当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Renal CD14 expression correlates with the progression of cystic kidney disease.

Renal CD14 expression correlates with the progression of cystic kidney disease.

Abstract：

:Monocyte and macrophage markers are among the most highly overexpressed genes in cpk mouse kidneys with severely progressive renal cystic disease. We show here that one of these markers, CD14, is abnormally transcribed, activated and shed in cystic kidneys. However, these abnormalities were not associated with an increased number of interstitial CD14-positive mononuclear cells. Instead, we found that most non-cystic and cystic renal tubular epithelia were CD14-positive; even distal nephron-derived principal cells. Cd14 was significantly overexpressed in the kidneys of 5-day-old cpk mice and further increased as the disease progressed. In the cpk model with variable rates of cystic kidney enlargement (due to an intercross of two distinct genetic backgrounds), Cd14 expression positively correlated with kidney volume, exceeding the correlation with MCP-1, an established marker of autosomal-dominant polycystic kidney disease (ADPKD). In 16 patients with ADPKD, the baseline urinary CD14 level showed some tendency to correlate with the 2-year change in total kidney volume; however, the tendency was not statistically significant. But the association was significant when the analysis was confined to males. Clearly more studies need to be done to evaluate the utility of CD14 as a marker for outcomes in ADPKD.

journal_name

Kidney Int

journal_title

Kidney international

authors

Zhou J,Ouyang X,Cui X,Schoeb TR,Smythies LE,Johnson MR,Guay-Woodford LM,Chapman AB,Mrug M

doi

10.1038/ki.2010.175

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

550-60

issue

6

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)54580-8

journal_volume

78

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Expression of CR1 (CD35) mRNA in podocytes from adult and fetal human kidneys.

    abstract：:The presence of CR1 mRNA in podocytes was investigated using a 35S-labeled CR1 cDNA probe and in situ hybridization in sections from fetal and adult human kidneys. CR1 mRNA was only detected in immature podocytes at early stages of glomerular differentiation in the fetal kidney. In contrast, CR1 antigen was abundantly...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.198

    authors： Appay MD,Kazatchkine MD,Levi-Strauss M,Hinglais N,Bariety J

    更新日期：1990-08-01 00:00:00

  • Gene expression variance based on random sequencing in rat remnant kidney.

    abstract：BACKGROUND:Several examinations have been performed to identify the genes involved in chronic renal failure using 5/6 nephrectomized rats. Recently, many systematic techniques for examining molecular expression have been developed. They might also be effective in elucidating the molecular mechanism of progressive renal...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00704.x

    authors： Horiba N,Masuda S,Takeuchi A,Saito H,Okuda M,Inui K

    更新日期：2004-07-01 00:00:00

  • Humoral control of water and electrolyte excretion during water restriction.

    abstract：:The goals of the present study were twofold: first, to assess the renal excretory and hormonal responses to chronic water restriction in dogs whose sodium retaining mechanisms had been stimulated through dietary sodium (Na+) deprivation; second, to determine the mediator(s) of the natriuresis which was observed with w...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1986.121

    authors： Merrill DC,Skelton MM,Cowley AW Jr

    更新日期：1986-06-01 00:00:00

  • Renal ENaC subunit, Na-K-2Cl and Na-Cl cotransporter abundances in aged, water-restricted F344 x Brown Norway rats.

    abstract：:Renal sodium reabsorption is a key determinant of final urine concentration. Our aim was to determine whether differences existed between aged and young rats in their response to water restriction with regard to the regulation of abundance of any of the major distal renal sodium transporter proteins. Male Fisher 344 x...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000076

    authors： Tian Y,Riazi S,Khan O,Klein JD,Sugimura Y,Verbalis JG,Ecelbarger CA

    更新日期：2006-01-01 00:00:00

  • Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts.

    abstract：:Screening for chronic kidney disease is recommended in people at high risk, but data on the independent and combined associations of estimated glomerular filtration rate (eGFR) and albuminuria with all-cause and cardiovascular mortality are limited. To clarify this, we performed a collaborative meta-analysis of 10 coh...

    journal_title：Kidney international

    pub_type： 杂志文章,meta分析

    doi：10.1038/ki.2010.536

    authors： van der Velde M,Matsushita K,Coresh J,Astor BC,Woodward M,Levey A,de Jong P,Gansevoort RT,Chronic Kidney Disease Prognosis Consortium.,van der Velde M,Matsushita K,Coresh J,Astor BC,Woodward M,Levey AS,de Jong PE,Gansevoo

    更新日期：2011-06-01 00:00:00

  • Nature of glomerular dysfunction in pre-eclampsia.

