Abstract：
:The possibility that the rabbit collecting tubule is heterogeneous with respect to electrical and morphologic properties was examined in isolated segments. Collecting tubules from rabbits treated with desoxycorticosterone acetate were dissected from various locations within the cortex and outer medulla, and the transepithelial potential was measured. The cortical collecting tubule always displayed a negative potential. In contrast, collecting tubules dissected from the inner stripe of the outer medulla displayed a positive potential. That this change is a function of position within the kidney is supported by the observation that some tubules generated a negative potential at the superficial (cortical) end and a positive potential at the deep (medullary) end of the same tubule. Histologic evaluation of tubules after perfusion resulted in a striking correlation between the existence of a negative potential and the presence of dark cells. The results of this study provide evidence that the collecting tubule is heterogeneous with respect to active transport processes and suggest that these functional differences may correlate with morphologic differences between the cortical segment and the medullary segment of the collecting tubule.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Stokes JB,Tisher CC,Kokko JPdoi
10.1038/ki.1978.167subject
Has Abstractpub_date
1978-12-01 00:00:00pages
585-93issue
6eissn
0085-2538issn
1523-1755pii
S0085-2538(15)32004-4journal_volume
14pub_type
杂志文章abstract：:We examined the circulating levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 alpha, IL-6, granulocyte macrophage-colony stimulating factor (GM-CSF), and the anti-inflammatory cytokine IL-10, and their expression in kidneys acutely infected with murine malaria parasite...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.1998.00848.x
更新日期：1998-04-01 00:00:00
abstract：:It is no a secret that we are confronted by an alarmingly increasing number of patients with progressive renal disease. There is ample evidence for the notion that angiotensin II (Ang II) is a major culprit in progression. The vasopeptide Ang II turned out to have also multiple nonhemodynamic pathophysiologic actions ...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1111/j.1523-1755.2005.00145.x
更新日期：2005-03-01 00:00:00
abstract：:Neuropilin1 (Nrp1) is a co-receptor best known to regulate the development of endothelial cells and is a target of anticancer therapies. However, its role in other vascular cells including pericytes is emergent. The kidney is an organ with high pericyte density and cancer patients develop severe proteinuria following ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2016.10.010
更新日期：2017-04-01 00:00:00
abstract：:Chronic kidney disease is characterized as impaired renal function along with the imbalance and dysregulation of mineral metabolism; recognized as chronic kidney disease-mineral and bone disorder. Hyperphosphatemia, characterized by altered phosphate homeostasis along with elevated fibroblast growth factor-23 and inta...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.02.040
更新日期：2020-08-01 00:00:00
abstract：:Cardiovascular disease is the leading cause of death in kidney transplant recipients in many transplant registries. An analysis of transplant recipients from the United Kingdom using propensity score matching (PSM) suggests there are limited or no benefits to cardiovascular screening before transplant listing. We sugg...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2020.10.043
更新日期：2021-02-01 00:00:00
abstract：:In rodents, mercuric chloride (HgCl2) causes an autoimmune disorder with glomerulonephritis (GN), and represents an animal model for the pathogenesis of GN. We have tested the hypothesis that HgCl2 induces major histocompatibility complex (MHC) expression in renal parenchymal cells, and studied the kinetics of this in...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1991.33
更新日期：1991-02-01 00:00:00
abstract：:Adoptive immunotherapy in patients with advanced cancer produces significant regression of metastatic disease in selected patients, but it is complicated by severe side effects. Prevention of these complications is still limited because their precise mechanisms remain unknown. For this reason we have investigated rena...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1991.215
更新日期：1991-08-01 00:00:00
abstract：:Nephrin is a slit diaphragm protein critical for structural and functional integrity of visceral glomerular epithelial cells (podocytes) and is known to be tyrosine phosphorylated by Src family kinases. We studied the role of phosphoinositide 3-kinase (PI3K), activated via the phosphorylation of nephrin, in actin cyto...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5002691
