Dopamine inhibits renal Na+:HCO3- cotransporter in rabbits and normotensive rats but not in spontaneously hypertensive rats.

abstract：:A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR...

journal_title：Kidney international

authors： Abboud HE

更新日期：2013-05-01 00:00:00

abstract：:The possibility that hypercalciuria could cause calcium stone formation through a mechanism other than by increasing urinary saturation of stone-forming calcium salts was explored. The effect of increasing calcium concentration on the inhibitor activity against the spontaneous precipitation of calcium oxalate was exam...

journal_title：Kidney international

authors： Zerwekh JE,Hwang TI,Poindexter J,Hill K,Wendell G,Pak CY

更新日期：1988-05-01 00:00:00

abstract：:Recipients of kidney transplants have elevated cancer risk compared with the general population. Improvements over time in transplant care and cancer treatment may have affected incidence and outcomes of cancer among recipients of kidney transplant. To evaluate this, we used linked United States transplant and cancer ...

journal_title：Kidney international

authors： Blosser CD,Haber G,Engels EA

更新日期：2020-11-04 00:00:00

abstract：:Healthy male rats were exposed to a chronic ingesta of an isotonic NaCl solution during a period of four months. Two different preparations were utilized to study the effect of this treatment on the active mechanisms of Na+ reabsorption of kidney proximal tubular cells: outermost kidney cortex slices (rich in proximal...

journal_title：Kidney international

authors： Marín R,Obando MA,Proverbio T,Proverbio F

更新日期：1986-10-01 00:00:00

abstract：:The survival of patients with diabetes mellitus in the general population has improved in recent years. Here we assessed whether similar trends have occurred in 1688 kidney recipients, including 413 with diabetes prior to transplant between 1996 and 2007. Compared to patients without diabetes, the 5-year mortality was...

journal_title：Kidney international

authors： Keddis MT,El Ters M,Rodrigo E,Dean P,Wohlfahrtova M,Kudva YC,Lorenz EC,Cosio FG

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Fistula failure has been classified as early and late. Early failure refers to those cases in which the arteriovenous (AV) fistula never develops to the point that it can be used or fails within the first 3 months of usage. It has been common practice to abandon these early failures; however, aggressive eval...

journal_title：Kidney international

authors： Beathard GA,Arnold P,Jackson J,Litchfield T,Physician Operators Forum of RMS Lifeline.

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Hemodialysis access thrombosis is a significant cause of morbidity for hemodialysis patients and results from decreased access flow caused by venous outflow tract stenosis. Ultrasound dilution (UD) is a practical, noninvasive, and reliable indicator of access flow and is effective in predicting venous stenos...

journal_title：Kidney international

authors： Goldstein SL,Allsteadt A

更新日期：2001-06-01 00:00:00

abstract：:Zhang et al. found that plasma concentrations of the thiamine antimetabolite oxythiamine are significantly increased in patients with end-stage renal disease. These investigators discuss the potential sources of oxythiamine and the consequences of its plasma elevation. This commentary addresses the significance of the...

journal_title：Kidney international

authors： Moradi H,Said HM

更新日期：2016-08-01 00:00:00

abstract：:Renal sodium reabsorption is a key determinant of final urine concentration. Our aim was to determine whether differences existed between aged and young rats in their response to water restriction with regard to the regulation of abundance of any of the major distal renal sodium transporter proteins. Male Fisher 344 x...

journal_title：Kidney international

authors： Tian Y,Riazi S,Khan O,Klein JD,Sugimura Y,Verbalis JG,Ecelbarger CA

更新日期：2006-01-01 00:00:00

abstract：:Hypocalcemia, hyperphosphatemia, and resistance to the action of PTH are well characterized features in the setting of advanced chronic renal failure (CRF). Although the underlying mechanisms are ill-understood, clinical and experimental evidence points to both PTH receptor down-regulation and post-receptor abnormalit...

journal_title：Kidney international

authors： Ureña P,Kubrusly M,Mannstadt M,Hruby M,Trinh MM,Silve C,Lacour B,Abou-Samra AB,Segre GV,Drüeke T

更新日期：1994-02-01 00:00:00

abstract：:We have previously shown that ultrasonography can detect hyperechogenic crystal deposits in the kidney medulla of patients with gout. In this cross-sectional study we investigated the frequency and clinical correlates of hyperechogenic kidney medulla in 502 consecutive primary consultants for gout (ACR/EULAR criteria)...