    abstract：BACKGROUND:Pre-eclampsia is characterized by hypertension, proteinuria and edema. Simultaneous studies of kidney function and structure have not been reported. We wished to explore the degree and nature of glomerular dysfunction in pre-eclampsia. METHODS:Physiologic techniques were used to estimate glomerular filtrati...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00097.x

    authors： Lafayette RA,Druzin M,Sibley R,Derby G,Malik T,Huie P,Polhemus C,Deen WM,Myers BD

    更新日期：1998-10-01 00:00:00

  • Modulation by calcium of the inhibitor activity of naturally occurring urinary inhibitors.

    abstract：:The possibility that hypercalciuria could cause calcium stone formation through a mechanism other than by increasing urinary saturation of stone-forming calcium salts was explored. The effect of increasing calcium concentration on the inhibitor activity against the spontaneous precipitation of calcium oxalate was exam...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.100

    authors： Zerwekh JE,Hwang TI,Poindexter J,Hill K,Wendell G,Pak CY

    更新日期：1988-05-01 00:00:00

  • Developmental regulation and partial-length cloning of tubulointerstitial nephritis antigen of murine metanephros.

    abstract：:Tubulointerstitial nephritis antigen (TIN-ag) is an extracellular matrix (ECM) glycoprotein that has been recently isolated and cloned from the rabbit kidney. It is an integral component of the basal lamina, and unlike other basement membrane proteins it is exclusively expressed in the tubular basement membranes (TBMs...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.375

    authors： Kumar A,Ota K,Wada J,Wallner EI,Charonis AS,Carone FA,Kanwar YS

    更新日期：1997-09-01 00:00:00

  • Adrenergic modulation of extrarenal potassium disposal in men with end-stage renal disease.

    abstract：:In normal subjects, beta-adrenergic stimulation lowers the serum potassium, whereas alpha-stimulation raises it. Epinephrine, a mixed alpha and beta agonist, acutely lowers the blood potassium in normal subjects, but not in patients with end-stage renal disease. This study was designed to determine whether the resista...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1991.321

    authors： Allon M,Shanklin N

    更新日期：1991-12-01 00:00:00

  • Time to consider ACE insertion/deletion genotypes and individual renoprotective treatment in diabetic nephropathy?

    abstract：:One reason for the inadequacy of current renoprotective therapy and the persistent poor renal prognosis in diabetic nephropathy is the large interindividual variation in response to treatment. Genetic as well as non-genetic factors are known to influence treatment efficacy. This Commentary summarizes the impact of the...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/sj.ki.5000283

    authors： Jacobsen PK,Tarnow L,Parving HH

    更新日期：2006-04-01 00:00:00

  • Classical complement pathway activation in membranoproliferative glomerulonephritis.

    abstract：:Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1976.6

    authors： Ooi YM,Vallota EH,West CD

    更新日期：1976-01-01 00:00:00

  • Cardiac hypertrophy and remodeling in relation to ACE and angiotensinogen genes genotypes in Chinese dialysis patients.

    abstract：BACKGROUND:Genetic polymorphisms of the angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) genes are associated with increased risk of hypertension and left ventricular hypertrophy (LVH) in hypertensive subjects. However, the extent to which these polymorphisms are related to LVH and remodeling in dialysis p...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00933.x

    authors： Wang AY,Chan JC,Wang M,Poon E,Lui SF,Li PK,Sanderson J

    更新日期：2003-05-01 00:00:00

  • Characterization of glycosaminoglycans in tubular epithelial cells: calcium oxalate and oxalate ions effects.

    abstract：BACKGROUND:The interaction between tubular epithelial cells and calcium oxalate crystals or oxalate ions is a very precarious event in the lithogenesis. Urine contains ions, glycoproteins and glycosaminoglycans that inhibit the crystallization process and may protect the kidney against lithogenesis. We examined the eff...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00577.x

    authors： Borges FT,Michelacci YM,Aguiar JA,Dalboni MA,Garófalo AS,Schor N

    更新日期：2005-10-01 00:00:00

  • Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or II.

    abstract：BACKGROUND:Hyperoxaluria may be idiopathic, secondary, or due to primary hyperoxaluria (PH). Hepatic alanine:glyoxylate aminotransferase (AGT) or glyoxylate/hydroxypyruvate reductase (GR/HPR) deficiency causes PHI or PHII, respectively. Hepatic glycolate oxidase (GO) is a candidate enzyme for a third form of inherited ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00468.x

    authors： Monico CG,Persson M,Ford GC,Rumsby G,Milliner DS

    更新日期：2002-08-01 00:00:00

  • Effect of acute potassium load on reabsorption in Henle's loop in chronic renal failure in the rat.

