Chronic potassium depletion increases adrenal progesterone production that is necessary for efficient renal retention of potassium.

abstract：:Renal function measurement by clearance methods relies on accurately timed urine collection. In small experimental animals, renal function measurement is usually performed under anesthesia and/or with the application of bladder catheters to ensure accurate urine collection. To avoid both anesthesia and the need for bl...

journal_title：Kidney international

authors： Marcel de Vries PA,Navis G,de Boer E,de Jong PE,de Zeeuw D

更新日期：1997-07-01 00:00:00

abstract：:Monocyte chemoattractant protein 1 (MCP-1) is a C-C chemokine with potent monocyte chemotactic and activating properties that may contribute to glomerular macrophage infiltration in anti-GBM Ab GN. We have previously reported increased glomerular steady state expression of MCP-1 mRNA relative to GAPDH mRNA in the hete...

journal_title：Kidney international

authors： Tang WW,Qi M,Warren JS

更新日期：1996-08-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-1) is a peptide growth factor that is synthesized in cultured mesangial cells and induces hyperplasia. We tested whether incubation with IGF-1 at concentrations of 7 nM, 70 nM, and 350 nM stimulates mesangial cell extracellular matrix mRNA and protein levels, and whether it influences...

journal_title：Kidney international

authors： Feld SM,Hirschberg R,Artishevsky A,Nast C,Adler SG

更新日期：1995-07-01 00:00:00

abstract：:In summary, it is evident that malnutrition is highly prevalent in ESRD patients. This is clearly related to multiple factors encountered during the pre-dialysis stage, as well as during maintenance dialysis therapy. A body of evidence highlights the existence of relationship between malnutrition and outcome in this p...

journal_title：Kidney international

authors： Ikizler TA,Hakim RM

更新日期：1996-08-01 00:00:00

abstract：:Intrauterine growth retardation (IUGR) aggravates the course of acute mesangioproliferative glomerulonephritis (GN) in the rat. Observational studies in children suggest that IUGR may be associated with a severe course of kidney diseases such as IgA nephropathy. We tested the hypothesis that IUGR leads to aggravation ...

journal_title：Kidney international

authors： Plank C,Ostreicher I,Hartner A,Marek I,Struwe FG,Amann K,Hilgers KF,Rascher W,Dötsch J

更新日期：2006-12-01 00:00:00

abstract：:Although much emphasis has been placed on screening for albuminuria in type II diabetic patients, less attention has been focused on the role of glomerular filtration rate (GFR) in the assessment of risk. Herein, we examined the association between GFR and vascular complications in a consecutive cohort of 5174 type II...

journal_title：Kidney international

authors： Kong AP,So WY,Szeto CC,Chan NN,Luk A,Ma RC,Ozaki R,Ng VW,Ho CS,Lam CW,Chow CC,Cockram CS,Chan JC,Tong PC

更新日期：2006-01-01 00:00:00

abstract：:The primary goal of this study was to determine if the ability to undergo catch-up growth following a transient injury is preserved in an experimental model of moderate chronic renal failure (CRF) and the effect of growth hormone (GH) administration on such phenomenon. Young rats were subtotally nephrectomized (days 0...

journal_title：Kidney international

authors： Molinos I,Santos F,Carbajo-Perez E,Garcia E,Rodriguez J,Garcia-Alvarez O,Gil H,Ordoñez FA,Loredo V,Mallada L

更新日期：2006-12-01 00:00:00

abstract：:A controlled trial of cyclosporine in patients diagnosed with progressive membranous nephropathy (MGN) was carried out to determine whether cyclosporine (D) would be more effective than placebo (P) in reducing the rate of deterioration in renal function. Patients (N = 64) with MGN were placed on a restricted protein d...

journal_title：Kidney international

authors： Cattran DC,Greenwood C,Ritchie S,Bernstein K,Churchill DN,Clark WF,Morrin PA,Lavoie S

更新日期：1995-04-01 00:00:00

abstract：:Thrombotic microangiopathy (TMA) is a pattern of endothelial damage that can be found in association with diverse clinical conditions such as malignant hypertension. Although the pathophysiological mechanisms differ, accumulating evidence links complement dysregulation to various TMA syndromes and in particular the at...

journal_title：Kidney international

authors： Timmermans SAMEG,Abdul-Hamid MA,Vanderlocht J,Damoiseaux JGMC,Reutelingsperger CP,van Paassen P,Limburg Renal Registry.

