors： Hou J,Markowitz GS,Bomback AS,Appel GB,Herlitz LC,Barry Stokes M,D'Agati VD

更新日期：2014-02-01 00:00:00

abstract：:In a variety of recent studies in animals with chronic renal diseases, investigators have found a tight correlation between the elevation in glomerular pressures and flows versus glomerular hypertrophy. To investigate a possible causal link between the glomerular hyperfunction and hypertrophy, we studied the functiona...

journal_title：Kidney international

authors： Yoshida Y,Fogo A,Ichikawa I

更新日期：1989-02-01 00:00:00

abstract：:The incidence of acute kidney injury (AKI) is high in elderly people, and is difficult to prevent and treat. One of its major causes is renal ischemia-reperfusion injury (IRI). A young systemic environment may prevent the senescence of old organs. However, it is unknown whether a young milieu may reduce renal IRI in t...

journal_title：Kidney international

authors： Liu D,Lun L,Huang Q,Ning Y,Zhang Y,Wang L,Yin Z,Zhang Y,Xia L,Yin Z,Fu B,Cai G,Sun X,Chen X

更新日期：2018-08-01 00:00:00

abstract：:In a rat model of glomerular immune injury induced by administration of anti-glomerular basement membrane antibody and resembling human rapidly progressive glomerulonephritis, we explored whether activation of inducible nitric oxide synthase (iNOS) regulates synthesis of eicosanoids originating from cyclooxygenation o...

journal_title：Kidney international

authors： Lianos EA,Guglielmi K,Sharma M

更新日期：1998-03-01 00:00:00

abstract：:Suramin is a polysulfonated naphthylurea originally designed as a treatment for trypanosomiasis; but that has also been used to treat rodent models of fulminant hepatic failure and focal brain ischemia. In this study, we determined the effects of suramin on renal ischemia/reperfusion-induced acute kidney injury in mic...

journal_title：Kidney international

authors： Zhuang S,Lu B,Daubert RA,Chavin KD,Wang L,Schnellmann RG

更新日期：2009-02-01 00:00:00

abstract：:Among patients with proteinuric chronic kidney disease (CKD), current guideline recommendations mandate the use of agents blocking the renin angiotensin aldosterone system (RAAS) as first-line antihypertensive therapy based on randomized trials demonstrating that RAAS inhibitors are superior to other antihypertensive ...

journal_title：Kidney international

authors： Georgianos PI,Agarwal R

更新日期：2018-02-01 00:00:00

abstract：:Glutamine accumulation in rat kidney was investigated by giving large loads of gluta, mate and aspartate and measuring glutamine changes in seven completely defined portions of the nephron and in small patches from the thin limb area and from the papilla. Both glutamate and aspartate (which is partly coverted to gluta...

journal_title：Kidney international

authors： Burch HB,Chan AW,Alvey TR,Lowry OH

更新日期：1978-11-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF)-D, a specific PDGF receptor β (PDGFR-β) ligand, mediates mesangial proliferation in vitro and in vivo. However, its role in renal development, physiology, and fibrosis is relatively unknown. In healthy murine kidneys, PDGF-D was found to be expressed on renal mesenchymal cells (me...

journal_title：Kidney international

authors： Buhl EM,Djudjaj S,Babickova J,Klinkhammer BM,Folestad E,Borkham-Kamphorst E,Weiskirchen R,Hudkins K,Alpers CE,Eriksson U,Floege J,Boor P

更新日期：2016-04-01 00:00:00

abstract：:The association between dietary sodium and potassium intake with the development of kidney disease remains unclear, particularly among younger individuals. Here, we determined whether dietary sodium and potassium intake are associated with incident chronic kidney disease (CKD) using data from 1,030 adults (age 23-35 i...

journal_title：Kidney international

authors： Elfassy T,Zhang L,Raij L,Bibbins-Domingo K,Lewis CE,Allen NB,Liu KJ,Peralta CA,Odden MC,Zeki Al Hazzouri A

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Bone marrow reconstitution using genetically-modified hematopoietic stem cells has been reported to confer resistance to inflammation and prevent renal injury in glomerulonephritis. Although this strategy has potentials for clinical use, taking hematopoietic stem cells from bone marrow is highly stressful fo...

journal_title：Kidney international

authors： Yokoo T,Ohashi T,Utsunomiya Y,Okamoto A,Suzuki T,Shen JS,Tanaka T,Kawamura T,Hosoya T

更新日期：2003-07-01 00:00:00

abstract：:From the urine of patients with calcium nephrolithiasis, and of control subjects, we isolated organic substances according to molecular size and tested them for effects on calcium oxalate precipitation. Nine subgroup materials of varying sizes were prepared by ultrafiltration and Sephadex G-200 column chromatography f...

