Lanthanum and phosphate: science, policy, and survival.

abstract：BACKGROUND:Osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7), a member of the transforming growth factor-beta superfamily, has been shown to prevent kidney damage from ischemia/reperfusion injury in rats. The molecular events involved in OP-1 action on kidney are not yet understood. METHODS:In this study,...

journal_title：Kidney international

authors： Bosukonda D,Shih MS,Sampath KT,Vukicevic S

更新日期：2000-11-01 00:00:00

abstract：:The formation of the non-sulphated glycosaminoglycan hyaluronan by cells of the renal glomerulus in diabetes may contribute to altered matrix composition. We describe an increased production of hyaluronan from mesangial cell-enriched glomerular cores from diabetic animals, and further show that increased hyaluronan pr...

journal_title：Kidney international

authors： Dunlop ME,Clark S,Mahadevan P,Muggli E,Larkins RG

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Left ventricular enlargement is very common at the inception of dialysis therapy, and highly predictive of future cardiac morbidity and mortality. It is not known whether cardiac size increases further while on dialysis therapy and whether potentially reversible risk factors for later progression can be iden...

journal_title：Kidney international

authors： Foley RN,Parfrey PS,Kent GM,Harnett JD,Murray DC,Barre PE

更新日期：1998-11-01 00:00:00

abstract：:Proteomics-based assays have substantially improved diagnostic accuracy in systemic amyloidosis and have led to the discovery of novel amyloidogenic proteins. The observation that human apolipoproteins are increasingly represented is intriguing and highlights the complex, and partially known, mutual effects of the mis...

journal_title：Kidney international

authors： Obici L,Nuvolone M,Merlini G

更新日期：2016-09-01 00:00:00

abstract：INTRODUCTION:Monocyte chemoattractant protein-1 (MCP-1) promotes renal inflammation, thereby contributing to acute and chronic nephropathies. Its production is stimulated by oxidative stress. Thus, this study tested whether pro-oxidant iron/carbohydrate complexes, used to treat iron deficiency, induce MCP-1 in renal/ex...

journal_title：Kidney international

authors： Zager RA

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Regular access monitoring is recommended to detect and treat access stenosis in order to prevent access thrombosis and failure. METHODS:In 1999, we instituted monthly access blood flow monitoring using the ultrasound dilution technique (UDT). In a sequential observational trial, 222 patients were studied fo...

journal_title：Kidney international

authors： Shahin H,Reddy G,Sharafuddin M,Katz D,Franzwa BS,Dixon BS

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Cell membranes and their lipids play critical roles in calcification. Specific membrane phospholipids promote the formation of calcium phosphate and become a part of the organic matrix of growing calcification. We propose that membrane lipids also promote the formation of calcium oxalate (CaOx) and calcium p...

journal_title：Kidney international

authors： Khan SR,Glenton PA,Backov R,Talham DR

更新日期：2002-12-01 00:00:00

abstract：:Water and small solute fluxes through cell membranes are ensured in many tissues by selective pores that belong to the major intrinsic protein family (MIP). This family includes the water channels or aquaporins (AQP) and the neutral solute facilitators such as the glycerol facilitator (GlpF). We have compared the char...

journal_title：Kidney international

authors： Duchesne L,Deschamps S,Pellerin I,Lagree V,Froger A,Thomas D,Bron P,Delamarche C,Hubert JF

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Approximately 8% of autosomal-dominant polycystic kidney disease (ADPKD) patients have intracranial aneurysms. The risk of growth and rupture of those discovered by presymptomatic screening is key to the feasibility and success of a screening program. This study was initiated to ascertain this risk. METHODS...

journal_title：Kidney international

authors： Gibbs GF,Huston J 3rd,Qian Q,Kubly V,Harris PC,Brown RD Jr,Torres VE

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DCs) uniquely serve as conduits between innate and cognate arms of the immune system. The normal kidney contains an extensive population of interstitial DCs but their role in the pathogenesis of acute renal injury is not known. METHODS:Renal DCs were studied by flow cytometric analysis of c...

journal_title：Kidney international

authors： Dong X,Swaminathan S,Bachman LA,Croatt AJ,Nath KA,Griffin MD

更新日期：2005-09-01 00:00:00

abstract：:Fifty-one adults with HIV infection, including 20 chronic hemodialysis patients with superimposed HIV infection and 31 patients with HIV-associated nephropathy requiring chronic maintenance hemodialysis were followed to evaluate survival on outpatient dialysis in relation to the clinical stage of the HIV infection. Re...

