The renal PTH/PTHrP receptor is down-regulated in rats with chronic renal failure.

abstract：:Low density lipoprotein (LDL) deposition and local oxidation play a key role in the pathogenesis of atherosclerosis and may likewise contribute to glomerular injury. These studies were designed to determine whether cultured human mesangial cells oxidize homologous LDL and to compare the effects of unmodified and oxidi...

journal_title：Kidney international

authors： Wheeler DC,Chana RS,Topley N,Petersen MM,Davies M,Williams JD

更新日期：1994-06-01 00:00:00

abstract：:Despite the importance of cardiovascular disease in dialysis patients, the frequency of atrial fibrillation in incident dialysis patients has not been determined. We analyzed the prevalence of atrial fibrillation in patients starting dialysis over a 4-year period, its occurrence over the course of dialysis, and its in...

journal_title：Kidney international

authors： Vazquez E,Sanchez-Perales C,Garcia-Garcia F,Castellano P,Garcia-Cortes MJ,Liebana A,Lozano C

更新日期：2009-08-01 00:00:00

abstract：:Urinary proteomics is a promising tool for biomarker investigation, particularly in complex kidney diseases. Fabris and colleagues report that urinary laminin subunit alpha-2 is a potential diagnostic marker of medullary sponge kidney (MSK) disease by using a label-free quantitative proteomics platform and a clinicall...

journal_title：Kidney international

authors： Chutipongtanate S

更新日期：2017-02-01 00:00:00

abstract：:Metabolic changes due to chronic renal failure (CRF) were studied in isolated liver cells. In 14 CRF and 14 sham-operated rats, liver cells were isolated by the Berry and Friend method and incubated with various substrates in order to study gluconeogenesis, ureagenesis, ketogenesis, oxygen consumption as well as cytos...

journal_title：Kidney international

authors： Cano N,Catelloni F,Fontaine E,Novaretti R,di Costanzo-Dufetel J,Reynier JP,Leverve XM

更新日期：1995-06-01 00:00:00

abstract：:Congenital chloride diarrhea is due to mutations in the intestinal Cl(-)/HCO(3)(-) exchange (SLC26A3) which results in sodium chloride and fluid depletion leading to hypochloremic and hypokalemic metabolic alkalosis. Although treatment with sodium and potassium chloride offers protection from renal involvement in chil...

journal_title：Kidney international

authors： Wedenoja S,Ormälä T,Berg UB,Halling SF,Jalanko H,Karikoski R,Kere J,Holmberg C,Höglund P

更新日期：2008-10-01 00:00:00

abstract：:The kidneys excrete the daily acid load mainly by generating and excreting ammonia but the underlying molecular mechanisms are not fully understood. Here we evaluated the role of the inwardly rectifying potassium channel subunit Kir4.2 (Kcnj15 gene product) in this process. In mice, Kir4.2 was present exclusively at t...

journal_title：Kidney international

authors： Bignon Y,Pinelli L,Frachon N,Lahuna O,Figueres L,Houillier P,Lourdel S,Teulon J,Paulais M

更新日期：2020-02-01 00:00:00

abstract：:Aboriginal dialysis patients have reduced access to kidney transplantation. The reasons for this disparity are unknown. Tonelli et al. show that in Canada, residence location does not significantly impact on an Aboriginal dialysis patient's likelihood of receiving kidney transplantation. This Commentary explores the i...

journal_title：Kidney international

authors： Yeates KE

更新日期：2006-09-01 00:00:00

abstract：:Nephronophthisis is an autosomal recessive chronic tubulointerstitial disease that progresses to end-stage renal disease (ESRD) in about 10% of cases during infancy. Mutations in the INVS (NPHP2) gene were found in a few patients with infantile nephronophthisis. Mutations of NPHP3, known to be associated with adolesce...

journal_title：Kidney international

authors： Tory K,Rousset-Rouvière C,Gubler MC,Morinière V,Pawtowski A,Becker C,Guyot C,Gié S,Frishberg Y,Nivet H,Deschênes G,Cochat P,Gagnadoux MF,Saunier S,Antignac C,Salomon R

更新日期：2009-04-01 00:00:00

abstract：:Low nephron number has been related to low birth weight and hypertension. In the southeastern United States, the estimated prevalence of chronic kidney disease due to hypertension is five times greater for African Americans than white subjects. This study investigates the relationships between total glomerular number ...

journal_title：Kidney international

authors： Hughson MD,Douglas-Denton R,Bertram JF,Hoy WE

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Transforming growth factor-beta (TGF-beta) is known to play an important role in the pathophysiology of renal tubular disease. Researchers have recently identified a novel mitogen-activated protein kinase kinase kinase (MAPKKK), TAK (TGF-beta activated kinase)1, which stimulates the MKK3/6-p38K pathway. The ...