journal_title：Kidney international

authors： Bardin T,Nguyen QD,Tran KM,Le NH,Do MD,Richette P,Letavernier E,Correas JM,Resche-Rigon M

更新日期：2021-01-01 00:00:00

abstract：:Interstitial monocytic infiltration of the kidney occurs within hours of acute kidney injury and is an important determinant of functional decline and fibrosis. Li et al. used several surface markers to distinguish between dendritic cells and inflammatory monocytes following acute kidney injury and to identify two che...

journal_title：Kidney international

authors： Swaminathan S,Griffin MD

更新日期：2008-12-01 00:00:00

abstract：:The normal pattern of mRNA metabolism almost certainly becomes altered after uninephrectomy, especially during the first day when ribosomes accumulate in the proximal tubular cells of the remaining kidney. For example, within the first hour after nephrectomy, the fraction of newly synthesized poly(A)-deficient mRNA in...

journal_title：Kidney international

authors： Ouellette AJ

更新日期：1983-04-01 00:00:00

abstract：:Acute urinary obstruction causes interstitial inflammation with leukocyte accumulation and the secretion of soluble mediators. Here we show that unilateral ureteral ligation caused a progressive increase in renal F4/80(+) and F4/80(-) dendritic cells, monocytes, neutrophils and T-cells 24-72 h following obstruction. D...

journal_title：Kidney international

authors： Dong X,Bachman LA,Miller MN,Nath KA,Griffin MD

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Gap junctional intercellular communication (GJIC) plays an important role in the regulation of cell growth, migration, and differentiation. Ultrastructural and histochemical studies indicate the existence of a high density of gap junctions among mesangial cells (MCs), but little is known about their regulati...

journal_title：Kidney international

authors： Yao J,Morioka T,Oite T

更新日期：2000-05-01 00:00:00

abstract：:Recently, 4 new risk scores for the prediction of mortality and cardiovascular events were especially tailored for hemodialysis patients; these scores performed much better than previous scores. Tripepi et al. found that these risk scores were even more predictive for all-cause and cardiovascular death than the measur...

journal_title：Kidney international

authors： Kronenberg F,Schwaiger JP

更新日期：2017-03-01 00:00:00

abstract：:X-ray films of the hand skeleton (mammography technique), serum chemistry, and quantitative bone histology (micromorphometry of undecalcified sections, iliac crest spongiosa) were compared in 25 patients on maintenance hemodialysis. The X-ray findings correlated better with serum PTH levels than with bone histology. O...

journal_title：Kidney international

authors： Ritz E,Prager P,Krempien B,Bommer J,Malluche HH,Schmidt-Gayk H

更新日期：1978-04-01 00:00:00

abstract：:Kidney fibrosis is one of the most promising treatment targets in nephrology. To design effective treatment approaches, a detailed understanding of the initiating mechanisms is of great importance. Kim and Pandanilam now find that renal nerves are a major trigger for renal fibrosis. Both afferent and efferent nerve fi...

journal_title：Kidney international

authors： Boor P,Papasotiriou ME

更新日期：2015-02-01 00:00:00

abstract：:Screening for chronic kidney disease is recommended in people at high risk, but data on the independent and combined associations of estimated glomerular filtration rate (eGFR) and albuminuria with all-cause and cardiovascular mortality are limited. To clarify this, we performed a collaborative meta-analysis of 10 coh...

journal_title：Kidney international

authors： van der Velde M,Matsushita K,Coresh J,Astor BC,Woodward M,Levey A,de Jong P,Gansevoort RT,Chronic Kidney Disease Prognosis Consortium.,van der Velde M,Matsushita K,Coresh J,Astor BC,Woodward M,Levey AS,de Jong PE,Gansevoo

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Arteriovenous (AV) fistulas used for hemodialysis access may affect cardiac load by increasing the preload while decreasing the afterload. In dogs, AV fistulas have also been shown to affect coronary perfusion negatively. We investigated the net effect of AV fistulas on cardiac oxygen supply and demand. MET...