journal_title：Kidney international

authors： Ortiz C,Meneses R,Jaffe D,Fernandez JA,Perez G,Bourgoignie JJ

更新日期：1988-08-01 00:00:00

abstract：:Coronary artery stenosis induces renal inflammation and kidney injury in pigs even in the absence of myocardial infarction or clinically significant heart failure. This effect is aggravated by experimentally induced renovascular hypertension. Interestingly, oxidative stress originating from the ischemic myocardium was...

journal_title：Kidney international

authors： Rump LC,Stegbauer J

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The aim of this study was to establish whether there is a differential effect of mode of dialysis, hemodialysis (HD), or continuous ambulatory peritoneal dialysis (CAPD) on the dyslipidemia of renal failure. METHODS:The lipoprotein profile was determined in 61 non-diabetic patients on chronic HD (N = 30) an...

journal_title：Kidney international

authors： Attman PO,Samuelsson OG,Moberly J,Johansson AC,Ljungman S,Weiss LG,Knight-Gibson C,Alaupovic P

更新日期：1999-04-01 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) and MHC class II (Ia) antigens are increased on proximal tubular epithelial cells (TEC) in autoimmune nephritis and transplant rejection. ICAM-1 is a member of the immunoglobulin gene superfamily that increases the avidity of T cell interactions with antigen-presenting cells ...

journal_title：Kidney international

authors： Jevnikar AM,Wuthrich RP,Takei F,Xu HW,Brennan DC,Glimcher LH,Rubin-Kelley VE

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Nuclear factor-kappaB (NF-kappaB) and activated protein-1 (AP-1) are transcription factors that regulate many genes involved in the progression of renal disease. Recent data have shown that NF-kappaB is activated in tubules and glomeruli in various experimental models of renal injury. In vitro studies also s...

journal_title：Kidney international

authors： Mezzano SA,Barría M,Droguett MA,Burgos ME,Ardiles LG,Flores C,Egido J

更新日期：2001-10-01 00:00:00

abstract：:Long-term outcomes of kidney allografts have shown only marginal improvement over the last three decades, despite the remarkable improvement in acute rejection and one-year graft survival. Novel biomarkers of tubular injury may prevent irreversible damage to the tubulointerstitial compartment and improve allograft sur...

journal_title：Kidney international

authors： Abulezz S

更新日期：2008-03-01 00:00:00

abstract：:We sought to study glomerular pathophysiology in a model of IgA nephropathy (IgAN). Preliminary experiments with oral immunization indicated that Lewis rats had higher IgA levels and IgA/IgG ratios than Wistar, Fischer or Sprague-Dawley rats. Six groups of Lewis rats were studied: four continuously orally immunized fo...

journal_title：Kidney international

authors： Gesualdo L,Emancipator SN,Kesselheim C,Lamm ME

更新日期：1992-07-01 00:00:00

abstract：:Interstitial monocytic infiltration of the kidney occurs within hours of acute kidney injury and is an important determinant of functional decline and fibrosis. Li et al. used several surface markers to distinguish between dendritic cells and inflammatory monocytes following acute kidney injury and to identify two che...

journal_title：Kidney international

authors： Swaminathan S,Griffin MD

更新日期：2008-12-01 00:00:00

abstract：:In the course of studying the genetics of chlorambucil mutagenesis, we have uncovered a new model for autosomal polycystic kidney disease (PKD). In the homozygous condition, the gene, jcpk, causes a very severe disease characterized by cysts in all segments of the nephron. Death usually occurs before 10 days of age. E...

journal_title：Kidney international

authors： Flaherty L,Bryda EC,Collins D,Rudofsky U,Montogomery JC

更新日期：1995-02-01 00:00:00

abstract：:Protein misfolding in the endoplasmic reticulum (ER) leads to ER stress. The unfolded protein response and ER-associated degradation (ERAD) interact in a coordinated manner with the ubiquitin-proteasome system and autophagy to alleviate protein misfolding or its consequences. The intersecting actions of these processe...

journal_title：Kidney international

authors： Cybulsky AV

更新日期：2013-07-01 00:00:00

abstract：:Previous studies have demonstrated that dietary potassium deprivation in healthy human subjects eating diets otherwise containing normal quantities of NaCl is accompanied by an increase in urinary calcium excretion. This increase in urinary Ca excretion occurs in association with reductions in urinary Na and Cl excret...

