Hypertension, glomerular number, and birth weight in African Americans and white subjects in the southeastern United States.

abstract：BACKGROUND:Wegener's granulomatosis (WG) is characterized by systemic vasculitis with crescentic glomerulonephritis (CGN) and circulating autoantibodies directed against neutrophil cytoplasmic antigens (ANCA). Proteinase 3 (PR-3), a neutral serine proteinase in neutrophils implicated in the growth control of myeloid ce...

journal_title：Kidney international

authors： Schwarting A,Hagen D,Odenthal M,Brockmann H,Dienes HP,Wandel E,Rumpelt HJ,Zum Büschenfelde KH,Galle PR,Mayet W

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Recent advances enable the direct measurement of small molecule clearance, Kecn, during each dialysis. Average Kecn and treatment length, t, are multiplied giving total clearance, Kt. The body surface area (BSA) is a fixed transformation of height and weight and is a well recognized measure of body size. Thi...

journal_title：Kidney international

authors： Lowrie EG,Li Z,Ofsthun N,Lazarus JM

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Patients on continuous ambulatory peritoneal dialysis (CAPD) are dependent on residual renal function for solute and water clearances, and this declines with time on dialysis. Loop diuretics have been postulated to slow this decline. METHODS:Sixty-one patients new to dialysis were randomly assigned to eithe...

journal_title：Kidney international

authors： Medcalf JF,Harris KP,Walls J

更新日期：2001-03-01 00:00:00

abstract：:Excessive intraperitoneal absorption of glucose during peritoneal dialysis has both local cytotoxic and systemic metabolic effects. Here we evaluate peritoneal dialysis solutions containing L-carnitine, an osmotically active compound that induces fluid flow across the peritoneum. In rats, L-carnitine in the peritoneal...

journal_title：Kidney international

authors： Bonomini M,Pandolfi A,Di Liberato L,Di Silvestre S,Cnops Y,Di Tomo P,D'Arezzo M,Monaco MP,Giardinelli A,Di Pietro N,Devuyst O,Arduini A

更新日期：2011-09-01 00:00:00

abstract：:Sudden death is one of the more frequent causes of death for hemodialysis patients, but the underlying mechanisms, contribution of arrhythmia, and associations with serum chemistries or the dialysis procedure are incompletely understood. To study this, implantable loop recorders were utilized for continuous cardiac rh...

journal_title：Kidney international

authors： Roy-Chaudhury P,Tumlin JA,Koplan BA,Costea AI,Kher V,Williamson D,Pokhariyal S,Charytan DM,MiD investigators and committees.

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Proteinase 3 is the major autoantigen in Wegener's granulomatosis (WG). Membrane PR3 expression is bimodal; low expressing cells (mPR3(low)) can be distinguished from cells with high expression (mPR3(high)) within a given individual. High mPR3 expression is a WG risk factor and is associated with relapse. Ho...

journal_title：Kidney international

authors： Schreiber A,Luft FC,Kettritz R

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:A family history increases the risk of kidney stone passage independent of dietary risk factors. However, the metabolic basis for familial aggregation of urolithiasis is unknown. METHODS:We evaluated metabolic risk factors in families with at least two sibs with a history of calcium stones. Sibs underwent o...

journal_title：Kidney international

authors： Tessier J,Petrucci M,Trouvé ML,Valiquette L,Guay G,Ouimet D,Bonnardeaux A

更新日期：2001-09-01 00:00:00

abstract：:Mineral metabolism in chronic kidney disease is attracting intense interest and unprecedented levels of research. The pharmaceutical industry has responded by developing various new agents. Bervoets et al. report the use of an unusual combination of basic-science techniques to increase understanding of the kinetics of...

journal_title：Kidney international

authors： Hutchison AJ

更新日期：2009-02-01 00:00:00

abstract：:Erythropoiesis stimulating agent (ESA) treatment has been a major advance in the care of patients with kidney disease, resulting in reduced symptoms and blood transfusions, and improved quality of life. Recent studies, however, have indicated that attempts to treat to near normal Hgb targets may result in increased ri...

journal_title：Kidney international

authors： Fishbane S

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:The aim of this study was to establish whether there is a differential effect of mode of dialysis, hemodialysis (HD), or continuous ambulatory peritoneal dialysis (CAPD) on the dyslipidemia of renal failure. METHODS:The lipoprotein profile was determined in 61 non-diabetic patients on chronic HD (N = 30) an...

journal_title：Kidney international

authors： Attman PO,Samuelsson OG,Moberly J,Johansson AC,Ljungman S,Weiss LG,Knight-Gibson C,Alaupovic P