更新日期：2008-03-01 00:00:00
abstract：:E-64d, a membrane-permeable cysteine protease inhibitor, was tested for its ability to inhibit PTH-induced contraction in intact mouse MC-3T3-E1 osteoblastic cells. Incubation of MC-3T3-E1 cells with vehicle (DMSO) or E-64c, a nonpermeant cysteine protease inhibitor, in the presence or in the absence of PTH had no eff...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1993.99
更新日期：1993-03-01 00:00:00
abstract：:The importance of the endothelial isoform of nitric oxide synthase (eNOS) has been well established. Endothelium-derived nitric oxide has been shown to be essential for vascular homeostasis and modulation of eNOS has thus become a target in prevention of cardiovascular disease. The role of the inducible form of nitric...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1046/j.1523-1755.2002.00235.x
更新日期：2002-03-01 00:00:00
abstract：:Chronic inflammation contributes to increased mortality in hemodialysis (HD) patients. YKL-40 is a novel marker of inflammation, tissue remodeling, and highly expressed in macrophages inside vascular lesions. Elevated levels of YKL-40 have been reported for HD patients but how it integrates into the proinflammatory me...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2017.07.010
更新日期：2018-01-01 00:00:00
abstract：:The impacts of IgA nephropathy and pregnancy on each other were evaluated in 118 women who conceived 168 times between 1970 and 1988. Rates of spontaneous abortion, normal delivery, live birth and perinatal death were 9, 66, 87 and 4%, respectively. Infants born to women with glomerular filtration rates (GFR) lower th...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1991.320
更新日期：1991-12-01 00:00:00
abstract：:Adiponectin levels are increased in patients with type I diabetes especially in the presence of microangiopathy. Here we determined the predictive value of serum adiponectin levels and 8 adiponectin gene polymorphisms for mortality, cardiovascular events and end-stage renal disease in type I diabetic patients. This pr...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2008.201
更新日期：2008-09-01 00:00:00
abstract：:The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of the target genes. We have shown that the interaction of VDRs with VDREs is inhibited by uremic toxins. We hypothesize that uremic toxins form Schiff bases with the lysine re...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1996.469
更新日期：1996-11-01 00:00:00
abstract：:Levels of prepro epidermal growth factor (EGF) mRNA in renal cortical tissue and urinary EGF excretion have been determined during cisplatin and ischemia-induced acute renal failure in the rat. Northern analysis of polyadenylated RNAs of kidney cortical tissue showed diminished renal preproEGF mRNA in rats injected wi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1989.266
更新日期：1989-11-01 00:00:00
abstract：:Administration of antibody, directed against glomerular basement membrane (GBM) heparan sulfate-proteoglycan, into a presensitized rat results in the induction of membranous nephropathy with subepithelial immune-complex deposits. In this investigation, we examined the mechanisms responsible for the formation of subepi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1988.166
更新日期：1988-08-01 00:00:00
abstract：:The incidence of acute kidney injury (AKI) is high in elderly people, and is difficult to prevent and treat. One of its major causes is renal ischemia-reperfusion injury (IRI). A young systemic environment may prevent the senescence of old organs. However, it is unknown whether a young milieu may reduce renal IRI in t...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2018.03.019
更新日期：2018-08-01 00:00:00
abstract：:This report of the NIH-supported National Continuous Ambulatory Peritoneal Dialysis (CAPD) Registry summarizes data on 7,404 patients treated with CAPD during the three-year period 1981 through 1983, or nearly one-half of patients treated in the USA who were treated with CAPD during this time. While age and diabetes m...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1985.141
更新日期：1985-08-01 00:00:00
abstract：:How much dialysis is required for optimal well-being and long-term survival? The Frequent Hemodialysis Network completed two prospective trials examining the effect of more frequent, short hours and, now, of nocturnal hemodialysis compared with standard thrice-weekly treatments. Whereas the short-hours trial reported ...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2011.267