journal_title：Kidney international

authors： Lemann J Jr,Pleuss JA,Hornick L,Hoffman RG

更新日期：1995-03-01 00:00:00

abstract：:The possibility that the rabbit collecting tubule is heterogeneous with respect to electrical and morphologic properties was examined in isolated segments. Collecting tubules from rabbits treated with desoxycorticosterone acetate were dissected from various locations within the cortex and outer medulla, and the transe...

journal_title：Kidney international

authors： Stokes JB,Tisher CC,Kokko JP

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:Although atherosclerotic renovascular disease is increasingly recognized in chronic kidney disease, few national level studies have examined its clinical epidemiology. METHODS:Claims data from a 5% random sample of the United States Medicare population were used to select patients without atherosclerotic re...

journal_title：Kidney international

authors： Kalra PA,Guo H,Kausz AT,Gilbertson DT,Liu J,Chen SC,Ishani A,Collins AJ,Foley RN

更新日期：2005-07-01 00:00:00

abstract：:Meprins are zinc-dependent metalloproteinases that are highly expressed in the brush-border membranes of both the kidney and the intestines. Meprins are capable of proteolytically degrading extracellular matrix proteins, proteolytically processing bioactive proteins, and play a role in inflammatory processes. In this ...

journal_title：Kidney international

authors： Herzog C,Seth R,Shah SV,Kaushal GP

更新日期：2007-05-01 00:00:00

abstract：:In early clinical testing, acute addition of alanyl-glutamine (AlaGln) to glucose-based peritoneal dialysis (PD) fluids restored peritoneal cellular stress responses and leukocyte function. This study was designed to test the effect of extended treatment with AlaGln-supplemented PD fluid on biomarkers of peritoneal he...

journal_title：Kidney international

authors： Vychytil A,Herzog R,Probst P,Ribitsch W,Lhotta K,Machold-Fabrizii V,Wiesholzer M,Kaufmann M,Salmhofer H,Windpessl M,Rosenkranz AR,Oberbauer R,König F,Kratochwill K,Aufricht C

更新日期：2018-12-01 00:00:00

abstract：:Macrophages are inflammatory cells with important roles in the propagation of renal injury. More recently they have also been shown to be important in the resolution of inflammation. Wang et al. show that macrophages can be modulated ex vivo by cytokine stimulation, localize to renal tissue, and slow progression of ex...

journal_title：Kidney international

authors： Kluth DC

更新日期：2007-08-01 00:00:00

abstract：:Cytomegalovirus (CMV) seropositivity is associated with increased risk for atherosclerotic disease in patients with end-stage renal disease. This association is due to a unique peripheral blood CD4(+) T cell population which lack CD28 (CD4(+)CD28(-) T cells). Here we found that this patient population has a significan...

journal_title：Kidney international

authors： Betjes MG,Huisman M,Weimar W,Litjens NH

更新日期：2008-09-01 00:00:00

abstract：:Chronic kidney disease (CKD) is a key cause of hypertension and a potent independent risk for cardiovascular disease. Epidemiological studies suggest a strong genetic component determining susceptibility for renal disease and, by inference, the associated cardiovascular risk. With a subtotal nephrectomy model of kidne...

journal_title：Kidney international

authors： Salzler HR,Griffiths R,Ruiz P,Chi L,Frey C,Marchuk DA,Rockman HA,Le TH

更新日期：2007-11-01 00:00:00

abstract：:In recent years, a substantial body of experimental and clinical work has been devoted to C3 glomerulopathy and Ig-mediated membranoproliferative glomerulonephritis. Despite the rapid accumulation of data, several uncertainties about these 2 rare forms of nephropathies persist. They concern their pathophysiology, clas...

journal_title：Kidney international

authors： Fakhouri F,Le Quintrec M,Frémeaux-Bacchi V

更新日期：2020-11-01 00:00:00

abstract：:Nephrons possess a segmental organization where each segment is specialized for the secretion and reabsorption of particular solutes. The developmental control of nephron segment patterning remains one of the enigmas within the field of renal biology. Achieving an understanding of the mechanisms that direct nephron se...

journal_title：Kidney international

authors： Wingert RA,Davidson AJ

更新日期：2008-05-01 00:00:00