    abstract：:To determine the effect of an acute load of potassium on potassium reabsorption by the loop of Henle in chronic renal failure, the right kidney was removed and branches of the left renal artery were ligated in 17 rats. One week later and after 2 days of a potassium-free diet, rats were studied before (period 1) and af...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1985.100

    authors： Milanes CL,Jamison RL

    更新日期：1985-06-01 00:00:00

  • Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro.

    abstract：:Membranous nephropathy is a major cause of nephrotic syndrome in adults where podocyte injuries were found to mediate the development of proteinuria. Triptolide, a major active component of Tripterygium wilfordii Hook F, has potent immunosuppressive, anti-inflammatory and antiproteinuric effects. To study its antiprot...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2010.41

    authors： Chen ZH,Qin WS,Zeng CH,Zheng CX,Hong YM,Lu YZ,Li LS,Liu ZH

    更新日期：2010-06-01 00:00:00

  • Alpha-adrenoceptors and angiotensinogen gene expression in opossum kidney cells.

    abstract：:To investigate whether alpha (alpha)-adrenoceptor agonists have a stimulatory effect on the expression of the angiotensinogen (Ang) gene in opossum kidney (OK) cells, we used OK 27 cells with a fusion gene containing the 5'-flanking regulatory sequence of the rat angiotensinogen gene fused with a human growth hormone ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.277

    authors： Wang TT,Lachance S,Delalandre A,Carrière S,Chan JS

    更新日期：1995-07-01 00:00:00

  • Carbamylation-induced alterations in low-density lipoprotein metabolism.

    abstract：:Low-density lipoprotein was derived from carbamyl (carbamyl-LDL) by incubating LDL in potassium cyanate (KCNO). The proportion of free amino groups in the carbamyl-LDL was negatively correlated (r = -0.95) with the time of incubation in potassium cyanate (ranged from 5 to 360 min). The carbamylation did not change the...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1992.179

    authors： Hörkkö S,Savolainen MJ,Kervinen K,Kesäniemi YA

    更新日期：1992-05-01 00:00:00

  • Subtotal nephrectomy impairs ischemia-induced angiogenesis and hindlimb re-perfusion in rats.

    abstract：:Kidney disease is associated with increased cardiovascular morbidity, but underlying mechanisms are poorly understood. We tested the hypothesis that chronic renal insufficiency impairs angioadaptation in a rat model of hindlimb ischemia. Twenty male Sprague-Dawley rats (8 weeks old) underwent subtotal nephrectomy (5/6...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000448

    authors： Jacobi J,Porst M,Cordasic N,Namer B,Schmieder RE,Eckardt KU,Hilgers KF

    更新日期：2006-06-01 00:00:00

  • Role of cGMP as second messenger of adenosine in the inhibition of renin release.

    abstract：:Adenosine is known to be a potent inhibitor of renin release from the kidneys. The aim of this study was to investigate the transmembrane signalling avenue that the second messenger of adenosine causes inhibition of renal renin release. Using short term cultures of juxtaglomerular cells isolated from rat kidneys, we f...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.70

    authors： Kurtz A,Della Bruna R,Pfeilschifter J,Bauer C

    更新日期：1988-04-01 00:00:00

  • Chronic renal failure with gout: a marker of chronic lead poisoning.

    abstract：:EDTA (calcium disodium edetate) lead mobilization and x-ray fluorescence (XRF) finger bone lead tests were done in 42 patients with chronic renal failure and without persisting lead intoxication. Nineteen of 23 patients with gout and 8 of 19 without gout had positive EDTA lead mobilization tests. Those patients with g...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1984.175

    authors： Craswell PW,Price J,Boyle PD,Heazlewood VJ,Baddeley H,Lloyd HM,Thomas BJ,Thomas BW

    更新日期：1984-09-01 00:00:00

  • Cardiorenal effects of celecoxib as compared with the nonsteroidal anti-inflammatory drugs diclofenac and ibuprofen.

    abstract：:The cardiorenal safety database from the Celecoxib Long-term Arthritis Safety Study (CLASS) was analyzed to examine whether supratherapeutic doses of celecoxib are associated with decreased renal function and blood pressure (BP) effects compared with standard doses of diclofenac and ibuprofen in osteoarthritis (OA) an...

    journal_title：Kidney international

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/sj.ki.5001766

    authors： Whelton A,Lefkowith JL,West CR,Verburg KM

    更新日期：2006-10-01 00:00:00

  • Role of the 11beta-hydroxysteroid dehydrogenase type 2 in blood pressure regulation.

    abstract：:The renal 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) enzyme inactivates 11-hydroxy steroids in the kidney, thus protecting the nonselective mineralocorticoid receptor (MR) from occupation by glucocorticoids. The gene is highly expressed in all sodium-transporting epithelia, but also in human placenta, pan...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1046/j.1523-1755.2000.00978.x

    authors： Ferrari P,Krozowski Z

    更新日期：2000-04-01 00:00:00

  • Hereditary systemic amyloidosis associated with a new apolipoprotein AII stop codon mutation Stop78Arg.