更新日期：1999-04-01 00:00:00

abstract：:Changes in macula densa intracellular pH (pHi) were used to monitor the direction of flux mediated by the apical Na:2Cl:K cotransporter. At the macula densa, a decrease in luminal [Cl] ([Cl]1) from 60 to 1 mM produced cellular alkalinization secondary to a cascade of events involving a decrease in apical Na:2Cl:K cotr...

journal_title：Kidney international

authors： Lapointe JY,Laamarti A,Hurst AM,Fowler BC,Bell PD

更新日期：1995-03-01 00:00:00

abstract：:Since 1992 and the discovery of an MIP (major intrinsic protein of lens fiber cell) homologue protein that selectively permeates water, aquaporin (AQP), there has been an explosion of research in this field. Early research speculated that aquaporins played indispensible physiological roles in bacteria and plants, as w...

journal_title：Kidney international

authors： Yamamoto T,Sasaki S

更新日期：1998-10-01 00:00:00

abstract：:The purpose of this study was to explore risk factors affecting the incidence of chronic kidney disease (CKD) in general population. We conducted a 10-year follow-up study with 123 764 (male: 41 012, female: 82 752) adults aged 40 years and over who received community-based annual examinations. The primary outcome for...

journal_title：Kidney international

authors： Yamagata K,Ishida K,Sairenchi T,Takahashi H,Ohba S,Shiigai T,Narita M,Koyama A

更新日期：2007-01-01 00:00:00

abstract：:Targeted therapies and immune checkpoint inhibitors have advanced the treatment landscape of Renal Cell Carcinoma (RCC) over the last decade. While checkpoint inhibitors have demonstrated survival benefit and are currently approved in the front-line and second-line settings, primary and secondary resistance is common....

journal_title：Kidney international

authors： Wang X,Lopez R,Luchtel RA,Hafizi S,Gartrell B,Shenoy N

更新日期：2021-01-01 00:00:00

abstract：:Many transgenic and knockout mice with increased urine flow have structural abnormalities of the renal pelvis and inner medulla. Here, we used high resolution contrast enhanced T1-weighted magnetic resonance imaging of mice whose urea transporters UT-A1 and UT-A3 were deleted (UT-A1/3(-/-) mice) as a model for the in ...

journal_title：Kidney international

authors： Jacob VA,Harbaugh CM,Dietz JR,Fenton RA,Kim SM,Castrop H,Schnermann J,Knepper MA,Chou CL,Anderson SA

更新日期：2008-11-01 00:00:00

abstract：:Peptides representing potential antigenic regions of the NC-1 and 7-S domains of the human alpha 1 and alpha 2, and bovine alpha 3 chains of type IV collagen were synthesized either chemically or by the recombinant DNA technique and tested by ELISA using antibodies raised in rabbits against the whole type IV collagen ...

journal_title：Kidney international

authors： Kefalides NA,Ohno N,Wilson CB,Fillit H,Zabriski J,Rosenbloom J

更新日期：1993-01-01 00:00:00

abstract：:Although the goal glomerular filtration rate (GFR) for chronic dialysis initiation is currently above 5 ml/min per 1.73 m(2), there is no convincing evidence that patients will benefit from this approach. With close follow-up of advanced chronic kidney disease patients, aiming to start dialysis at an estimated GFR (eG...

journal_title：Kidney international

authors： Rosansky SJ,Durkin MW

更新日期：2014-10-01 00:00:00

abstract：:These studies were undertaken to examine effects of elevated glucose levels on glycolysis, sorbitol pathway activity, and the cytosolic redox state of NADH/NAD+ in isolated glomeruli. Blood-free glomeruli were isolated from kidneys of male, Sprague-Dawley rats using standard sieving techniques, then incubated for one ...

journal_title：Kidney international

authors： Tilton RG,Baier LD,Harlow JE,Smith SR,Ostrow E,Williamson JR

更新日期：1992-04-01 00:00:00

abstract：:Chronic balance studies were performed in six adrenalectomized patients to investigate the renal and systemic acid-base consequences of mineralocorticoid deficiency in the absence of either glucocorticoid deficiency or parenchymal renal disease. Constant glucocorticoid replacement was provided with dexamethasone, 750 ...

journal_title：Kidney international

authors： Sebastian A,Sutton JM,Hulter HN,Schambelan M,Poler SM

更新日期：1980-12-01 00:00:00

abstract：:Clinical studies have demonstrated a poor correlation between localization tests, which are designed to determine the site of urinary tract infection, and symptoms of upper urinary tract infection. One explanation is that microorganisms may be present in the kidney but not initiate an inflammatory response with associ...