journal_title：Kidney international

authors： Bos WJ,Zietse R,Wesseling KH,Westerhof N

更新日期：1999-05-01 00:00:00

abstract：:Podocytes are highly differentiated cells that play an important role in maintaining glomerular filtration barrier integrity; a function regulated by small GTPase proteins of the Rho family. To investigate the role of Rho A in podocyte biology, we created transgenic mice expressing doxycycline-inducible constitutively...

journal_title：Kidney international

authors： Wang L,Ellis MJ,Gomez JA,Eisner W,Fennell W,Howell DN,Ruiz P,Fields TA,Spurney RF

更新日期：2012-06-01 00:00:00

abstract：:Progressive renal fibrosis is the final common pathway leading to renal failure irrespective of the initiating cause. Clinical studies of renal fibrosis found that prominent mast cell accumulation correlated with worse outcomes. Mast cells are pluripotent innate immune cells that synthesize and secrete profibrotic med...

journal_title：Kidney international

authors： Summers SA,Gan PY,Dewage L,Ma FT,Ooi JD,O'Sullivan KM,Nikolic-Paterson DJ,Kitching AR,Holdsworth SR

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Urea kinetic modeling (UKM) and food records are widely used to assess the dialysis adequacy. Clinicians use these methods in individual patients to decide whether the dialysis prescription should be adjusted. We determined the variation in UKM parameters and dietary intake within individual patients in orde...

journal_title：Kidney international

authors： Kloppenburg WD,Stegeman CA,Hooyschuur M,van der Ven J,de Jong PE,Huisman RM

更新日期：1999-05-01 00:00:00

abstract：:The essential role of the glycoprotein hormone erythropoietin (Epo) in the control of red blood cell production is well established. Synthesis of Epo is induced in response to low oxygen (hypoxia). In response to stimulation, increases in serum Epo levels are paralleled by changes in the abundance of Epo mRNA. These c...

journal_title：Kidney international

authors： Göpfert T,Eckardt KU,Geb B,Kurtz A

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Guidelines for treating anemia in dialysis patients accept, as high-end range of serum ferritin useful to optimize erythropoietin therapy, values high as 500 to 900 microg/L, on the hypothesis that ferritin might be not representative of iron overload. METHODS:A superconducting quantum interference device (...

journal_title：Kidney international

authors： Canavese C,Bergamo D,Ciccone G,Longo F,Fop F,Thea A,Martina G,Piga A

更新日期：2004-03-01 00:00:00

abstract：:Platelet activating factor (PAF) is a potent lipid mediator with a broad range of biologic activities. Experimental evidence suggests that PAF plays a role in the pathogenesis of a variety of inflammatory processes including allograft rejection. In this study, we evaluated the effects of the PAF antagonist BN52021 on ...

journal_title：Kidney international

authors： Butterly DW,Spurney RF,Ruiz P,Pirotzky E,Braquet P,Coffman TM

更新日期：1995-08-01 00:00:00

abstract：:Compared to normal tissue, hyperplastic parathyroid glands of patients with chronic kidney disease on dialysis express lower levels of FGFR1 and Klotho proteins. Similar findings are reported in uremic rats with advanced chronic kidney disease. Moreover, in these animals, FGF23 administration fails to reduce PTH serum...

journal_title：Kidney international

authors： Lafage-Proust MH

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. The purpose of this investigation was to examine the expression, regulation, and function of IAP genes in cultured rat mesangial cells. METHODS:Basal and inducible expression of c-IAP1, c-IAP2, ...

journal_title：Kidney international

authors： Furusu A,Nakayama K,Xu Q,Konta T,Sugiyama H,Kitamura M

更新日期：2001-08-01 00:00:00

abstract：:We have previously suggested that albumin in tubule fluid at concentrations found in the nephrotic syndrome (NS) binds furosemide, thereby diminishing diuretic effect. This mechanism may contribute to diuretic resistance in NS. If this hypothesis is correct, displacement of albumin from furosemide should restore diure...

journal_title：Kidney international

authors： Kirchner KA,Voelker JR,Brater DC

更新日期：1991-09-01 00:00:00

abstract：:Multiple-relapsing minimal-change disease (MCD) often requires exposure to potentially toxic agents in an attempt to achieve a lasting remission of nephrotic syndrome. Munyentwali and co-workers describe an experience using rituximab in adults with multiple-relapsing MCD that supports both efficacy and safety of this ...

journal_title：Kidney international

authors： Glassock RJ

更新日期：2013-03-01 00:00:00