journal_title：Kidney international

authors： Terada Y,Nakashima O,Inoshita S,Kuwahara M,Sasaki S,Marumo F

更新日期：1999-10-01 00:00:00

abstract：:Vascular sclerosis has been linked to many risk factors, including smoking, family history, low birth weight, and hypertension. In interesting studies, Goforth et al. show an increased rate of mutations in thrombophilic molecules in patients with vascular sclerosis in renal biopsies, suggesting yet another mechanism. ...

journal_title：Kidney international

authors： Fogo AB

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:The glomerular podocyte is the kidney cell most affected during the development of nephrotic syndrome, and mutations in podocyte proteins are responsible for a variety of inherited forms of nephrotic syndrome. Although glucocorticoids are a primary treatment for nephrotic syndrome, neither their target cell ...

journal_title：Kidney international

authors： Ransom RF,Vega-Warner V,Smoyer WE,Klein J

更新日期：2005-04-01 00:00:00

abstract：:Heterozygous mutations of the tissue-specific transcription factor hepatocyte nuclear factor (HNF)1beta, cause maturity onset diabetes of the young (MODY5) and kidney anomalies including agenesis, hypoplasia, dysplasia and cysts. Because of these renal anomalies, HNF1beta is classified as a CAKUT (congenital anomalies...

journal_title：Kidney international

authors： Dudziak K,Mottalebi N,Senkel S,Edghill EL,Rosengarten S,Roose M,Bingham C,Ellard S,Ryffel GU

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Hyperoxaluria may be idiopathic, secondary, or due to primary hyperoxaluria (PH). Hepatic alanine:glyoxylate aminotransferase (AGT) or glyoxylate/hydroxypyruvate reductase (GR/HPR) deficiency causes PHI or PHII, respectively. Hepatic glycolate oxidase (GO) is a candidate enzyme for a third form of inherited ...

journal_title：Kidney international

authors： Monico CG,Persson M,Ford GC,Rumsby G,Milliner DS

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Only few noninvasive methods have the potential to quantitate renal blood flow (RBF) in humans. Positron emission tomography (PET) is a clinical imaging method that can be used to measure the tissue blood flow noninvasively. The purpose of this study was to validate PET measurement of RBF using 15O-labeled w...

journal_title：Kidney international

authors： Juillard L,Janier MF,Fouque D,Lionnet M,Le Bars D,Cinotti L,Barthez P,Gharib C,Laville M

更新日期：2000-06-01 00:00:00

abstract：:We identified a novel mutation in the COL4A5 gene of a Japanese patient with Alport syndrome. A combination of in vitro amplification of the exons with single strand conformation polymorphisms (SSCP) analysis suggested the presence of a mutation in exon 48. Sequencing of the amplified DNA revealed a single base (T) in...

journal_title：Kidney international

authors： Nakazato H,Hattori S,Matsuura T,Koitabashi Y,Endo F,Matsuda I

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:The benefit of the potent chemotherapeutic agent cisplatin in treating neoplasms is limited by nephrotoxicity. We tested the hypothesis that CD54 [intercellular adhesion molecule-1 (ICAM-1)] is an important mediator in cisplatin-mediated renal failure. METHODS:The effect of a monoclonal anti-CD54 antibody w...

journal_title：Kidney international

authors： Kelly KJ,Meehan SM,Colvin RB,Williams WW,Bonventre JV

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Arteriovenous (AV) fistulas used for hemodialysis access may affect cardiac load by increasing the preload while decreasing the afterload. In dogs, AV fistulas have also been shown to affect coronary perfusion negatively. We investigated the net effect of AV fistulas on cardiac oxygen supply and demand. MET...

journal_title：Kidney international

authors： Bos WJ,Zietse R,Wesseling KH,Westerhof N

更新日期：1999-05-01 00:00:00

abstract：:In previous studies from this laboratory it has been shown that ATP-ase activity in situ in the glomerular basement membrane (GBM) is clearly reduced in rats rendered nephrotic after treatment with adriamycin (ADR). The question was raised whether this reduction of ATP-ase activity in the GBM is due to toxic activity ...

journal_title：Kidney international

authors： Bakker WW,Kalicharan D,Donga J,Hulstaert CE,Hardonk MJ

更新日期：1987-03-01 00:00:00

abstract：:Residual kidney function (RKF) may confer a variety of benefits to patients on maintenance dialysis. RKF provides continuous clearance of middle molecules and protein-bound solutes. Whereas the definition of RKF varies across studies, interdialytic urine volume may emerge as a pragmatic alternative to more cumbersome ...