journal_title：Kidney international

authors： Miller TE,Findon G,Rainer SP,Gavin JB

更新日期：1992-05-01 00:00:00

abstract：:Cytomegalovirus (CMV) seropositivity is associated with increased risk for atherosclerotic disease in patients with end-stage renal disease. This association is due to a unique peripheral blood CD4(+) T cell population which lack CD28 (CD4(+)CD28(-) T cells). Here we found that this patient population has a significan...

journal_title：Kidney international

authors： Betjes MG,Huisman M,Weimar W,Litjens NH

更新日期：2008-09-01 00:00:00

abstract：:The beta-amino acid transport capabilities of rat renal epithelium were assessed using brushborder membrane vesicles (BBMV). Taurine, a metabolically inert sulfur-containing amino acid, was studied with emphasis on the renal adaptation to dietary sulfur amino acid alteration. Three isoproteinic diets were given to Spr...

journal_title：Kidney international

authors： Chesney RW,Gusowski N,Friedman AL

更新日期：1983-11-01 00:00:00

abstract：:We previously demonstrated that urinary endothelin excretion is increased in rats with extensive renal mass reduction, a model of progressive renal disease. Here we explored whether the increased urinary endothelin in this model were due to induction of renal pre-pro-endothelin-1 gene and whether changes in endothelin...

journal_title：Kidney international

authors： Orisio S,Benigni A,Bruzzi I,Corna D,Perico N,Zoja C,Benatti L,Remuzzi G

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Tubulointerstitial fibrosis is a morphologic hallmark of chronic kidney disease and is a key factor in the prediction of progression to end-stage renal failure. Disruption of tubular basement membrane and interstitial extracellular matrix (ECM) via cytokine-induced alterations in matrix metalloproteinases (M...

journal_title：Kidney international

authors： Nee LE,McMorrow T,Campbell E,Slattery C,Ryan MP

更新日期：2004-10-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) transforms endogenous glucocorticoids to their respective "biologically inert" 11-dehydro derivatives. A decrease in enzyme activity allows glucocorticoids to induce mineralocorticoid-like renal sodium retention. Since positive sodium balance is required for optimum ...

journal_title：Kidney international

authors： Brem AS,Bina B,Matheson KL,Barnes JL,Morris DJ

更新日期：1994-03-01 00:00:00

abstract：:The Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure, an important risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). However, it is unclear whether adherence to a DASH diet confers protection against future ESRD, especially among those with pre-existing CKD and h...

journal_title：Kidney international

authors： Banerjee T,Crews DC,Tuot DS,Pavkov ME,Burrows NR,Stack AG,Saran R,Bragg-Gresham J,Powe NR,Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team.

更新日期：2019-06-01 00:00:00

abstract：:The safety of dietary protein and phosphorous restriction was evaluated in the Modification of Diet in Renal Disease (MDRD) Study. In Study A, 585 patients with a glomerular filtration rate (GFR) of 25 to 55 ml/min/1.73 m2 were randomly assigned to a usual-protein diet (1.3 g/kg/day) or a low-protein diet (0.58 g/kg/d...

journal_title：Kidney international

authors： Kopple JD,Levey AS,Greene T,Chumlea WC,Gassman JJ,Hollinger DL,Maroni BJ,Merrill D,Scherch LK,Schulman G,Wang SR,Zimmer GS

更新日期：1997-09-01 00:00:00

abstract：:Tissandié and colleagues report in this issue on their studies of IgA1 glycosylation and biological activities of IgA1-containing circulating immune complexes in patients with alcoholic cirrhosis who developed secondary renal disease with IgA deposits, secondary IgA nephropathy. Their seminal findings demonstrate abno...

journal_title：Kidney international

authors： Novak J,Julian BA

更新日期：2011-12-01 00:00:00

abstract：:IgM in the blood of normal individuals consists mainly of 'natural' polyreactive antibodies. Natural IgM is thought to provide an initial defense against infection and to promote the healing of wounded cells. Yet, as Panzer and colleagues show, these benefits can be eclipsed when the IgM binds to damaged cells of the ...

journal_title：Kidney international

authors： Platt JL,Cascalho M

更新日期：2015-09-01 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy (TMA) caused by dysregulated complement activation. Clinically, aHUS is effectively treated by an anti-C5 monoclonal antibody (mAb) but whether the disease is mediated by the C5a receptor (C5aR) or C5b-9 pathway, or both, is unknown. Her...

journal_title：Kidney international

authors： Ueda Y,Miwa T,Ito D,Kim H,Sato S,Gullipalli D,Zhou L,Golla M,Song D,Dunaief JL,Palmer MB,Song WC

更新日期：2019-07-01 00:00:00