journal_title：Kidney international

authors： Kitamura T,Zerwekh JE,Pak CY

更新日期：1982-02-01 00:00:00

abstract：:Progressive kidney fibrosis precedes end-stage renal failure in up to a third of patients with diabetes mellitus. Elevated intra-renal transforming growth factor-beta (TGF-beta) is thought to underlie disease progression by promoting deposition of extracellular matrix and epithelial-mesenchymal transition. GW788388 is...

journal_title：Kidney international

authors： Petersen M,Thorikay M,Deckers M,van Dinther M,Grygielko ET,Gellibert F,de Gouville AC,Huet S,ten Dijke P,Laping NJ

更新日期：2008-03-01 00:00:00

abstract：:Recent studies have shown renoprotective effects of the peroxisome proliferator-activated receptor-α (PPAR-α), but its role in kidney fibrosis is unknown. In order to gain insight into this, we examined the effect of a novel PPAR-α agonist, BAY PP1, in two rat models of renal fibrosis: unilateral ureteral obstruction ...

journal_title：Kidney international

authors： Boor P,Celec P,Martin IV,Villa L,Hodosy J,Klenovicsová K,Esposito C,Schäfer S,Albrecht-Küpper B,Ostendorf T,Heidland A,Šebeková K

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to establish whether there is a differential effect of mode of dialysis, hemodialysis (HD), or continuous ambulatory peritoneal dialysis (CAPD) on the dyslipidemia of renal failure. METHODS:The lipoprotein profile was determined in 61 non-diabetic patients on chronic HD (N = 30) an...

journal_title：Kidney international

authors： Attman PO,Samuelsson OG,Moberly J,Johansson AC,Ljungman S,Weiss LG,Knight-Gibson C,Alaupovic P

更新日期：1999-04-01 00:00:00

abstract：:This study was undertaken to test the hypothesis that, given equal arterial pressure reductions, the combination of an angiotensin converting enzyme (ACE) inhibitor and calcium antagonist slows declines in renal function and yields greater reductions in albuminuria over either agent alone. This hypothesis was evaluate...

journal_title：Kidney international

authors： Bakris GL,Barnhill BW,Sadler R

更新日期：1992-04-01 00:00:00

abstract：:To date direct evidence for the presence of a H-K-ATPase in the medulla comes from proton and potassium transport studies performed on K-restricted animals and K dependent ATP hydrolysis and Rb uptake in both normal and K-depleted animals. The present work examines K-dependent acidification in the medulla of rabbits o...

journal_title：Kidney international

authors： Curran KA,Hebert MJ,Cain BD,Wingo CS

更新日期：1992-11-01 00:00:00

abstract：:Congenital nephrotic syndrome is clinically and genetically heterogeneous. The majority of cases can be attributed to mutations in the genes NPHS1, NPHS2, and WT1. By homozygosity mapping in a consanguineous family with isolated congenital nephrotic syndrome, we identified a potential candidate region on chromosome 3p...

journal_title：Kidney international

authors： Hasselbacher K,Wiggins RC,Matejas V,Hinkes BG,Mucha B,Hoskins BE,Ozaltin F,Nürnberg G,Becker C,Hangan D,Pohl M,Kuwertz-Bröking E,Griebel M,Schumacher V,Royer-Pokora B,Bakkaloglu A,Nürnberg P,Zenker M,Hildebrandt F

更新日期：2006-09-01 00:00:00

abstract：:Inflammation is a protective response to remove dangerous stimuli from the body. The multiprotein complex called the inflammasome regulates inflammation through the cleavage of proinflammatory cytokines into mature forms. Shahzad et al. unravel the importance of the Nlrp3 inflammasome, especially activated in glomerul...

journal_title：Kidney international

authors： Sakai N,Wada T

更新日期：2015-01-01 00:00:00

abstract：:X-ray crystal interferometer-based X-ray phase-contrast microtomography (phase-contrast microtomography) is able to image microstructures within soft tissue without the use of a contrast agent. Here we determined the feasibility of using this technique in the non-destructive inspection of formalin-fixed kidney tissue ...

journal_title：Kidney international

authors： Wu J,Takeda T,Lwin TT,Momose A,Sunaguchi N,Fukami T,Yuasa T,Akatsuka T

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Strict glycemic control and antihypertensive treatment may decrease but not eliminate the risk of progressive nephropathy in diabetic patients. C-peptide has been shown to exert beneficial effects on complications, including incipient nephropathy, in type 1 diabetes. METHODS:Renal effects of 14 days of intr...

journal_title：Kidney international

authors： Samnegård B,Jacobson SH,Jaremko G,Johansson BL,Sjöquist M

更新日期：2001-10-01 00:00:00