journal_title：Kidney international

authors： Mathew AT,Fishbane S,Obi Y,Kalantar-Zadeh K

更新日期：2016-08-01 00:00:00

abstract：:The safety of dietary protein and phosphorous restriction was evaluated in the Modification of Diet in Renal Disease (MDRD) Study. In Study A, 585 patients with a glomerular filtration rate (GFR) of 25 to 55 ml/min/1.73 m2 were randomly assigned to a usual-protein diet (1.3 g/kg/day) or a low-protein diet (0.58 g/kg/d...

journal_title：Kidney international

authors： Kopple JD,Levey AS,Greene T,Chumlea WC,Gassman JJ,Hollinger DL,Maroni BJ,Merrill D,Scherch LK,Schulman G,Wang SR,Zimmer GS

更新日期：1997-09-01 00:00:00

abstract：:Surgical creation of new anastomosis has been proposed as the preferred treatment for perianastomotic stenoses of fistulae. However, disadvantages of surgical approach have included (1) frequent conversion of fistula to a graft by using synthetic graft material to create a new anastomosis, (2) shortening the length of...

journal_title：Kidney international

authors： Asif A,Lenz O,Merrill D,Cherla G,Cipleu CD,Ellis R,Francois B,Epstein DL,Pennell P

更新日期：2006-05-01 00:00:00

abstract：:The autoregulatory ability of the renal vascular system in the split hydronephrotic kidney was quantitated with intravital microscopy. The luminal diameters of the arcuate and interlobular arteries as well as the afferent and efferent arterioles were measured. Glomerular blood flow was determined by the dual slit tech...

journal_title：Kidney international

authors： Steinhausen M,Blum M,Fleming JT,Holz FG,Parekh N,Wiegman DL

更新日期：1989-05-01 00:00:00

abstract：:Healthy volunteers (N = 9) and patients with varying degrees of renal insufficiency (N = 36) were given a low dose of dopamine and/or amino acids intravenously during a simultaneous measurement of the glomerular filtration rate and the effective renal plasma flow. Dopamine infusion led to a rise in the glomerular filt...

journal_title：Kidney international

authors： ter Wee PM,Rosman JB,van der Geest S,Sluiter WJ,Donker AJ

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Among the members of the small leucine-rich proteoglycan family, decorin, biglycan, and fibromodulin have been proposed to be potent modulators of transforming growth factor-beta (TGF-beta) activity, thereby playing an important role in the pathogenesis of fibrotic kidney diseases. Furthermore, decorin expre...

journal_title：Kidney international

authors： Schaefer L,Gröne HJ,Raslik I,Robenek H,Ugorcakova J,Budny S,Schaefer RM,Kresse H

更新日期：2000-10-01 00:00:00

abstract：:The acutely injured mammalian kidney mounts a cellular and molecular response to repair itself. However, in patchy regions such intrinsic processes are impaired and dysregulated leading to chronic kidney disease. Currently, no therapy exists to treat established acute kidney injury per se. Strategies to augment human ...

journal_title：Kidney international

authors： Kumar S

更新日期：2018-01-01 00:00:00

abstract：:The effect of glycine on hypoxia- and ionomycin-induced increases in calpain activity in rat proximal tubules was determined. Calpain activity was determined both in vitro and in the intact cell using the fluorescent substrate N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methyl coumarin (N-succinyl-Leu-Leu-Val-Tyr-AMC) and We...

journal_title：Kidney international

authors： Edelstein CL,Ling H,Gengaro PE,Nemenoff RA,Bahr BA,Schrier RW

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:A family history increases the risk of kidney stone passage independent of dietary risk factors. However, the metabolic basis for familial aggregation of urolithiasis is unknown. METHODS:We evaluated metabolic risk factors in families with at least two sibs with a history of calcium stones. Sibs underwent o...

journal_title：Kidney international

authors： Tessier J,Petrucci M,Trouvé ML,Valiquette L,Guay G,Ouimet D,Bonnardeaux A

更新日期：2001-09-01 00:00:00

abstract：:Polycystic renal disease was induced in rats by feeding 2-amino-4,5-diphenylthiazole. Tubular (TBM) and glomerular basement membranes (GBM) were purified and analyzed for possible structural changes that may be a factor in the development of the tubular dilations and cysts. Changes in the relative quantities of TBM po...

journal_title：Kidney international

authors： Butkowski RJ,Carone FA,Grantham JJ,Hudson BG

更新日期：1985-11-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common kidney malignancy and has a poor prognosis owing to its resistance to chemotherapy. RCC cells overexpress the transcription factor, PAX2, normally expressed in fetal kidney but downregulated at birth. Since Pax2 suppresses apoptosis during renal development, we reasoned th...

journal_title：Kidney international

authors： Hueber PA,Waters P,Clark P,Eccles M,Goodyer P

更新日期：2006-04-01 00:00:00