更新日期：2011-11-01 00:00:00
abstract：:Modern dietary habits are characterized by high-sodium and low-potassium intakes, each of which was correlated with a higher risk for hypertension. In this study, we examined whether long-term variations in the intake of sodium and potassium induce lasting changes in the plasma concentration of circulating steroids by...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2011.15
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Cellular and molecular mechanisms responsible for cisplatin-induced nephrotoxicity to renal tubular epithelial cells are not well understood. Although caspases play a critical role in the execution of the cell death pathway, their specific role in toxic injury to renal tubular epithelial cells has not been e...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.00026.x
更新日期：2001-11-01 00:00:00
abstract：:The early identification of renal transplant recipients at enhanced risk of developing acute and subclinical rejection would allow individualized adjustment of immunosuppression before functional graft injury occurs and would exclude these patients from drug-weaning studies. Protein and reverse transcriptase-polymeras...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5000343
更新日期：2006-05-01 00:00:00
abstract：:These studies were undertaken to examine effects of elevated glucose levels on glycolysis, sorbitol pathway activity, and the cytosolic redox state of NADH/NAD+ in isolated glomeruli. Blood-free glomeruli were isolated from kidneys of male, Sprague-Dawley rats using standard sieving techniques, then incubated for one ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1992.121
更新日期：1992-04-01 00:00:00
abstract：:To investigate whether alpha (alpha)-adrenoceptor agonists have a stimulatory effect on the expression of the angiotensinogen (Ang) gene in opossum kidney (OK) cells, we used OK 27 cells with a fusion gene containing the 5'-flanking regulatory sequence of the rat angiotensinogen gene fused with a human growth hormone ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1995.277
更新日期：1995-07-01 00:00:00
abstract：:In order to study the effects of acute ureteral obstruction on glomerular hemodynamics, glomerular hydrostatic capillary pressure (PG), pressure in the first-order peritubular capillaries (EAP), and intratubular pressure (PT) were directly measured in superficial nephrons on Munich-Wistar rats by micropuncture with a ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1977.131
更新日期：1977-12-01 00:00:00
abstract：:In recent times, therapy for renal anemia has changed dramatically in that iron administration has increased and doses of erythropoiesis-stimulating agents (ESAs) have decreased. Here we used a prospective, observational, multicenter design and measured the serum ferritin and hemoglobin levels every 3 months for 2 yea...
journal_title：Kidney international
pub_type： 杂志文章,多中心研究
doi：10.1038/ki.2014.114
更新日期：2014-10-01 00:00:00
abstract：:A model of glomerular dynamics has been developed by using network thermodynamics and the SPICE 2 computer program to further explore the determinants of glomerular filtration. The model is designed to be holistic and self-adjusting, taking cognizance of and permitting quantitation of the secondary alterations in indi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1981.27
更新日期：1981-02-01 00:00:00
abstract：:Serum calcitriol and the free calcitriol index together with factors considered to regulate calcitriol production were measured in eleven patients with moderate chronic renal failure (MCRF) and eleven age- and sex-matched normal subjects. Although the serum dialysable calcium levels were similar in the two groups, the...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1988.58
更新日期：1988-03-01 00:00:00
abstract：:Diabetes mellitus is associated with natriuresis, whereas estrogen has been shown to be renoprotective in diabetic nephropathy and may independently regulate renal sodium reabsorption. The aim of this study was to determine the effects of 17-beta estradiol (E(2)) replacement to diabetic, ovariectomized (OVX) female ra...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5000140
更新日期：2006-02-01 00:00:00
abstract：:Micropuncture studies were carried out in surface nephrons of rats with nephrotoxic-serum (NTS)-induced nephrotic syndrome during a period of active sodium and water retention. It was found that hydrostatic pressure and tubular diameter were increased in the proximal tubules (13.4 +/- 0.2 vs. 10.4 +/- 0.2 mm Hg; 31.3 ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1979.166
更新日期：1979-11-01 00:00:00