    abstract：UNLABELLED:Hereditary systemic amyloidosis associated with a new apolipoprotein AII stop codon mutation Stop78Arg. BACKGROUND:Mutations in the gene for apolipoprotein AII (apoAII) have recently been found to cause hereditary renal amyloidosis. In each case amyloid deposition has been associated with a peptide extensio...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00047.x

    authors： Yazaki M,Liepnieks JJ,Barats MS,Cohen AH,Benson MD

    更新日期：2003-07-01 00:00:00

  • Hemolysis-associated hemoglobin cast nephropathy results from a range of clinicopathologic disorders.

    abstract：:Intravascular hemolysis is relatively rare but can lead to acute kidney injury (AKI), from increased destruction of erythrocytes and release of free hemoglobin. Since hemolysis and hemoglobinuria are known causes of acute kidney injury we sought to define clinicopathologic findings and outcomes of patients with hemoly...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2019.08.026

    authors： Dvanajscak Z,Walker PD,Cossey LN,Messias NC,Boils CL,Kuperman MB,Larsen CP

    更新日期：2019-12-01 00:00:00

  • Prospective assessment of antidonor cellular alloreactivity is a tool for guidance of immunosuppression in kidney transplantation.

    abstract：:Current characterization of the immune risk in renal transplant patients is only focused on the assessment of preformed circulating alloantibodies; however, alloreactive memory T cells are key players in mediating allograft rejection. Immune monitoring of antidonor alloreactive memory/effector T cells using an IFN-γ E...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.236

    authors： Bestard O,Cruzado JM,Lucia M,Crespo E,Casis L,Sawitzki B,Vogt K,Cantarell C,Torras J,Melilli E,Mast R,Martinez-Castelao A,Gomà M,Reinke P,Volk HD,Grinyó JM

    更新日期：2013-12-01 00:00:00

  • Cyclosporin in idiopathic glomerular disease associated with the nephrotic syndrome : workshop recommendations.

    abstract：:Management of idiopathic glomerular disease associated with nephrotic syndrome (INS) remains controversial and one of the most complex areas relates to utilization of the drug cyclosporin. This is despite its demonstrated effectiveness in several histologic types of the INS in randomized controlled trials. Cyclosporin...

    journal_title：Kidney international

    pub_type： 共识发展会议,杂志文章

    doi：10.1038/sj.ki.5002553

    authors： Cattran DC,Alexopoulos E,Heering P,Hoyer PF,Johnston A,Meyrier A,Ponticelli C,Saito T,Choukroun G,Nachman P,Praga M,Yoshikawa N

    更新日期：2007-12-01 00:00:00

  • An angiotensin II receptor blocker-calcium channel blocker combination prevents cardiovascular events in elderly high-risk hypertensive patients with chronic kidney disease better than high-dose angiotensin II receptor blockade alone.

    abstract：:The OSCAR study was a multicenter, prospective randomized open-label blinded end-point study of 1164 Japanese elderly hypertensive patients comparing the efficacy of angiotensin II receptor blocker (ARB) uptitration to an ARB plus calcium channel blocker (CCB) combination. In this prospective study, we performed presp...

    journal_title：Kidney international

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/ki.2012.326

    authors： Kim-Mitsuyama S,Ogawa H,Matsui K,Jinnouchi T,Jinnouchi H,Arakawa K

    更新日期：2013-01-01 00:00:00

  • Effect of early glucocorticoid treatment on MR and GR in late gestation ovine kidney.

    abstract：BACKGROUND:The ontogeny of the renal mineralocorticoid (MR) and glucocorticoid (GR) receptors in the ovine fetus, and the effects of early exposure to synthetic or natural glucocorticoids on the expression of these genes in late gestation were examined. METHODS:A partial cDNA sequence for the ovine MR was cloned and u...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00157.x

    authors： Hantzis V,Albiston A,Matsacos D,Wintour EM,Peers A,Koukoulas I,Myles K,Moritz K,Dodic M

    更新日期：2002-02-01 00:00:00

  • Role of an improvement in acid-base status and nutrition in CAPD patients.

    abstract：:Short-term correction of metabolic acidosis in normal and uremic subjects has been shown to decrease protein degradation, but the long-term effects of better correction of acidosis on nutrition in ESRF are unknown. The aim of this study was to assess the possible benefits, in the nutritional state and morbidity, of im...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/ki.1997.433

    authors： Stein A,Moorhouse J,Iles-Smith H,Baker F,Johnstone J,James G,Troughton J,Bircher G,Walls J

    更新日期：1997-10-01 00:00:00