更新日期：2017-06-01 00:00:00

abstract：:Among Canadians starting dialysis, patients of East Asian and Indo Asian background are less likely than whites to receive a renal allograft. Although the reasons for such variation are complex, less living donation may contribute significantly. More studies are needed to confirm these differences and to evaluate stra...

journal_title：Kidney international

authors： Prasad GV

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Adrenomedullin (ADM) exerts antiproliferative effects on rat mesangial cells in vitro and, therefore is a possible renoprotective agent. In contrast, nitric oxide (NO) is capable of exerting both cytoprotective and cytotoxic actions. It was the objective of the present study to examine whether NO stimulates ...

journal_title：Kidney international

authors： Dötsch J,Schoof E,Schöcklmann HO,Brüne B,Knerr I,Repp R,Rascher W

更新日期：2002-05-01 00:00:00

abstract：:Patients cared for in the intensive care unit (ICU) undergo multiple interventions to treat serious medical conditions. In addition to the acute illness being treated, underlying chronic conditions require ongoing drug therapy. As a result, these patients are exposed to numerous pharmaceutical agents, many of which ha...

journal_title：Kidney international

authors： Perazella MA

更新日期：2012-06-01 00:00:00

abstract：:Multiple microRNAs (miRs) are implicated in muscle cell differentiation and muscle mass regulation. Pharmacological agents targeting miR-486 and other miRs, involved in muscle mass regulation, could potentially be developed into therapeutic agents for muscle wasting. Muscle wasting is prevalent among patients with chr...

journal_title：Kidney international

authors： Mak RH,Cheung WW

更新日期：2012-08-01 00:00:00

abstract：:Despite the high cardiovascular risk associated with chronic kidney disease, a recent systematic review confirmed that patients with kidney disease remain underrepresented in cardiovascular trials. Two ongoing trials are assessing the risk:benefit of aggressive evaluation and intervention for ischemic heart disease in...

journal_title：Kidney international

authors： Wyatt CM,Shineski M,Chertow GM,Bangalore S

更新日期：2016-06-01 00:00:00

abstract：:Incorporation in vivo of labeled orotate into RNA and total nucleotides was measured in isolated glomeruli and whole renal cortex. In 2-day diabetic animals, glomerular RNA was increased, and there was greater incorporation of orotate into total nucleotides and RNA as compared with controls. Insulin reversed the exagg...

journal_title：Kidney international

authors： Cortes P,Dumler F,Venkatachalam KK,Goldman J,Sastry KS,Venkatachalam H,Bernstein J,Levin NW

更新日期：1981-10-01 00:00:00

abstract：:Toward an etiological classification of developmental disorders of the kidney and upper urinary tract. There are a large number of developmental disorders and syndromes that affect the kidney and upper urinary tract. These have generally been classified according to morphological criteria established decades ago. Alth...

journal_title：Kidney international

authors： Pohl M,Bhatnagar V,Mendoza SA,Nigam SK

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The feasibility of simultaneously infusing glucose and amino acid (AA)-based peritoneal dialysis solutions was tested to determine whether peritoneal dialysis patients could achieve an adequate nonprotein calorie/nitrogen ratio while preventing a marked increase in blood urea nitrogen (BUN), which is usually...

journal_title：Kidney international

authors： Canepa A,Carrea A,Menoni S,Verrina E,Trivelli A,Gusmano R,Perfumo F

更新日期：2001-05-01 00:00:00

abstract：:Alport syndrome is experiencing a remarkable increase in preclinical investigations. To proactively address the needs of the Alport syndrome community, as well as offer clarity for future clinical research sponsors, the Alport Syndrome Foundation hosted a workshop to generate consensus recommendations for prospective ...

journal_title：Kidney international

authors： Weinstock BA,Feldman DL,Fornoni A,Gross O,Kashtan CE,Lagas S,Lennon R,Miner JH,Rheault MN,Simon JF,Workshop Participants.

更新日期：2020-06-01 00:00:00

abstract：:In organ donation, the donor, recipient, and transplant team must all accept potential health risks to the donor and any uncertainties. To gauge these risks, we surveyed general altruism and risk-taking behaviors in 112 potential donors, 111 potential recipients, and 51 transplant professionals. Next, participants ind...

journal_title：Kidney international

authors： Young A,Karpinski M,Treleaven D,Waterman A,Parikh CR,Thiessen-Philbrook H,Yang RC,Garg AX

更新日期：2008-05-01 00:00:00

abstract：:To test the contribution of bicarbonate (Bi) to hemodynamic stability during hemodialysis (HD), we compared the effects of ultrafiltration dialysis with bicarbonate and with acetate under conditions of high-sodium (141 mEq/liter) and low-sodium (130 mEq/liter) dialysate concentrations in 12 stable HD patients. Group 1...

journal_title：Kidney international

authors： Velez RL,Woodard TD,Henrich WL

更新日期：1984-07-01 00:00:00

abstract：:To analyze the role of clusterin in renal diseases involving a regenerative process, we have used a novel rodent model to compare temporal and spatial expression of clusterin mRNA. Thus, renal artery stenosis was used to induce unilateral non-infarctive renal atrophy. After several weeks, when cellular pathology of at...

journal_title：Kidney international

authors： Gobé GC,Buttyan R,Wyburn KR,Etheridge MR,Smith PJ

更新日期：1995-02-01 00:00:00

abstract：:The sympathetic nervous system modulates renal function through its receptors namely beta1 (cardiac output and renin release), alpha1 (systemic and renovascular constriction), and beta2 renovascular dilation. Sympathetic overactivity is commonly seen in chronic kidney disease (CKD) and is an important contributor to i...

journal_title：Kidney international

authors： Bakris GL,Hart P,Ritz E

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:We have recently found evidence for increased reactive oxygen species (ROS) in rats with lead-induced hypertension. We hypothesized that increased ROS activity may contribute to hypertension by enhancing inactivation of nitric oxide (NO) in this model. METHODS:Rats were treated for 12 weeks with either lead...

journal_title：Kidney international

authors： Vaziri ND,Liang K,Ding Y

更新日期：1999-10-01 00:00:00

abstract：:In experimental membranous nephropathy, antibody binding to glomerular epithelial cell membrane antigens results in complement activation and formation of complement C5b-9 membrane attack complexes in glomeruli. During active disease, the C5b-9 complexes are shed into the urine. To test the hypothesis that a similar m...

journal_title：Kidney international

authors： Schulze M,Donadio JV Jr,Pruchno CJ,Baker PJ,Johnson RJ,Stahl RA,Watkins S,Martin DC,Wurzner R,Gotze O

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:The cardiovascular effects of angiotensin II are mediated by the angiotensin II type 1 receptor (AGT1R); one polymorphism of the AGT1R gene, A1166-->C, has been associated with hypertension. The hemodynamic response to angiotensin II is blunted in women compared to men, but interactions between gender, blood...

journal_title：Kidney international

authors： Reich H,Duncan JA,Weinstein J,Cattran DC,Scholey JW,Miller JA

更新日期：2003-04-01 00:00:00

abstract：:The defect in urinary acidification induced by amphotericin B (AMB) was further characterized in turtle bladder. Since AMB has been shown to increase the hydrogen ion (H+) permeability of this epithelium in the absence of exogenous bicarbonate ions (HCO3-), we explored the permeability characteristics in the presence ...

journal_title：Kidney international

authors： Finn JT,Cohen LH,Steinmetz PR

更新日期：1977-04-01 00:00:00

abstract：:Monocyte and macrophage markers are among the most highly overexpressed genes in cpk mouse kidneys with severely progressive renal cystic disease. We show here that one of these markers, CD14, is abnormally transcribed, activated and shed in cystic kidneys. However, these abnormalities were not associated with an incr...

journal_title：Kidney international

authors： Zhou J,Ouyang X,Cui X,Schoeb TR,Smythies LE,Johnson MR,Guay-Woodford LM,Chapman AB,Mrug M

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Renal tract malformations are, on occasion, associated with uterine malformations. The transcription factor hepatocyte nuclear factor (HNF)-1beta is expressed from the earliest stages of development of the Wolffian duct, the mesonephros and metanephros, and the Müllerian ducts in the mouse. In adult mice HNF...

journal_title：Kidney international

authors： Bingham C,Ellard S,Cole TR,Jones KE,Allen LI,Goodship JA,Goodship TH,Bakalinova-Pugh D,Russell GI,Woolf AS,Nicholls AJ,Hattersley AT

更新日期：2002-04-01 00:00:00

abstract：:Although angiotensin-converting enzyme (ACE) inhibitors are well-established drugs in the treatment of hypertension, they are not supposed to be sufficient in the inhibition of aldosterone formation. The present study analyzes the effect of aldosterone receptor antagonist, spironolactone and ACE inhibitor, captopril o...

journal_title：Kidney international

authors： Pechanova O,Matuskova J,Capikova D,Jendekova L,Paulis L,Simko F

更新日期：2006-07-01 00:00:00

abstract：:Cilnidipine, a dual L-/N-type calcium channel blocker, dilates both efferent and afferent arterioles and is renoprotective. Our multi-center, open-labeled, and randomized trial compared the antiproteinuric effect of cilnidipine with that of amlodipine in hypertensive patients with kidney disease. A group of 339 patien...

journal_title：Kidney international

authors： Fujita T,Ando K,Nishimura H,Ideura T,Yasuda G,Isshiki M,Takahashi K,Cilnidipine versus Amlodipine Randomised Trial for Evaluation in Renal Desease(CARTER) Study Investigators.

更新日期：2007-12-01 00:00:00